Lancet Diabetes & Endocrinology

Lancet Diabetes & Endocrinology

柳叶刀糖尿病与内分泌学

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Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables 209
Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials 177
Effects of dapagliflozin on development and progression of kidney disease in patients with type 2 diabetes: an analysis from the DECLARE-TIMI 58 randomised trial 133
Canagliflozin and renal outcomes in type 2 diabetes: results from the CANVAS Program randomised clinical trials 100
SGLT2 inhibitors for the prevention of kidney failure in patients with type 2 diabetes: a systematic review and meta-analysis 96
Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis 91
Non-alcoholic fatty liver disease: causes, diagnosis, cardiometabolic consequences, and treatment strategies 87
Cardiovascular outcomes with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a meta-analysis 83
Type 2 diabetes in adolescents and young adults 81
Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial 80
Association of BMI with overall and cause-specific mortality: a population-based cohort study of 3.6 million adults in the UK 80
Dulaglutide versus insulin glargine in patients with type 2 diabetes and moderate-to-severe chronic kidney disease (AWARD-7): a multicentre, open-label, randomised trial 75
Semaglutide versus dulaglutide once weekly in patients with type 2 diabetes (SUSTAIN 7): a randomised, open-label, phase 3b trial 74
Cardiometabolic outcomes and mortality in medically treated primary aldosteronism: a retrospective cohort study 69
Glycaemic variability in diabetes: clinical and therapeutic implications 68
Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: a position statement 67
Effects of vitamin D supplementation on musculoskeletal health: a systematic review, meta-analysis, and trial sequential analysis 63
Interventions to prevent global childhood overweight and obesity: a systematic review 62
Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial 56
Morbidity and mortality after lifestyle intervention for people with impaired glucose tolerance: 30-year results of the Da Qing Diabetes Prevention Outcome Study 53
Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study 52
Genetics of obesity: what genetic association studies have taught us about the biology of obesity and its complications 49
Frequency and phenotype of type 1 diabetes in the first six decades of life: a cross-sectional, genetically stratified survival analysis from UK Biobank 48
Dulaglutide as add-on therapy to SGLT2 inhibitors in patients with inadequately controlled type 2 diabetes (AWARD-10): a 24-week, randomised, double-blind, placebo-controlled trial 44
Cortical and trabecular bone microarchitecture as an independent predictor of incident fracture risk in older women and men in the Bone Microarchitecture International Consortium (BoMIC): a prospective study 41
Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies 40
Transition from metabolic healthy to unhealthy phenotypes and association with cardiovascular disease risk across BMI categories in 90 257 women (the Nurses' Health Study): 30 year follow-up from a prospective cohort study 40
Disease progression and treatment response in data-driven subgroups of type 2 diabetes compared with models based on simple clinical features: an analysis using clinical trial data 40
Incidence and progression of diabetic retinopathy: a systematic review 40
Hypoglycaemia, cardiovascular disease, and mortality in diabetes: epidemiology, pathogenesis, and management 39
Efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment (PIONEER 5): a placebo-controlled, randomised, phase 3a trial 39
Efficacy and safety of oral semaglutide with flexible dose adjustment versus sitagliptin in type 2 diabetes (PIONEER 7): a multicentre, open-label, randomised, phase 3a trial 39
Change in albuminuria and subsequent risk of end-stage kidney disease: an individual participant-level consortium meta-analysis of observational studies 38
Semaglutide once weekly as add-on to SGLT-2 inhibitor therapy in type 2 diabetes (SUSTAIN 9): a randomised, placebo-controlled trial 37
Prevalence of obesity, hypertension, and diabetes, and cascade of care in sub-Saharan Africa: a cross-sectional, population-based study in rural and urban Malawi 37
Change in albuminuria as a surrogate endpoint for progression of kidney disease: a meta-analysis of treatment effects in randomised clinical trials 37
Metabolically healthy obesity: the low-hanging fruit in obesity treatment? 37
Lixisenatide and renal outcomes in patients with type 2 diabetes and acute coronary syndrome: an exploratory analysis of the ELIXA randomised, placebo-controlled trial 34
Diabetes structured self-management education programmes: a narrative review and current innovations 34
Worldwide burden of cancer attributable to diabetes and high body-mass index: a comparative risk assessment 33
Effect of once-daily, modified-release hydrocortisone versus standard glucocorticoid therapy on metabolism and innate immunity in patients with adrenal insufficiency (DREAM): a single-blind, randomised controlled trial 32
Systemic effects of periodontitis treatment in patients with type 2 diabetes: a 12 month, single-centre, investigator-masked, randomised trial 32
2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase randomised controlled trial 30
Efficacy and safety of once-weekly semaglutide versus daily canagliflozin as add-on to metformin in patients with type 2 diabetes (SUSTAIN 8): a double-blind, phase 3b, randomised controlled trial 30
Mycophenolate plus methylprednisolone versus methylprednisolone alone in active, moderate-to-severe Graves' orbitopathy (MINGO): a randomised, observer-masked, multicentre trial 29
The challenge of modulating beta-cell autoimmunity in type 1 diabetes 29
Sucrose octasulfate dressing versus control dressing in patients with neuroischaemic diabetic foot ulcers (Explorer): an international, multicentre, double-blind, randomised, controlled trial 29
Epidemiology and determinants of type 2 diabetes in south Asia 29
Follicular thyroid cancer and Hurthle cell carcinoma: challenges in diagnosis, treatment, and clinical management 28
Mean HbA(1c), HbA(1c) variability, and mortality in people with diabetes aged 70 years and older: a retrospective cohort study 28
Progress and challenges in anti-obesity pharmacotherapy 26
Gastric bypass versus sleeve gastrectomy in patients with type 2 diabetes (Oseberg): a single-centre, triple-blind, randomised controlled trial 26
Cardiovascular and renal burdens of prediabetes in the USA: analysis of data from serial cross-sectional surveys, 1988-2014 26
Albuminuria-lowering effect of dapagliflozin alone and in combination with saxagliptin and effect of dapagliflozin and saxagliptin on glycaemic control in patients with type 2 diabetes and chronic kidney disease (DELIGHT): a randomised, double-blind, placebo-controlled trial 26
Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study 26
Primary therapy of Graves' disease and cardiovascular morbidity and mortality: a linked-record cohort study 25
Denosumab versus risedronate in glucocorticoid-induced osteoporosis: a multicentre, randomised, double-blind, active-controlled, double-dummy, non-inferiority study 25
Availability and affordability of essential medicines for diabetes across high-income, middle-income, and low-income countries: a prospective epidemiological study 24
Precision nutrition for prevention and management of type 2 diabetes 23
Effect of neprilysin inhibition on renal function in patients with type 2 diabetes and chronic heart failure who are receiving target doses of inhibitors of the renin-angiotensin system: a secondary analysis of the PARADIGM-HF trial 22
Do sulphonylureas still have a place in clinical practice? 21
Efficacy and safety of burosumab in children aged 1-4 years with X-linked hypophosphataemia: a multicentre, open-label, phase 2 trial 21
Risk of suicide and non-fatal self-harm after bariatric surgery: results from two matched cohort studies 20
Safety and efficacy of testosterone for women: a systematic review and meta-analysis of randomised controlled trial data 20
Islet transplantation versus insulin therapy in patients with type 1 diabetes with severe hypoglycaemia or poorly controlled glycaemia after kidney transplantation (TRIMECO): a multicentre, randomised controlled trial 19
Antigen-based immune modulation therapy for type 1 diabetes: the era of precision medicine 19
Effectiveness and safety of the tri-iodothyronine analogue Triac in children and adults with MCT8 deficiency: an international, single-arm, open-label, phase 2 trial 19
The dietary transition and its association with cardiometabolic mortality among Chinese adults, 1982-2012: a cross-sectional population-based study 19
The physiology of endocrine systems with ageing 18
Efficacy and safety of once-monthly pasireotide in Cushing's disease: a 12 month clinical trial 18
Odanacatib for the treatment of postmenopausal osteoporosis: results of the LOFT multicentre, randomised, double-blind, placebo-controlled trial and LOFT Extension study 18
LeucoPatch system for the management of hard-to-heal diabetic foot ulcers in the UK, Denmark, and Sweden: an observer-masked, randomised controlled trial 18
Bone and mineral disorders in chronic kidney disease: implications for cardiovascular health and ageing in the general population 18
Estimation of global insulin use for type 2 diabetes, 2018-30: a microsimulation analysis 18
Economic development and the nutritional status of Chinese school-aged children and adolescents from 1995 to 2014: an analysis of five successive national surveys 18
Advances in the medical treatment of Cushing's syndrome 17
Clinical management of type 2 diabetes in south Asia 17
Frailty and the endocrine system 17
Adjunctive liraglutide treatment in patients with persistent or recurrent type 2 diabetes after metabolic surgery (GRAVITAS): a randomised, double-blind, placebo-controlled trial 16
Efficacy and safety of suspend-before-low insulin pump technology in hypoglycaemia-prone adults with type 1 diabetes (SMILE): an open-label randomised controlled trial 16
Use of liraglutide and risk of major cardiovascular events: a register-based cohort study in Denmark and Sweden 16
Asfotase alfa for infants and young children with hypophosphatasia: 7 year outcomes of a single-arm, open-label, phase 2 extension trial 16
Outcome after ablation in patients with low-risk thyroid cancer (ESTIMABL1): 5-year follow-up results of a randomised, phase equivalence trial 16
Autoimmune thyroid disease during pregnancy 16
Intermediate hyperglycaemia to predict progression to type 2 diabetes (ELSA-Brasil): an occupational cohort study in Brazil 15
Effect of a high-fat Mediterranean diet on bodyweight and waist circumference: a prespecified secondary outcomes analysis of the PREDIMED randomised controlled trial 15
SGLT2 inhibitors as adjunctive therapy for type 1 diabetes: balancing benefits and risks 15
Long-term adverse events after sleeve gastrectomy or gastric bypass: a 7-year nationwide, observational, population-based, cohort study 15
Association of preconception serum 25-hydroxyvitamin D concentrations with livebirth and pregnancy loss: a prospective cohort study 14
Work stress and risk of death in men and women with and without cardiometabolic disease: a multicohort study 14
Community groups or mobile phone messaging to prevent and control type 2 diabetes and intermediate hyperglycaemia in Bangladesh (DMagic): a cluster-randomised controlled trial 14
Combined immunosuppression and radiotherapy in thyroid eye disease (CIRTED): a multicentre, 2 x 2 factorial, double-blind, randomised controlled trial 13
Sex-specific relevance of diabetes to occlusive vascular and other mortality: a collaborative meta-analysis of individual data from 980793 adults from 68 prospective studies 13
Intensive systolic blood pressure control and incident chronic kidney disease in people with and without diabetes mellitus: secondary analyses of two randomised controlled trials 13
Precision medicine in the management of type 2 diabetes 13
Polyvascular disease, type 2 diabetes, and long-term vascular risk: a secondary analysis of the IMPROVE-IT trial 13
Reference intervals in the diagnosis of thyroid dysfunction: treating patients not numbers 13
Efficacy and safety of oral basal insulin versus subcutaneous insulin glargine in type 2 diabetes: a randomised, double-blind, phase 2 trial 13
Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention 12
Effect of testosterone replacement on measures of mobility in older men with mobility limitation and low testosterone concentrations: secondary analyses of the Testosterone Trials 12
Effect of diabetes duration and glycaemic control on 14-year cause-specific mortality in Mexican adults: a blood-based prospective cohort study 12
Successful treatment of prediabetes in clinical practice using physiological assessment (STOP DIABETES) 12
Natural history, treatment, and long-term follow up of patients with multiple endocrine neoplasia type 2B: an international, multicentre, retrospective study 12
Recurrence after low-dose radioiodine ablation and recombinant human thyroid-stimulating hormone for differentiated thyroid cancer (HiLo): long-term results of an open-label, non-inferiority randomised controlled trial 12
Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial 11
New pharmacological strategies for protecting kidney function in type 2 diabetes 11
The burden of diabetes and use of diabetes care in humanitarian crises in low-income and middle-income countries 11
Association between maternal pre-pregnancy obesity and preterm birth according to maternal age and race or ethnicity: a population-based study 10
Blood glucose meters and test strips: global market and challenges to access in low-resource settings 10
Effect of metformin in addition to dietary and lifestyle advice for pregnant women who are overweight or obese: the GRoW randomised, double-blind, placebo-controlled trial 10
Maternal thyroid function during pregnancy and child brain morphology: a time window-specific analysis of a prospective cohort 9
Advanced neuroendocrine tumours of the small intestine and pancreas: clinical developments, controversies, and future strategies 9
Bone health during endocrine therapy for cancer 9
Efficacy of a novel inhibitor of vascular adhesion protein-1 in reducing albuminuria in patients with diabetic kidney disease (ALBUM): a randomised, placebo-controlled, phase 2 trial 9
Macrovascular disease and risk factors in youth with type 1 diabetes: time to be more attentive to treatment? 9
Gender-affirming hormones and surgery in transgender children and adolescents 9
Metabolic health in the Middle East and north Africa 9
Fully closed-loop insulin delivery in inpatients receiving nutritional support: a two-centre, open-label, randomised controlled trial 8
Durability of insulin degludec plus liraglutide versus insulin glargine U100 as initial injectable therapy in type 2 diabetes (DUAL VIII): a multicentre, open-label, phase 3b, randomised controlled trial 8
Ageing and endocrinology 3 Clinical aspects of thyroid function during ageing 8
Efficacy and safety of levoketoconazole in the treatment of endogenous Cushing's syndrome (SONICS): a phase multicentre, open-label, single-arm trial 8
Diabetes in pregnancy and epigenetic mechanisms-how the first 9 months from conception might affect the child' s epigenome and later risk of disease 8
Distal technologies and type 1 diabetes management 8
A genetic approach to evaluation of short stature of undetermined cause 8
Effect of fenofibrate on uric acid and gout in type 2 diabetes: a post-hoc analysis of the randomised, controlled FIELD study 7
Public health and health systems: implications for the prevention and management of type 2 diabetes in south Asia 7
Dorzagliatin monotherapy in Chinese patients with type 2 diabetes: a dose-ranging, randomised, double-blind, placebo-controlled, phase 2 study 7
Aiding sleep in type 2 diabetes: therapeutic considerations 7
Moderate salt restriction with or without paricalcitol in type 2 diabetes and losartan-resistant macroalbuminuria (PROCEED): a randomised, double-blind, placebo-controlled, crossover trial 6
Clinical efficacy and safety of a light mask for prevention of dark adaptation in treating and preventing progression of early diabetic macular oedema at 24 months (CLEOPATRA): a multicentre, phase randomised controlled trial 6
Optimisation of follow-up after metabolic surgery 6
Combination denosumab and high dose teriparatide for postmenopausal osteoporosis (DATA-HD): a randomised, controlled phase 4 trial 6
Worldwide burden of cancer attributable to diabetes and high body-mass index: a comparative risk assessment 6
Repaglinide versus insulin for newly diagnosed diabetes in patients with cystic fibrosis: a multicentre, open-label, randomised trial 5
Testosterone treatment in older men: clinical implications and unresolved questions from the Testosterone Trials 5
Glucose screening in pregnancy and future risk of cardiovascular disease in women: a retrospective, population-based cohort study 4
Challenges associated with providing diabetes care in humanitarian settings 4
Rethinking good cholesterol: a clinicians' guide to understanding HDL 4
A clinical algorithm to diagnose differences of sex development 4
Association of preoperative glucose concentration with myocardial injury and death after non-cardiac surgery (GlucoVISION): a prospective cohort study 4
Long-term effects of intensive multifactorial therapy in individuals with screen-detected type 2 diabetes in primary care: 10-year follow-up of the ADDITION-Europe cluster-randomised trial 2
Cushing's disease-from Minnie G to key issues in the early 21st century 2
The role of blood volume in cardiac dysfunction and reduced exercise tolerance in patients with diabetes 2
Oestrogen versus androgen in hormone-replacement therapy for complete androgen insensitivity syndrome: a multicentre, randomised, double-dummy, double-blind crossover trial 0
Television The truth in beige and white 0