| Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017-Utility and Limitations |
69 |
| CRISPR-Mediated Tagging of Endogenous Proteins with a Luminescent Peptide |
43 |
| Quantitative Live-Cell Kinetic Degradation and Mechanistic Profiling of PROTAC Mode of Action |
38 |
| Playing with the Molecules of Life |
38 |
| Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis |
28 |
| Enzyme-Activated Fluorogenic Probes for Live-Cell and in Vivo Imaging |
28 |
| CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine |
27 |
| SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate |
26 |
| The Role of ClpP Protease in Bacterial Pathogenesis and Human Diseases |
24 |
| Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications |
24 |
| PROTAC-Mediated Degradation of Bruton's Tyrosine Kinase Is Inhibited by Covalent Binding |
23 |
| Directed Evolution of Split APEX2 Peroxidase |
23 |
| Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6 |
22 |
| Development of Stabilized Peptide-Based PROTACs against Estrogen Receptor alpha |
21 |
| Selective Small-Molecule Targeting of a Triple Helix Encoded by the Long Noncoding RNA, MALAT1 |
20 |
| Translation Termination Factor GSPT1 Is a Phenotypically Relevant Off-Target of Heterobifunctional Phthalimide Degraders |
20 |
| Cellular Resistance Mechanisms to Targeted Protein Degradation Converge Toward Impairment of the Engaged Ubiquitin Transfer Pathway |
19 |
| NCI Program for Natural Product Discovery: A Publicly-Accessible Library of Natural Product Fractions for High-Throughput Screening |
19 |
| Editing the Genome Without Double-Stranded DNA Breaks |
18 |
| Design and Characterization of SGK3-PROTAC an Isoform Specific SGK3 Kinase PROTAC Degrader |
17 |
| Histone Deacetylase 11 Is a Fatty-Acid Deacylase |
17 |
| Modulating DNA Repair Pathways to Improve Precision Genome Engineering |
17 |
| Can CRISPR-Based Gene Drive Be Confined in the Wild? A Question for Molecular and Population Biology |
17 |
| Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader |
16 |
| A Single-Chain Photoswitchable CRISPR-Cas9 Architecture for Light-Inducible Gene Editing and Transcription |
16 |
| Multistep Inhibition of alpha-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine |
16 |
| The Role of Reactive Oxygen Species and Ferroptosis in Heme-Mediated Activation of Human Platelets |
16 |
| Dual Allosteric Inhibition of SHP2 Phosphatase |
16 |
| Precise Small Molecule Degradation of a Noncoding RNA Identifies Cellular Binding Sites and Modulates an Oncogenic Phenotype |
16 |
| Specific Recognition of Promoter G-Quadruplex DNAs by Small Molecule Ligands and Light-up Probes |
15 |
| DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome |
15 |
| Genetic Code Expansion in Animals |
15 |
| Chemistry of Photosensitive Fluorophores for Single-Molecule Localization Microscopy |
15 |
| Biosynthesis and Chemical Applications of Thioamides |
14 |
| Homo-PROTACs for the Chemical Knockdown of Cereblon |
14 |
| Fluorescent Chemosensors as Future Tools for Cancer Biology |
14 |
| Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity |
13 |
| Secondary Forces in Protein Folding |
13 |
| Mechanisms of Incorporation for D-Amino Acid Probes That Target Peptidoglycan Biosynthesis |
13 |
| Norbornene Probes for the Detection of Cysteine Sulfenic Acid in Cells |
13 |
| Chemoenzymatic Synthesis of N-glycan Positional Isomers and Evidence for Branch Selective Binding by Monoclonal Antibodies and Human C-type Lectin Receptors |
13 |
| Antibody Fucosylation Lowers the Fc gamma RIIIa/CD16a Affinity by Limiting the Conformations Sampled by the N162-Glycan |
13 |
| Mitochondrial-Localized Versus Cytosolic Intracellular CO-Releasing Organic PhotoCORMs: Evaluation of CO Effects Using Bioenergetics |
12 |
| Unexpected Bacterial Origin of the Antibiotic Icosalide: Two-Tailed Depsipeptide Assembly in Multifarious Burkholderia Symbionts |
12 |
| Type II-C CRISPR-Cas9 Biology, Mechanism, and Application |
12 |
| High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl-2 Binding |
12 |
| Antimicrobial Metallopeptides |
12 |
| Human Milk Oligosaccharides (HMOs) Sensitize Group B Streptococcus to Clindamycin, Erythromycin, Gentamicin, and Minocycline on a Strain Specific Basis |
12 |
| Rational-Differential Design of Highly Specific Glycomimetic Ligands: Targeting DC-SIGN and Excluding Langerin Recognition |
12 |
| Predicting and Experimentally Validating Hot-Spot Residues at Protein-Protein Interfaces |
11 |
