Drug Discovery Today

Drug Discovery Today

今天的药物发现

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文章名称 引用次数
The rise of deep learning in drug discovery 151
Machine learning in chemoinformatics and drug discovery 111
The roles of ions on bone regeneration 42
Pharmaceutical nanocrystals: production by wet milling and applications 41
Pharmaceutical cocrystals: from serendipity to design to application 37
Artificial intelligence in drug development: present status and future prospects 33
NTM drug discovery: status, gaps and the way forward 29
Protein-peptide docking: opportunities and challenges 29
Luxturna: FDA documents reveal the value of a costly gene therapy 29
A bibliometric review of drug repurposing 28
Progress with covalent small-molecule kinase inhibitors 28
Targeting non-small cell lung cancer with small-molecule EGFR tyrosine kinase inhibitors 28
Role of IncRNAs in ovarian cancer: defining new biomarkers for therapeutic purposes 26
The next level in chemical space navigation: going far beyond enumerable compound libraries 25
ADMET modeling approaches in drug discovery 25
Neural network and deep-learning algorithms used in QSAR studies: merits and drawbacks 25
Cell membrane-coated nanocarriers: the emerging targeted delivery system for cancer theranostics 25
Approved CAR T cell therapies: ice bucket challenges on glaring safety risks and long-term impacts 24
Repurposing host-based therapeutics to control coronavirus and influenza virus 24
Reshaping drug development using 3D printing 23
Carbon dots: emerging theranostic nanoarchitectures 23
Recent advances in siRNA delivery for cancer therapy using smart nanocarriers 22
Locked nucleic acid: modality, diversity, and drug discovery 22
Solid nanoparticles for oral antimicrobial drug delivery 22
Discovery of hidden allosteric sites as novel targets for allosteric drug design 21
Recent advances in pharmaceutical dosage forms and devices using additive manufacturing technologies 21
Applications of stimuli-responsive nanoscale drug delivery systems in translational research 21
Computational prediction of chemical reactions: current status and outlook 21
Recent advances in intra-articular drug delivery systems for osteoarthritis therapy 20
A new generation of antidepressants: an update on the pharmaceutical pipeline for novel and rapid-acting therapeutics in mood disorders based on glutamate/GABA neurotransmitter systems 20
Recent advances in bacteriophage-based methods for bacteria detection 19
Facilitating the translation of nanomedicines to a clinical product: challenges and opportunities 19
The use of nanoparticles as biomaterials in dentistry 19
Targeting intrinsically disordered proteins at the edge of chaos 19
Effects of antidiabetic drugs on NLRP3 inflammasome activity, with a focus on diabetic kidneys 19
Bioactive glasses entering the mainstream 19
Cyclodextrins as excipients in tablet formulations 19
Current potential and challenges in the advances of liquid crystalline nanoparticles as drug delivery systems 18
Therapeutic implications of nanomedicine for ocular drug delivery 17
Recent advances in near-infrared light-responsive nanocarriers for cancer therapy 17
Updates on the pathogenicity status of Pseudomonas aeruginosa 17
Therapy for glioblastoma: is it working? 17
The emerging role of copper-64 radiopharmaceuticals as cancer theranostics 17
Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties 17
Anticancer activity of palladium-based complexes against triple-negative breast cancer 17
PI3K/AKT/mTOR pathway inhibitors in triple-negative breast cancer: a review on drug discovery and future challenges 17
Exosomal miRNA in chemoresistance, immune evasion, metastasis and progression of cancer 16
Mitochondrial permeability transition pore: a potential drug target for neurodegeneration 16
Present drug-likeness filters in medicinal chemistry during the hit and lead optimization process: how far can they be simplified? 16
Poloxamer-based in situ gelling thermoresponsive systems for ocular drug delivery applications 16