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Bile duct ligation impairs function and expression of breast cancer resistance protein in rat blood-retinal barrier mainly due to both the increased ammonia and bilirubi
Author: Lin, Zijin; Wu, Runze; Yang, Yiting; Ji, Mingrui; Liu, Xiaodong; Liu, Li; Yang, Hanyu
Journal: DRUG METABOLISM AND DISPOSITION. 2026; Vol. 54, Issue 5, pp. -. DOI: 10.1016/j.dmd.2026.100282
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Drug-drug interactions induced by immunosuppressants through inhibition of human carboxylesterase
Author: Yang, Yuxin; Liang, Jiahong; Liao, Chenyuan; Fan, Yuzhi; Ma, Yulin; Long, Fei; Liu, Zhenzhong; Du, Zuo
Journal: DRUG METABOLISM AND DISPOSITION. 2026; Vol. 54, Issue 4, pp. -. DOI: 10.1016/j.dmd.2026.100267
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A semimechanistic PK/PD model-informed Taxus tablets' development: Accelerating early clinical translation of a taxane-based antitumor agen
Author: Li, Yagang; Jiang, Tianyang; Mo, Guanwen; He, Yuzhen; Tang, Haozheng; Gong, Likun; Tian, Ying; Cai, Yonglong; Wang, Long; Wan, Xiuwen; Lin, Daozheng; Zhang, Weichen; Gao, Yue; Wen, Haitang; Zhong, Guoping; Jin, Jing; Huang, Min
Journal: DRUG METABOLISM AND DISPOSITION. 2026; Vol. 54, Issue 4, pp. -. DOI: 10.1016/j.dmd.2026.100262
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Impact of POR and cytochrome b5 variability on the genotype-phenotype discordance of CYP2A6 and CYP2D6: A quantitative analysis in Chinese human liver
Author: Fang, Yan; Wang, Jiyao; Liu, Demeng; Li, Junle; Tian, Xin; Gao, Na; Zhang, Haifeng; Wen, Qiang; Qiao, Hailing
Journal: DRUG METABOLISM AND DISPOSITION. 2026; Vol. 54, Issue 4, pp. -. DOI: 10.1016/j.dmd.2026.100264
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Pregnane X receptor, constitutive androstane receptor, or peroxisome proliferator-activated receptor a activation does not affect yes-associated protein phase separation under physiological and hyperosmotic condition
Author: Zhao, Pengfei; Fan, Shicheng; Zhou, Yanying; Tian, Jianing; Huang, Min; Lai, Yong; Zuo, Zhong; Bi, Huichang; Gao, Yue
Journal: DRUG METABOLISM AND DISPOSITION. 2026; Vol. 54, Issue 4, pp. -. DOI: 10.1016/j.dmd.2026.100272
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Drug-drug interaction by metabolites: Challenges and solutions during therapeutics innovatio
Author: Fu, Shujun; Yu, Feifei; Sun, Tao; Hu, Zhuohan
Journal: DRUG METABOLISM AND DISPOSITION. 2026; Vol. 54, Issue 4, pp. -. DOI: 10.1016/j.dmd.2026.100251
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Lysine- and cysteine-based protein adduction resulting from metabolic activation of fraxinellone in Dictamni Corte
Author: Pan, Jie; Zhang, Enfu; Wu, Chutian; Gong, Bowen; Hu, Zixia; Ding, Yuan; Tan, Rong; Zhang, Shiyu; Liao, Yufen; Liu, Ting; Peng, Ying; Li, Weiwei; Zheng, Jiang
Journal: DRUG METABOLISM AND DISPOSITION. 2026; Vol. 54, Issue 4, pp. -. DOI: 10.1016/j.dmd.2026.100259
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Venlafaxine upregulates cortical catechol-O-methyltransferase expression and activity in rats and mic
Author: Qian, Liqiang; Xu, Zijun; Ye, Qianli; Jiang, Tianxin; Wu, Wenhan; Liu, Xiaodong; Liu, Li
Journal: DRUG METABOLISM AND DISPOSITION. 2026; Vol. 54, Issue 4, pp. -. DOI: 10.1016/j.dmd.2026.100232
