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Caffeic acid phenethyl ester suppresses intestinal FXR signaling and ameliorates nonalcoholic fatty liver disease by inhibiting bacterial bile salt hydrolase activity
Author: Zhong, Xian-Chun; Liu, Ya-Meng; Gao, Xiao-Xia; Krausz, Kristopher W.; Niu, Bing; Gonzalez, Frank J.; Xie, Cen
Journal: ACTA PHARMACOLOGICA SINICA. 2023; Vol. 44, Issue 1, pp. 145-156. DOI: 10.1038/s41401-022-00921-7
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Hepatocyte-derived MANF mitigates ethanol-induced liver steatosis in mice via enhancing ASS1 activity and activating AMPK pathway
Author: Xu, Han-Yang; Jiao, Yan-Hong; Li, Shi-Yu; Zhu, Xu; Wang, Sheng; Zhang, Yu-Yang; Wei, Yi-Jun; Shen, Yu-Jun; Wang, Wei; Shen, Yu-Xian; Shao, Jun-Tang
Journal: ACTA PHARMACOLOGICA SINICA. 2023; Vol. 44, Issue 1, pp. 157-168. DOI: 10.1038/s41401-022-00920-8
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Urolithin A ameliorates obesity-induced metabolic cardiomyopathy in mice via mitophagy activation
Author: Huang, Jian-rong; Zhang, Ming-hua; Chen, Ying-jie; Sun, Yu-ling; Gao, Zhi-min; Li, Zhuo-jia; Zhang, Gui-ping; Qin, Yuan; Dai, Xiao-yan; Yu, Xi-yong; Wu, Xiao-qian
Journal: ACTA PHARMACOLOGICA SINICA. 2023; Vol. 44, Issue 2, pp. 321-331. DOI: 10.1038/s41401-022-00919-1
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Calcipotriol abrogates cancer-associated fibroblast-derived IL-8-mediated oxaliplatin resistance in gastric cancer cells via blocking PI3K/Akt signaling
Author: Zhao, Zhen-Xiong; Zhang, Yan-Qiu; Sun, Hui; Chen, Zi-Qi; Chang, Jin-Jia; Wang, Xin; Wang, Xu; Tan, Cong; Ni, Shu-Juan; Weng, Wei-Wei; Zhang, Meng; Wang, Lei; Huang, Dan; Feng, Yun; Sheng, Wei-Qi; Xu, Mi-Die
Journal: ACTA PHARMACOLOGICA SINICA. 2023; Vol. 44, Issue 1, pp. 178-188. DOI: 10.1038/s41401-022-00927-1
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Pharmacokinetics, mass balance, and metabolism of [C-14]TPN171, a novel PDE5 inhibitor, in humans for the treatment of pulmonary arterial hypertension
Author: He, Yi-fei; Liu, Yin; Yu, Jing-hua; Cheng, Huan; Odilov, Abdullajon; Yang, Fei-pu; Tian, Guang-hui; Yao, Xiu-mei; Duan, Hua-qing; Yu, Cheng-yin; Yu, Chen; Liu, Yan-mei; Liu, Gang-yi; Shen, Jing-shan; Wang, Zhen; Diao, Xing-xing
Journal: ACTA PHARMACOLOGICA SINICA. 2023; Vol. 44, Issue 1, pp. 221-233. DOI: 10.1038/s41401-022-00922-6
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Dectin-1 plays a deleterious role in high fat diet-induced NAFLD of mice through enhancing macrophage activation
Author: Wang, Min-xiu; Luo, Wu; Ye, Lin; Jin, Lei-ming; Yang, Bin; Zhang, Qian-hui; Qian, Jian-chang; Wang, Yi; Zhang, Yi; Liang, Guang
Journal: ACTA PHARMACOLOGICA SINICA. 2023; Vol. 44, Issue 1, pp. 120-132. DOI: 10.1038/s41401-022-00926-2
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Dual-responsive nanoparticles loading bevacizumab and gefitinib for molecular targeted therapy against non-small cell lung cancer
Author: Zhao, Zi-tong; Wang, Jue; Fang, Lei; Qian, Xin-di; Cai, Ying; Cao, Hai-qiang; Wang, Guan-ru; He, Mei-lin; Jiang, Yan-yan; Wang, Dang-ge; Li, Ya-ping
Journal: ACTA PHARMACOLOGICA SINICA. 2023; Vol. 44, Issue 1, pp. 244-254. DOI: 10.1038/s41401-022-00930-6
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Silybin regulates P450s activity by attenuating endoplasmic reticulum stress in mouse nonalcoholic fatty liver disease
Author: Wu, Jing; Lou, Yun-ge; Yang, Xu-le; Wang, Rui; Zhang, Ran; Aa, Ji-ye; Wang, Guang-ji; Xie, Yuan
Journal: ACTA PHARMACOLOGICA SINICA. 2023; Vol. 44, Issue 1, pp. 133-144. DOI: 10.1038/s41401-022-00924-4
