| Real time monitoring and quantification of reactive oxygen species in breast cancer cell line MCF-7 by 2 ',7 '-dichlorofluorescin diacetate (DCFDA) assay |
12 |
| Cross - site comparison of excitation-contraction coupling using impedance and field potential recordings in hiPSC cardiomyocytes |
12 |
| mRNA transfection retrofits cell-based assays with xenobiotic metabolism |
9 |
| CiPA challenges and opportunities from a non-clinical, clinical and regulatory perspectives. An overview of the safety pharmacology scientific discussion |
7 |
| Comparative analysis of media effects on human induced pluripotent stem cell-derived cardiomyocytes in proarrhythmia risk assessment |
7 |
| Zebrafish models: do we have valid paradigms for depression? |
6 |
| Response of human induced pluripotent stem cell-derived cardiomyocytes to several pharmacological agents when intrinsic syncytial pacing is overcome by acute external stimulation |
6 |
| Larval zebrafish model for studying the effects of valproic acid on neurodevelopment: An approach towards modeling autism |
6 |
| Development of a bioreactor system for cytotoxic evaluation of pharmacological compounds in living cells using NMR spectroscopy |
6 |
| Cerulein-induced chronic pancreatitis in Swiss albino mice: An improved short-term model for pharmacological screening |
6 |
| Characterization of immune cell, endothelial, and renal responses upon experimental human endotoxemia |
5 |
| Protocol for evaluation of topical ophthalmic drug products in different compartments of fresh eye tissues in a rabbit model |
5 |
| Electrophysiological characteristics and pharmacological sensitivity of two lines of human induced pluripotent stem cell derived cardiomyocytes coming from two different suppliers |
5 |
| Drug potency on inhibiting late Na+ current is sensitive to gating modifier and current region where drug effects were measured |
4 |
| Safety screening in early drug discovery: An optimized assay panel |
4 |
| Simultaneous assessment of compound activity on cardiac Nav1.5 peak and late currents in an automated patch clamp platform |
4 |
| Electrophysiological characterization of drug response in hSC-derived cardiomyocytes using voltage-sensitive optical platforms |
4 |
| NOEL and NOAEL: A retrospective analysis of mention in a sample of recently conducted safety pharmacology studies |
4 |
| Establishment of a cell-based wound healing assay for bio-relevant testing of wound therapeutics |
4 |
| Impact of calcium-sensitive dyes on the beating properties and pharmacological responses human iPS-derived cardiomyocytes using the calcium transient assay |
4 |
| Seizure liability assessments using the hippocampal tissue slice: Comparison of non-clinical species |
4 |
| Decreased contractility and altered responses to inotropic agents in myocytes from tachypacing-induced heart failure canines |
4 |
| Precipitation of test chemicals in reaction solutions used in the amino acid derivative reactivity assay and the direct peptide reactivity assay |
3 |
| Revisiting the binding kinetics and inhibitory potency of cardiac glycosides on Na+, K+-ATPase (alpha 1 beta 1): Methodological considerations |
3 |
| Predicting cardiac safety using human induced pluripotent stem cell-derived cardiomyocytes combined with multi-electrode array (MEA) technology: A conference report |
3 |
| Nagarse treatment of cardiac subsarcolemmal and interfibrillar mitochondria leads to artefacts in mitochondrial protein quantification |
3 |
| Two immunoassays for the detection of 2C-B and related hallucinogenic phenethylamines |
3 |
| Individual variability in female and male mice in a test-retest protocol of the forced swim test |
3 |
| Increased susceptibility to oxidative stress-induced toxicological evaluation by genetically modified nrf2a-deficient zebrafish |
3 |
| An overview of the safety pharmacology society strategic plan |
3 |
| In vitro secondary pharmacological profiling: An IQ-DruSafe industry survey on current practices |
3 |
| A new telemetry-based system for assessing cardiovascular function in group-housed large animals. Taking the 3Rs to a new level with the evaluation of remote measurement via cloud data transmission |
3 |
| Expanding the applicability of the amino acid derivative reactivity assay: Determining a weight for preparation of test chemical solutions that yield a predictive capacity identical to the conventional method using molar concentration and demonstrating the capacity to detect sensitizers in liquid mixtures |
3 |
| Liquid chromatography-tandem mass spectrometry for rapid and selective simultaneous determination of fluoroquinolones level in human aqueous humor |
3 |
| Establishment of a rodent cooperation assay as a model of social cognition |
3 |
| Increased stress associated with head-out plethysmography testing can exacerbate respiratory effects and lead to mortality in rats |
3 |
| A real time screening assay for cannabinoid CB1 receptor-mediated signaling |
3 |
| Short-term oral gavage administration of adenine induces a model of fibrotic kidney disease in rats |
3 |
| The functional observational battery and modified Irwin test as global neurobehavioral assessments in the rat: Pharmacological validation data and a comparison of methods |
3 |
| An automated epifluorescence microscopy imaging assay for the identification of phospho-AKT level modulators in breast cancer cells |
2 |
| Pharmacological validation of individual animal locomotion, temperature and behavioural analysis in group-housed rats using a novel automated home cage analysis system: A comparison with the modified Irwin test |
2 |
| In vitro model for predicting acute inhalation toxicity by using a Calu-3 epithelium cytotoxicity assay |
2 |
| Targeted quantitative proteomic analysis of drug metabolizing enzymes and transporters by nano LC-MS/MS in the sandwich cultured human hepatocyte model |
2 |
| A fast paraquat quantitation method in human serum using probe electrospray ionization-tandem mass spectrometry for emergency settings |
2 |
| Translatability of the S7A core battery respiratory safety pharmacology studies: Preclinical respiratory and related clinical adverse events |
2 |
| HiPSC-CMs from different sex and ethnic origin donors exhibit qualitatively different responses to several classes of pharmacological challenges |
2 |
| Exposure-response analysis of drug-induced QT interval prolongation in telemetered monkeys for translational prediction to human |
2 |
| Incidence of spontaneous arrhythmias in freely moving healthy untreated Sprague-Dawley rats |
2 |
| Metabolic, stress, and inflammatory biomarker responses to glucose administration in Fischer-344 rats: intraperitoneal vs. oral delivery |
2 |
| Extra collagen overlay prolongs the differentiated phenotype in sandwich-cultured rat hepatocytes |
2 |
