| RoB 2: a revised tool for assessing risk of bias in randomised trials |
618 |
| Mortality due to cirrhosis and liver cancer in the United States, 1999-2016: observational study |
124 |
| Dose-response associations between accelerometry measured physical activity and sedentary time and all cause mortality: systematic review and harmonised meta-analysis |
117 |
| Global, regional, and national burden of suicide mortality 1990 to 2016: systematic analysis for the Global Burden of Disease Study 2016 |
89 |
| Consumption of ultra-processed foods and cancer risk: results from NutriNet-Sante prospective cohort |
89 |
| Immune-related adverse events for anti-PD-1 and anti-PD-L1 drugs: systematic review and meta-analysis |
88 |
| Pulmonary arterial hypertension: pathogenesis and clinical management |
86 |
| Accuracy of Patient Health Questionnaire-9 (PHQ-9) for screening to detect major depression: individual participant data meta-analysis |
86 |
| Pre-eclampsia: pathophysiology and clinical implications |
80 |
| Postsurgical prescriptions for opioid naive patients and association with overdose and misuse: retrospective cohort study |
77 |
| Ultra-processed food intake and risk of cardiovascular disease: prospective cohort study (NutriNet-Sante) |
69 |
| Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians |
68 |
| Efficacy of PD-1 or PD-L1 inhibitors and PD-L1 expression status in cancer: meta-analysis |
68 |
| Detecting cervical precancer and reaching underscreened women by using HPV testing on self samples: updated meta-analyses |
66 |
| Associations of grip strength with cardiovascular, respiratory, and cancer outcomes and all cause mortality: prospective cohort study of half a million UK Biobank participants |
64 |
| Prevalence of diagnosed type 1 and type 2 diabetes among US adults in 2016 and 2017: population based study |
64 |
| What are the respiratory effects of e-cigarettes? |
60 |
| Anticholinergic drugs and risk of dementia: case-control study |
59 |
| Comparative safety of immune checkpoint inhibitors in cancer: systematic review and network meta-analysis |
59 |
| Prevalence of vaping and smoking among adolescents in Canada, England, and the United States: repeat national cross sectional surveys |
55 |
| Low cigarette consumption and risk of coronary heart disease and stroke: meta-analysis of 141 cohort studies in 55 study reports |
54 |
| Sodium glucose cotransporter 2 inhibitors and risk of serious adverse events: nationwide register based cohort study |
50 |
| The role of the gut microbiome in systemic inflammatory disease |
49 |
| Artificial pancreas treatment for outpatients with type 1 diabetes: systematic review and meta-analysis |
48 |
| Recent trends in life expectancy across high income countries: retrospective observational study |
48 |
| Association between consumption of ultra-processed foods and all cause mortality: SUN prospective cohort study |
47 |
| Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care |
47 |
| A guide to systematic review and meta-analysis of prognostic factor studies |
47 |
| Arthroscopic hip surgery compared with physiotherapy and activity modification for the treatment of symptomatic femoroacetabular impingement: multicentre randomised controlled trial |
46 |
| Comparison of prostatic artery embolisation (PAE) versus transurethral resection of the prostate (TURP) for benign prostatic hyperplasia: randomised, open label, non-inferiority trial |
45 |
| Personalized evidence based medicine: predictive approaches to heterogeneous treatment effects |
45 |
| Prevalence, severity, and nature of preventable patient harm across medical care settings: systematic review and meta-analysis |
45 |
| Increased cardiovascular risk in rheumatoid arthritis: mechanisms and implications |
45 |
| Clinical course of untreated cervical intraepithelial neoplasia grade 2 under active surveillance: systematic review and meta-analysis |
43 |
| CONSORT 2010 statement: extension to randomised crossover trials |
43 |
| Environmental toxic metal contaminants and risk of cardiovascular disease: systematic review and meta-analysis |
42 |
| Prostate cancer screening with prostate-specific antigen (PSA) test: a systematic review and meta-analysis |
42 |
| Endovascular treatment for acute ischaemic stroke in routine clinical practice: prospective, observational cohort study (MR CLEAN Registry) |
41 |
| Reporting of stepped wedge cluster randomised trials: extension of the CONSORT 2010 statement with explanation and elaboration |
40 |
| Role of maternal age and pregnancy history in risk of miscarriage: prospective register based study |
40 |
| The reporting of studies conducted using observational routinely collected health data statement for pharmacoepidemiology (RECORD-PE) |
39 |
| Association between ambient temperature and mortality risk and burden: time series study in 272 main Chinese cities |
38 |
| Trends in incidence of total or type 2 diabetes: systematic review |
37 |
| Migraine and risk of cardiovascular diseases: Danish population based matched cohort study |
37 |
| Preterm birth and risk of chronic kidney disease from childhood into mid-adulthood: national cohort study |
36 |
| Prevalence and outcomes of incidental imaging findings: umbrella review |
36 |
| Operative treatment versus nonoperative treatment of Achilles tendon ruptures: systematic review and meta-analysis |
36 |
| Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial |
36 |
| Role of diet in type 2 diabetes incidence: umbrella review of meta-analyses of prospective observational studies |
36 |
| Trends in survival after a diagnosis of heart failure in the United Kingdom 2000-2017: population based cohort study |
36 |
| Angiotensin converting enzyme inhibitors and risk of lung cancer: population based cohort study |
35 |
| Risk of meticillin resistant Staphylococcus aureus and Clostridium difficile in patients with a documented penicillin allergy: population based matched cohort study |
34 |
| Association between vitamin D supplementation and mortality: systematic review and meta-analysis |
33 |
| Effectiveness of the Stand More AT (SMArT) Work intervention: cluster randomised controlled trial |
33 |
| Long term risk of symptomatic recurrent venous thromboembolism after discontinuation of anticoagulant treatment for first unprovoked venous thromboembolism event: systematic review and meta-analysis |
33 |
| Preoperative physiotherapy for the prevention of respiratory complications after upper abdominal surgery: pragmatic, double blinded, multicentre randomised controlled trial |
33 |
| Fluoroquinolone use and risk of aortic aneurysm and dissection: nationwide cohort study |
32 |
| Incidence of type 1 diabetes in China, 2010-13: population based study |
32 |
| Estimates of all cause mortality and cause specific mortality associated with proton pump inhibitors among US veterans: cohort study |
32 |
| Impact of patient and public involvement on enrolment and retention in clinical trials: systematic review and meta-analysis |
32 |
| Laparoscopic cholecystectomy versus percutaneous catheter drainage for acute cholecystitis in high risk patients (CHOCOLATE): multicentre randomised clinical trial |
31 |
| Data sharing and reanalysis of randomized controlled trials in leading biomedical journals with a full data sharing policy: survey of studies published in The BMJ and PLOS Medicine |
31 |
| Rotating night shift work and adherence to unhealthy lifestyle in predicting risk of type 2 diabetes: results from two large US cohorts of female nurses |
31 |
| Comparative efficacy and acceptability of non-surgical brain stimulation for the acute treatment of major depressive episodes in adults: systematic review and network meta-analysis |
30 |
| Association of paternal age with perinatal outcomes between 2007 and 2016 in the United States: population based cohort study |
30 |
| Changes in midlife death rates across racial and ethnic groups in the United States: systematic analysis of vital statistics |
30 |
| Vertebroplasty versus sham procedure for painful acute osteoporotic vertebral compression fractures (VERTOS IV): randomised sham controlled clinical trial |
30 |
| Patient relevant outcomes of unicompartmental versus total knee replacement: systematic review and meta-analysis |
30 |
| Breast cancer risk in transgender people receiving hormone treatment: nationwide cohort study in the Netherlands |
30 |
| Statins for primary prevention of cardiovascular events and mortality in old and very old adults with and without type 2 diabetes: retrospective cohort study |
30 |
| Appropriateness of outpatient antibiotic prescribing among privately insured US patients: ICD-10-CM based cross sectional study |
29 |
| Evaluation of the diet wide contribution to serum urate levels: meta-analysis of population based cohorts |
29 |
| Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study |
29 |
| Contributions of prescribed and non-prescribed opioids to opioid related deaths: population based cohort study in Ontario, Canada |
29 |
| Dementia And Physical Activity (DAPA) trial of moderate to high intensity exercise training for people with dementia: randomised controlled trial |
29 |
| Physical activity trajectories and mortality: population based cohort study |
29 |
| Omega- omega- and total dietary polyunsaturated fat for prevention and treatment of type 2 diabetes mellitus: systematic review and meta-analysis of randomised controlled trials |
28 |
| Relaxation of the one child policy and trends in caesarean section rates and birth outcomes in China between 2012 and 2016: observational study of nearly seven million health facility births |
28 |
| Maternal-fetal transmission and adverse perinatal outcomes in pregnant women infected with Zika virus: prospective cohort study in French Guiana |
28 |
| International variation in radiation dose for computed tomography examinations: prospective cohort study |
28 |
| Prevalence of cervical disease at age 20 after immunisation with bivalent HPV vaccine at age 12-13 in Scotland: retrospective population study |
28 |
| Effect of breakfast on weight and energy intake: systematic review and meta-analysis of randomised controlled trials |
27 |
| Predicted lean body mass, fat mass, and all cause and cause specific mortality in men: prospective US cohort study |
27 |
| Biases in electronic health record data due to processes within the healthcare system: retrospective observational study |
27 |
| Within country inequalities in caesarean section rates: observational study of 72 low and middle income countries |
27 |
| Autism spectrum disorder: advances in diagnosis and evaluation |
26 |
| Polygenic hazard score to guide screening for aggressive - prostate cancer: development and validation in large scale - cohorts |
26 |
| STATISTICS NOTES Population attributable fraction |
26 |
| Six months versus 12 months dual antiplatelet therapy after drug-eluting stent implantation in ST-elevation myocardial infarction (DAPT-STEMI): randomised, multicentre, non-inferiority trial |
26 |
| Chronic use of tramadol after acute pain episode: cohort study |
25 |
| Primary cervical screening with high risk human papillomavirus testing: observational study |
25 |
| Cardiovascular outcomes associated with canagliflozin versus other non-gliflozin antidiabetic drugs: population based cohort study |
25 |
| Efficacy and safety of dual SGLT 1/2 inhibitor sotagliflozin in type 1 diabetes: meta-analysis of randomised controlled trials |
25 |
| Non-alcoholic fatty liver disease and risk of incident acute myocardial infarction and stroke: findings from matched cohort study of 18 million European adults |
25 |
| Use of sodium glucose cotransporter 2 inhibitors and risk of major cardiovascular events and heart failure: Scandinavian register based cohort study |
25 |
| Effects of Helicobacter pylori treatment and vitamin and garlic supplementation on gastric cancer incidence and mortality: follow-up of a randomized intervention trial |
25 |
| Physical inactivity, cardiometabolic disease, and risk of dementia: an individual-participant meta-analysis |
25 |
| Subacromial decompression versus diagnostic arthroscopy for shoulder impingement: randomised, placebo surgery controlled clinical trial |
24 |
| Key design considerations for adaptive clinical trials: a primer for clinicians |
24 |
| Lifetime risk of atrial fibrillation according to optimal, borderline, or elevated levels of risk factors: cohort study based on longitudinal data from the Framingham Heart Study |
24 |
| Association of changes in red meat consumption with total and cause specific mortality among US women and men: two prospective cohort studies |
24 |
| Common conditions associated with hereditary haemochromatosis genetic variants: cohort study in UK Biobank |
24 |
| Effect of tai chi versus aerobic exercise for fibromyalgia: comparative effectiveness randomized controlled trial |
24 |
| Education and myopia: assessing the direction of causality by mendelian randomisation |
24 |
| Diclofenac use and cardiovascular risks: series of nationwide cohort studies |
23 |
| Socioeconomic status, non-communicable disease risk factors, and walking speed in older adults: multi-cohort population based study |
23 |
| Duration of dual antiplatelet therapy after percutaneous coronary intervention with drug-eluting stent: systematic review and network meta-analysis |
23 |
| Prediction system for risk of allograft loss in patients receiving kidney transplants: international derivation and validation study |
23 |
| Data sharing practices of medicines related apps and the mobile ecosystem: traffic, content, and network analysis |
23 |
| Prenatal and infant exposure to ambient pesticides and autism spectrum disorder in children: population based case-control study |
23 |
| DELTA(2) guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial |
22 |
| Dipeptidyl peptidase-4 inhibitors and incidence of inflammatory bowel disease among patients with type 2 diabetes: population based cohort study |
22 |
| Short term exposure to fine particulate matter and hospital admission risks and costs in the Medicare population: time stratified, case crossover study |
21 |
| Sepsis associated acute kidney injury |
21 |
| Advances in optimizing the prescription of antibiotics in outpatient settings |
20 |
| Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium |
20 |
| Management of acute upper gastrointestinal bleeding |
20 |
| Sugary drink consumption and risk of cancer: results from NutriNet-Sante prospective cohort |
20 |
| Sex differences in risk factors for myocardial infarction: cohort study of UK Biobank participants |
20 |
| Immediate impact of minimum unit pricing on alcohol purchases in Scotland: controlled interrupted time series analysis for 2015-18 |
20 |
| Impact and sustainability of centralising acute stroke services in English metropolitan areas: retrospective analysis of hospital episode statistics and stroke national audit data |
19 |
| Sulfonylureas as second line drugs in type 2 diabetes and the risk of cardiovascular and hypoglycaemic events: population based cohort study |
19 |
| Improving adherence to healthy dietary patterns, genetic risk, and long term weight gain: gene-diet interaction analysis in two prospective cohort studies |
19 |
| Compliance with requirement to report results on the EU Clinical Trials Register: cohort study and web resource |
19 |
| Stress related disorders and risk of cardiovascular disease: population based, sibling controlled cohort study |
19 |
| Association between patient outcomes and accreditation in US hospitals: observational study |
19 |
| Prevalence of potentially inappropriate prescribing in older people in primary care and its association with hospital admission: longitudinal study |
19 |
| Maternal diabetes during pregnancy and early onset of cardiovascular disease in offspring: population based cohort study with 40 years of follow-up |
19 |
| How to avoid common problems when using ClinicalTrials.gov in research: 10 issues to consider |
18 |
| Benefits and harms of spinal manipulative therapy for the treatment of chronic low back pain: systematic review and meta-analysis of randomised controlled trials |
18 |
| Long term adjuvant endocrine therapy and risk of cardiovascular disease in female breast cancer survivors: systematic review |
18 |
| Clopidogrel plus aspirin versus aspirin alone for acute minor ischaemic stroke or high risk transient ischaemic attack: systematic review and meta-analysis |
18 |
| Cancer risk associated with chronic diseases and disease markers: prospective cohort study |
18 |
| Antibiotic management of urinary tract infection in elderly patients in primary care and its association with bloodstream infections and all cause mortality: population based cohort study |
18 |
| TIDieR-PHP: a reporting guideline for population health and policy interventions |
18 |
| Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants |
18 |
| Understanding the consequences of education inequality on cardiovascular disease: mendelian randomisation study |
18 |
| Development and validation of outcome prediction models for aneurysmal subarachnoid haemorrhage: the SAHIT multinational cohort study |
18 |
| A guide to prospective meta-analysis |
18 |
| Hospital revisits within 30 days after discharge for medical conditions targeted by the Hospital Readmissions Reduction Program in the United States: national retrospective analysis |
17 |
| Plasma 25-hydroxyvitamin D concentration and subsequent risk of total and site specific cancers in Japanese population: large case-cohort study within Japan Public Health Center-based Prospective Study cohort |
17 |
| Pre-eclampsia and risk of later kidney disease: nationwide cohort study |
17 |
| Role of obesity in smoking behaviour: Mendelian randomisation study in UK Biobank |
17 |
| Efficacy and safety of first line treatments for patients with advanced epidermal growth factor receptor mutated, non-small cell lung cancer: systematic review and network meta-analysis |
17 |
| Respiratory syncytial virus infection in adults |
17 |
| Living network meta-analysis compared with pairwise meta-analysis in comparative effectiveness research: empirical study |
17 |
| Cognitive symptoms of Alzheimer's disease: clinical management and prevention |
16 |
| Doctor Referral of Overweight People to Low Energy total diet replacement Treatment (DROPLET): pragmatic randomised controlled trial |
16 |
| Ischaemic stroke, haemorrhage, and mortality in older patients with chronic kidney disease newly started on anticoagulation for atrial fibrillation: a population based study from UK primary care |
16 |
| Status of care for end stage kidney disease in countries and regions worldwide: international cross sectional survey |
16 |
| Long term exposure to ambient fine particulate matter and incidence of stroke: prospective cohort study from the China-PAR project |
16 |
| Design characteristics, risk of bias, and reporting of randomised controlled trials supporting approvals of cancer drugs by European Medicines Agency, 2014-16: cross sectional analysis |
16 |
| Comparative effectiveness of rituximab, abatacept, and tocilizumab in adults with rheumatoid arthritis and inadequate response to TNF inhibitors: prospective cohort study |
16 |
| Associations between gabapentinoids and suicidal behaviour, unintentional overdoses, injuries, road traffic incidents, and violent crime: population based cohort study in Sweden |
16 |
| Statistical methods to compare functional outcomes in - randomized controlled trials with high mortality |
16 |
| Clinical trial design and dissemination: comprehensive analysis of clinicaltrials.gov and PubMed data since 2005 |
15 |
| Alternative approaches for confounding adjustment in observational studies using weighting based on the propensity score: a primer for practitioners |
15 |
| Secondary peritonitis: principles of diagnosis and intervention |
15 |
| Severe and predominantly active atopic eczema in adulthood and long term risk of cardiovascular disease: population based cohort study |
15 |
| Antidepressant utilisation and incidence of weight gain during 10 years' follow-up: population based cohort study |
15 |
| Risks of ischaemic heart disease and stroke in meat eaters, fish eaters, and vegetarians over 18 years of follow-up: results from the prospective EPIC-Oxford study |
15 |
| Diagnosis of elevated intracranial pressure in critically ill adults: systematic review and meta-analysis |
15 |
| Association of China's universal two child policy with changes in births and birth related health factors: national, descriptive comparative study |
14 |
| Pre-eclampsia and risk of dementia later in life: nationwide cohort study |
14 |
| True 99th centile of high sensitivity cardiac troponin for hospital patients: prospective, observational cohort study |
14 |
| Association of genetically predicted testosterone with thromboembolism, heart failure, and myocardial infarction: mendelian randomisation study in UK Biobank |
14 |
| Food sources of fructose-containing sugars and glycaemic control: systematic review and meta-analysis of controlled intervention studies |
14 |
| Trends in outpatient antibiotic use and prescribing practice among US older adults, 2011-15: observational study |
14 |
| Temporal trends in use of tests in UK primary care, 2000-15: retrospective analysis of 250 million tests |
14 |
| Enterovirus as trigger of coeliac disease: nested case-control study within prospective birth cohort |
14 |
| Patient safety after implementation of a coproduced family centered communication programme: multicenter before and after intervention study |
14 |
| Alcohol consumption and risk of dementia: 23 year follow-up of Whitehall II cohort study |
14 |
| Impact of 2017 ACC/AHA guidelines on prevalence of hypertension and eligibility for antihypertensive treatment in United States and China: nationally representative cross sectional study |
13 |
| Effectiveness of text message based, diabetes self management support programme (SMS4BG): two arm, parallel randomised controlled trial |
13 |
| Peripartum cardiomyopathy |
13 |
| Age trends in 30 day hospital readmissions: US national retrospective analysis |
13 |
| Diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome: review of acute decompensated diabetes in adult patients |
13 |
| Effect of restricting the legal supply of prescription opioids on buying through online illicit marketplaces: interrupted time series analysis |
13 |
| Use of postmenopausal hormone therapy and risk of Alzheimer's disease in Finland: nationwide case-control study |
13 |
| Determinants of the decline in mortality from acute stroke in England: linked national database study of 795 869 adults |
13 |
| Overdiagnosis in primary care: framing the problem and finding solutions |
13 |
| Association between ambient fine particulate pollution and hospital admissions for cause specific cardiovascular disease: time series study in 184 major Chinese cities |
13 |
| Revisiting the association of blood pressure with mortality in oldest old people in China: community based, longitudinal prospective study |
13 |
| Body mass index and all cause mortality in HUNT and UK Biobank studies: linear and non-linear mendelian randomisation analyses |
12 |
| Antithrombotic treatment after coronary artery bypass graft surgery: systematic review and network meta-analysis |
12 |
| Impact of national cancer policies on cancer survival trends and socioeconomic inequalities in England, 1996-2013: population based study |
12 |
| Association between maternal adherence to healthy lifestyle practices and risk of obesity in offspring: results from two prospective cohort studies of mother-child pairs in the United States |
12 |
| Joint association of urinary sodium and potassium excretion with cardiovascular events and mortality: prospective cohort study |
12 |
| Effect of high dose folic acid supplementation in pregnancy on pre-eclampsia (FACT): double blind, phase III, randomised controlled, international, multicentre trial |
12 |
| State gun laws, gun ownership, and mass shootings in the US: cross sectional time series |
12 |
| Clostridioides difficile: diagnosis and treatments |
12 |
| Potential impact on prevalence of obesity in the UK of a 20% price increase in high sugar snacks: modelling study |
12 |
| Colorectal cancer screening with faecal immunochemical testing, sigmoidoscopy or colonoscopy: a microsimulation modelling study |
12 |
| When continuous outcomes are measured using different scales: guide for meta-analysis and interpretation |
12 |
| Changes in, and factors associated with, frequency of sex in Britain: evidence from three National Surveys of Sexual Attitudes and Lifestyles (Natsal) |
12 |
| Does general anesthesia affect neurodevelopment in infants and children? |
12 |
| Trends in opioid use in commercially insured and Medicare Advantage populations in 2007-16: retrospective cohort study |
12 |
| Efficacy of antibiotic treatment in patients with chronic low back pain and Modic changes (the AIM study): double blind, -randomised, placebo controlled, multicentre trial |
12 |
| Triple therapy in the management of chronic obstructive pulmonary disease: systematic review and meta-analysis |
12 |
| Quantifying the impact of genes on body mass index during the obesity epidemic: longitudinal findings from the HUNT Study |
11 |
