Toxicology And Applied Pharmacology

Toxicology And Applied Pharmacology

毒理学与应用药理学

  • 3区 中科院分区
  • Q2 JCR分区

高引用文章

文章名称 引用次数
Regulatory crosstalk between the oxidative stress-related transcription factor Nfe212/Nrf2 and mitochondria 26
Knockdown of lncRNA H19 restores chemo-sensitivity in paclitaxel-resistant Check triple-negative breast cancer through triggering apoptosis and regulating Akt signaling pathway 24
Rotenone exerts developmental neurotoxicity in a human brain spheroid model 22
Olmesartan ameliorates chemically-induced ulcerative colitis in rats via modulating NF kappa B and Nrf-2/HO-1 signaling crosstalk 22
Polyphyllin I modulates MALAT1/STAT3 signaling to induce apoptosis in gefitinib-resistant non-small cell lung cancer 21
Curcumin plays neuroprotective roles against traumatic brain injury partly via Nrf2 signaling 21
H a novel hederagenin derivative, reverses multidrug resistance in vitro and in vivo 20
Strategies to improve the regulatory assessment of developmental neurotoxicity (DNT) using in vitro methods 19
Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes 17
Polydatin inhibits proliferation and promotes apoptosis of doxorubicin-resistant osteosarcoma through LncRNA TUG1 mediated suppression of Akt signaling 16
Pesticides and cardiotoxicity. Where do we stand? 16
Cadmium-induced apoptosis through reactive oxygen species-mediated mitochondrial oxidative stress and the JNK signaling pathway in TM3 cells, a model of mouse Leydig cells 16
Fluoride induces apoptosis via inhibiting SIRT1 activity to activate mitochondrial p53 pathway in human neuroblastoma SH-SY5Y cells 16
The asbestos-carbon nanotube analogy: An update 15
Flavonoids interfere with NLRP3 inflammasome activation 15
Modulating impacts of quercetin/sitagliptin combination on streptozotocin-induced diabetes mellitus in rats 15
Andrographolide triggers autophagy-mediated inflammation inhibition and attenuates chronic unpredictable mild stress (CUMS)-induced depressive-like behavior in mice 15
Astragaloside IV protects blood-brain barrier integrity from LPS-induced disruption via activating Nrf2 antioxidant signaling pathway in mice 14
Nrf2 activator for the treatment of kidney diseases 14
Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway 14
Pharmacological and toxicological aspects of carbon nanotubes (CNTs) to vascular system: A review 14
A comparison of asbestos fiber potency and elongate mineral particle (EMP) potency for mesothelioma in humans 13
Resveratrol inhibits cancer cell proliferation by impairing oxidative phosphorylation and inducing oxidative stress 13
Systematic developmental neurotoxicity assessment of a representative PAH Superfund mixture using zebrafish 13
Epithelial-mesenchymal transition in breast epithelial cells treated with cadmium and the role of Snail 13
Association of pesticide exposure with human congenital abnormalities 13
PCB 126 induces monocyte/macrophage polarization and inflammation through AhR and NF-kappa B pathways 12
Course dose and stage-dependent toxic effects of prenatal dexamethasone exposure on long bone development in fetal mice 12
The cardenolide ouabain suppresses coronaviral replication via augmenting a Na+/K+-ATPase-dependent PI3K_PDK1 axis signaling 12
Early life exposure to air pollution particulate matter (PM) as risk factor for attention deficit/hyperactivity disorder (ADHD): Need for novel strategies Check for updates for mechanisms and causalities 12
Inhibitory effects of flavonoids on P-glycoprotein in vitro and in vivo: Food/herb-drug interactions and structure-activity relationships 12
Testing for developmental neurotoxicity using a battery of in vitro assays for key cellular events in neurodevelopment 11
Nrf2 in alcoholic liver disease 11
Caffeic acid prevents UVB radiation induced photocarcinogenesis through regulation of PTEN signaling in human dermal fibroblasts and mouse skin 11
Neuroprotective effect of linagliptin against cuprizone-induced demyelination and behavioural dysfunction in mice: A pivotal role of AMPK/SIRT1 and JAK2/STAT3/NF-kappa B signalling pathway modulation 11
5-Oxo-hexahydroquinoline derivatives as modulators of P-gp, MRP1 and BCRP transporters to overcome multidrug resistance in cancer cells 11
Estrogen down regulates COMT transcription via promoter DNA methylation in human breast cancer cells 10
L-Carnosine protects against Oxaliplatin-induced peripheral neuropathy in colorectal cancer patients: A perspective on targeting Nrf-2 and NF-kappa B pathways 10
Doxorubicin obliterates mouse ovarian reserve through both primordial follicle atresia and overactivation 10
M1 macrophage mediated increased reactive oxygen species (ROS) influence wound healing via the MAPK signaling in vitro and in vivo 10
Roles of the KEAP1-NRF2 system in mammalian skin exposed to UV radiation 10
Increased butyrate priming in the gut stalls microbiome associated-gastrointestinal inflammation and hepatic metabolic reprogramming in a mouse model of Gulf War Illness 10
Roles of ROS, Nrf and autophagy in cadmium-carcinogenesis and its prevention by sulforaphane 10
Polychlorinated biphenyl exposures differentially regulate hepatic metabolism and pancreatic function: Implications for nonalcoholic steatohepatitis and diabetes 10
Low-level arsenic causes proteotoxic stress and not oxidative stress 10
MitoQ ameliorates testis injury from oxidative attack by repairing mitochondria and promoting the Keap1-Nrf2 pathway 10
Dexmedetomidine attenuates lipopolysaccharide-induced liver oxidative stress and cell apoptosis in rats by increasing GSK-3 beta/MKP-1/Nrf2 pathway activity via the alpha 2 adrenergic receptor 10
Comparison of the neurotoxicity associated with cobalt nanoparticles and cobalt chloride in Wistar rats 10
Anxiolytic- and antidepressant-like effects of Silymarin compared to diazepam and fluoxetine in a mouse model of mild traumatic brain injury 9
Pulmonary toxicity of two different multi-walled carbon nanotubes in rat: Comparison between intratracheal instillation and inhalation exposure 9