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Adeno-Associated Virus Gene Delivery to Hard-to-Transduce Tissues: Biological Barriers, Engineering Strategies, and Clinical Challenge
Author: Nan, Xiaoyu; Sun, Jiawen; Jiao, Yunuo; Li, Wangan; Chen, Yujuan; Liu, Yurong; Xu, Bo; Yu, Li; Guo, Wenyan; Wu, Yang
Journal: HUMAN GENE THERAPY. 2026; Vol. 37, Issue 11-12, pp. 463-481. DOI: 10.1177/10430342261432669
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Strategies and Advances in Site-Specific Integration of Exogenous Large Gene
Author: Wu, Zhencheng; Chen, Jia; Huang, Manqi; Hu, Wenqi; Liu, Yiyu; Shao, Hongwei; Zhang, Wenfeng
Journal: HUMAN GENE THERAPY. 2026; Vol. , Issue , pp. -. DOI: 10.1177/10430342261445050
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An Engineered Adeno-Associated Virus Variant Enables Efficient Gene Editing in Human T Cell
Author: Leng, Mi; Gan, Chunmei; Zheng, Zhaoyue; He, Siwu; Liu, Yu; Zhou, Lixing; Cheng, Rui; Zhou, Jiao; Xiao, Lin; Ye, Jingya; Chen, Zhian; Xu, Liangting; Valencia, C. Alexander; Chow, Hoi Yee; Zhang, Yan; Dong, Biao
Journal: HUMAN GENE THERAPY. 2026; Vol. , Issue , pp. -. DOI: 10.1177/10430342261424779
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Construct Optimization Enables Oncolytic Virus-Mediated Functional Membrane Localization of Calreticulin and Macrophage Reprogrammin
Author: Zhang, Xinyuan; Xiong, Shengfeng; Zhang, Song; Si, Yao; Dai, Zhoutong; Ji, Teng; Huang, Xiaoyuan; Chen, Dong; Li, Fei; Hu, Fayong; Li, Xi
Journal: HUMAN GENE THERAPY. 2026; Vol. , Issue , pp. -. DOI: 10.1177/10430342261423100
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Targeted E3 Region Engineering Boosts Antitumor Efficacy of Conditionally Replicating Adenoviruses in an Immunocompetent Tumor Mode
Author: Si, Yao; Jin, Xin; Xiong, Shengfeng; Xiao, Dan; Sun, Xiaohui; Huang, Xiaoyuan; Ji, Teng; Ma, Ding; Ding, Yi; Han, Yingyan; Li, Fei
Journal: HUMAN GENE THERAPY. 2026; Vol. , Issue , pp. -. DOI: 10.1177/10430342251411042
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Lipid Nanoparticle-Delivered mRNA Therapy Corrects Neonatal Murine MPS I-
Author: Fu, Jiamei; Luo, Mei; Jin, Xiu; Su, Jing; Song, Li; Xu, Qiuxia; Liu, Fanfei; Wu, Xiaoyi; Luo, Min; Ye, Qin; Li, Qiqi; An, Yifang; Ren, Chengda; Hu, Ming; Liu, Man; Li, Manjun; Yao, Shaohua; Yang, Yang
Journal: HUMAN GENE THERAPY. 2026; Vol. , Issue , pp. -. DOI: 10.1177/10430342251412392
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Hepatocyte Growth Factor-Modified Dental Pulp Stem Cells Potentially Regulate Novel Renal Fibrosis-Associated Gene via PI3K/AKT/GSK3β Pathway to Alleviate Renal Fibrosi
Author: Shao, Jingyuan; Xu, Weiming; Tao, Ning; Du, Haitao; He, Zhichao; Wang, Liang; Wu, Chu-Tse; Wang, Hua
Journal: HUMAN GENE THERAPY. 2025; Vol. , Issue , pp. -. DOI: 10.1089/hum.2025.044
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AAV8-LDLR Gene Therapy in Ldlr-KO and Homozygous Ldlr p.W483X Mic
Author: Li, Qingao; Tang, Muyun; Jin, Ye; Su, Gengchen; Li, Yufan; Ju, Kaide; Zhang, Shijie; Zhang, Shuyang; Luan, Xiaodong
Journal: HUMAN GENE THERAPY. 2025; Vol. , Issue , pp. -. DOI: 10.1089/hum.2024.164
