Immunity

Immunity

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The Immune Landscape of Cancer 443
Regulation and Function of the PD-L1 Checkpoint 206
Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes 184
Transforming Growth Factor-beta Signaling in Immunity and Cancer 173
Inflammation and Cancer: Triggers, Mechanisms, and Consequences 145
The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages 126
T Follicular Helper Cell Biology: A Decade of Discovery and Diseases 119
Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species 119
Intratumoral Tcf1(+)PD-1(+)CD8(+) T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy 119
The IL-17 Family of Cytokines in Health and Disease 110
Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-gamma and IL-12 105
Targeting Interleukin-6 Signaling in Clinic 96
The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages 96
Shared and Distinct Functions of Type I and Type III Interferons 95
Regulation of the Immune Response by the Aryl Hydrocarbon Receptor 88
The Cytokines of Asthma 87
Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity 86
Cancer-Cell-Intrinsic Mechanisms Shaping the Tumor Immune Landscape 82
Human FOXP3(+) Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer 81
Caspases in Cell Death, Inflammation, and Disease 78
IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation 78
High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease 75
Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1(-)CD8(+) Tumor-Infiltrating T Cells 75
Developmental and Functional Heterogeneity of Monocytes 75
Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy 70
Human T Cell Development, Localization, and Function throughout Life 70
Combination Cancer Therapy with Immune Checkpoint Blockade: Mechanisms and Strategies 66
Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus 65
Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche 64
Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and ROR gamma t(+) Regulatory T Cells and Exacerbate Colitis in Mice 63
Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8(+) T Cells 62
High-Dimensional Single-Cell Analysis Identifies Organ-Specific Signatures and Conserved NK Cell Subsets in Humans and Mice 61
Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions 60
Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells 60
Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit 60
Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease 58
Dietary Fiber Confers Protection against Flu by Shaping Ly6c(-) Patrolling Monocyte Hematopoiesis and CD8(+) T Cell Metabolism 58
The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity 57
The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis 57
Niches for Hematopoietic Stem Cells and Their Progeny 56
PD-1 Controls Follicular T Helper Cell Positioning and Function 54
Targeting the Latent Reservoir for HIV-1 54
Plasmacytoid Dendritic Cells: Development, Regulation, and Function 53
A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult 52
Pleiotropy and Specificity: Insights from the Interleukin 6 Family of Cytokines 52
TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision 51
Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules 50
Tumor-Derived cGAMP Triggers a STING-Mediated Interferon Response in Non-tumor Cells to Activate the NK Cell Response 50
Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation 50
Innate Lymphoid Cells: Diversity, Plasticity, and Unique Functions in Immunity 50
Understanding Subset Diversity in T Cell Memory 49
Trained Memory of Human Uterine NK Cells Enhances Their Function in Subsequent Pregnancies 48
Unconventional T Cell Targets for Cancer Immunotherapy 48
A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion 47
Interferons and Proinflammatory Cytokines in Pregnancy and Fetal Development 47
IgA Responses to Microbiota 46
Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8(+) T Cells 46
Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity 46
The Environmental Sensor AHR Protects from Inflammatory Damage by Maintaining Intestinal Stem Cell Homeostasis and Barrier Integrity 44
HIV-1 Vaccines Based on Antibody Identification, B Cell Ontogeny, and Epitope Structure 44
Class-Switch Recombination Occurs Infrequently in Germinal Centers 44
The Immunobiology of the Interleukin-12 Family: Room for Discovery 44
The gamma(c) Family of Cytokines: Basic Biology to Therapeutic Ramifications 43
Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches 42
Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells 41
A Neutrophil Timer Coordinates Immune Defense and Vascular Protection 41
Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens 40
Immune Signaling in Neurodegeneration 40
A Map of Toll-like Receptor Expression in the Intestinal Epithelium Reveals Distinct Spatial, Cell Type-Specific, and Temporal Patterns 40
Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis 40
Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity 39
KLRG1(+) Effector CD8(+) T Cells Lose KLRG Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity 39
Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues 38
Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology 37
The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages 37
B Cells Are the Dominant Antigen-Presenting Cells that Activate Naive CD4(+) T Cells upon Immunization with a Virus-Derived Nanoparticle Antigen 37
Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1 beta 37
Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1(+) Stem-like CD8(+) T Cells during Chronic Infection 36
CD4(+) T Cell Help Is Required for the Formation of a Cytolytic CD8(+) T Cell Subset that Protects against Chronic Infection and Cancer 36
Butyrophilin-like 3 Directly Binds a Human V gamma 4(+) T Cell Receptor Using a Modality Distinct from Clonally-Restricted Antigen 36
Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis 36
T Cells in Nonlymphoid Tissues Give Rise to Lymph-Node-Resident Memory T Cells 35
Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells 35
Hemogenic Endothelial Fate Mapping Reveals Dual Developmental Origin of Mast Cells 35
Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis 34
The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression 34
Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy 33
Tissue-Resident Group 2 Innate Lymphoid Cells Differentiate by Layered Ontogeny and In Situ Perinatal Priming 33
Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers 32
Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance 32
Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration 32
Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells 31
The Intestine Harbors Functionally Distinct Homeostatic Tissue-Resident and Inflammatory Th17 Cells 31
T Follicular Helper Cell-Germinal Center B Cell Interaction Strength Regulates Entry into Plasma Cell or Recycling Germinal Center Cell Fate 31
The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons 31
Chanzyme TRPM7 Mediates the Ca2+ Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation 30
An Interleukin-23-Interleukin-22 Axis Regulates Intestinal Microbial Homeostasis to Protect from Diet-Induced Atherosclerosis 30
Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization 30
Glucocorticoids Drive Diurnal Oscillations in T Cell Distribution and Responses by Inducing Interleukin-7 Receptor and CXCR4 30
Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner 30
Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation 29
Defining HLA-II Ligand Processing and Binding Rules with Mass Spectrometry Enhances Cancer Epitope Prediction 29
GM-CSF, IL- and IL-5 Family of Cytokines: Regulators of Inflammation 29
Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis 29
Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution 29
The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1 alpha by Thrombin 28
Antibodies Set Boundaries Limiting Microbial Metabolite Penetration and the Resultant Mammalian Host Response 28
A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation 28
Spatial and Temporal Mapping of Human Innate Lymphoid Cells Reveals Elements of Tissue Specificity 28
Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses 28
Metabolite-Sensing Receptor Ffar2 Regulates Colonic Group 3 Innate Lymphoid Cells and Gut Immunity 27
B Cell Receptor and CD40 Signaling Are Rewired for Synergistic Induction of the c-Myc Transcription Factor in Germinal Center B Cells 27
A Single-Cell Transcriptomic Atlas of Thymus Organogenesis Resolves Cell Types and Developmental Maturation 27
Microbiota-Derived Lactate Activates Production of Reactive Oxygen Species by the Intestinal NADPH Oxidase Nox and Shortens Drosophila Lifespan 27
Commensals Suppress Intestinal Epithelial Cell Retinoic Acid Synthesis to Regulate Interleukin-22 Activity and Prevent Microbial Dysbiosis 27
Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12R beta 1 27
Paracrine Wnt5a-beta-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization 27
Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion 26
Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages 26
An Id2(RFP)-Reporter Mouse Redefines Innate Lymphoid Cell Precursor Potentials 26
Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function 26
PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways 26
Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and-22 Production and Promotes Intestinal Barrier Integrity 26
Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch 26
CCR7 Chemokine Receptor-Inducible Inc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1 alpha-Mediated Glycolysis 26
LAG3(+) Regulatory T Cells Restrain Interleukin-23 Producing CX3CR1(+) Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis 26
Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors 26
Innate Lymphoid Cell Development: A T Cell Perspective 26
Pas de Deux: Control of Anti-tumor Immunity by Cancer-Associated Inflammation 26
Cytokine Circuits in Cardiovascular Disease 26
Interleukin-10 Directly Inhibits CD8(+) T Cell Function by Enhancing N-Glycan Branching to Decrease Antigen Sensitivity 25
Quiescent Tissue Stem Cells Evade Immune Surveillance 25
Inflammasomes: Threat-Assessment Organelles of the Innate Immune System 25
Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis 25
Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis 25
Gut Mycobiota in Immunity and Inflammatory Disease 25
The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors 25
SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer 25
Liver-Resident NK Cells Control Antiviral Activity of Hepatic T Cells via the PD-1-PD-L1 Axis 25
Dysregulated Lung Commensal Bacteria Drive Interleukin-17B Production to Promote Pulmonary Fibrosis through Their Outer Membrane Vesicles 25
Hyaluronan ReceptorLYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen 25
Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons 25
A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated V gamma 9V delta 2 T Cell Activation 24
Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function 24
The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation 24
Critical Role for the Microbiota in CX(3)CR1(+) Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell Responses 24
Gain-of-Function Mutation of Card14 Leads to Spontaneous Psoriasis-like Skin Inflammation through Enhanced Keratinocyte Response to IL-17A 24
Polychromic Reporter Mice Reveal Unappreciated Innate Lymphoid Cell Progenitor Heterogeneity and Elusive ILC3 Progenitors in Bone Marrow 23
Specific Decrease in B-Cell-Derived Extracellular Vesicles Enhances Post-Chemotherapeutic CD8(+) T Cell Responses 23
The Nuclear Receptor PPAR gamma Controls Progressive Macrophage Polarization as a Ligand-Insensitive Epigenomic Ratchet of Transcriptional Memory 23
Innate-like Cytotoxic Function of Bystander-Activated CD8(+) T Cells Is Associated with Liver Injury in Acute Hepatitis A 23
The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages 23
Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation 22
Co-inhibitory Molecule B7 Superfamily Member 1 Expressed by Tumor-Infiltrating Myeloid Cells Induces Dysfunction of Anti-tumor CD8(+) T Cells 22
Neutrophil Extracellular Traps Initiate Gallstone Formation 22
The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases 22
Proteomic Analyses of Human Regulatory T Cells Reveal Adaptations in Signaling Pathways that Protect Cellular Identity 22
Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses 22
High Glucose Intake Exacerbates Autoimmunity through Reactive-Oxygen-Species-Mediated TGF-beta Cytokine Activation 22
A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages 22
Amphiregulin-Producing Pathogenic Memory T Helper 2 Cells Instruct Eosinophils to Secrete Osteopontin and Facilitate Airway Fibrosis 22
LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells 22
MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota 21
Transformation of Accessible Chromatin and 3D Nucleome Underlies Lineage Commitment of Early T Cells 21
Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 Cells 21
Mitochondria-Endoplasmic Reticulum Contact Sites Function as Immunometabolic Hubs that Orchestrate the Rapid Recall Response of Memory CD8(+) T Cells 21
Western Diet and the Immune System: An Inflammatory Connection 21
Human Fetal TNF-alpha-Cytokine-Producing CD4(+) Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life 21
CD8(+) T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity 21
Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope 20
A Macrophage Colony-Stimulating-Factor-Producing gamma delta T Cell Subset Prevents Malarial Parasitemic Recurrence 20
Gata6(+) Pericardial Cavity Macrophages Relocate to the Injured Heart and Prevent Cardiac Fibrosis 20
Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability 19
The Transcription Factor Bhlhe40 Programs Mitochondria! Regulation of Resident CD8(+) T Cell Fitness and Functionality 19
Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation 19
Why Innate Lymphoid Cells? 19
Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation 19
Dengue Virus Immunity Increases Zika Virus-Induced Damage during Pregnancy 19
Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure 19
Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R-STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity 19
Protein Amounts of the MYC Transcription Factor Determine Germinal Center B Cell Division Capacity 18
The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment 18
Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8(+) T Cell-Derived Interferon-gamma 18
Chemokine Receptor Redundancy and Specificity Are Context Dependent 18
An Interleukin-25-Mediated Autoregulatory Circuit in Keratinocytes Plays a Pivotal Role in Psoriatic Skin Inflammation 18
Lymph Node Mesenchymal and Endothelial Stromal Cells Cooperate via the RANK-RANKL Cytokine Axis to Shape the Sinusoidal Macrophage Niche 18
Treg-Cell Control of a CXCL5-IL-17 Inflammatory Axis Promotes Hair-Follicle-Stem-Cell Differentiation During Skin-Barrier Repair 18
Clonal Deletion of Tumor-Specific T Cells by Interferon-gamma Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade 18
Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide alpha-CGRP Modulates Group 2 Innate Lymphoid Cell Responses 18
Sympathetic Neuronal Activation Triggers Myeloid Progenitor Proliferation and Differentiation 18
Cbl Ubiquitin Ligases Control B Cell Exit from the Germinal-Center Reaction 18
The Transcription Factor Runx3 Establishes-Chromatin Accessibility of cis-Regulatory Landscapes that Drive Memory Cytotoxic T Lymphocyte Formation 18
Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge 17
Intestinal Epithelial Wnt Signaling Mediates Acetylcholine-Triggered Host Defense against Infection 17
Anti-apoptotic Protein BIRC5 Maintains Survival of HIV-1-Infected CD4(+) T Cells 17
Transcription Factor IRF8 Orchestrates the Adaptive Natural Killer Cell Response 17
Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock 17
Negative Co-stimulation Constrains T Cell Differentiation by Imposing Boundaries on Possible Cell States 17
Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM 17
A Subset of Skin Macrophages Contributes to the Surveillance and Regeneration of Local Nerves 17