| What Contributes to Serotonin-Norepinephrine Reuptake Inhibitors' Dual-Targeting Mechanism? The Key Role of Transmembrane Domain 6 in Human Serotonin and Norepinephrine Transporters Revealed by Molecular Dynamics Simulation |
37 |
| Drug-Target Kinetics in Drug Discovery |
33 |
| Nerve Agents: What They Are, How They Work, How to Counter Them |
27 |
| Genistein: A Dual Inhibitor of Both Amyloid beta and Human Islet Amylin Peptides |
26 |
| Brain Delivery of Curcumin Using Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Preparation, Optimization, and Pharmacokinetic Evaluation |
21 |
| Raman Spectroscopy: An Emerging Tool in Neurodegenerative Disease Research and Diagnosis |
21 |
| Down-Regulation of m6A mRNA Methylation Is Involved in Dopaminergic Neuronal Death |
20 |
| Norepinephrine Inhibits Alzheimer's Amyloid-beta Peptide Aggregation and Destabilizes Amyloid-beta Protofibrils: A Molecular Dynamics Simulation Study |
19 |
| Increased Iron Deposition on Brain Quantitative Susceptibility Mapping Correlates with Decreased Cognitive Function in Alzheimer's Disease |
18 |
| Oligomer Diversity during the Aggregation of the Repeat Region of Tau |
17 |
| Molecular Mechanism of Binding Selectivity of Inhibitors toward BACE1 and BACE2 Revealed by Multiple Short Molecular Dynamics Simulations and Free-Energy Predictions |
17 |
| Peptides, Peptidomimetics, and Carbohydrate-Peptide Conjugates as Amyloidogenic Aggregation Inhibitors for Alzheimer's Disease |
16 |
| Peripheral Nerve Conduit: Materials and Structures |
16 |
| Hydroxylated Single-Walled Carbon Nanotubes Inhibit A beta(42) Fibrillogenesis, Disaggregate Mature Fibrils, and Protect against A beta(42)-Induced Cytotoxicity |
16 |
| O-GlcNAc Modification Protects against Protein Misfolding and Aggregation in Neurodegenerative Disease |
16 |
| Reconsideration of Anticholinesterase Therapeutic Strategies against Alzheimer's Disease |
16 |
| Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading |
16 |
| Impact of Dopamine Oxidation on Dopaminergic Neurodegeneration |
15 |
| Perturbation Theory/Machine Learning Model of ChEMBL Data for Dopamine Targets: Docking, Synthesis, and Assay of New L-Prolyk-L-leucyl-glycinamide Peptidomimetics |
15 |
| Effects of N,N-Dimethyltryptamine on Rat Behaviors Relevant to Anxiety and Depression |
15 |
| Functional Relevance of Endocannabinoid-Dependent Synaptic Plasticity in the Central Nervous System |
15 |
| Honokiol Alleviates Oxidative Stress-Induced Neurotoxicity via Activation of Nrf2 |
15 |
| Advanced Glycation End Products Modulate Amyloidogenic APP Processing and Tau Phosphorylation: A Mechanistic Link between Glycation and the Development of Alzheimer's Disease |
15 |
| Dark Classics in Chemical Neuroscience: N,N-Dimethyltryptamine (DMT) |
14 |
| Shedding Light on the Molecular Pathology of Amyloid Plaques in Transgenic Alzheimer's Disease Mice Using Multimodal MALDI Imaging Mass Spectrometry |
14 |
| Rapamycin Confers Neuroprotection against Colistin-Induced Oxidative Stress, Mitochondria Dysfunction, and Apoptosis through the Activation of Autophagy and mTOR/Akt/CREB Signaling Pathways |
14 |
| Rett Syndrome: A Genetic Update and Clinical Review Focusing on Comorbidities |
14 |
| SQSTM1/p62: A Potential Target for Neurodegenerative Disease |
14 |
| Targeting Neuroinflammation as a Therapeutic Strategy for Alzheimer's Disease: Mechanisms, Drug Candidates, and New Opportunities |
14 |
| How Does Chirality Determine the Selective Inhibition of Histone Deacetylase 6? A Lesson from Trichostatin A Enantiomers Based on Molecular Dynamics |
14 |
| Dark Classics in Chemical Neuroscience: Delta(9)-Tetrahydrocannabinol |
13 |
| Multi-metal, Multi-wavelength Surface-Enhanced Raman Spectroscopy Detection of Neurotransmitters |
13 |
| Exploring the Binding Mechanism of Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators in Clinical Trials by Molecular Dynamics Simulations |
13 |
| Intracellular GPCRs Play Key Roles in Synaptic Plasticity |
12 |
| Zebrafish-Based Discovery of Antiseizure Compounds from the Red Sea: Pseurotin A(2) and Azaspirofuran A |
12 |
| Effects of Baicalein on Cortical Proinflammatory Cytokines and the Intestinal Microbiome in Senescence Accelerated Mouse Prone 8 |
12 |
| Stabilization and Characterization of Cytotoxic A beta(40) Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions |
12 |
| Glycosylation Changes in Brain Cancer |
12 |
| Real-Time, in Vivo Correlation of Molecular Structure with Drug Distribution in the Brain Striatum Following Convection Enhanced Delivery |
12 |
| Raman Spectroscopy to Diagnose Alzheimer's Disease and Dementia with Lewy Bodies in Blood |
12 |
| KA- a Novel Pyrrolidine-5-dione Derived Broad-Spectrum Anticonvulsant: Its Antiepileptogenic, Antinociceptive Properties and in Vitro Characterization |
11 |
| Inhibitory Effect of a Flavonoid Dihydromyricetin against A beta 40 Amyloidogenesis and Its Associated Cytotoxicity |
11 |
| Cardiolipin Promotes Pore-Forming Activity of Alpha-Synuclein Oligomers in Mitochondrial Membranes |
11 |
| Neuroprotective Effect of Swertiamain on Cerebral Ischemia/Reperfusion Injury by Inducing the Nrf2 Protective Pathway |
11 |
| Impact of Gold Nanoparticles on Amyloid beta-Induced Alzheimer's Disease in a Rat Animal Model: Involvement of STIM Proteins |
11 |
| Pathological Changes of Tau Related to Alzheimer's Disease |
11 |
| Advances in the Research of Risk Factors and Prodromal Biomarkers of Parkinson's Disease |
11 |
| Potential Value of Plasma Amyloid-beta, Total Tau, and Neurofilament Light for Identification of Early Alzheimer's Disease |
11 |
| DARK Classics in Chemical Neuroscience: Morphine |
10 |
| Hybrid Multifunctional Modulators Inhibit Multifaceted A beta Toxicity and Prevent Mitochondrial Damage |
10 |
