| How many human proteoforms are there? |
82 |
| MCC950 directly targets the NLRP3 ATP- hydrolysis motif for inflammasome inhibition |
81 |
| FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation |
68 |
| Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation |
68 |
| The chemical basis of ferroptosis |
54 |
| The dTAG system for immediate and target-specific protein degradation |
52 |
| BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design |
52 |
| Plasticity in binding confers selectivity in ligand-induced protein degradation |
51 |
| Escherichia coli Marionette strains with 12 highly optimized small-molecule sensors |
48 |
| Chemical proteomics reveals new targets of cysteine sulfinic acid reductase |
45 |
| Identification of a cellularly active SIRT6 allosteric activator |
45 |
| Development of targeted protein degradation therapeutics |
44 |
| Pharmacological targeting of the unfolded protein response for disease intervention |
43 |
| N-6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation |
43 |
| Lytic xylan oxidases from wood-decay fungi unlock biomass degradation |
42 |
| SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate |
41 |
| Affinity-based capture and identification of protein effectors of the growth regulator ppGpp |
39 |
| Harnessing the anti-cancer natural product nimbolide for targeted protein degradation |
38 |
| HIP1R targets PD-L1 to lysosomal degradation to alter T cell-mediated cytotoxicity |
36 |
| Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16 |
36 |
| MCC950 closes the active conformation of NLRP3 to an inactive state |
36 |
| IFITM3 directly engages and shuttles incoming virus particles to lysosomes |
35 |
| A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters |
35 |
| FTO controls reversible m(6)Am RNA methylation during snRNA biogenesis |
35 |
| Programmable and printable Bacillus subtilis biofilms as engineered living materials |
35 |
| Insights into the biogenesis, function, and regulation of ADP-ribosylation |
34 |
| Designing microbial consortia with defined social interactions |
32 |
| A role for 2-Cys peroxiredoxins in facilitating cytosolic protein thiol oxidation |
32 |
| Designing macrocyclic disulfide-rich peptides for biotechnological applications |
30 |
| Rewiring T-cell responses to soluble factors with chimeric antigen receptors |
30 |
| Discovery and characterization of highly potent and selective allosteric USP7 inhibitors |
30 |
| Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands |
29 |
| Biosynthesis of redox-active metabolites in response to iron deficiency in plants |
28 |
| Partial DNA-guided Cas9 enables genome editing with reduced off-target activity |
28 |
| Next-generation biocontainment systems for engineered organisms |
28 |
| S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate |
27 |
| Expression system for structural and functional studies of human glycosylation enzymes |
27 |
| Evolution of chalcone isomerase from a noncatalytic ancestor |
26 |
| Ligand-receptor co-evolution shaped the jasmonate pathway in land plants |
26 |
| Small-molecule inhibition of TLR8 through stabilization of its resting state |
26 |
| Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues |
26 |
| Structural insights into binding specificity, efficacy and bias of a beta(2)AR partial agonist |
26 |
| Computational redesign of enzymes for regio- and enantioselective hydroamination |
26 |
| Engineered synthetic scaffolds for organizing proteins within the bacterial cytoplasm |
25 |
| An OPR3-independent pathway uses 5-didehydrojasmonate for jasmonate synthesis |
25 |
| Structural and evolutionary insights into ribosomal RNA methylation |
25 |
| Acetylation of intrinsically disordered regions regulates phase separation |
25 |
| A multicolor riboswitch-based platform for imaging of RNA in live mammalian cells |
24 |
| Employing a biochemical protecting group for a sustainable indigo dyeing strategy |
23 |
| A lanthipeptide library used to identify a protein-protein interaction inhibitor |
23 |
