| A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup |
32 |
| Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation |
26 |
| Treatment with the poly(ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and cognitive performance in aged mice, supporting the NAD plus depletion hypothesis of neurovascular aging |
24 |
| Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment |
23 |
| Nrf2 dysfunction and impaired cellular resilience to oxidative stressors in the aged vasculature: from increased cellular senescence to the pathogenesis of age-related vascular diseases |
22 |
| The potential role of necroptosis in inflammaging and aging |
19 |
| Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial |
19 |
| Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice |
19 |
| Composition and richness of the serum microbiome differ by age and link to systemic inflammation |
17 |
| Age-related impairment of neurovascular coupling responses: a dynamic vessel analysis (DVA)-based approach to measure decreased flicker light stimulus-induced retinal arteriolar dilation in healthy older adults |
16 |
| A window into extreme longevity; the circulating metabolomic signature of the naked mole-rat, a mammal that shows negligible senescence |
15 |
| Lipotoxicity, aging, and muscle contractility: does fiber type matter? |
15 |
| Overexpression of catalase targeted to mitochondria improves neurovascular coupling responses in aged mice |
14 |
| A novel high-throughput assay for respiration in isolated brain microvessels reveals impaired mitochondrial function in the aged mice |
14 |
| Sulforaphane-role in aging and neurodegeneration |
14 |
| Cerebral venous congestion promotes blood-brain barrier disruption and neuroinflammation, impairing cognitive function in mice |
14 |
| Age-related decline in peripheral vascular health predicts cognitive impairment |
14 |
| Assessment of age-related decline of neurovascular coupling responses by functional near-infrared spectroscopy (fNIRS) in humans |
14 |
| An expanding GSK3 network: implications for aging research |
14 |
| Gastro-intestinal and oral microbiome signatures associated with healthy aging |
14 |
| Astrocyte senescence may drive alterations in GFAP alpha, CDKN2A p14(ARF), and TAU3 transcript expression and contribute to cognitive decline |
13 |
| Efficacy of curcumin for age-associated cognitive decline: a narrative review of preclinical and clinical studies |
12 |
| Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects |
12 |
| Fusogenic liposomes effectively deliver resveratrol to the cerebral microcirculation and improve endothelium-dependent neurovascular coupling responses in aged mice |
11 |
| Age modifies the risk factor profiles for acute kidney injury among recently diagnosed type 2 diabetic patients: a population-based study |
10 |
| PACAP deficiency as a model of aging |
10 |
| Sympathetic nervous system as a target for aging and obesity-related cardiovascular diseases |
10 |
| Calorie restriction induces reversible lymphopenia and lymphoid organ atrophy due to cell redistribution |
10 |
| Systolic hypertension-induced neurovascular unit disruption magnifies vascular cognitive impairment in middle-age atherosclerotic LDLr-/-:hApoB(+/+) mice |
9 |
| Effect of caloric restriction and rapamycin on ovarian aging in mice |
9 |
| Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts |
9 |
| Hydrogen sulfide ameliorates aging-associated changes in the kidney |
9 |
| The influence of GDF11 on brain fate and function |
9 |
| The enigmatic role of growth hormone in age-related diseases, cognition, and longevity |
9 |
| The effect of fear of falling on prefrontal cortex activation and efficiency during walking in older adults |
8 |
| Genomic instability and innate immune responses to self-DNA in progeria |
8 |
| ComBATing aging-does increased brown adipose tissue activity confer longevity? |
8 |
| Age-dependent effects of caloric restriction on mTOR and ubiquitin-proteasome pathways in skeletal muscles |
8 |
| The plasma metabolome as a predictor of biological aging in humans |
8 |
| Measurement of respiratory function in isolated cardiac mitochondria using Seahorse XFe24 Analyzer: applications for aging research |
8 |
| Age-related alterations of articular cartilage in pituitary adenylate cyclase-activating polypeptide (PACAP) gene-deficient mice |
7 |
| Taming expectations of metformin as a treatment to extend healthspan |
7 |
| Genetic heterogeneity of Alzheimer's disease in subjects with and without hypertension |
7 |
| Age- and AD-related redox state of NADH in subcellular compartments by fluorescence lifetime imaging microscopy |
7 |
| Systemic milieu and age-related deterioration |
7 |
| Sex differences in health and aging: a dialog between the brain and gonad? |
7 |
| Transforming growth factor-beta promotes basement membrane fibrosis, alters perivascular cerebrospinal fluid distribution, and worsens neurological recovery in the aged brain after stroke |
6 |
| Microvascular contributions to age-related macular degeneration (AMD): from mechanisms of choriocapillaris aging to novel interventions |
6 |
| Simultaneous assessment of cognitive function, circadian rhythm, and spontaneous activity in aging mice |
6 |
| Correlations between age, functional status, and the senescence-associated proteins HMGB2 and p16(INK4a) |
6 |
