| 3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs |
74 |
| A synthetic biology approach to transform Yarrowia lipolytica into a competitive biotechnological producer of beta-carotene |
45 |
| Progression of continuous downstream processing of monoclonal antibodies: Current trends and challenges |
20 |
| cGMP production and analysis of BG505 SOSIP. an extensively glycosylated, trimeric HIV-1 envelope glycoprotein vaccine candidate |
19 |
| Fine-tuning the (2S)-naringenin synthetic pathway using an iterative high-throughput balancing strategy |
18 |
| Advances in applications of rhamnolipids biosurfactant in environmental remediation: A review |
18 |
| A reference genome of the Chinese hamster based on a hybrid assembly strategy |
18 |
| Lignocellulosic biomass to biofuels and biochemicals: A comprehensive review with a focus on ethanol organosolv pretreatment technology |
18 |
| 3D aggregate culture improves metabolic maturation of human pluripotent stem cell derived cardiomyocytes |
17 |
| CRISPR-Cas9(D10A) nickase-assisted base editing in the solvent producer Clostridium beijerinckii |
17 |
| Engineering Escherichia coli for malate production by integrating modular pathway characterization with CRISPRi-guided multiplexed metabolic tuning |
16 |
| Photoautotrophic production of macular pigment in a Chlamydomonas reinhardtii strain generated by using DNA-free CRISPR-Cas9 RNP-mediated mutagenesis |
14 |
| Production of itaconic acid from acetate by engineering acid-tolerant Escherichia coli W |
14 |
| Optimized protocol for the hepatic differentiation of induced pluripotent stem cells in a fluidic microenvironment |
14 |
| Enhancement of biomass and lipid productivity by overexpression of a bZIP transcription factor in Nannochloropsis salina |
14 |
| Synthetic biology for bioengineering virus-like particle vaccines |
14 |
| Consolidated bioprocessing of lignocellulosic biomass to lactic acid by a synthetic fungal-bacterial consortium |
13 |
| Burkholderia cepacia lipase: A versatile catalyst in synthesis reactions |
13 |
| Karyotype variation of CHO host cell lines over time in culture characterized by chromosome counting and chromosome painting |
13 |
| Glucose-stimulated insulin release: Parallel perifusion studies of free and hydrogel encapsulated human pancreatic islets |
13 |
| A new generation of predictive models: The added value of hybrid models for manufacturing processes of therapeutic proteins |
13 |
| Impact of cell culture media additives on IgG glycosylation produced in Chinese hamster ovary cells |
13 |
| Metabolic engineering of Escherichia coli for the enhanced production of L-tyrosine |
12 |
| Enhanced isobutanol production from acetate by combinatorial overexpression of acetyl-CoA synthetase and anaplerotic enzymes in engineered Escherichia coli |
12 |
| Antibody glycoengineering strategies in mammalian cells |
12 |
| Development of target-tunable P22 VLP-based delivery nanoplatforms using bacterial superglue |
12 |
| Current achievements in the mechanically pretreated conversion of plant biomass |
11 |
| Epigenetic regulation of gene expression in Chinese Hamster Ovary cells in response to the changing environment of a batch culture |
11 |
| Combination drug delivery via multilamellar vesicles enables targeting of tumor cells and tumor vasculature |
11 |
| Enhanced production of poly-gamma-glutamic acid by improving ATP supply in metabolically engineered Bacillus licheniformis |
11 |
| Filter-based isolation, enrichment, and characterization of circulating tumor cells |
11 |
| Combinatorial synthetic pathway fine-tuning and comparative transcriptomics for metabolic engineering of Raoultella ornithinolytica BF60 to efficiently synthesize 5-furandicarboxylic acid |
11 |
| Vitamins in cell culture media: Stability and stabilization strategies |
11 |
| Mechanisms driving the lactate switch in Chinese hamster ovary cells |
11 |
| Product solubility control in cellooligosaccharide production by coupled cellobiose and cellodextrin phosphorylase |
10 |
| Vascularized microfluidic platforms to mimic the tumor microenvironment |
10 |
| Functional expression of aryl-alcohol oxidase in Saccharomyces cerevisiae and Pichia pastoris by directed evolution |
10 |
| Biosynthesis of a ganoderic acid in Saccharomyces cerevisiae by expressing a cytochrome P450 gene from Ganoderma lucidum |
10 |
| Modular pathway engineering of key carbon-precursor supply-pathways for improved N-acetylneuraminic acid production in Bacillus subtilis |
10 |
| Genome-wide identification of tolerance mechanisms toward p-coumaric acid in Pseudomonas putida |
10 |
| Central pathway engineering for enhanced succinate biosynthesis from acetate in Escherichia coli |
10 |
| Intracellular response to process optimization and impact on productivity and product aggregates for a high-titer CHO cell process |
10 |
| Temperature-dependent dynamic control of the TCA cycle increases volumetric productivity of itaconic acid production by Escherichia coli |
10 |
| Improved performance of Pseudomonas putida in a bioelectrochemical system through overexpression of periplasmic glucose dehydrogenase |
10 |
| Anodic electro-fermentation: Anaerobic production of L-Lysine by recombinant Corynebacterium glutamicum |
10 |
| Reduced apoptosis in Chinese hamster ovary cells via optimized CRISPR interference |
9 |
| A tailor-made, self-sufficient and recyclable monooxygenase catalyst based on coimmobilized cytochrome P450 BM3 and glucose dehydrogenase |
9 |
| Resemblance of the human liver sinusoid in a fluidic device with biomedical and pharmaceutical applications |
9 |
| Comparison of microbial and transient expression (tobacco plants and plant-cell packs) for the production and purification of the anticancer mistletoe lectin viscumin |
9 |
| Consequences of trace metal variability and supplementation on Chinese hamster ovary (CHO) cell culture performance: A review of key mechanisms and considerations |
9 |
