| Shedding light on the cell biology of extracellular vesicles |
720 |
| New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer |
336 |
| Mechanism and medical implications of mammalian autophagy |
326 |
| Regulation of microRNA function in animals |
309 |
| AMPK: guardian of metabolism and mitochondrial homeostasis |
304 |
| Regulation of microRNA biogenesis and its crosstalk with other cellular pathways |
179 |
| A brave new world of RNA-binding proteins |
174 |
| Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins |
170 |
| Sphingolipids and their metabolism in physiology and disease |
168 |
| Understanding the diversity of membrane lipid composition |
162 |
| The next generation of CRISPR-Cas technologies and applications |
150 |
| Dynamics and function of DNA methylation in plants |
146 |
| The functions and unique features of long intergenic non-coding RNA |
144 |
| The coming of age of chaperone-mediated autophagy |
144 |
| Dynamics and functions of lipid droplets |
143 |
| The diverse roles of DNA methylation in mammalian development and disease |
141 |
| Mechanisms of clathrin-mediated endocytosis |
132 |
| The multiple mechanisms that regulate p53 activity and cell fate |
128 |
| The proteostasis network and its decline in ageing |
117 |
| A new era for understanding amyloid structures and disease |
116 |
| Integrins as biomechanical sensors of the microenvironment |
106 |
| Adipogenesis and metabolic health |
106 |
| The functions and regulation of the PTEN tumour suppressor: new modes and prospects |
100 |
| Mitochondrial proteins: from biogenesis to functional networks |
99 |
| The machineries, regulation and cellular functions of mitochondrial calcium |
98 |
| Autophagy as a promoter of longevity: insights from model organisms |
96 |
| DNA double-strand break repair-pathway choice in somatic mammalian cells |
96 |
| Functions and mechanisms of non-histone protein acetylation |
91 |
| Haematopoietic stem cell activity and interactions with the niche |
90 |
| Reading, writing and erasing mRNA methylation |
85 |
| Quality and quantity control of gene expression by nonsense-mediated mRNA decay |
84 |
| Hippo-YAP/TAZ signalling in organ regeneration and regenerative medicine |
82 |
| Contextual determinants of TGF beta action in development, immunity and cancer |
80 |
| The Hsp70 chaperone network |
79 |
| Breaking the chains: deubiquitylating enzyme specificity begets function |
79 |
| Functional 5 ' UTR mRNA structures in eukaryotic translation regulation and how to find them |
78 |
| The cytoplasmic dynein transport machinery and its many cargoes |
75 |
| Building and decoding ubiquitin chains for mitophagy |
72 |
| Regulation of heat shock transcription factors and their roles in physiology and disease |
70 |
| Actin-microtubule crosstalk in cell biology |
70 |
| Ubiquitylation at the crossroads of development and disease |
69 |
| Metabolic regulation of cell growth and proliferation |
68 |
| The roles of DNA, RNA and histone methylation in ageing and cancer |
67 |
| Codon optimality, bias and usage in translation and mRNA decay |
65 |
| Once and only once: mechanisms of centriole duplication and their deregulation in disease |
64 |
| The mitochondrial UPR: mechanisms, physiological functions and implications in ageing |
64 |
| Ten principles of heterochromatin formation and function |
60 |
| Linking cellular stress responses to systemic homeostasis |
60 |
| Mechanisms of signalling and biased agonism in G protein-coupled receptors |
59 |
| Microtubule dynamics: an interplay of biochemistry and mechanics |
57 |
| Biochemical and cellular properties of insulin receptor signalling |
56 |
| To degrade or not to degrade: mechanisms and significance of endocytic recycling |
56 |
| PI3K isoforms in cell signalling and vesicle trafficking |
56 |
| Crosstalk between metabolism and circadian clocks |
56 |
| Ribosome assembly coming into focus |
54 |
| Regulation of proteasome assembly and activity in health and disease |
53 |
| Transcription regulation by the Mediator complex |
52 |
| Eukaryotic core promoters and the functional basis of transcription initiation |
52 |
| Mechanisms and functions of ribosome-associated protein quality control |
50 |
| The role of 3D genome organization in development and cell differentiation |
49 |
| Mechanisms of 3D cell migration |
49 |
| Regulation of chromatin and gene expression by metabolic enzymes and metabolites |
48 |
| Identification of bioactive metabolites using activity metabolomics |
48 |
| Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes |
47 |
| Establishing and regulating the composition of cilia for signal transduction |
47 |
| Mitochondrial diseases: the contribution of organelle stress responses to pathology |
47 |
| The emerging complexity of the tRNA world: mammalian tRNAs beyond protein synthesis |
46 |
| Metabolites as regulators of insulin sensitivity and metabolism |
46 |
| Functions and mechanisms of epigenetic inheritance in animals |
46 |
| The regulation, functions and clinical relevance of arginine methylation |
45 |
| Emerging roles of linker histones in regulating chromatin structure and function |
45 |
| Born to run: control of transcription elongation by RNA polymerase II |
44 |
| The roles of structural dynamics in the cellular functions of RNAs |
43 |
| Spatial proteomics: a powerful discovery tool for cell biology |
42 |
| Dynamics of the epigenetic landscape during the maternal-to-zygotic transition |
41 |
| Advances in protein structure prediction and design |
40 |
| Roles and regulation of histone methylation in animal development |
38 |
| Roadblocks and resolutions in eukaryotic translation |
36 |
| The role of transcription in shaping the spatial organization of the genome |
35 |
| Translation deregulation in human disease |
32 |
| Cellular and epigenetic drivers of stem cell ageing |
29 |
| Designing cell function: assembly of synthetic gene circuits for cell biology applications |
25 |
| Unravelling cellular relationships during development and regeneration using genetic lineage tracing |
23 |
| The DNA damage response to transcription stress |
21 |
| Control of DNA replication timing in the 3D genome |
20 |
| Integrative regulation of physiology by histone deacetylase 3 |
20 |
| A changing paradigm of transcriptional memory propagation through mitosis |
19 |
| Cellular crosstalk in the development and regeneration of the respiratory system |
14 |
| Chromatin dependencies in cancer and inflammation |
8 |
| Single-cell transcriptional profiling: a window into embryonic cell-type specification |
7 |
