| Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis |
176 |
| Atezolizumab plus bevacizumab and chemotherapy in non-small-cell lung cancer (IMpower150): key subgroup analyses of patients with EGFR mutations or baseline liver metastases in a randomised, open-label phase 3 trial |
152 |
| Diagnostic criteria for idiopathic pulmonary fibrosis: a Fleischner Society White Paper |
110 |
| Invasive aspergillosis in patients admitted to the intensive care unit with severe influenza: a retrospective cohort study |
104 |
| Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial |
103 |
| The global burden of paediatric and neonatal sepsis: a systematic review |
71 |
| Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial |
70 |
| Childhood predictors of lung function trajectories and future COPD risk: a prospective cohort study from the first to the sixth decade of life |
64 |
| Predictors of exacerbation risk and response to budesonide in patients with chronic obstructive pulmonary disease: a post-hoc analysis of three randomised trials |
62 |
| The global tuberculosis epidemic and progress in care, prevention, and research: an overview in year 3 of the End TB era |
60 |
| Triple therapy with budesonide/glycopyrrolate/formoterol fumarate with co-suspension delivery technology versus dual therapies in chronic obstructive pulmonary disease (KRONOS): a double-blind, parallel-group, multicentre, phase 3 randomised controlled trial |
57 |
| E-cigarette, or vaping, product use associated lung injury (EVALI): case series and diagnostic approach |
55 |
| Chronic obstructive pulmonary disease in China: a nationwide prevalence study |
51 |
| Venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis |
49 |
| Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study |
49 |
| Post-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): a multicentre, prospective observational study |
48 |
| Effect of bedaquiline on mortality in South African patients with drug-resistant tuberculosis: a retrospective cohort study |
40 |
| Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017: an analysis for the Global Burden of Disease Study 2017 |
40 |
| Erlotinib versus vinorelbine plus cisplatin as adjuvant therapy in Chinese patients with stage IIIA EGFR mutation-positive non-small-cell lung cancer (EVAN) a randomised, open-label, phase 2 trial |
39 |
| Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial |
39 |
| Deep learning for classifying fibrotic lung disease on high-resolution computed tomography: a case-cohort study |
38 |
| Exploring the relevance and extent of small airways dysfunction in asthma (ATLANTIS): baseline data from a prospective cohort study |
38 |
| Safety, tolerability, pharmacokinetics, and pharmacodynamics of GLPG a novel autotaxin inhibitor, to treat idiopathic pulmonary fibrosis (FLORA): a phase 2a randomised placebo-controlled trial |
38 |
| Blood eosinophils and treatment response with triple and dual combination therapy in chronic obstructive pulmonary disease: analysis of the IMPACT trial |
38 |
| The microbiome in respiratory disease 2 Functional effects of the microbiota in chronic respiratory disease |
37 |
| Prehospital antibiotics in the ambulance for sepsis: a multicentre, open label, randomised trial |
37 |
| Ipilimumab and nivolumab in the treatment of recurrent malignant pleural mesothelioma (INITIATE): results of a prospective, single-arm, phase 2 trial |
37 |
| Perioperative mortality and morbidity after sublobar versus lobar resection for early-stage non-small-cell lung cancer: post-hoc analysis of an international, randomised, phase 3 trial (CALGB/Alliance 140503) |
36 |
| Trends in smoking prevalence and implication for chronic diseases in China: serial national cross-sectional surveys from 2003 to 2013 |
36 |
| Personalised mechanical ventilation tailored to lung morphology versus low positive end-expiratory pressure for patients with acute respiratory distress syndrome in France (the LIVE study): a multicentre, single-blind, randomised controlled trial |
36 |
| Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study |
35 |
| Long-term safety and tolerability of nintedanib in patients with idiopathic pulmonary fibrosis: results from the open-label extension study, INPULSIS-ON |
35 |
| Tremelimumab combined with durvalumab in patients with mesothelioma (NIBIT-MESO-1): an open-label, non-randomised, phase 2 study |
34 |
| Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies |
33 |
| Tiotropium and olodaterol in the prevention of chronic obstructive pulmonary disease exacerbations (DYNAGITO): a double-blind, randomised, parallel-group, active-controlled trial |
33 |
| Pulmonary sarcoidosis |
33 |
| DNA methylation in childhood asthma: an epigenome-wide meta-analysis |
32 |
| Small airways disease in mild and moderate chronic obstructive pulmonary disease: a cross-sectional study |
32 |
| Epigenetic prediction of response to anti-PD-1 treatment in non-small-cell lung cancer: a multicentre, retrospective analysis |
31 |
| Respiratory syncytial virus prevention and asthma in healthy preterm infants: a randomised controlled trial |
31 |
| Predictors of enhanced response with benralizumab for patients with severe asthma: pooled analysis of the SIROCCO and CALIMA studies |
31 |
| Pembrolizumab in patients with advanced non-small-cell lung cancer (KEYNOTE-001): 3-year results from an open-label, phase 1 study |
31 |
| DNA methylation in nasal epithelium, atopy, and atopic asthma in children: a genome-wide study |
31 |
| Anti-influenza hyperimmune intravenous immunoglobulin for adults with influenza A or B infection (FLU-IVIG): a double-blind, randomised, placebo-controlled trial |
31 |
| Tralokinumab for severe, uncontrolled asthma (STRATOS 1 and STRATOS 2): two randomised, double-blind, placebo-controlled, phase 3 clinical trials |
31 |
| Ivacaftor treatment of cystic fibrosis in children aged 12 to < 24 months and with a CFTR gating mutation (ARRIVAL): a phase 3 single-arm study |
31 |
| Lung function trajectories from pre-school age to adulthood and their associations with early life factors: a retrospective analysis of three population-based birth cohort studies |
31 |
| Machine learning for real-time prediction of complications in critical care: a retrospective study |
30 |
| Effect of ambulatory oxygen on quality of life for patients with fibrotic lung disease (AmbOx): a prospective, open-label mixed-method, crossover randomised controlled trial |
30 |
| Aggressive versus symptom-guided drainage of malignant pleural effusion via indwelling pleural catheters (AMPLE-2): an open-label randomised trial |
29 |
| Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study |
29 |
| Anti-influenza immune plasma for the treatment of patients with severe influenza A: a randomised, double-blind, phase 3 trial |
29 |
| Diaphragmatic myotrauma: a mediator of prolonged ventilation and poor patient outcomes in acute respiratory failure |
28 |
| Normothermic ex-vivo preservation with the portable Organ Care System Lung device for bilateral lung transplantation (INSPIRE): a randomised, open-label, non-inferiority, phase 3 study |
28 |
| Lung function trajectories in health and disease |
28 |
| Safety and immunogenicity of the novel tuberculosis vaccine ID93+GLA-SE in BCG-vaccinated healthy adults in South Africa: a randomised, double-blind, placebo-controlled phase 1 trial |
25 |
| Surgical and endoscopic interventions that reduce lung volume for emphysema: a systemic review and meta-analysis |
25 |
| Non-invasive ventilation versus high-flow nasal cannula oxygen therapy with apnoeic oxygenation for preoxygenation before intubation of patients with acute hypoxaemic respiratory failure: a randomised, multicentre, open-label trial |
25 |
| Alectinib versus crizotinib in untreated Asian patients with anaplastic lymphoma kinase-positive non-small-cell lung cancer (ALESIA): a randomised phase 3 study |
25 |
| Effect of tralokinumab, an interleukin-13 neutralising monoclonal antibody, on eosinophilic airway inflammation in uncontrolled moderate-to-severe asthma (MESOS): a multicentre, double-blind, randomised, placebo-controlled phase 2 trial |
23 |
| Effect of lung deflation with indacaterol plus glycopyrronium on ventricular filling in patients with hyperinflation and COPD (CLAIM): a double-blind, randomised, crossover, placebo-controlled, single-centre trial |
23 |
| Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis |
23 |
| Lung transplantation for idiopathic pulmonary fibrosis |
23 |
| Individualised perioperative open-lung approach versus standard protective ventilation in abdominal surgery (iPROVE): a randomised controlled trial |
23 |
| Time for a change: is idiopathic pulmonary fibrosis still idiopathic and only fibrotic? |
22 |
| Crizotinib in patients with advanced, inoperable inflammatory myofibroblastic tumours with and without anaplastic lymphoma kinase gene alterations (European Organisation for Research and Treatment of Cancer 90101 CREATE): a multicentre, single-drug, prospective, non-randomised phase 2 trial |
22 |
| Detection of EGFR mutations in plasma circulating tumour DNA as a selection criterion for first-line gefitinib treatment in patients with advanced lung adenocarcinoma (BENEFIT): a phase single-arm, multicentre clinical trial |
21 |
| Fractional exhaled nitric oxide as a predictor of response to inhaled corticosteroids in patients with non-specific respiratory symptoms and insignificant bronchodilator reversibility: a randomised controlled trial |
21 |
| Outcomes in patients with non-small-cell lung cancer and acquired Thr790Met mutation treated with osimertinib: a genomic study |
21 |
| Bacterial and viral respiratory tract microbiota and host characteristics in children with lower respiratory tract infections: a matched case-control study |
21 |
| Pulmonary alveolar proteinosis in adults: pathophysiology and clinical approach |
21 |
| Eosinophil-guided corticosteroid therapy in patients admitted to hospital with COPD exacerbation (CORTICO-COP): a multicentre, randomised, controlled, open-label, non-inferiority trial |
21 |
| Nintedanib in combination with pemetrexed and cisplatin for chemotherapy-naive patients with advanced malignant pleural mesothelioma (LUME-Meso): a double-blind, randomised, placebo-controlled phase 3 trial |
21 |
| Inhaled liposomal ciprofloxacin in patients with non-cystic fibrosis bronchiectasis and chronic lung infection with Pseudomonas aeruginosa (ORBIT-3 and ORBIT-4): two phase randomised controlled trials |
20 |
| Live-attenuated Mycobacterium tuberculosis vaccine MTBVAC versus BCG in adults and neonates: a randomised controlled, double-blind dose-escalation trial |
20 |
| Laparoscopic anti-reflux surgery for the treatment of idiopathic pulmonary fibrosis (WRAP-IPF): a multicentre, randomised, controlled phase 2 trial |
19 |
| Use of a molecular classifier to identify usual interstitial pneumonia in conventional transbronchial lung biopsy samples: a prospective validation study |
19 |
| Normal polysomnography parameters in healthy adults: a systematic review and meta-analysis |
19 |
| Tropism, replication competence, and innate immune responses of influenza virus: an analysis of human airway organoids and ex-vivo bronchus cultures |
19 |
| Efficacy and safety of delamanid in combination with an optimised background regimen for treatment of multidrug-resistant tuberculosis: a multicentre, randomised, double-blind, placebo-controlled, parallel group phase 3 trial |
19 |
| Precision medicine in obstructive sleep apnoea |
18 |
| Analysis of protein-altering variants in telomerase genes and their association with MUC5B common variant status in patients with idiopathic pulmonary fibrosis: a candidate gene sequencing study |
18 |
| Prognostic and predictive biomarkers for patients with idiopathic pulmonary fibrosis treated with pirfenidone: post-hoc assessment of the CAPACITY and ASCEND trials |
17 |
| Acute respiratory failure in immunocompromised adults |
17 |
| Efficacy, immunogenicity, and safety evaluation of an MF59-adjuvanted quadrivalent influenza virus vaccine compared with non-adjuvanted influenza vaccine in children: a multicentre, randomised controlled, observer-blinded, phase 3 trial |
17 |
| Routine monitoring with pleural manometry during therapeutic large-volume thoracentesis to prevent pleural-pressure-related complications: a multicentre, single-blind randomised controlled trial |
17 |
| Macitentan for the treatment of portopulmonary hypertension (PORTICO): a multicentre, randomised, double-blind, placebo-controlled, phase 4 trial |
16 |
| Increased monocyte count as a cellular biomarker for poor outcomes in fibrotic diseases: a retrospective, multicentre cohort study |
16 |
| Safety, pharmacokinetics, and pharmacodynamics of lumacaftor and ivacaftor combination therapy in children aged 2-5 years with cystic fibrosis homozygous for F508del-CFTR: an open-label phase 3 study |
16 |
| The heterogeneity of chronic cough: a case for endotypes of cough hypersensitivity |
15 |
| Inhaled hypertonic saline in preschool children with cystic fibrosis (SHIP): a multicentre, randomised, double-blind, placebo-controlled trial |
15 |
| Bedaquiline, moxifloxacin, pretomanid, and pyrazinamide during the first 8 weeks of treatment of patients with drug-susceptible or drug-resistant pulmonary tuberculosis: a multicentre, open-label, partially randomised, phase 2b trial |
15 |
| Comparison of different treatments for isoniazid-resistant tuberculosis: an individual patient data meta-analysis |
15 |
| Bronchiectasis: new therapies and new perspectives |
15 |
| Physiotherapy breathing retraining for asthma: a randomised controlled trial |
14 |
| Diagnostic accuracy of whole-body MRI versus standard imaging pathways for metastatic disease in newly diagnosed non-small-cell lung cancer: the prospective Streamline L trial |
14 |
| The Lancet Respiratory Medicine Commission: 2019 update: epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant and incurable tuberculosis |
14 |
| The CF-Sputum Induction Trial (CF-SpIT) to assess lower airway bacterial sampling in young children with cystic fibrosis: a prospective internally controlled interventional trial |
13 |
| Diagnosis and management of pulmonary toxicity associated with cancer immunotherapy |
13 |
| Anti-inflammatory effects of roflumilast in chronic obstructive pulmonary disease (ROBERT): a 16-week, randomised, placebo-controlled trial |
13 |
| Expiratory airflow in late adolescence and early adulthood in individuals born very preterm or with very low birthweight compared with controls born at term or with normal birthweight: a meta-analysis of individual participant data |
13 |
| Effects of saline or albumin fluid bolus in resuscitation: evidence from re-analysis of the FEAST trial |
13 |
| Extracorporeal carbon dioxide removal for lowering the risk of mechanical ventilation: research questions and clinical potential for the future |
12 |
| Long-term developmental effects of withholding parenteral nutrition for 1 week in the paediatric intensive care unit: a 2-year follow-up of the PEPaNIC international, randomised, controlled trial |
12 |
| Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study |
12 |
| The efficacy and safety of inhaled antibiotics for the treatment of bronchiectasis in adults: a systematic review and meta-analysis |
11 |
| Long-term macrolide antibiotics for the treatment of bronchiectasis in adults: an individual participant data meta-analysis |
11 |
| Biomarkers of extracellular matrix turnover in patients with idiopathic pulmonary fibrosis given nintedanib (INMARK study): a randomised, placebo-controlled study |
11 |
| Safety and efficacy of tiotropium in children aged 1-5 years with persistent asthmatic symptoms: a randomised, double-blind, placebo-controlled trial |
11 |
| Paediatric tuberculosis transmission outside the household: challenging historical paradigms to inform future public health strategies |
11 |
| Comparative effectiveness of LABA-ICS versus LAMA as initial treatment in COPD targeted by blood eosinophils: a population-based cohort study |
11 |
| Portable normothermic ex-vivo lung perfusion, ventilation, and functional assessment with the Organ Care System on donor lung use for transplantation from extended-criteria donors (EXPAND): a single-arm, pivotal trial |
11 |
| Long-term treatment with recombinant human pentraxin 2 protein in patients with idiopathic pulmonary fibrosis: an open-label extension study |
11 |
| Subcutaneous treprostinil for the treatment of severe non-operable chronic thromboembolic pulmonary hypertension (CTREPH): a double-blind, phase randomised controlled trial |
10 |
| Pathophysiological role of respiratory dysbiosis in hospital-acquired pneumonia |
10 |
| Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations |
10 |
| The microbiome in respiratory disease 1 The microbiome and tuberculosis: state of the art, potential applications, and defining the clinical research agenda |
10 |
| Riociguat for idiopathic interstitial pneumonia-associated pulmonary hypertension (RISE-IIP): a randomised, placebo-controlled phase 2b study |
10 |
| The role of glucocorticoids as adjunctive treatment for sepsis in the modern era |
9 |
| Induced hypothermia in patients with septic shock and respiratory failure (CASS): a randomised, controlled, open-label trial |
9 |
| Efficacy of oral amoxicillin-clavulanate or azithromycin for non-severe respiratory exacerbations in children with bronchiectasis (BEST-1): a multicentre, three-arm, double-blind, randomised placebo-controlled trial |
8 |
| Effect of a fluid bolus on cardiovascular collapse among critically ill adults undergoing tracheal intubation (PrePARE): a randomised controlled trial |
7 |
| Beyond the guidelines for non-invasive ventilation in acute respiratory failure: implications for practice |
7 |
| Understanding irresponsible use of intensive care unit resources in the USA |
6 |
| Determining the outcomes of interventions to prevent respiratory syncytial virus disease in children: what to measure? |
6 |
| Insights and challenges in tuberculosis vaccine development |
6 |
| Pitfalls and caveats in alpha 1-antitrypsin deficiency testing: a guide for clinicians |
6 |
| Challenges in the diagnosis of paediatric pneumonia in intervention field trials: recommendations from a pneumonia field trial working group |
5 |
| Oral prednisolone in preschool children with virus-associated wheeze: a prospective, randomised, double-blind, placebo-controlled trial |
5 |
| Bubble continuous positive airway pressure for children with high-risk conditions and severe pneumonia in Malawi: an open label, randomised, controlled trial |
5 |
| Ventilatory support after extubation in critically ill patients |
5 |
| Pragmatic methods to avoid intensive care unit admission when it does not align with patient and family goals |
4 |
| Prediction of mortality in patients with chronic obstructive pulmonary disease with the new Global Initiative for Chronic Obstructive Lung Disease 2017 classification: a cohort study |
4 |
| Effectiveness of influenza vaccination on influenza-associated hospitalisations over time among children in Hong Kong: a test-negative case-control study |
4 |
| Prevalence and clinical associations of Staphylococcus aureus small-colony variant respiratory infection in children with cystic fibrosis (SCVSA): a multicentre, observational study |
3 |
| Effectiveness of WHO's pragmatic screening algorithm for child contacts of tuberculosis cases in resource-constrained settings: a prospective cohort study in Uganda |
3 |
| Effect of a Russian-backbone live-attenuated influenza vaccine with an updated pandemic H1N1 strain on shedding and immunogenicity among children in The Gambia: an open-label, observational, phase 4 study |
3 |
| Aligning use of intensive care with patient values in the USA: past, present, and future |
3 |
| Early-life exposure to electronic cigarettes: cause for concern |
2 |
| Early-onset emphysema in a large French-Canadian family: a genetic investigation |
0 |
