| Circular RNAs function as ceRNAs to regulate and control human cancer progression |
169 |
| Kinase-targeted cancer therapies: progress, challenges and future directions |
132 |
| Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway |
132 |
| Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape |
120 |
| The novel roles of circRNAs in human cancer |
98 |
| Targeting PI3K in cancer: mechanisms and advances in clinical trials |
93 |
| Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p PTEN expression |
92 |
| Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance |
91 |
| Circular RNA AKT3 upregulates PIK3R1 to enhance cisplatin resistance in gastric cancer via miR-198 suppression |
84 |
| The role of m(6)A RNA methylation in human cancer |
82 |
| Biomarkers for predicting efficacy of PD-1/PD-L1 inhibitors |
78 |
| FBXW7: a critical tumor suppressor of human cancers |
77 |
| METTL3 facilitates tumor progression via an m(6)A-IGF2BP2-dependent mechanism in colorectal carcinoma |
77 |
| Long non-coding RNA PVT1 promotes tumor progression by regulating the miR-143/HK2 axis in gallbladder cancer |
76 |
| The circRNA circAGFG1 acts as a sponge of miR-195-5p to promote triple-negative breast cancer progression through regulating CCNE1 expression |
76 |
| A novel lncRNA MCM3AP-AS1 promotes the growth of hepatocellular carcinoma by targeting miR-194-5p/FOXA1 axis |
75 |
| Role of hypoxia in cancer therapy by regulating the tumor microenvironment |
70 |
| METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner |
68 |
| CircPSMC3 suppresses the proliferation and metastasis of gastric cancer by acting as a competitive endogenous RNA through sponging miR-296-5p |
67 |
| Role of Bruton's tyrosine kinase in B cells and malignancies |
66 |
| Mechanisms of receptor tyrosine kinase activation in cancer |
66 |
| The long noncoding RNA SNHG1 regulates colorectal cancer cell growth through interactions with EZH2 and miR-154-5p |
65 |
| LINC01133 as ceRNA inhibits gastric cancer progression by sponging miR-106a-3p to regulate APC expression and the Wnt/beta-catenin pathway |
65 |
| Effect of exosomal miRNA on cancer biology and clinical applications |
65 |
| Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4 |
64 |
| Cancer-associated fibroblasts as abettors of tumor progression at the crossroads of EMT and therapy resistance |
64 |
| Management of acquired resistance to EGFR TKI-targeted therapy in advanced non-small cell lung cancer |
64 |
| Circular RNAs in Cancer: emerging functions in hallmarks, stemness, resistance and roles as potential biomarkers |
63 |
| RNA N6-methyladenosine demethylase FTO promotes breast tumor progression updates through inhibiting BNIP3 |
61 |
| Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities |
61 |
| Circular RNA 100146 functions as an oncogene through direct binding to miR-361-3p and miR-615-5p in non-small cell lung cancer |
59 |
| Exosomes in the tumor microenvironment as mediators of cancer therapy resistance |
59 |
| Circular RNA circTADA2A promotes osteosarcoma progression and metastasis by sponging miR-203a-3p and regulating CREB3 expression |
59 |
| LncRNA PTAR promotes EMT and invasion-metastasis in serous ovarian cancer by competitively binding miR-101-3p to regulate ZEB1 expression |
59 |
| Exosomal circRNAs: biogenesis, effect and application in human diseases |
58 |
| EIF4A3-induced circular RNA MMP9 (circMMP9) acts as a sponge of miR-124 and promotes glioblastoma multiforme cell tumorigenesis |
58 |
| Role of the NLRP3 inflammasome in cancer |
58 |
| KRAS oncogene in non-small cell lung cancer: clinical perspectives on the treatment of an old target |
57 |
| CircRNA microarray profiling identifies a novel circulating biomarker for detection of gastric cancer |
57 |
| Hypoxic BMSC-derived exosomal miRNAs promote metastasis of lung cancer cells via STAT3-induced EMT |
56 |
| Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis |
56 |
| BRD4 and Cancer: going beyond transcriptional regulation |
52 |
| Circular RNA circ-DONSON facilitates gastric cancer growth and invasion via NURF complex dependent activation o transcription factor SOX4 |
51 |
| CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer |
51 |
| Circular RNA cTFRC acts as the sponge of MicroRNA-107 to promote bladder carcinoma progression |
51 |
| circKIF4A acts as a prognostic factor and mediator to regulate the progression of triple-negative breast cancer |
50 |
| New insights into long noncoding RNAs and their roles in glioma |
50 |
| Nuclear functions of mammalian MicroRNAs in gene regulation, immunity and cancer |
50 |
| Critical role of FOXO3a in carcinogenesis |
49 |
| Knockdown of long non-coding RNA NEAT1 inhibits glioma cell migration and invasion via modulation of SOX2 targeted by miR-132 |
49 |
| METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer |
49 |
| Effects of exosomes on pre-metastatic niche formation in tumors |
48 |
| Exosomal long noncoding RNA HOTTIP as potential novel diagnostic and prognostic biomarker test for gastric cancer |
48 |
| Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosis |
48 |
| Mechanisms associated with biogenesis of exosomes in cancer |
47 |
| Synergistic effect of immune checkpoint blockade and anti-angiogenesis in cancer treatment |
47 |
| The emerging role of microRNAs and long noncoding RNAs in drug resistance of hepatocellular carcinoma |
47 |
| Exosome-transmitted miR-128-3p increase chemosensitivity of oxaliplatin-resistant colorectal cancer |
47 |
| The IncRNA MACC1-AS1 promotes gastric cancer cell metabolic plasticity via AMPK/Lin28 mediated mRNA stability of MACC1 |
46 |
| Emerging role of exosome-derived long non-coding RNAs in tumor microenvironment |
46 |
| The pro-metastasis effect of circANKS1B in breast cancer |
46 |
| Activation of LncRNA TINCR by H3K27 acetylation promotes Trastuzumab resistance and epithelial-mesenchymal transition by targeting MicroRNA-125b in breast Cancer |
46 |
| Circular RNA circSLC8A1 acts as a sponge of miR-130b/miR-494 in suppressing bladder cancer progression via regulating PTEN |
46 |
| Serum long noncoding RNA HOTAIR as a novel diagnostic and prognostic biomarker in glioblastoma multiforme |
46 |
| The role of necroptosis in cancer biology and therapy |
46 |
| Circular RNA hsa_circ_0008305 (circPTK2) inhibits TGF-beta-induced epithelial- mesenchymal transition and metastasis by controlling TIF1 gamma in non-small cell lung cancer |
45 |
| Circular RNA circTRIM33-12 acts as the sponge of MicroRNA-191 to suppress hepatocellular carcinoma progression |
44 |
| LncRNA MT1JP functions as a ceRNA in regulating FBXW7 through competitively binding to miR-92a-3p in gastric cancer |
44 |
| Tumor microenvironment participates in metastasis of pancreatic cancer |
43 |
| Extracellular vesicles in the tumor microenvironment: old stories, but new tales |
42 |
| Extracellular vesicles-mediated intercellular communication: roles in the tumor microenvironment and anti-cancer drug resistance |
42 |
| Advances in studies of tyrosine kinase inhibitors and their acquired resistance |
41 |
| The role of exosomal PD-L1 in tumor progression and immunotherapy |
41 |
| Neoantigen vaccine: an emerging tumor immunotherapy |
40 |
| Long noncoding RNA DANCR, working as a competitive endogenous RNA, promotes ROCK1-mediated proliferation and metastasis via decoying of miR-335-5p and miR-1972 in osteosarcoma |
40 |
| Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m(6)A reader YTHDF3 |
40 |
| KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3 |
39 |
| Third generation EGFR TKIs: current data and future directions |
39 |
| The role of exosomal noncoding RNAs in cancer |
39 |
| Molecular characterization and clinical relevance of m(6)A regulators across 33 cancer types |
39 |
| MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer |
39 |
| m(6)A-induced lncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1 |
39 |
| STAT3-induced lncRNA HAGLROS overexpression contributes to the malignant progression of gastric cancer cells via mTOR signal-mediated inhibition of autophagy |
38 |
| Liquid biopsy in hepatocellular carcinoma: circulating tumor cells and circulating tumor DNA |
38 |
| Invasion-related circular RNA circFNDC3B inhibits bladder cancer progression through the miR-1178-3p/G3BP2/SRC/FAK axis |
38 |
| Emerging function and potential diagnostic value of circular RNAs in cancer |
37 |
| Targeting Tyro Axl and MerTK (TAM receptors): implications for macrophages in the tumor microenvironment |
37 |
| RNA-Seq profiling of circular RNAs in human colorectal Cancer liver metastasis and the potential biomarkers |
37 |
| Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLC epsilon-NF-B signaling pathway and VEGF-C/ Bcl-2 expression |
37 |
| Tumor-originated exosomal lncUEGC1 as a circulating biomarker for early-stage gastric cancer |
35 |
| Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review |
35 |
| Long non-coding RNA GBCDRlnc1 induces chemoresistance of gallbladder cancer cells by activating autophagy |
35 |
| MicroRNA-494 promotes cancer progression and targets adenomatous polyposis coli in colorectal cancer |
34 |
| Novel insights on m(6)A RNA methylation in tumorigenesis: a double-edged sword |
34 |
| Exosome-orchestrated hypoxic tumor microenvironment |
34 |
| Long non-coding RNAs in Oral squamous cell carcinoma: biologic function, mechanisms and clinical implications |
34 |
| Circ-AKT3 inhibits clear cell renal cell carcinoma metastasis via altering miR-296-3p/E-cadherin signals |
34 |
| The relationship between autophagy and the immune system and its applications for tumor immunotherapy |
34 |
| Circular RNA YAP1 inhibits the proliferation and invasion of gastric cancer cells by regulating the miR-367-5p/p27 (Kip1) axis |
34 |
| Circular RNA circRHOT1 promotes hepatocellular carcinoma progression by initiation of NR2F6 expression |
33 |
| LncRNA PVT1 triggers Cyto-protective autophagy and promotes pancreatic ductal adenocarcinoma development via the miR-20a-5p/ULK1 Axis |
33 |
| Current perspectives on the immunosuppressive tumor microenvironment in hepatocellular carcinoma: challenges and opportunities |
33 |
| Functions of N6-methyladenosine and its role in cancer |
33 |
| A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1 |
33 |
| Circular RNA F-circEA-2a derived from EML4-ALK fusion gene promotes cell migration and invasion in non-small cell lung cancer |
32 |
| The long non-coding RNA PTTG3P promotes cell growth and metastasis via up-regulating PTTG1 and activating PI3K/AKT signaling in hepatocellular carcinoma |
31 |
| Novel long noncoding RNA OTUD6B-AS1 indicates poor prognosis and inhibits clear cell renal cell carcinoma proliferation via the Wnt/beta-catenin signaling pathway |
31 |
| YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma |
31 |
| Reactive oxygen species: a volatile driver of field cancerization and metastasis |
31 |
| Therapy resistance mediated by exosomes |
31 |
| MiR-25-3p promotes the proliferation of triple negative breast cancer by targeting BTG2 |
31 |
| Next generation chimeric antigen receptor T cells: safety strategies to overcome toxicity |
31 |
| Long noncoding RNA AFAP1-AS1 predicts a poor prognosis and regulates non-small cell lung cancer cell proliferation by epigenetically repressing p21 expression |
30 |
| Long noncoding RNA Pvt1 regulates the immunosuppression activity of granulocytic myeloid-derived suppressor cells in tumor-bearing mice |
30 |
| Long noncoding RNA HULC accelerates liver cancer by inhibiting PTEN via autophagy cooperation to miR15a |
30 |
| Role of hypoxia-induced exosomes in tumor biology |
30 |
| EGFR-TKIs resistance via EGFR-independent signaling pathways |
30 |
| Pyruvate kinase M2 fuels multiple aspects of cancer cells: from cellular metabolism, transcriptional regulation to extracellular signaling |
30 |
| Exosomes promote pre-metastatic niche formation in ovarian cancer |
30 |
| Exosome-mediated secretion of LOXL4 promotes hepatocellular carcinoma cell invasion and metastasis |
30 |
| Expression signatures of exosomal long non-coding RNAs in urine serve as novel non-invasive biomarkers for diagnosis and recurrence prediction of bladder cancer |
29 |
| Exosomes in gastric cancer: roles, mechanisms, and applications |
29 |
| CircDLST promotes the tumorigenesis and metastasis of gastric cancer by sponging miR-502-5p and activating the NRAS/MEK1/ERK1/2 signaling |
28 |
| Natural killer group 2D receptor and its ligands in cancer immune escape |
28 |
| Circular RNA profiling and its potential for esophageal squamous cell cancer diagnosis and prognosis |
28 |
| PTEN/PTENP1: 'Regulating the regulator of RTK-dependent PI3K/Akt signalling', new targets for cancer therapy |
28 |
| Crosstalk between autophagy and epithelial-mesenchymal transition and its application in cancer therapy |
28 |
| LncRNA DLEU1 contributes to colorectal cancer progression via activation of KPNA3 |
28 |
| LncRNA MIR31HG targets HIF1A and P21 to facilitate head and neck cancer cell proliferation and tumorigenesis by promoting cell-cycle progression |
28 |
| LncRNAs regulate the cytoskeleton and related Rho/ROCK signaling in cancer metastasis |
28 |
| AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications |
28 |
| The forkhead-box family of transcription factors: key molecular players in colorectal cancer pathogenesis |
28 |
| Circular RNA BCRC-3 suppresses bladder cancer proliferation through miR-182-5p/p27 axis |
28 |
| CircFAT1 sponges miR-375 to promote the expression of Yes-associated protein 1 in osteosarcoma cells |
27 |
| The microbiota and microbiome in pancreatic cancer: more influential than expected |
27 |
| A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling |
27 |
| Paracrine and epigenetic control of CAF-induced metastasis: the role of HOTAIR stimulated by TGF-beta 1 secretion |
27 |
| Circular RNA circFGFR1 promotes progression and anti-PD-1 resistance by sponging miR-381-3p in non-small cell lung cancer cells |
27 |
| miR-190 suppresses breast cancer metastasis by regulation of TGF-beta-induced epithelial-mesenchymal transition |
27 |
| LncRNA ANRIL regulates AML development through modulating the glucose metabolism pathway of AdipoR1/AMPK/SIRT1 |
26 |
| The long noncoding RNA LINC00312 induces lung adenocarcinoma migration and vasculogenic mimicry through directly binding YBX1 |
26 |
| CD103-positive CSC exosome promotes EMT of clear cell renal cell carcinoma: role of remote MiR-19b-3p |
26 |
| Targeting interleukin-6 as a strategy to overcome stroma-induced resistance to chemotherapy in gastric cancer |
26 |
| RNA-Seq profiling of circular RNA in human lung adenocarcinoma and squamous cell carcinoma |
26 |
| Circular RNA FOXP1 promotes tumor progression and Warburg effect in gallbladder cancer by regulating PKLR expression |
26 |
| Receptor tyrosine kinases (RTKs) in breast cancer: signaling, therapeutic implications and challenges |
26 |
| Exosome-transmitted long non-coding RNA PTENP1 suppresses bladder cancer progression |
26 |
| The curious case of vacuolar ATPase: regulation of signaling pathways |
26 |
| The functional role of integrins during intra- and extravasation within the metastatic cascade |
25 |
| Novel evidence for a PIWI-interacting RNA (piRNA) as an oncogenic mediator of disease progression, and a potential prognostic biomarker in colorectal cancer |
25 |
| Tumor-derived exosomes induce N2 polarization of neutrophils to promote gastric cancer cell migration |
25 |
| The roles of extracellular vesicles in gastric cancer development, microenvironment, anti-cancer drug resistance, and therapy |
25 |
| Biogenesis, functions and clinical significance of circRNAs in gastric cancer |
25 |
| Exosomal let-7d-3p and miR-30d-5p as diagnostic biomarkers for non-invasive screening of cervical cancer and its precursors |
24 |
| Exosomal tRNA-derived small RNA as a promising biomarker for cancer diagnosis |
24 |
| Linc00210 drives Wnt/beta-catenin signaling activation and liver tumor progression through CTNNBIP1-dependent manner |
24 |
| Recent updates on CAR T clinical trials for multiple myeloma |
24 |
| The c-Myc-regulated lncRNA NEAT1 and paraspeckles modulate imatinib-induced apoptosis in CML cells |
24 |
| The decade of exosomal long RNA species: an emerging cancer antagonist |
24 |
| Long non-coding RNA HOTAIR promotes exosome secretion by regulating RAB35 and SNAP23 in hepatocellular carcinoma |
24 |
| STING: a master regulator in the cancer-immunity cycle |
24 |
| The long non-coding RNA CYTOR drives colorectal cancer progression by interacting with NCL and Sam68 |
24 |
| Effects of tumor metabolic microenvironment on regulatory T cells |
23 |
| Recent advances in understanding tumor stroma-mediated chemoresistance in breast cancer |
23 |
| Emerging roles and therapeutic value of exosomes in cancer metastasis |
23 |
| p53-targeted lincRNA-p21 acts as a tumor suppressor by inhibiting JAK2/STAT3 signaling pathways in head and neck squamous cell carcinoma |
23 |
| Novel targeted therapies and immunotherapy for advanced thyroid cancers |
23 |
| Tumour-originated exosomal miR-155 triggers cancer-associated cachexia to promote tumour progression |
22 |
| Nuclear lncRNA HOXD-AS1 suppresses colorectal carcinoma growth and metastasis via inhibiting HOXD3-induced integrin 3 transcriptional activating and MAPK/AKT signalling |
22 |
| Chronic myeloid leukemia: the paradigm of targeting oncogenic tyrosine kinase signaling and counteracting resistance for successful cancer therapy |
22 |
| Ai-lncRNA EGOT enhancing autophagy sensitizes paclitaxel cytotoxicity via upregulation of ITPR1 expression by RNA-RNA and RNA-protein interactions in human cancer |
21 |
| Exo-circRNAs: a new paradigm for anticancer therapy |
21 |
| Circular RNA ACVR2A suppresses bladder cancer cells proliferation and metastasis through miR-626/EYA4 axis |
21 |
| LncRNA SATB2-AS1 inhibits tumor metastasis and affects the tumor immune cell microenvironment in colorectal cancer by regulating SATB2 |
20 |
| PIWI-interacting RNA-36712 restrains breast cancer progression and chemoresistance by interaction with SEPW1 pseudogene SEPW1P RNA |
20 |
| The lncRNA UCA1 promotes proliferation, migration, immune escape and inhibits apoptosis in gastric cancer by sponging anti-tumor miRNAs |
20 |
| New insights into the regulatory role of microRNA in tumor angiogenesis and clinical implications |
20 |
| Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation |
20 |
| Extracellular vesicles of carcinoma-associated fibroblasts creates a pre-metastatic niche in the lung through activating fibroblasts |
20 |
| Comparative proteogenomic analysis of right-sided colon cancer, left-sided colon cancer and rectal cancer reveals distinct mutational profiles |
20 |
| Circular RNA circERBB2 promotes gallbladder cancer progression by regulating PA2G4-dependent rDNA transcription |
20 |
| WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1 |
20 |
| Circular RNA circNHSL1 promotes gastric cancer progression through the miR-1306-3p/SIX1/vimentin axis |
20 |
| Long non-coding RNA NEAT1-modulated abnormal lipolysis via ATGL drives hepatocellular carcinoma proliferation |
20 |
| Neddylation: a novel modulator of the tumor microenvironment |
20 |
| Regulation of Sox2 and stemness by nicotine and electronic-cigarettes in non-small cell lung cancer |
20 |
| Shedding of bevacizumab in tumour cells-derived extracellular vesicles as a new therapeutic escape mechanism in glioblastoma |
19 |
| LncRNA-HGBC stabilized by HuR promotes gallbladder cancer progression by regulating miR-502-3p/SET/AKT axis |
19 |
| Therapeutic advances in anaplastic thyroid cancer: a current perspective |
19 |
| Sunitinib-suppressed miR-452-5p facilitates renal cancer cell invasion and metastasis through modulating SMAD4/SMAD7 signals |
19 |
| Circular RNA circ-ZKSCAN1 inhibits bladder cancer progression through miR-1178-3p/p21 axis and acts as a prognostic factor of recurrence |
19 |
| Circular RNA F-circSR derived from SLC34A2-ROS1 fusion gene promotes cell migration in non-small cell lung cancer |
19 |
| A novel AR translational regulator lncRNA LBCS inhibits castration resistance of prostate cancer |
19 |
| Role of the dynamic tumor microenvironment in controversies regarding immune checkpoint inhibitors for the treatment of non-small cell lung cancer (NSCLC) with EGFR mutations |
19 |
| CircPLEKHM3 acts as a tumor suppressor through regulation of the miR-9/BRCA1/DNAJB6/KLF4/AKT1 axis in ovarian cancer |
19 |
| A positive feed-forward loop between LncRNA-URRCC and EGFL7/P-AKT/FOXO3 signaling promotes proliferation and metastasis of clear cell renal cell carcinoma |
19 |
| Linc0 a long noncoding RNA, acts as novel oncogene in regulating cancer cell growth in colorectal cancer |
18 |
| Suppression of PDHX by microRNA-27b deregulates cell metabolism and promotes growth in breast cancer |
18 |
| Targeting Gas6/TAM in cancer cells and tumor microenvironment |
18 |
| m(6)A mRNA methylation regulates CTNNB1 to promote the proliferation of hepatoblastoma |
18 |
