| STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets |
1469 |
| SWISS-MODEL: homology modelling of protein structures and complexes |
1191 |
| UniProt: a worldwide hub of protein knowledge |
1117 |
| The PRIDE database and related tools and resources in 2019: improving support for quantification data |
1080 |
| The Pfam protein families database in 2019 |
744 |
| Interactive Tree Of Life (iTOL) v4: recent updates and new developments |
742 |
| MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis |
739 |
| The EMBL-EBI search and sequence analysis tools APIs in 2019 |
662 |
| The Gene Ontology Resource: 20 years and still GOing strong |
649 |
| DrugBank 5.0: a major update to the DrugBank database for 2018 |
627 |
| Ensembl 2018 |
529 |
| HMDB 4.0: the human metabolome database for 2018 |
487 |
| The Reactome Pathway Knowledgebase |
437 |
| antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline |
436 |
| PubChem 2019 update: improved access to chemical data |
431 |
| COSMIC: the Catalogue Of Somatic Mutations In Cancer |
416 |
| miRBase: from microRNA sequences to function |
413 |
| The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY |
413 |
| PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools |
407 |
| The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2018 update |
387 |
| New approach for understanding genome variations in KEGG |
387 |
| miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions |
360 |
| CADD: predicting the deleteriousness of variants throughout the human genome |
335 |
| The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019 |
317 |
| ClinVar: improving access to variant interpretations and supporting evidence |
310 |
| InterPro in 2019: improving coverage, classification and access to protein sequence annotations |
294 |
| GENCODE reference annotation for the human and mouse genomes |
283 |
| 20 years of the SMART protein domain annotation resource |
264 |
| MODOMICS: a database of RNA modification pathways. 2017 update |
250 |
| g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update) |
243 |
| The UNITE database for molecular identification of fungi: handling dark taxa and parallel taxonomic classifications |
234 |
| WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs |
219 |
| JASPAR 2018: update of the open-access database of transcription factor binding profiles and its web framework |
217 |
| Ensembl 2019 |
210 |
| The Encyclopedia of DNA elements (ENCODE): data portal update |
197 |
| RCSB Protein Data Bank: biological macromolecular structures enabling research and education in fundamental biology, biomedicine, biotechnology and energy |
192 |
| LinkedOmics: analyzing multi-omics data within and across 32 cancer types |
192 |
| The BioGRID interaction database: 2019 update |
186 |
| The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database |
175 |
| dbCAN2: a meta server for automated carbohydrate-active enzyme annotation |
160 |
| IMG/M v.5.0: an integrated data management and comparative analysis system for microbial genomes and microbiomes |
160 |
| GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis |
157 |
| The Comparative Toxicogenomics Database: update 2019 |
155 |
| FlyBase 2.0: the next generation |
155 |
| CASTp 3.0: computed atlas of surface topography of proteins |
148 |
| RefSeq: an update on prokaryotic genome annotation and curation |
146 |
| Rfam 13.0: shifting to a genome-centric resource for non-coding RNA families |
144 |
| OrganellarGenomeDRAW (OGDRAW) version 1.3.1: expanded toolkit for the graphical visualization of organellar genomes |
143 |
| VFDB 2019: a comparative pathogenomic platform with an interactive web interface |
141 |
| HMMER web server: 2018 update |
140 |
