| Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication |
392 |
| Recognition of RNA N-6- methyladenosine by IGF2BP proteins enhances mRNA stability and translation |
189 |
| Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation |
180 |
| Cargo recognition and degradation by selective autophagy |
164 |
| mTOR as a central hub of nutrient signalling and cell growth |
153 |
| Cellular functions of long noncoding RNAs |
139 |
| Mechanisms of mitophagy in cellular homeostasis, physiology and pathology |
133 |
| Super-resolution microscopy demystified |
122 |
| The lysosome as a cellular centre for signalling, metabolism and quality control |
120 |
| m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer |
115 |
| A brief history of autophagy from cell biology to physiology and disease |
110 |
| The multifaceted contributions of mitochondria to cellular metabolism |
106 |
| YAP/TAZ upstream signals and downstream responses |
106 |
| Life, death and autophagy |
89 |
| Extracellular vesicle-packaged HIF-1 alpha-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells |
86 |
| Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models |
83 |
| Mitochondrial dynamics in adaptive and maladaptive cellular stress responses |
75 |
| BAP1 links metabolic regulation of ferroptosis to tumour suppression |
73 |
| The dynamic nature of senescence in cancer |
73 |
| Mechanoreciprocity in cell migration |
72 |
| Tumour heterogeneity and metastasis at single-cell resolution |
66 |
| Non-redundant functions of EMT transcription factors |
64 |
| Autophagy and the cell biology of age-related disease |
63 |
| Emerging views of the nucleus as a cellular mechanosensor |
57 |
| Intergenerational and transgenerational epigenetic inheritance in animals |
56 |
| Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs |
53 |
| Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells |
53 |
| Integrin activation by talin, kindlin and mechanical forces |
53 |
| The autophagic network and cancer |
52 |
| Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived beta cells |
52 |
| Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours |
52 |
| Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells |
51 |
| Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening |
50 |
| GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability |
49 |
| RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF NF1-and RAS-driven cancers |
48 |
| 5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs |
48 |
| A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation |
47 |
| RNA modifications regulating cell fate in cancer |
46 |
| Aspartate is an endogenous metabolic limitation for tumour growth |
45 |
| NAD(+) metabolism governs the proinflammatory senescence-associated secretome |
41 |
| TBK1 and IKK epsilon prevent TNF-induced cell death by RIPK1 phosphorylation |
41 |
| ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway |
40 |
| Establishment of porcine and human expanded potential stem cells |
40 |
| Self-assembly of embryonic and two extra- embryonic stem cell types into gastrulating embryo-like structures |
38 |
| Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development |
37 |
| Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis |
37 |
| Non-canonical function of IRE1 alpha determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics |
37 |
| Mesenchymal-epithelial transition in development and reprogramming |
36 |
| Mechanisms and impact of altered tumour mechanics |
35 |
| Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms |
35 |
| Stem cell dynamics, migration and plasticity during wound healing |
34 |
| Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy |
34 |
| ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann-Pick type C |
33 |
| Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization |
33 |
| Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient |
33 |
| Genome-wide screening of NEAT1 regulators reveals cross-regulation between paraspeckles and mitochondria |
33 |
| Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis |
33 |
| Integrin trafficking in cells and tissues |
32 |
| PSPC1 mediates TGF-beta 1 autocrine signalling and Smad2/3 target switching to promote EMT, stemness and metastasis |
32 |
| Denervation-activated STAT3-IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis |
31 |
| A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain |
31 |
| Metabolism as a guiding force for immunity |
30 |
| Chromatin regulatory mechanisms and therapeutic opportunities in cancer |
30 |
| Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification |
29 |
| U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies |
29 |
| Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis |
29 |
| Stage-specific requirement for Mettl3-dependent m(6)A mRNA methylation during haematopoietic stem cell differentiation |
29 |
| Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons |
28 |
| Advances in genome editing through control of DNA repair pathways |
28 |
| Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors |
28 |
| ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression |
27 |
| Dormant tumour cells, their niches and the influence of immunity |
26 |
| Multicolour single-molecule tracking of mRNA interactions with RNP granules |
26 |
| Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy |
26 |
| Distinct functions of ATG16L1 isoforms in membrane binding and LC3B lipidation in autophagy-related processes |
26 |
| Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification |
25 |
| Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression |
25 |
| HER2 recruits AKT1 to disrupt STING signalling and suppress antiviral defence and antitumour immunity |
25 |
| Deconstructing and reconstructing the mouse and human early embryo |
25 |
| Mitochondrial protein-induced stress triggers a global adaptive transcriptional programme |
25 |
| SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis |
25 |
| Nanopillar force measurements reveal actin-cap-mediated YAP mechanotransduction |
25 |
| Early lineage segregation of multipotent embryonic mammary gland progenitors |
24 |
| Turning back time with emerging rejuvenation strategies |
24 |
| The cryo-EM structure of intraflagellar transport trains reveals how dynein is inactivated to ensure unidirectional anterograde movement in cilia |
24 |
| The RNA N-6-methyladenosine modification landscape of human fetal tissues |
24 |
| Advances in stem cell research and therapeutic development |
24 |
| Unresolved recombination intermediates lead to ultra-fine anaphase bridges, chromosome breaks and aberrations |
24 |
| IL-1 beta inflammatory response driven by primary breast cancer prevents metastasis-initiating cell colonization |
24 |
| Single-cell multi-omics sequencing of human early embryos |
24 |
| XMAP215 is a microtubule nucleation factor that functions synergistically with the gamma-tubulin ring complex |
23 |
| AMPK-mediated activation of MCU stimulates mitochondrial Ca2+ entry to promote mitotic progression |
23 |
| A microRNA-inducible CRISPR-Cas9 platform serves as a microRNA sensor and cell-type-specific genome regulation tool |
23 |
| Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP |
23 |
| A chromosome folding intermediate at the condensin-to-cohesin transition during telophase |
23 |
| Non-invasive perturbations of intracellular flow reveal physical principles of cell organization |
22 |
| RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis |
22 |
| AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions |
22 |
| Microtubules gate tau condensation to spatially regulate microtubule functions |
22 |
| LncGata6 maintains stemness of intestinal stem cells and promotes intestinal tumorigenesis |
22 |
| Metastatic niche functions and therapeutic opportunities |
22 |
| A lipid-based partitioning mechanism for selective incorporation of proteins into membranes of HIV particles |
21 |
| N6-methyldeoxyadenine is a transgenerational epigenetic signal for mitochondrial stress adaptation |
21 |
| Serial genomic inversions induce tissue-specific architectural stripes, gene misexpression and congenital malformations |
21 |
| A chromatin integration labelling method enables epigenomic profiling with lower input |
21 |
| Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer |
21 |
| Regulation of cell cycle progression by cell-cell and cell-matrix forces |
21 |
| Tracing the temporal-spatial transcriptome landscapes of the human fetal digestive tract using single-cell RNA-sequencing |
21 |
| Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments |
21 |
| The diverse consequences of aneuploidy |
20 |
| Ultrastructure and dynamics of the actin-myosin II cytoskeleton during mitochondrial fission |
20 |
| Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos |
20 |
| The cell cycle in stem cell proliferation, pluripotency and differentiation |
20 |
| Single-fluorophore biosensors for sensitive and multiplexed detection of signalling activities |
20 |
| Spatial orchestration of mitochondrial translation and OXPHOS complex assembly |
20 |
| A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase-Ragulator lysosomal scaffold |
19 |
| Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response |
19 |
| Mechanical cues control mutant p53 stability through a mevalonate-RhoA axis |
19 |
| Clonal analysis of Notch1-expressing cells reveals the existence of unipotent stem cells that retain long-term plasticity in the embryonic mammary gland |
19 |
| Multicolour lineage tracing reveals clonal dynamics of squamous carcinoma evolution from initiation to metastasis |
19 |
| Haematopoiesis in the era of advanced single-cell technologies |
18 |
| Myosin-Va is required for preciliary vesicle transportation to the mother centriole during ciliogenesis |
18 |
| A 3D model of a human epiblast reveals BMP4-driven symmetry breaking |
18 |
| Decrease in plasma membrane tension triggers PtdIns(5)P-2 phase separation to inactivate TORC2 |
18 |
| The AMPK-Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome |
18 |
| ERBB3 and NGFR mark a distinct skeletal muscle progenitor cell in human development and hPSCs |
17 |
| IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma |
17 |
| TFAP2C regulates transcription in human naive pluripotency by opening enhancers |
17 |
| Defining essential genes for human pluripotent stem cells by CRISPR-Cas9 screening in haploid cells |
17 |
| A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8(+) T cells |
17 |
| Engineering a haematopoietic stem cell niche by revitalizing mesenchymal stromal cells |
17 |
| Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis |
17 |
| Single particle trajectories reveal active endoplasmic reticulum luminal flow |
17 |
| DNA replication acts as an error correction mechanism to maintain centromere identity by restricting CENP-A to centromeres |
17 |
| Profiling chromatin states using single-cell itChIP-seq |
17 |
| An ARF6-Exportin-5 axis delivers pre-miRNA cargo to tumour microvesicles |
16 |
| H4K20meO recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids |
16 |
| Adaptive endoplasmic reticulum stress signalling via IRE1 alpha-XBP1 preserves self-renewal of haematopoietic and pre-leukaemic stem cells |
16 |
| A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival |
16 |
| Modelling liver cancer initiation with organoids derived from directly reprogrammed human hepatocytes |
16 |
| AMP kinase promotes glioblastoma bioenergetics and tumour growth |
16 |
| IRE1 alpha governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A |
16 |
| A Tppp3(+)Pdgfra(+) tendon stem cell population contributes to regeneration and reveals a shared role for PDGF signalling in regeneration and fibrosis |
15 |
| Diurnal oscillations of endogenous H2O2 sustained by p66(Shc) regulate circadian clocks |
15 |
| Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis |
15 |
| Endothelial proteolytic activity and interaction with non-resorbing osteoclasts mediate bone elongation |
15 |
| 53BP1 nuclear bodies enforce replication timing at under-replicated DNA to limit heritable DNA damage |
15 |
| Snail-induced claudin-11 prompts collective migration for tumour progression |
15 |
| MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer |
15 |
| Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymes |
15 |
| Haematopoietic stem cells in perisinusoidal niches are protected from ageing |
15 |
| CLN8 is an endoplasmic reticulum cargo receptor that regulates lysosome biogenesis |
15 |
| Myc and Dnmt1 impede the pluripotent to totipotent state transition in embryonic stem cells |
15 |
| Deconstructing the pluripotency gene regulatory network |
14 |
| Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation |
14 |
| Polarized microtubule dynamics directs cell mechanics and coordinates forces during epithelial morphogenesis |
14 |
| Two succeeding fibroblastic lineages drive dermal development and the transition from regeneration to scarring |
14 |
| Scale-invariant patterning by size-dependent inhibition of Nodal signalling |
14 |
| STRIPAK integrates upstream signals to initiate the Hippo kinase cascade |
14 |
| A nuclear phosphoinositide kinase complex regulates p53 |
14 |
| Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains |
13 |
| Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism |
13 |
| CRISPR-Cas9-mediated base-editing screening in mice identifies DND1 amino acids that are critical for primordial germ cell development |
13 |
| A single-cell transcriptional roadmap for cardiopharyngeal fate diversification |
13 |
| Multiple phosphorylations control recruitment of the KMN network onto kinetochores |
13 |
| TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/beta-catenin signalling |
13 |
| FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis |
13 |
| CK1 alpha suppresses lung tumour growth by stabilizing PTEN and inducing autophagy |
13 |
| Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon(+) alpha-cells |
13 |
| The mTOR-S6K pathway links growth signalling to DNA damage response by targeting RNF168 |
12 |
| The inner centromere is a biomolecular condensate scaffolded by the chromosomal passenger complex |
12 |
| Fluidization-mediated tissue spreading by mitotic cell rounding and non-canonical Wnt signalling |
12 |
| A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage |
12 |
| Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration |
12 |
| Flexible fate determination ensures robust differentiation in the hair follicle |
12 |
| NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming |
12 |
| KLF4 is involved in the organization and regulation of pluripotency-associated three-dimensional enhancer networks |
12 |
| Apical-basal polarity inhibits epithelial-mesenchymal transition and tumour metastasis by PAR-complex-mediated SNAI1 degradation |
11 |
| Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins |
11 |
| Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway |
11 |
| Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity |
11 |
| EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells |
11 |
| Mitochondrial fusion regulates lipid homeostasis and stem cell maintenance in the Drosophila testis |
11 |
| Coupling of beta(2) integrins to actin by a mechanosensitive molecular clutch drives complement receptor-mediated phagocytosis |
11 |
| TP53INP2 regulates adiposity by activating beta-catenin through autophagy-dependent sequestration of GSK3 beta |
11 |
| Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage |
11 |
| Local control of intracellular microtubule dynamics by EB1 photodissociation |
11 |
| RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix detached cells |
11 |
| Direct generation of human naive induced pluripotent stem cells from somatic cells in microfluidics |
10 |
| A complex containing lysine-acetylated actin inhibits the formin INF2 |
10 |
| A homeostatic apical microtubule network shortens cells for epithelial folding via a basal polarity shiftA homeostatic apical microtubule network shortens cells for epithelial folding via a basal polarity shift |
10 |
| Human germline genome editing |
10 |
| Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation |
10 |
| The NSL complex maintains nuclear architecture stability via lamin A/C acetylation |
9 |
| Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway |
9 |
| Translational reprogramming marks adaptation to asparagine restriction in cancer |
9 |
| Epigenetic modulation of a hardwired 3D chromatin landscape in two naive states of pluripotency |
9 |
| Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells |
9 |
| A tension-mediated glycocalyx-integrin feedback loop promotes mesenchymal-like glioblastoma |
9 |
| The light-sensitive dimerizer zapalog reveals distinct modes of immobilization for axonal mitochondria |
9 |
