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Synthesis of Novel Kidney-Type Glutaminase Allosteric Inhibitors Targeting the Critical Lys-320 Residue
Author: Song, Jun; Pan, Chuqiao; Li, Jinxiu; Bai, Ruisong; Zeng, Ziying; Han, Yunying; Chen, Zhao; Hou, Wei; Li, Yong; Ruan, Benfang Helen
Journal: ACS MEDICINAL CHEMISTRY LETTERS. 2023; Vol. 14, Issue 1, pp. 11-17. DOI: 10.1021/acsmedchemlett.2c00302
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Design, Synthesis, and Bioevaluation of Pyrido[2,3-d]pyrimidin-7-ones as Potent SOS1 Inhibitors
Author: Liu, Meiying; Zhou, Guizhen; Su, Wenhong; Gu, Yuejiao; Gao, Mingshan; Wang, Kun; Huo, Ruifeng; Li, Yupeng; Zhou, Zehui; Chen, Kaixian; Zheng, Mingyue; Zhang, Sulin; Xu, Tianfeng
Journal: ACS MEDICINAL CHEMISTRY LETTERS. 2023; Vol. , Issue , pp. -. DOI: 10.1021/acsmedchemlett.2c00490
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Design, Synthesis, and Bioevaluation of Pyrido[2,3-d]pyrimidin-7-ones as Potent SOS1 Inhibitors
Author: Liu, Meiying; Zhou, Guizhen; Su, Wenhong; Gu, Yuejiao; Gao, Mingshan; Wang, Kun; Huo, Ruifeng; Li, Yupeng; Zhou, Zehui; Chen, Kaixian; Zheng, Mingyue; Zhang, Sulin; Xu, Tianfeng
Journal: ACS MEDICINAL CHEMISTRY LETTERS. 2023; Vol. , Issue , pp. 183-190. DOI: 10.1021/acsmedchemlett.2c00490183
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Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design
Author: Yu, Yang; Huang, Junhong; He, Hu; Han, Jing; Ye, Geyan; Xu, Tingyang; Sun, Xianqiang; Chen, Xiumei; Ren, Xiaoming; Li, Chunlai; Li, Huijuan; Huang, Wei; Liu, Yangyang; Wang, Xinjuan; Gao, Yongzhi; Cheng, Nianhe; Guo, Na; Chen, Xibo; Feng, Jianxia; Hua, Yuxia; Liu, Chong; Zhu, Guoyun; Xie, Zhi; Yao, Lili; Zhong, Wenge; Chen, Xinde; Liu, Wei; Li, Hailong
Journal: ACS MEDICINAL CHEMISTRY LETTERS. 2023; Vol. , Issue , pp. -. DOI: 10.1021/acsmedchemlett.2c00515
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Diselenide Covalent Allosteric Inhibitors of Glutaminase with Strong In Vivo Anticancer Activity
Author: Hou, Wei; Chen, Zhao; Pan, Chuqiao; Ni, Maowei; Ruan, Haoqiang; Song, Jun; Lu, Shiying; Bhasin, Aman; Ruan, Benfang Helen
Journal: ACS MEDICINAL CHEMISTRY LETTERS. 2023; Vol. , Issue , pp. -. DOI: 10.1021/acsmedchemlett.2c00470
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Development and Characterization of Fluorescent Probes for the G Protein-Coupled Receptor 35
Author: Wei, Lai; Xiang, Kaijing; Kang, Hongjian; Yu, Yancheng; Fan, Hongjie; Zhou, Han; Hou, Tao; Ge, Yonglin; Wang, Jixia; Guo, Zhimou; Chen, Yang; Zhao, Yaopeng; Liang, Xinmiao
Journal: ACS MEDICINAL CHEMISTRY LETTERS. 2023; Vol. , Issue , pp. -. DOI: 10.1021/acsmedchemlett.2c00461
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Development of the Inverse Sonogashira Reaction for DEL Synthesis
Author: Luo, Ayun; Zhou, Hongxia; Hua, Qini; An, Yufang; Ma, Hangke; Zhao, Xue; Yang, Kexin; Hu, Yun Jin
Journal: ACS MEDICINAL CHEMISTRY LETTERS. 2023; Vol. , Issue , pp. -. DOI: 10.1021/acsmedchemlett.2c00477
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Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR7 Allosteric Agonist
Author: Dickson, Louise; Teall, Martin; Chevalier, Elodie; Cheung, Toni; Liwicki, Gemma M.; Mack, Stephen; Stephenson, Anne; White, Kathryn; Fosbeary, Richard; Harrison, David C.; Brice, Nicola L.; Doyle, Kevin; Ciccocioppo, Roberto; Wu, Chaobo; Almond, Sarah; Patel, Toshal R.; Mitchell, Philip; Barnes, Matt; Ayscough, Andrew P.; Dawson, Lee A.; Carlton, Mark; Burli, Roland W.
Journal: ACS MEDICINAL CHEMISTRY LETTERS. 2023; Vol. , Issue , pp. -. DOI: 10.1021/acsmedchemlett.2c00529
