| Cancer immunotherapy using checkpoint blockade |
705 |
| Organic and solution-processed tandem solar cells with 17.3% efficiency |
677 |
| Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors |
585 |
| Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients |
490 |
| The spread of true and false news online |
454 |
| Shifting the limits in wheat research and breeding using a fully annotated reference genome |
361 |
| Detection and localization of surgically resectable cancers with a multi-analyte blood test |
359 |
| CAR T cell immunotherapy for human cancer |
331 |
| The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients |
311 |
| Tuning superconductivity in twisted bilayer graphene |
304 |
| Magnetic hysteresis up to 80 kelvin in a dysprosium metallocene single-molecule magnet |
279 |
| Reducing food's environmental impacts through producers and consumers |
277 |
| Enhanced photovoltage for inverted planar heterojunction perovskite solar cells |
275 |
| CO2 electroreduction to ethylene via hydroxide-mediated copper catalysis at an abrupt interface |
273 |
| Spatial and temporal patterns of mass bleaching of corals in the Anthropocene |
261 |
| Pan-tumor genomic biomarkers for PD-1 checkpoint blockade-based immunotherapy |
255 |
| Challenges for commercializing perovskite solar cells |
255 |
| Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes |
243 |
| Declining oxygen in the global ocean and coastal waters |
243 |
| Thermodynamically stabilized beta-CsPbI3-based perovskite solar cells with efficiencies > 18% |
237 |
| Coactivator condensation at super-enhancers links phase separation and gene control |
227 |
| Analysis of shared heritability in common disorders of the brain |
218 |
| Atomically dispersed Fe3+ sites catalyze efficient CO2 electroreduction to CO |
206 |
| Beyond fossil fuel-driven nitrogen transformations |
203 |
| Emergent ferromagnetism near three-quarters filling in twisted bilayer graphene |
200 |
| Multiplexed and portable nucleic acid detection platform with Cas Cas12a, and Csm6 |
199 |
| CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity |
198 |
| The global tree restoration potential |
191 |
| Methylammonium-free, high-performance, and stable perovskite solar cells on a planar architecture |
187 |
| Two-dimensional magnetic crystals and emergent heterostructure devices |
185 |
| Evidence for Majorana bound states in an iron-based superconductor |
185 |
| A global atlas of the dominant bacteria found in soil |
182 |
| SOLAR CELLS Carrier lifetimes of > 1 mu s in Sn-Pb perovskites enable efficient all-perovskite tandem solar cells |
181 |
| Giant tunneling magnetoresistance in spin-filter van der Waals heterostructures |
180 |
| Dissecting racial bias in an algorithm used to manage the health of populations |
178 |
| 3D bioprinting of collagen to rebuild components of the human heart |
177 |
| Efficient, stable solar cells by using inherent bandgap of alpha-phase formamidinium lead iodide |
176 |
| Dissipative Kerr solitons in optical microresonators |
175 |
| Patient-derived organoids model treatment response of metastatic gastrointestinal cancers |
174 |
| BIOMEDICINE Multivascular networks and functional intravascular topologies within biocompatible hydrogels |
174 |
| A bioinspired flexible organic artificial afferent nerve |
173 |
| Nitrogen fixation and reduction at boron |
172 |
| What would it take for renewably powered electrosynthesis to displace petrochemical processes? |
171 |
| Exceptional points in optics and photonics |
170 |
| Amphibian fungal panzootic causes catastrophic and ongoing loss of biodiversity |
170 |
| Stabilizing halide perovskite surfaces for solar cell operation with wide-bandgap lead oxysalts |
165 |
| CRISPR-Cas guides the future of genetic engineering |
164 |
| Classifying drivers of global forest loss |
162 |
| Polyamide membranes with nanoscale Turing structures for water purification |
160 |
| A general reinforcement learning algorithm that masters chess, shogi, and Go through self-play |
160 |
| Single-crystal x-ray diffraction structures of covalent organic frameworks |
158 |
| Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution |
157 |
| A Eu3+-Eu2+ ion redox shuttle imparts operational durability to Pb-I perovskite solar cells |
156 |
| Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma |
154 |
| Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice |
153 |
| Three-dimensional intact-tissue sequencing of single-cell transcriptional states |
152 |
| Topological insulator laser: Experiments |
151 |
| Probing magnetism in 2D van der Waals crystalline insulators via electron tunneling |
150 |
| Quantum internet: A vision for the road ahead |
150 |
| Quantifying hot carrier and thermal contributions in plasmonic photocatalysis |
150 |
| Inverse molecular design using machine learning: Generative models for matter engineering |
149 |
| Somatic mutant clones colonize the human esophagus with age |
148 |
| Ordered macro-microporous metal-organic framework single crystals |
148 |
| Ultralow-loading platinum-cobalt fuel cell catalysts derived from imidazolate frameworks |
147 |
| Worldwide emergence of resistance to antifungal drugs challenges human health and food security |
147 |
| 3D charge and 2D phonon transports leading to high out-of-plane ZT in n-type SnSe crystals |
147 |
| Gene therapy comes of age |
147 |
| Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy |
146 |
| Decline of the North American avifauna |
146 |
| Engineering bunched Pt-Ni alloy nanocages for efficient oxygen reduction in practical fuel cells |
146 |
| Multimessenger observations of a flaring blazar coincident with high-energy neutrino IceCube-170922A |
145 |
| Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics |
144 |
| Ethane/ethylene separation in a metal-organic framework with iron-peroxo sites |
143 |
| Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos |
141 |
| Field-deployable viral diagnostics using CRISPR-Cas13 |
140 |
| Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap |
138 |
| Net-zero emissions energy systems |
138 |
| Hierarchically porous polymer coatings for highly efficient passive daytime radiative cooling |
133 |
| Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder |
132 |
| Energy storage: The future enabled by nanomaterials |
132 |
| Multicomponent intermetallic nanoparticles and superb mechanical behaviors of complex alloys |
131 |
| Engineered CRISPR-Cas9 nuclease with expanded targeting space |
128 |
| Moving in the Anthropocene: Global reductions in terrestrial mammalian movements |
126 |
| Mediator and RNA polymerase II clusters associate in transcription-dependent condensates |
126 |
| A major chromatin regulator determines resistance of tumor cells to T cell-mediated killing |
126 |
| Carbothermal shock synthesis of high-entropy-alloy nanoparticles |
122 |
| Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease |
121 |
| Light-induced lattice expansion leads to high-efficiency perovskite solar cells |
120 |
| A radiative cooling structural material |
120 |
| The transcriptional landscape of polyploid wheat |
119 |
| Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice |
118 |
| Composites with carbon nanotubes and graphene: An outlook |
117 |
| Photocatalytic decarboxylative alkylations mediated by triphenylphosphine and sodium iodide |
115 |
| Pervasive human-driven decline of life on Earth points to the need for transformative change |
115 |
| Increase in crop losses to insect pests in a warming climate |
115 |
| Mechanically robust, readily repairable polymers via tailored noncovalent cross-linking |
115 |
| Metal-free three-dimensional perovskite ferroelectrics |
114 |
| All-optical machine learning using diffractive deep neural networks |
114 |
| Transcutaneous ultrasound energy harvesting using capacitive triboelectric technology |
113 |
| Reversible epitaxial electrodeposition of metals in battery anodes |
113 |
| Single-cell profiling of the developing mouse brain and spinal cord with split-pool barcoding |
113 |
| RNA buffers the phase separation behavior of prion-like RNA binding proteins |
112 |
| Large-area graphene-nanomesh/carbon-nanotube hybrid membranes for ionic and molecular nanofiltration |
111 |
| Translocation of a gut pathobiont drives autoimmunity in mice and humans |
111 |
| Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells |
110 |
| Super-resolution chromatin tracing reveals domains and cooperative interactions in single cells |
109 |
| Observation of the quantum spin Hall effect up to 100 kelvin in a monolayer crystal |
109 |
| Multidimensional quantum entanglement with large-scale integrated optics |
108 |
| Measurement of the fine-structure constant as a test of the Standard Model |
107 |
| Topological insulator laser: Theory |
106 |
| The gut microbiota at the intersection of diet and human health |
105 |
| Spermidine in health and disease |
105 |
| One-third of global protected land is under intense human pressure |
104 |
| The influence of human disturbance on wildlife nocturnality |
104 |
| A single fast radio burst localized to a massive galaxy at cosmological distance |
104 |
| Anomalously low dielectric constant of confined water |
104 |
| Slab a comprehensive subduction zone geometry model |
104 |
| Hydraulically amplified self-healing electrostatic actuators with muscle-like performance |
102 |
| Meat consumption, health, and the environment |
102 |
| Spatiotemporal light control with active metasurfaces |
101 |
| Molecular electrocatalysts can mediate fast, selective CO2 reduction in a flow cell |
101 |
| Fake news on Twitter during the 2016 US presidential election |
101 |
| Composites from renewable and sustainable resources: Challenges and innovations |
100 |
| Imaging-based molecular barcoding with pixelated dielectric metasurfaces |
100 |
| Eliminating nonradiative decay in Cu(I) emitters: > 99% quantum efficiency and microsecond lifetime |
99 |
| Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria |
99 |
| Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death |
98 |
| Plastic waste associated with disease on coral reefs |
97 |
| Personalized vaccines for cancer immunotherapy |
96 |
| Giant piezoelectricity of Sm-doped Pb(Mg1/3Nb2/3)O-3-PbTiO3 single crystals |
96 |
| Glutamate triggers long-distance, calcium-based plant defense signaling |
96 |
| Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation |
96 |
| BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis |
96 |
| Volatile chemical products emerging as largest petrochemical source of urban organic emissions |
96 |
| Synthetic glycolate metabolism pathways stimulate crop growth and productivity in the field |
95 |
| The nature of nurture: Effects of parental genotypes |
95 |
| Spontaneous behaviors drive multidimensional, brainwide activity |
95 |
| Keyhole threshold and morphology in laser melting revealed by ultrahigh-speed x-ray imaging |
95 |
| The chromatin accessibility landscape of primary human cancers |
94 |
| The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight |
94 |
| CANCER Genetic diversity of tumors with mismatch repair deficiency influences anti-PD-1 immunotherapy response |
94 |
| Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region |
93 |
| Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches |
93 |
| Thermal unequilibrium of strained black CsPbI3 thin films |
93 |
| Mechanoresponsive self-growing hydrogels inspired by muscle training |
93 |
| cGAS in action: Expanding roles in immunity and inflammation |
92 |
| Ultrahigh-energy density lead-free dielectric films via polymorphic nanodomain design |
92 |
| High thermoelectric performance in low-cost SnS0.91Se0.09 crystals |
92 |
| A topological quantum optics interface |
92 |
| Enantioselective C(sp(3))-H bond activation by chiral transition metal catalysts |
92 |
| Cancer modeling meets human organoid technology |
91 |
| Observation of topological superconductivity on the surface of an iron-based superconductor |
91 |
| Seeded growth of single-crystal two-dimensional covalent organic frameworks |
90 |
| Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells |
90 |
| Visualizing and discovering cellular structures with super-resolution microscopy |
90 |
| RNA modifications modulate gene expression during development |
90 |
| Emergent simplicity in microbial community assembly |
89 |
| Resonantly driven CNOT gate for electron spins |
89 |
| Single-cell mapping of gene expression landscapes and lineage in the zebrafish embryo |
89 |
| Predicting reaction performance in C-N cross-coupling using machine learning |
89 |
| Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care |
89 |
| Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes |
88 |
| Tracking the global footprint of fisheries |
88 |
| Joint profiling of chromatin accessibility and gene expression in thousands of single cells |
88 |
| Volumetric additive manufacturing via tomographic reconstruction |
87 |
| Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model |
87 |
| Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection |
87 |
| The microbiome in cancer immunotherapy: Diagnostic tools and therapeutic strategies |
86 |
| DNA-induced liquid phase condensation of cGAS activates innate immune signaling |
86 |
| Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors |
85 |
| Stabilizing heterostructures of soft perovskite semiconductors |
85 |
| A robotic platform for flow synthesis of organic compounds informed by AI planning |
85 |
| Assessment of methane emissions from the US oil and gas supply chain |
85 |
| An sp-hybridized molecular carbon allotrope, cyclo[18]carbon |
85 |
| A pathway for mitotic chromosome formation |
85 |
| Observation of bulk Fermi arc and polarization half charge from paired exceptional points |
84 |
| Systematic discovery of antiphage defense systems in the microbial pangenome |
84 |
| Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity |
83 |
| Here, there, and everywhere: The importance of ER membrane contact sites |
83 |
| Hierarchical interlocked orthogonal faulting in the 2019 Ridgecrest earthquake sequence |
83 |
| DNA loop extrusion by human cohesin |
83 |
| ORGANIC CHEMISTRY Copper's rapid ascent in visible-light photoredox catalysis |
83 |
| Imaging dynamic and selective low-complexity domain interactions that control gene transcription |
82 |
| Amyloid beta oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes |
82 |
| A molecular perovskite solid solution with piezoelectricity stronger than lead zirconate titanate |
82 |
| Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy |
81 |
| Constructive molecular configurations for surface-defect passivation of perovskite photovoltaics |
81 |
| Probing entanglement in a many-body-localized system |
81 |
| Single-cell reconstruction of developmental trajectories during zebrafish embryogenesis |
80 |
| Organic semiconductor photocatalyst can bifunctionalize arenes and heteroarenes |
80 |
| Generation and manipulation of Schrodinger cat states in Rydberg atom arrays |
80 |
| A gut-brain neural circuit for nutrient sensory transduction |
80 |
| Science of science |
80 |
| RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues |
79 |
| Landscapes that work for biodiversity and people |
79 |
| The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans |
78 |
| High thermoelectric cooling performance of n-type Mg3Bi2-based materials |
78 |
| Fermi-arc diversity on surface terminations of the magnetic Weyl semimetal Co3Sn2S2 |
78 |
| Magnetic Weyl semimetal phase in a Kagome crystal |
78 |
| Phase separation of a yeast prion protein promotes cellular fitness |
78 |
