Cancer Cell

Cancer Cell

癌细胞

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NRF2 and the Hallmarks of Cancer 157
Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer 156
Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer 148
T Cell Dysfunction in Cancer 137
Tumor Mutational Burden and Efficacy of Nivolumab Monotherapy and in Combination with Ipilimumab in Small-Cell Lung Cancer 130
The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy 117
Comprehensive Analysis of Alternative Splicing Across Tumors from 705 Patients 104
Genomic and Functional Approaches to Understanding Cancer Aneuploidy 100
lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer 96
The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers 96
Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer 95
Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets 94
The Intestinal Microbiota in Colorectal Cancer 85
Targeting Ferroptosis to Iron Out Cancer 83
Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress 83
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies 80
A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers 76
Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies 73
Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance 73
Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy 68
Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas 67
BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines 65
Emerging Concepts for Immune Checkpoint Blockade-Based Combination Therapies 62
KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer 59
Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1 57
The Platelet Lifeline to Cancer: Challenges and Opportunities 56
Transcriptional Regulation of the Warburg Effect in Cancer by SIX1 55
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia 55
Notch Signaling in the Tumor Microenvironment 54
Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors 52
A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo 51
Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells 49
Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer 48
Loss of the FAT1 Tumor Suppressor Promotes Resistance to CDK4/6 Inhibitors via the Hippo Pathway 48
An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer 46
Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells 46
The Link between the Multiverse of Immune Microenvironments in Metastases and the Survival of Colorectal Cancer Patients 46
CDK4/6 Inhibitors: The Mechanism of Action May Not Be as Simple as Once Thought 45
The Immune Revolution: A Case for Priming, Not Checkpoint 44
Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies 43
Glycosylation in the Era of Cancer-Targeted Therapy: Where Are We Heading? 43
Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis 41
Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy 41
Tumor-Repopulating Cells Induce PD-1 Expression in CD8(+) T Cells by Transferring Kynurenine and AhR Activation 40
Biological Role and Therapeutic Potential of IDH Mutations in Cancer 39
TIM-3 Regulates CD103(+) Dendritic Cell Function and Response to Chemotherapy in Breast Cancer 39
Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting 39
BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency 38
beta 2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer 38
ORY- a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia 37
Hacking the Cancer Genome: Profiling Therapeutically Actionable Long Non-coding RNAs Using CRISPR-Cas9 Screening 37
A Convergence-Based Framework for Cancer Drug Resistance 37
CD40 Ligand-Modified Chimeric Antigen Receptor T Cells Enhance Antitumor Function by Eliciting an Endogenous Antitumor Response 37
Gain Fat-Lose Metastasis: Converting Invasive Breast Cancer Cells into Adipocytes Inhibits Cancer Metastasis 37
Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression 37
Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors 36
Cytosolic DNA Sensing in Organismal Tumor Control 36
Mutant NPM1 Maintains the Leukemic State through HOX Expression 35
Loss of KDM6A Activates Super-Enhancers to Induce Gender-Specific Squamous-like Pancreatic Cancer and Confers Sensitivity to BET Inhibitors 35
Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia 35
RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis 35
Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality 34
A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia 34
The Integrated Genomic Landscape of Thymic Epithelial Tumors 34
Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion 34
Integrated Genomic Analysis of Hurthle Cell Cancer Reveals Oncogenic Drivers, Recurrent Mitochondrial Mutations, and Unique Chromosomal Landscapes 34
Systematic Functional Annotation of Somatic Mutations in Cancer 33
Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance 32
Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling 31
Evolutionary Trajectories of IDHWT Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial Diagnosis 31
Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation 30
Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Cancers 30
Combination Immunotherapy with CAR T Cells and Checkpoint Blockade for the Treatment of Solid Tumors 30
SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis 30
A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment 30
The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma 29
Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories 29
Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation 29
Oncolytic Viruses as Antigen-Agnostic Cancer Vaccines 29
Proteogenomic Characterization of Human Early-Onset Gastric Cancer 29
An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles 28
Ascorbic Acid in Cancer Treatment: Let the Phoenix Fly 28
Integrated Analysis of Genetic Ancestry and Genomic Alterations across Cancers 28
Molecular, Pathological, Radiological, and Immune Profiling of Non-brainstem Pediatric High-Grade Glioma from the HERBY Phase II Randomized Trial 28
Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma 28
Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy 28
Dysregulated IL-18 Is a Key Driver of Immunosuppression and a Possible Therapeutic Target in the Multiple Myeloma Microenvironment 28
Widespread Chromosomal Losses and Mitochondrial DNA Alterations as Genetic Drivers in Hurthle Cell Carcinoma 28
Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality 28
Genomic and Epigenomic Profiling of High-Risk Intestinal Metaplasia Reveals Molecular Determinants of Progression to Gastric Cancer 28
Non-conventional Inhibitory CD4(+)Foxp3(-)PD-1(hi) T Cells as a Biomarker of Immune Checkpoint Blockade Activity 28
Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms 27
Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer 27
Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer 27
Adenosine Metabolism: Emerging Concepts for Cancer Therapy 27
Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations 27
Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling 26
RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer 26
KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism 26
The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma 26
Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations 26
Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3 beta-MCL-1 Axis 25
Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase 25
Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development 25
The Proteogenomic Landscape of Curable Prostate Cancer 25
Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG 25
A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK 25
Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes 25
Toward the Early Detection of Cancer by Decoding the Epigenetic and Environmental Fingerprints of Cell-Free DNA 24
Unique Metabolic Adaptations Dictate Distal Organ-Specific Metastatic Colonization 24
Combining the Allosteric Inhibitor Asciminib with Ponatinib Suppresses Emergence of and Restores Efficacy against Highly Resistant BCR-ABL1 Mutants 24
Sense-Antisense lncRNA Pair Encoded by Locus 6p22.3 Determines Neuroblastoma Susceptibility via the USP36-CHD7-SOX9 Regulatory Axis 24
Integration of Genomic and Transcriptional Features in Pancreatic Cancer Reveals Increased Cell Cycle Progression in Metastases 24
Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia 24
Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma 24
Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling 23
Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants 23
Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia 23
Increased Serine and One-Carbon Pathway Metabolism by PKC lambda/l Deficiency Promotes Neuroendocrine Prostate Cancer 23
ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer 23
PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth 22
Pan-Cancer Landscape and Analysis of ERBB2 Mutations Identifies Poziotinib as a Clinically Active Inhibitor and Enhancer of T-DM1 Activity 22
EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation 22
Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging 22
Extrinsic Phagocyte-Dependent STING Signaling Dictates the Immunogenicity of Dying Cells 22
Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups 21
A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor 21
Genomic and Transcriptomic Analysis Reveals Incremental Disruption of Key Signaling Pathways during Melanoma Evolution 21
PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells 21
A-to-I RNA Editing Contributes to Proteomic Diversity in Cancer 21
PEGylated IL-10 (Pegilodecakin) Induces Systemic Immune Activation, CD8(+) T Cell Invigoration and Polyclonal T Cell Expansion in Cancer Patients 20
Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations 20
Anti-tumor Activity of the Type I PRMT Inhibitor, GSK336 Synergizes with PRMT5 Inhibition through MTAP Loss 20
Passenger Hotspot Mutations in Cancer 20
EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma 20
The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression 20
Th9 Cells Represent a Unique Subset of CD4(+) T Cells Endowed with the Ability to Eradicate Advanced Tumors 20
The Osteogenic Niche Is a Calcium Reservoir of Bone Micrometastases and Confers Unexpected Therapeutic Vulnerability 19
Small-Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy 19
Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor 19
The Origins and Vulnerabilities of Two Transmissible Cancers in Tasmanian Devils 18
UTX Mutations in Human Cancer 18
KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance 18
Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation 18
Clonally Expanded T Cells Reveal Immunogenicity of Rhabdoid Tumors 18
Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis 18
Targeting the HTLV-I-Regulated BATF3/IRF4 Transcriptional Network in Adult T Cell Leukemia/Lymphoma 18
Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas 18
Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS 17
Mutational Signature Analysis Reveals NTHL1 Deficiency to Cause a Multi-tumor Phenotype 17
Enhanced Anti-lymphoma Activity of CAR19-iNKT Cells Underpinned by Dual CD19 and CD1d Targeting 17
Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair 17
Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies 17
Cellular Pliancy and the Multistep Process of Tumorigenesis 17
Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation 17
Targeting p38 alpha Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells 16
Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy 16
Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer 16
HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice 16
A Pharmacogenomic Landscape in Human Liver Cancers 16
Prospective Isolation and Characterization of Genetically and Functionally Distinct AML Subclones 16
Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity 16
The Tandem Duplicator Phenotype Is a Prevalent Genome-Wide Cancer Configuration Driven by Distinct Gene Mutations 16
Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation 16
HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis 15
Identification of Chemotherapy-Induced Leukemic-Regenerating Cells Reveals a Transient Vulnerability of Human AML Recurrence 15
p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors 15
RAC1(P29S) Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance 15
MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis 15
Intratumor Adoptive Transfer of IL-12 mRNA Transiently Engineered Antitumor CD8(+)T Cells 15
The Roles of Initiating Truncal Mutations in Human Cancers: The Order of Mutations and Tumor Cell Type Matters 15
DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns 14
Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and Braf(V600E)- Induced Tumorigenesis 14
Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias 14
Undifferentiated Sarcomas Develop through Distinct Evolutionary Pathways 14
Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells 14
Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses 14
Disruption of the beta 1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner 14
The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma 13
Lymphocyte-Specific Chromatin Accessibility Pre-determines Glucocorticoid Resistance in Acute Lymphoblastic Leukemia 13
Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties 13
DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors 13
Hyper-Editing of Cell-Cycle Regulatory and Tumor Suppressor RNA Promotes Malignant Progenitor Propagation 13
p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors 12
Widespread Selection for Oncogenic Mutant Allele Imbalance in Cancer 12
Enhancer Architecture and Essential Core Regulatory Circuitry of Chronic Lymphocytic Leukemia 12
Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF 12
Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity 12
Selective Fc gamma R Co-engagement on APCs Modulates the Activity of Therapeutic Antibodies Targeting T Cell Antigens 12
The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation 11
MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation 11
The Fire within: Cell-Autonomous Mechanisms in Inflammation-Driven Cancer 11
Pan-cancer Convergence to a Small-Cell Neuroendocrine Phenotype that Shares Susceptibilities with Hematological Malignancies 11
A Murine Model of Chronic Lymphocytic Leukemia Based on B Cell-Restricted Expression of Sf3b1 Mutation and Atm Deletion 11
Targeting Tumors with IL-10 Prevents Dendritic Cell-Mediated CD8(+) T Cell Apoptosis 11
DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk 11
The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease 11
Molecular Signatures of Regression of the Canine Transmissible Venereal Tumor 10
Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis 10
Real-Time Molecular Diagnosis of Tumors Using Water-Assisted Laser Desorption/lonization Mass Spectrometry Technology 10