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Single-cell dissection of persistent tumor antigens in non-responders reveals opportunities for TAA-targeted vaccination after neoadjuvant therapy in esophageal squamous cell carcinom
Author: Zhang, Ruixiang; Qi, Shu; Zhou, Yang; Hu, Ying; Li, Yang; Li, Yue; Qin, Jianjun; Yang, Ai-Rong; Zhang, Henghui; Liu, Zhihua; Li, Yin
Journal: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2026; Vol. 14, Issue 4, pp. -. DOI: 10.1136/jitc-2025-014562
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Single-cell and spatial transcriptomics reveal that the CXCL12-CXCR4 axis drives the immune-desert phenotype in small cell lung cancer by recruiting immunosuppressive CXCR4+ neutrophils and S100A8+ monocyte
Author: Zeng, Peng; Li, Hai-Feng; Shu, Wen-Bin; Zhang, Jing; Zhao, Tian-Cheng; Hu, Jun-Wen; Wang, Jun-Fu; Wang, Cheng; Lu, Qing-Yun; Yang, Jia-Hui; An, Yan-Li; Chen, Rong
Journal: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2026; Vol. 14, Issue 4, pp. -. DOI: 10.1136/jitc-2025-013867
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Non-enzymatic Rnaseh2c orchestrates proliferating macrophage-driven immunosuppression and HCC progression via Cdk9 proliferation axis and CCL2/CCR2-mediated CD8+ Tex infiltration: a novel therapeutic paradigm with Rnaseh2c-In1 inhibito
Author: Wang, Zengbin; Xiao, Ruiying; Liu, Mengxin; Ceng, Lihua; Lin, Zikun; Zheng, Xinyu; Shi, Miaoxin; Ye, Hong; Wu, Linqing; Tang, Nanhong
Journal: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2026; Vol. 14, Issue 4, pp. -. DOI: 10.1136/jitc-2026-014993
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CD55-expressing myeloid-derived suppressor cells (MDSCs) drive cancer immunoevasio
Author: Jiang, Xiaotao; Yan, Ning; Wu, Hui; Wang, Wei; Wang, Xianzhe; Chen, Jingming; Wu, Anzhou; An, Jinqi; Wang, Changlong; Lin, Jie; Li, Yingqian; Wen, Yi; Zhuang, Kunhai; Xie, Linling; Li, Peiwu; Liu, Fengbin; Liu, Yufeng
Journal: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2026; Vol. 14, Issue 4, pp. -. DOI: 10.1136/jitc-2025-012980
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Anti-TIM-3 antibody TQB2618 in combination with penpulimab in relapsed or refractory classic Hodgkin lymphoma previously treated with PD-1/PD-L1 therapy: a multicenter, open-label, single-arm, phase Ib clinical tria
Author: Hong, Huangming; Chen, Zegeng; Cui, Jie; Zhang, Qingyuan; Li, Ping; Tao, Rong; Huang, He; Wang, Binghua; Li, Wuping; Wu, Hui; Wei, Jin; Su, Liping; Zhang, Zhihua; Zhong, Mingxing; Wang, Huaqing; Wang, Cong; Zhou, Hui; Wang, Jishi; Dong, Min; Lin, Tongyu
Journal: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2026; Vol. 14, Issue 4, pp. -. DOI: 10.1136/jitc-2026-014968
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RNA helicase SKIV2L impedes tumor immunity by reprogramming arginine metabolism of hepatocellular carcinoma
Author: Zhu, Lisheng; Wu, Meng; Feng, Bingbing; Zhang, Yu; Xu, Yang; Yu, Lili
Journal: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2026; Vol. 14, Issue 4, pp. -. DOI: 10.1136/jitc-2025-014192
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Deep learning-driven recognition of panoramic tumor microenvironment features in H&E sections and its applicatio
Author: Zhang, Han; Huang, Qinyi; Shang, Bing; Su, Guowei; Tu, Huakang
Journal: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2026; Vol. 14, Issue 4, pp. -. DOI: 10.1136/jitc-2025-014429
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SMAD7 drives natural killer cell antitumor activity through canonical TGF-β blockade and non-canonical transcriptional activation of STAT5
Author: Li, Jin; Liu, Tingting; Xiao, Wengan; Zhao, Dan; Li, Qian; Liu, Shunan; Li, Xin; Tong, Yi; Li, Huimin; Jiang, Hua; Wu, Shuangjie; Li, Zonghai; Tu, Hong; Gan, Yu
Journal: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2026; Vol. 14, Issue 4, pp. -. DOI: 10.1136/jitc-2025-014473
