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Piroctone olamine promotes BECN1 transcription and activates autophagy by targeting HDAC6 in colorectal cance
Author: Cui, Cui-yun; Li, Qiu-tong; Xiang, Xiong-yan; Fu, Ting-yu; Kong, Cun-quan; Yu, Lu; Ni, Wei-dong; Zhao, Zi-long; Liu, Huai; Zhao, Qing-chun; Ma, Cui-xia; Chen, Lin; Shi, Jing-li; Xie, Qi; Sun, Xiao-ya; Xu, Zhi-xiang; Yan, Bei-zhan; Jian, Yong-ping
Journal: ACTA PHARMACOLOGICA SINICA. 2026; Vol. , Issue , pp. -. DOI: 10.1038/s41401-026-01784-y
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Transcutaneous allicin oleogel restores energy homeostasis for obesity treatmen
Author: Xu, Quan-gang; Gu, Ze-yun; Chen, Wen-jie; Liu, Han; Li, Ze-yu; Cai, Wen-li; Huang, Jing; Muhitdinov, Bahtiyor; Liu, Er-gang; Aisa, Haji Akber; Huang, Yong-zhuo
Journal: ACTA PHARMACOLOGICA SINICA. 2026; Vol. , Issue , pp. -. DOI: 10.1038/s41401-026-01768-y
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A novel CDK8/19 inhibitor RO8323 mitigates allograft rejection through dual mechanisms of action to modulate regulatory T cell and myeloid cel
Author: Shen, Fang; Xie, Rou; Gan, Ye; Ren, Ping; Wu, Ran-ran; Yan, Jia-wei; Bian, Yu-ying; Liu, Cheng-cheng; Yang, Song; Han, Xin-chun; Zhou, Chen-gang; Wu, Yao; Tang, Yang; Xu, Zhi-heng; Yang, Jun; Qiu, Hong-xia; Yang, Ju-hao; Pu, Xue-yan; Li, Li; Gui, Yue; Xia, Gu-liang; Lassen, Kara G.; Shen, Hong C.; Huang, Hao-chu; Dai, Lue
Journal: ACTA PHARMACOLOGICA SINICA. 2026; Vol. , Issue , pp. -. DOI: 10.1038/s41401-026-01773-1
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5-OH-TMT mitigates colitis through HTRA2 binding-mediated activation of the Dectin-1 signaling pathwa
Author: Xiao, Chun-xiu; Wu, Wen-yuan; Li, Shi-cong; Dong, Mei-ling; Bian, Yu-hang; Yu, Meng; Lv, Xiang; Chen, Wei-guo; Hong, Min; Zhou, Jing; Sun, Yang; Ma, Hong-yue; Zhu, Yu-yu
Journal: ACTA PHARMACOLOGICA SINICA. 2026; Vol. , Issue , pp. -. DOI: 10.1038/s41401-026-01782-0
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Nanobody-based targeted cancer therapy and immunotherapy: fear not the futur
Author: Guo, Ma-di; Liao, Ran; Wang, Meng-yao; Wu, Li-jing; Zhang, Yong
Journal: ACTA PHARMACOLOGICA SINICA. 2026; Vol. , Issue , pp. -. DOI: 10.1038/s41401-026-01787-9
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Alkalization of the intracellular pH reprograms TNF-α signaling from inflammatory NF-κB activation to tumoricidal RIP kinase-dependent necroptosis in cancer cell
Author: Ying, Chang; Wang, Di; Zeng, Si-ying; Jin, Cheng-meng; Ying, Min-feng; Hu, Xun
Journal: ACTA PHARMACOLOGICA SINICA. 2026; Vol. , Issue , pp. -. DOI: 10.1038/s41401-026-01786-w
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Gut microbiota and renal fibrosis: novel mechanistic insights and therapeutic potentia
Author: Liu, Li-min; He, Xiao-fei; Zhang, Yu-lu; Zhou, Jing-teng; Miao, Hua; Zhao, Ying-yong
Journal: ACTA PHARMACOLOGICA SINICA. 2026; Vol. , Issue , pp. -. DOI: 10.1038/s41401-026-01801-0
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Astrocytic apelin mediates cortical neuronal function and prevents anxiety-like behaviors in mic
Author: Luo, Xi; Pei, Yu-ran; Yu, Wei; Dai, Ye-lin; Xiong, Zi-wei; Jia, Yan-bin; Zhang, Li; Zhang, Bo-rui
Journal: ACTA PHARMACOLOGICA SINICA. 2026; Vol. , Issue , pp. -. DOI: 10.1038/s41401-026-01785-x
