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Design, Synthesis and Biological Evaluation of Oxadiazole-Biphenyl Derivatives as Small Molecule Inhibitors Targeting PD-1/PD-L1 Immune Checkpoin
Author: Xie, Lingfeng; Zhu, Mingxuan; Zhao, Tong; Pei, Yifeng; Wei, Bo; Zhu, Shilong; Chen, Jiaoru; Zhang, Huibin; Zhou, Jinpei
Journal: ACS MEDICINAL CHEMISTRY LETTERS. 2026; Vol. 17, Issue 4, pp. 900-908. DOI: 10.1021/acsmedchemlett.6c00048
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Serial PNA-Transformer-Based Virtual Screening Identifies Nanomolar DYRK1A Inhibitors for Pancreatic Ductal Adenocarcinom
Author: Zhang, Hongyu; Wang, Ke; Wu, Xiaochuan; Zhou, Rui; Li, Chaofeng; Cai, Xiuyu; Zhuang, Yanyan
Journal: ACS MEDICINAL CHEMISTRY LETTERS. 2026; Vol. 17, Issue 3, pp. 695-703. DOI: 10.1021/acsmedchemlett.5c00723
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Design, Synthesis, Molecular Dynamics Simulations, and Biological Evaluation of PB2 Inhibitors as Anti-Influenza A Virus Agen
Author: Hu, Qibo; Xie, Huiru; Zhang, Qiuhong; Zhu, Lian; Che, Jingjing; Chen, Lixia; Li, Xingzhou
Journal: ACS MEDICINAL CHEMISTRY LETTERS. 2026; Vol. 17, Issue 3, pp. 688-694. DOI: 10.1021/acsmedchemlett.5c00719
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Antibody-Targeted Covalent Inhibitor Conjugate (Ab-TCI) Bridged by an Arsenic-Thiol Bond Enables Double Insurance Targeting of Cancer Cells and Kinase for Effective Cancer Treatmen
Author: Zhao, Xinyue; Zhao, Yang; Fang, Ziyang; Wei, Naijie; Chen, Jianbin; Wang, Qiuquan; Yan, Xiaowen
Journal: ACS MEDICINAL CHEMISTRY LETTERS. 2026; Vol. , Issue , pp. -. DOI: 10.1021/acsmedchemlett.6c00131
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Potentiated Tumor Photo-immunotherapy Based on Glutamine Starvation and Interferon Stimulatory DNA-Activated cGAS-STING Pathwa
Author: Zhu, Jinwen; Guo, Zhenzhen; Xia, Renpeng; Miao, Peng
Journal: ACS MEDICINAL CHEMISTRY LETTERS. 2026; Vol. , Issue , pp. -. DOI: 10.1021/acsmedchemlett.6c00074
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Recent Advances in GPCR Ligand Discovery Using DNA-Encoded Library Technology: From Affinity Binding to Functional Bias and Allosteric Modulatio
Author: Zhou, Ruolan; Wang, Jiajia; Li, Xiang; An, Yulong
Journal: ACS MEDICINAL CHEMISTRY LETTERS. 2026; Vol. , Issue , pp. -. DOI: 10.1021/acsmedchemlett.6c00113
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Design, Synthesis, and Protective Activity against Doxorubicin-Induced Cardiotoxicity of Novel Water-Soluble Small-Molecule GPx Mimic
Author: Yu, Zhenming; Shi, Wenxin; Qian, Zhijie; Mei, Xinning; Huang, Xinhui; Chen, Xi; Wang, Wentao; Zhang, Tianyi; Chen, Xin; Li, Zhiyong; Zheng, Canhui
Journal: ACS MEDICINAL CHEMISTRY LETTERS. 2026; Vol. , Issue , pp. -. DOI: 10.1021/acsmedchemlett.6c00185
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Repurposing Ilaprazole as a PP5 TPR Domain Binder with Modulatory Effects on MAPK Signalin
Author: He, Yanyi; Gu, Jinying; Hua, Liwen; Zhai, Daichao; Huang, Qifei; Pei, Jiayue; You, Qidong; Zhang, Qiuyue; Wang, Lei
Journal: ACS MEDICINAL CHEMISTRY LETTERS. 2026; Vol. , Issue , pp. -. DOI: 10.1021/acsmedchemlett.6c00068
