Cell Stem Cell

Cell Stem Cell

细胞干细胞

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文章名称 引用次数
Mesenchymal Stromal Cells: Clinical Challenges and Therapeutic Opportunities 229
Human Hippocampal Neurogenesis Persists throughout Aging 170
METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m(6)A Modification 114
Human Adult Neurogenesis: Evidence and Remaining Questions 109
Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity 102
Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development 73
Derivation of Human Trophoblast Stem Cells 71
Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression 71
Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development 71
Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer's Disease Patients 70
Targeting Cancer Stemness in the Clinic: From Hype to Hope 69
Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies 67
Cancer Stem Cells: The Architects of the Tumor Ecosystem 66
Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics 65
Targeting the RNA m(6)A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia 63
Single-Cell Transcriptomics Meets Lineage Tracing 63
YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration 63
Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance 60
Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility 60
A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening 57
Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition 54
PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy 51
High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping 51
Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging 49
Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise 48
Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications 46
Engineering Stem Cell Self-organization to Build Better Organoids 45
Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis 43
hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids 42
Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML 41
Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-beta in iPSC-Derived Alzheimer's Disease Neurons 40
Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging 40
Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation 39
Single-Cell RNA Sequencing Analysis Reveals Sequential Cell Fate Transition during Human Spermatogenesis 38
Causes and Consequences of Hematopoietic Stem Cell Heterogeneity 38
AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells 38
Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation 37
Mesenchymal Precursor Cells in Adult Nerves Contribute to Mammalian Tissue Repair and Regeneration 37
Paneth Cell Multipotency Induced by Notch Activation following Injury 37
Blood Development: Hematopoietic Stem Cell Dependence and Independence 36
Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis 36
Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells 35
Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response 35
Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson's Disease 35
Chronic Liver Injury Induces Conversion of Biliary Epithelial Cells into Hepatocytes 35
A First-in-Human, Phase I Study of Neural Stem Cell Transplantation for Chronic Spinal Cord Injury 34
The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance 34
Engineering Stem and Stromal Cell Therapies for Musculoskeletal Tissue Repair 31
Stem Cell Quiescence: Dynamism, Restraint, and Cellular Idling 31
Adult Neurogenesis Is Sustained by Symmetric Self-Renewal and Differentiation 31
Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges 31
Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway 29
Muscle Satellite Cell Cross-Talk with a Vascular Niche Maintains Quiescence via VEGF and Notch Signaling 28
In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity 28
TNF-alpha Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration 28
CD157 Marks Tissue-Resident Endothelial Stem Cells with Homeostatic and Regenerative Properties 28
Homeostatic Epidermal Stem Cell Self-Renewal Is Driven by Local Differentiation 28
Reciprocal Signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Promotes Malignant Progression 28
Orienting Muscle Stem Cells for Regeneration in Homeostasis, Aging, and Disease 27
Regenerating Eye Tissues to Preserve and Restore Vision 27
Somatic Cell Nuclear Transfer Reprogramming: Mechanisms and Applications 27
Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors 27
Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis 27
Endothelial Regeneration of Large Vessels Is a Biphasic Process Driven by Local Cells with Distinct Proliferative Capacities 26
Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids 25
CD150(high) Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine 25
CRISPR Activation Screens Systematically Identify Factors that Drive Neuronal Fate and Reprogramming 25
Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment 25
Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration 25
Esophageal Organoids from Human Pluripotent Stem Cells Delineate Sox2 Functions during Esophageal Specification 25
Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network 24
Single-Cell RNA-Seq Reveals Dynamic Early Embryonic-like Programs during Chemical Reprogramming 24
Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs 24
Reconstruction of the Human Colon Epithelium In Vivo 24
YAP, but Not RSPO-LGR4/ Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury 24
A Linc1405/Eomes Complex Promotes Cardiac Mesoderm Specification and Cardiogenesis 24
Hypoxic Induction of Vasorin Regulates Notch1 Turnover to Maintain Glioma Stem-like Cells 23
Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells 23
Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes 23
Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro 23
CRISPR-Based Chromatin Remodeling of the Endogenous Oct4 or Sox2 Locus Enables Reprogramming to Pluripotency 22
Defining Adult Stem Cell Function at Its Simplest: The Ability to Replace Lost Cells through Mitosis 22
Single-Cell Proteomics Reveal that Quantitative Changes in Co-expressed Lineage-Specific Transcription Factors Determine Cell Fate 21
Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate 21
Enhancing T Cell Receptor Stability in Rejuvenated iPSC-Derived T Cells Improves Their Use in Cancer Immunotherapy 21
Cellular Plasticity in Intestinal Homeostasis and Disease 21
Impaired Notch Signaling Leads to a Decrease in p53 Activity and Mitotic Catastrophe in Aged Muscle Stem Cells 20
Phase I Trial: Cirmtuzumab Inhibits ROR1 Signaling and Stemness Signatures in Patients with Chronic Lymphocytic Leukemia 20
Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche 20
Restricted Hematopoietic Progenitors and Erythropoiesis Require SCF from Leptin Receptor plus Niche Cells in the Bone Marrow 20
A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles 20
Direct&IT In Vivo&IT Reprogramming with Sendai Virus Vectors Improves Cardiac Function after Myocardial Infarction 20
A Subset of TREM2(+) Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth 20
Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells 20
Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis 19
SUMO Safeguards Somatic and Pluripotent Cell Identities by Enforcing Distinct Chromatin States 19
An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion 19
Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation 19
Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3 18
Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes 18
Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs 18
Temporal Layering of Signaling Effectors Drives Chromatin Remodeling during Hair Follicle Stem Cell Lineage Progression 17
Highly Efficient and Marker-free Genome Editing of Human Pluripotent Stem Cells by CRISPR-Cas9 RNP and AAV6 Donor-Mediated Homologous Recombination 17
Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping 17
GFAP Mutations in Astrocytes Impair Oligodendrocyte Progenitor Proliferation and Myelination in an hiPSC Model of Alexander Disease 17
Inhibition of Aberrant DNA Re-methylation Improves Post-implantation Development of Somatic Cell Nuclear Transfer Embryos 17
Myoepithelial Cells of Submucosal Glands Can Function as Reserve Stem Cells to Regenerate Airways after Injury 17
PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification 17
Fixation and Spread of Somatic Mutations in Adult Human Colonic Epithelium 16
Wnt4 from the Niche Controls the Mechano-Properties and Quiescent State of Muscle Stem Cells 16
Distinct Bone Marrow Sources of Pleiotrophin Control Hematopoietic Stem Cell Maintenance and Regeneration 16
Identification of Functionally Distinct Mx1+alpha SMA plus Periosteal Skeletal Stem Cells 16
The Dystrophin Glycoprotein Complex Regulates the Epigenetic Activation of Muscle Stem Cell Commitment 16
OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome 16
Mesenchymal Niche-Specific Expression of Cxcl12 Controls Quiescence of Treatment-Resistant Leukemia Stem Cells 16
Chronic Inflammation Directs an Olfactory Stem Cell Functional Switch from Neuroregeneration to Immune Defense 16
Autologous iPSC-Based Vaccines Elicit Anti-tumor Responses In Vivo 16
PGC-1 alpha Controls Skeletal Stem Cell Fate and Bone-Fat Balance in Osteoporosis and Skeletal Aging by Inducing TAZ 16
GRHL2-Dependent Enhancer Switching Maintains a Pluripotent Stem Cell Transcriptional Subnetwork after Exit from Naive Pluripotency 16
Neocortical Expansion Due to Increased Proliferation of Basal Progenitors Is Linked to Changes in Their Morphology 15
MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo 15
Epithelial Sodium Channel Regulates Adult Neural Stem Cell Proliferation in a Flow-Dependent Manner 15
Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance 15
Autocrine Mfge8 Signaling Prevents Developmental Exhaustion of the Adult Neural Stem Cell Pool 15
Phospho-regulation of ATOH1 Is Required for Plasticity of Secretory Progenitors and Tissue Regeneration 15
Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration 15
Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells 15
3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling 14
Notch-Induced miR-708 Antagonizes Satellite Cell Migration and Maintains Quiescence 14
Loss of H3K27me3 Imprinting in Somatic Cell Nuclear Transfer Embryos Disrupts Post-Implantation Development 14
Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation 14
Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells 14
FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration 14
Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma 14
Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron Chelation 14
Muscle Stem Cells Exhibit Distinct Clonal Dynamics in Response to Tissue Repair and Homeostatic Aging 14
Defining Human Pluripotency 14
Adult Neurogenesis, Glia, and the Extracellular Matrix 13
Spatially Restricted Stromal Wnt Signaling Restrains Prostate Epithelial Progenitor Growth through Direct and Indirect Mechanisms 13
Modeling the Pathological Long-Range Regulatory Effects of Human Structural Variation with Patient-Specific hiPSCs 13
A Non-canonical BCOR-PRC1.1 Complex Represses Differentiation Programs in Human ESCs 13
Capturing Totipotent Stem Cells 13
Prospective Isolation of Poised iPSC Intermediates Reveals Principles of Cellular Reprogramming 13
Id1 Ablation Protects Hematopoietic Stem Cells from Stress-Induced Exhaustion and Aging 13
The Adult Adrenal Cortex Undergoes Rapid Tissue Renewal in a Sex-Specific Manner 13
Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency 13
Human Pluripotent Stem Cell-Derived Cardiovascular Cells: From Developmental Biology to Therapeutic Applications 13
Integrative Proteomic Profiling Reveals PRC2-Dependent Epigenetic Crosstalk Maintains Ground-State Pluripotency 12
SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function 12
Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification 12
EGFR-Aurka Signaling Rescues Polarity and Regeneration Defects in Dystrophin-Deficient Muscle Stem Cells by Increasing Asymmetric Divisions 12
Mapping the Global Chromatin Connectivity Network for Sox2 Function in Neural Stem Cell Maintenance 12
Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis 12
Polycomb/Trithorax Antagonism: Cellular Memory in Stem Cell Fate and Function 12
Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation 12
Harnessing Hematopoietic Stem Cell Low Intracellular Calcium Improves Their Maintenance In Vitro 12
yylncT Defines a Class of Divergently Transcribed lncRNAs and Safeguards the T-mediated Mesodermal Commitment of Human PSCs 11
Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions 11
Radial Glial Fibers Promote Neuronal Migration and Functional Recovery after Neonatal Brain Injury 11
Cardiac Reprogramming Factors Synergistically Activate Genome-wide Cardiogenic Stage-Specific Enhancers 11
Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration 11
NHEJ-Mediated Repair of CRISPR-Cas9-Induced DNA Breaks Efficiently Corrects Mutations in HSPCs from Patients with Fanconi Anemia 11
Apelin(+) Endothelial Niche Cells Control Hematopoiesis and Mediate Vascular Regeneration after Myeloablative Injury 11
GPD1 Specifically Marks Dormant Glioma Stem Cells with a Distinct Metabolic Profile 10
Constructing and Deconstructing Cancers using Human Pluripotent Stem Cells and Organoids 10
The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis 10
Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal 10
Human ESC-Derived Chimeric Mouse Models of Huntington's Disease Reveal Cell-Intrinsic Defects in Glial Progenitor Cell Differentiation 10
Excluding Oct4 from Yamanaka Cocktail Unleashes the Developmental Potential of iPSCs 10
Complementary Activity of ETV RBPJ, and TCF3 Drives Formative Transition from Naive Pluripotency 10
Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons 10
Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency 10
Esrrb Unlocks Silenced Enhancers for Reprogramming to Naive Pluripotency 10
A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling 10
Single-Cell Transcriptomic Analyses of Cell Fate Transitions during Human Cardiac Reprogramming 10
TFAP2C-and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment 9
Combined Single-Cell Profiling of lncRNAs and Functional Screening Reveals that H19 Is Pivotal for Embryonic Hematopoietic Stem Cell Development 9
Epidermal Tissue Adapts to Restrain Progenitors Carrying Clonal p53 Mutations 9
Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia 9
An Intermediate Pluripotent State Controlled by MicroRNAs Is Required for the Naive-to-Primed Stem Cell Transition 9
Clinical Translation of Pluripotent Stem Cell Therapies: Challenges and Considerations 9
Lineage Tracing Reveals a Subset of Reserve Muscle Stem Cells Capable of Clonal Expansion under Stress 9
Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium 9
hPSC Modeling Reveals that Fate Selection of Cortical Deep Projection Neurons Occurs in the Subplate 9
Modeling Monogenic Diabetes using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A 8
Identification of Embryonic Neural Plate Border Stem Cells and Their Generation by Direct Reprogramming from Adult Human Blood Cells 8
Neutralizing Gatad2a-Chd4-Mbd3/NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency 8
Identification and Massively Parallel Characterization of Regulatory Elements Driving Neural Induction 8
Direct Induction of the Three Pre-implantation Blastocyst Cell Types from Fibroblasts 8
Skeletal Muscle Stem Cells from PSC-Derived Teratomas Have Functional Regenerative Capacity 8
Lentiviral Gene Therapy in HSCs Restores Lineage-Specific Foxp3 Expression and Suppresses Autoimmunity in a Mouse Model of IPEX Syndrome 8
Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential 8
In Vivo Labeling by CD73 Marks Multipotent Stromal Cells and Highlights Endothelial Heterogeneity in the Bone Marrow Niche 8
Human Pluripotent Stem Cell-Derived Endoderm for Modeling Development and Clinical Applications 8
Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics 8
Context-Specific Transcription Factor Functions Regulate Epigenomic and Transcriptional Dynamics during Cardiac Reprogramming 8
Antibody Conditioning Enables MHC-Mismatched Hematopoietic Stem Cell Transplants and Organ Graft Tolerance 7
RAL GTPases Drive Intestinal Stem Cell Function and Regeneration through Internalization of WNT Signalosomes 7
A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development 7
Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular Reprogramming 7