Drug Design Development And Therapy

Drug Design Development And Therapy

药物设计开发和治疗

  • 2区 中科院分区
  • Q1 JCR分区

高引用文章

文章名称 引用次数
Current development of biodegradable polymeric materials for biomedical applications 77
Leishmaniasis in humans: drug or vaccine therapy? 48
Linezolid: a review of its properties, function, and use in critical care 38
Bispecific antibodies: design, therapy, perspectives 38
Minoxidil and its use in hair disorders: a review 25
Tocilizumab in the treatment of rheumatoid arthritis: an evidence-based review and patient selection 23
2-Amino-4-thiadiazole as a potential scaffold for promising antimicrobial agents 22
Osteogenic effect of bone marrow mesenchymal stem cell-derived exosomes on steroid-induced osteonecrosis of the femoral head 21
Emodin alleviates myocardial ischemia/reperfusion injury by inhibiting gasdermin D-mediated pyroptosis in cardiomyocytes 19
Sevoflurane post-conditioning attenuates traumatic brain injury-induced neuronal apoptosis by promoting autophagy via the PI3K/AKT signaling pathway 19
Chloroquine and hydroxychloroquine are associated with reduced cardiovascular risk: a systematic review and meta-analysis 18
The combination of anti-KIR monoclonal antibodies with anti-PD-1/PD-L1 monoclonal antibodies could be a critical breakthrough in overcoming tumor immune escape in NSCLC 17
The cytochrome P450 isoenzyme and some new opportunities for the prediction of negative drug interaction in vivo 17
Treatment of tardive dyskinesia with VMAT-2 inhibitors: a systematic review and meta-analysis of randomized controlled trials 16
CTL019 (tisagenlecleucel): CAR-T therapy for relapsed and refractory B-cell acute lymphoblastic leukemia 16
Baicalein induces apoptosis and autophagy of breast cancer cells via inhibiting PI3K/AKT pathway in vivo and vitro 16
Berberine nanoparticles with enhanced in vitro bioavailability: characterization and antimicrobial activity 16
A novel ocular delivery of brinzolamide based on gellan gum: in vitro and in vivo evaluation 16
Pharmacological activities, mechanisms of action, and safety of salidroside in the central nervous system 15
Involvement of microRNA-146a in diabetic peripheral neuropathy through the regulation of inflammation 15
Synergistic combination therapy of lung cancer using paclitaxel- and triptolide-coloaded lipid-polymer hybrid nanopartices 15
Schisandrin B ameliorated chondrocytes inflammation and osteoarthritis via suppression of NF-kappa B and MAPK signal pathways 15
Copper-64: a real theranostic agent 15
Spotlight on anifrolumab and its potential for the treatment of moderate-to-severe systemic lupus erythematosus: evidence to date 15
Maresin 1 mitigates renal ischemia/reperfusion injury in mice via inhibition of the TLR4/MAPK/NF-kappa B pathways and activation of the Nrf2 pathway 14
Design and development of Nrf2 modulators for cancer chemoprevention and therapy: a review 14
Tendinopathy: injury, repair, and current exploration 14
Recent advances in the treatment of pathogenic infections using antibiotics and nano-drug delivery vehicles 14
Reference ranges for antiepileptic drugs revisited: a practical approach to establish national guidelines 14
Combination of Ginsenoside Rg1 and Astragaloside IV reduces oxidative stress and inhibits TGF-beta 1/Smads signaling cascade on renal fibrosis in rats with diabetic nephropathy 14
Spotlight on isavuconazole in the treatment of invasive aspergillosis and mucormycosis: design, development, and place in therapy 14
Paeoniflorin improves cardiac function and decreases adverse postinfarction left ventricular remodeling in a rat model of acute myocardial infarction 13
Ketamine ameliorates oxidative stress-induced apoptosis in experimental traumatic brain injury via the Nrf2 pathway 13
Mechanism involved in insulin resistance via accumulation of beta-amyloid and neurofibrillary tangles: link between type 2 diabetes and Alzheimer's disease 13
Chemopreventive activity of sulforaphane 12
Tanshinol ameliorates CCL4-induced liver fibrosis in rats through the regulation of Nrf2/HO-I and NF-kappa B/I kappa B alpha signaling pathway 12
Intra-articular platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis 12
Indirubin suppresses ovarian cancer cell viabilities through the STAT3 signaling pathway 12
Abemaciclib: a CDK4/6 inhibitor for the treatment of HR+/HER2-advanced breast cancer 12
Astragaloside IV/lncRNA-TUGI/TRAF5 signaling pathway participates in podocyte apoptosis of diabetic nephropathy rats 12
Inotuzumab ozogamicin: a CD22 mAb-drug conjugate for adult relapsed or refractory B-cell precursor acute lymphoblastic leukemia 12
Dexmedetomidine attenuates the neurotoxicity of propofol toward primary hippocampal neurons in vitro via Erk1/2/CREB/BDNF signaling pathways 11
Positives and negatives of nonsteroidal anti-inflammatory drugs in bone healing: the effects of these drugs on bone repair 11
Chrysin suppresses proliferation, migration, and invasion in glioblastoma cell lines via mediating the ERK/Nrf2 signaling pathway 11
Mechanistic research holds promise for bacterial vaccines and phage therapies for Pseudomonas aeruginosa 11
Epigallocatechin-3-gallate in the prevention and treatment of hepatocellular carcinoma: experimental findings and translational perspectives 11
Vitexin protects dopaminergic neurons in MPTP-induced Parkinson's disease through PI3K/Akt signaling pathway 11
miR-708-5p promotes fibroblast-like synoviocytes' cell apoptosis and ameliorates rheumatoid arthritis by the inhibition of Wnt3a/beta-caten n pathway 11
Exosomes Derived From Bone Marrow Mesenchymal Stem Cells Inhibit Complement Activation In Rats With Spinal Cord Injury 11
Profile of pitolisant in the management of narcolepsy: design, development, and place in therapy 11