-
Identification of an Orally Bioavailable Quinoline-Based Small-Molecule Tumor Necrosis Factor α (TNF-α) Inhibitor Featuring a Spirocyclic Scaffol
Author: Sun, Zeren; Zhang, Wenbin; He, Wanyong; Xu, Jie; Wang, Boning; He, Joshua M.; Zhang, Yuchen; Chen, Pu; Luo, Yao; Gu, Jia; Gu, Hongfeng; Wei, Ping; Sun, Yanan; Yin, Chunxiang; Xing, Hanxi; Luo, Yannan; Zhang, Jing-jing; Zhu, Qihua; Zou, Yi; Xu, Yungen
Journal: JOURNAL OF MEDICINAL CHEMISTRY. 2026; Vol. 69, Issue 8, pp. 8987-9008. DOI: 10.1021/acs.jmedchem.5c03457
-
Dual-Functional Anti-SIRPα-cGAMP Conjugate Reprograms the Tumor Immune Microenvironment and Enhances Antitumor Immunit
Author: Yu, Xiang; Hao, Xiaoyao; Chen, Mingjiu; Baigude, Huricha
Journal: JOURNAL OF MEDICINAL CHEMISTRY. 2026; Vol. 69, Issue 8, pp. 9603-9614. DOI: 10.1021/acs.jmedchem.6c00495
-
A Small-Molecule Platform Demonstrates Light-Activated Synergy Between Cuproptosis and Photodynamic Tumor Therap
Author: Yin, Jikai; Huang, Daipeng; Li, Haolan; Hu, Yifan; Yang, Yuxin; Zhou, Danhong; Long, Saran; Sun, Wen; Du, Jianjun; Fan, Jiangli; Peng, Xiaojun
Journal: JOURNAL OF MEDICINAL CHEMISTRY. 2026; Vol. 69, Issue 8, pp. 9570-9584. DOI: 10.1021/acs.jmedchem.6c00424
-
Nucleoside-ATTEC Conjugates for Targeting Inhibition of HIV Replication and Infectio
Author: Liao, Xiaofeng; Zhang, Kaifu; Wang, Chu; Liu, Mengmeng; Ren, Jinsong; Qu, Xiaogang
Journal: JOURNAL OF MEDICINAL CHEMISTRY. 2026; Vol. 69, Issue 8, pp. 8807-8817. DOI: 10.1021/acs.jmedchem.5c02422
-
Subamnex Ameliorates Hypoxia-Induced Pulmonary Arterial Hypertension through Modulation of the STAT3/p-STAT3 Pathwa
Author: Ge, Rui-Xiang; Shi, Jun-Zhuo; Guo, Bin-Hao; Zhang, Meng-Jie; Zeng, Min; An, Xiao-Rui; Ye, Jing-Song; Cheng, Guo; Fan, Xin; Wang, Meng-Wei; Zhou, Yun-Feng; Li, Xi; Pang, Xiao-Bin; Xie, Xin-Mei; Zhang, Hong-Da; Zhao, Lu-Ling; He, Yang-Yang; Kou, Jie-Jian; Ma, Jing; Yan, Yi
Journal: JOURNAL OF MEDICINAL CHEMISTRY. 2026; Vol. 69, Issue 8, pp. 8790-8806. DOI: 10.1021/acs.jmedchem.5c02221
-
Discovery of FLC-8 as the First Covalent FLT3 Inhibitor Targeting Cys807 for FLT3 Mutant Acute Myeloid Leukemi
Author: Wang, Zi-Xuan; Jing, Xiao-Long; Liu, Qian; Xian, Tong; Yang, Jin; Zhang, Meng-Yuan; Li, Qing-Qing; Cai, Jiao; Yu, Yan-Cheng; Sun, Shan-Liang; Shi, Zhi-Hao; Li, Nian-Guang
Journal: JOURNAL OF MEDICINAL CHEMISTRY. 2026; Vol. 69, Issue 8, pp. 9635-9663. DOI: 10.1021/acs.jmedchem.6c00511
-
New PROTAC Designs for Targeted Protein Degradation in 2021-2025: Novel E3 Ligases and Pre-PROTAC
Author: Peng, Wei; Pan, Xiaoyan; Wang, Shiqun; Huang, Guang; Qian, Yufeng
Journal: JOURNAL OF MEDICINAL CHEMISTRY. 2026; Vol. 69, Issue 8, pp. 8688-8718. DOI: 10.1021/acs.jmedchem.5c03330
-
Discovery and Evaluation of a PROTAC Degrader Targeting SAMHD1 for the Treatment of Pulmonary Fibrosi
Author: Chen, Xing; Zhou, Feilong; Chen, Qiansong; Dong, Jin; Zhang, Yu; Liu, Xinhua; Zhang, Yixuan; Xu, Jianfei
Journal: JOURNAL OF MEDICINAL CHEMISTRY. 2026; Vol. 69, Issue 8, pp. 9363-9385. DOI: 10.1021/acs.jmedchem.6c00025
