| The molecular machinery of regulated cell death |
149 |
| Mitochondrial metabolism and cancer |
140 |
| Dynamic transcriptomic m(6)A decoration: writers, erasers, readers and functions in RNA metabolism |
117 |
| Plasma membrane changes during programmed cell deaths |
105 |
| Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression |
102 |
| RNA N-6-methyladenosine modification in cancers: current status and perspectives |
86 |
| UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication |
72 |
| The adult human testis transcriptional cell atlas |
64 |
| Amyloid fibril structure of alpha-synuclein determined by cryoelectron microscopy |
63 |
| Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation |
50 |
| Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma |
46 |
| Modifications and functional genomics of human transfer RNA |
45 |
| Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta |
42 |
| A novel m(6)A reader Prrc2a controls oligodendroglial specification and myelination |
38 |
| Tissue clearing of both hard and soft tissue organs with the PEGASOS method |
35 |
| Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion |
34 |
| Single-cell RNA-seq uncovers dynamic processes and critical regulators in mouse spermatogenesis |
34 |
| PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy |
34 |
| Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis |
31 |
| Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade |
30 |
| A complex structure of arrestin-2 bound to a G protein-coupled receptor |
28 |
| METTL3-mediated N-6-methyladenosine mRNA modification enhances long-term memory consolidation |
28 |
| Structure of the receptor-activated human TRPC6 and TRPC3 ion channels |
27 |
| A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy |
26 |
| Structure of the intact 14-subunit human cytochrome c oxidase |
26 |
| Structure of the human activated spliceosome in three conformational states |
25 |
| PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins |
24 |
| BE-PLUS: a new base editing tool with broadened editing window and enhanced fidelity |
23 |
| Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids |
23 |
| MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models |
23 |
| Uncoupling therapeutic from immunotherapy-related adverse effects for safer and effective anti-CTLA-4 antibodies in CTLA4 humanized mice |
22 |
| Spatial transcriptomic survey of human embryonic cerebral cortex by single-cell RNA-seq analysis |
22 |
| Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders |
21 |
| Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens |
20 |
| Intragenic antagonistic roles of protein and circRNA in tumorigenesis |
20 |
| Circulating apoptotic bodies maintain mesenchymal stem cell homeostasis and ameliorate osteopenia via transferring multiple cellular factors |
19 |
| Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress |
19 |
| Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade |
18 |
| Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS |
18 |
| An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis |
18 |
| Cryo-EM structure of human mTOR complex 2 |
17 |
| A dynamic N-6-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors |
17 |
| A post-ingestive amino acid sensor promotes food consumption in Drosophila |
17 |
| Tracing the first hematopoietic stem cell generation in human embryo by single-cell RNA sequencing |
16 |
| Malate transported from chloroplast to mitochondrion triggers production of ROS and PCD in Arabidopsis thaliana |
16 |
| Virus-induced accumulation of intracellular bile acids activates the TGR5-beta-arrestin-SRC axis to enable innate antiviral immunity |
16 |
| Skeletal muscle mitochondrial remodeling in exercise and diseases |
16 |
| DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling |
16 |
| Integrative single-cell analysis of transcriptome, DNA methylome and chromatin accessibility in mouse oocytes |
15 |
| Structures of the human pre-catalytic spliceosome and its precursor spliceosome |
15 |
| Plant HP1 protein ADCP1 links multivalent H3K9 methylation readout to heterochromatin formation |
15 |
| Cryo-EM reveals ligand induced allostery underlying InsP(3)R channel gating |
14 |
| A cyclic nucleotide-gated channel mediates cytoplasmic calcium elevation and disease resistance in rice |
14 |
| Tamoxifen enhances stemness and promotes metastasis of ER alpha 36(+) breast cancer by upregulating ALDH1A1 in cancer cells |
14 |
| Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing |
14 |
| Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy |
14 |
| BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules |
14 |
| Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis |
14 |
| PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by regulating synaptic transmission in cerebellum |
13 |
| Ligand-triggered de-repression of Arabidopsis heterotrimeric G proteins coupled to immune receptor kinases |
12 |
| m-AAA proteases, mitochondrial calcium homeostasis and neurodegeneration |
12 |
| Structural basis for specific flagellin recognition by the NLR protein NAIP5 |
11 |
| Setd2 deficiency impairs hematopoietic stem cell self-renewal and causes malignant transformation |
11 |
| Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway |
11 |
| Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair |
11 |
| STAT3 associates with vacuolar H+-ATPase and regulates cytosolic and lysosomal pH |
11 |
| H5N1 influenza virus-specific miRNA-like small RNA increases cytokine production and mouse mortality via targeting poly(rC)-binding protein 2 |
11 |
| BH3-only proteins target BCL-xL/MCL- not BAX/BAK, to initiate apoptosis |
11 |
| Dynamic methylome of internal mRNA N-7-methylguanosine and its regulatory role in translation |
10 |
| Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis |
10 |
| Structures of the human spliceosomes before and after release of the ligated exon |
10 |
| Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia |
10 |
| Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction |
10 |
| Interferon-inducible cytoplasmic lncLrrc55-AS promotes antiviral innate responses by strengthening IRF3 phosphorylation |
10 |
| AIF-regulated oxidative phosphorylation supports lung cancer development |
10 |
| A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts |
9 |
| Calcium channel blockers reduce severe fever with thrombocytopenia syndrome virus (SFTSV) related fatality |
9 |
| Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors |
9 |
| Ubiquitination of Rheb governs growth factor-induced mTORC1 activation |
9 |
| Vitamin B-12 modulates Parkinson's disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection |
9 |
| Endothelial cell-derived GABA signaling modulates neuronal migration and postnatal behavior |
9 |
| Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death |
9 |
| Phosphorylation of glutaminase by PKC epsilon is essential for its enzymatic activity and critically contributes to tumorigenesis |
9 |
| Asymmetric distribution of cytokinins determines root hydrotropism in Arabidopsis thaliana |
8 |
| Human ESC-derived expandable hepatic organoids enable therapeutic liver repopulation and pathophysiological modeling of alcoholic liver injury |
8 |
| Histone H3 lysine 4 monomethylation modulates long-range chromatin interactions at enhancers |
8 |
| NDUFAB1 confers cardio-protection by enhancing mitochondrial bioenergetics through coordination of respiratory complex and supercomplex assembly |
8 |
| Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis |
8 |
| Pyruvate kinase M2 regulates homologous recombination-mediated DNA double-strand break repair |
7 |
| Coagulation factors VII, IX and X are effective antibacterial proteins against drug-resistant Gram-negative bacteria |
7 |
| Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol |
7 |
| LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition |
7 |
| Structural insights into a high fidelity variant of SpCas9 |
7 |
| Cryo-EM structure of human ATR-ATRIP complex |
7 |
| Whole-genome sequencing reveals principles of brain retrotransposition in neurodevelopmental disorders |
7 |
| Cortical branched actin determines cell cycle progression |
7 |
| SUMO suppresses and MYC amplifies transcription globally by regulating CDK9 sumoylation |
6 |
| Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition |
6 |
| Coupling of ssRNA cleavage with DNase activity in type III-A CRISPR-Csm revealed by cryo-EM and biochemistry |
6 |
| LSECtin on tumor-associated macrophages enhances breast cancer stemness via interaction with its receptor BTN3A3 |
6 |
| LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity |
6 |
| Preventing abnormal NF-kappa B activation and autoimmunity by Otub1-mediated p100 stabilization |
6 |
| Derivation of hypermethylated pluripotent embryonic stem cells with high potency |
6 |
| Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells |
6 |
| KRAB-type zinc-finger proteins PITA and PISA specifically regulate p53-dependent glycolysis and mitochondrial respiration |
5 |
| Structural basis of allosteric regulation of Tel1/ATM kinase |
5 |
| Cryo-EM structure of SMG1-SMG8-SMG9 complex |
5 |
| Hormones induce the formation of luminal-derived basal cells in the mammary gland |
5 |
| A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis |
5 |
| The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes |
5 |
| Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy |
5 |
| Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate |
5 |
| Anti-mitotic chemotherapeutics promote apoptosis through TL1A-activated death receptor 3 in cancer cells |
4 |
| Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis |
4 |
| Mouse embryonic stem cells have increased capacity for replication fork restart driven by the specific Filia-Floped protein complex |
3 |
| An NF90/NF110-mediated feedback amplification loop regulates dicer expression and controls ovarian carcinoma |
3 |
| Protein C receptor is a therapeutic stem cell target in a distinct group of breast cancers |
3 |
| Elimination of CD4(low)HLA-G(+) T cells overcomes castrationresistance in prostate cancer therapy |
3 |
| STIM1 thermosensitivity defines the optimal preference temperature for warm sensation in mice |
3 |
| Psp a novel regulator of autophagy that promotes autophagy-related protein translation |
2 |
| Poly(ADP-ribose) mediates asymmetric division of mouse oocyte |
2 |
| The BH3-only protein BAD mediates TNF alpha cytotoxicity despite concurrent activation of IKK and NF-kappa B in septic shock |
2 |
| LKB1 expressed in dendritic cells governs the development and expansion of thymus-derived regulatory T cells |
2 |
| NDP52 tunes cortical actin interaction with astral microtubules for accurate spindle orientation |
2 |
| Accurate annotation of accessible chromatin in mouse and human primordial germ cells |
2 |
| Glycolipid iGb3 feedback amplifies innate immune responses via CD1d reverse signaling |
1 |
| Succinate-acetate permease from Citrobacter koseri is an anion channel that unidirectionally translocates acetate |
1 |
| Distinct enhancer signatures in the mouse gastrula delineate progressive cell fate continuum during embryo development |
1 |
