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Design, synthesis, and anti-HPV activity evaluation of neocryptolepine derivatives with boronic acid modificatio
Author: Zhang, Kai; Li, Zhengjuan; Liu, Shan; Liu, Lu; Sunyang, Ziyi; Liu, Xiaochun; Zhao, Lili; Yin, Ruijuan; Jiang, Tao
Journal: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2026; Vol. 312, Issue , pp. -. DOI: 10.1016/j.ejmech.2026.118850
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Porphyrins modified fibroblast activation protein inhibitor for enhanced cancer radionuclide therap
Author: Wang, Yadong; Chen, Jiajun; Li, Xuanyang; Guo, Jingsi; Fan, Xisheng; Yang, Yuanyou; Liu, Ning; Liao, Jiali; Li, Feize
Journal: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2026; Vol. 311, Issue , pp. -. DOI: 10.1016/j.ejmech.2026.118820
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Rational design and synthesis of flavonolactam derivatives as potent topo I inhibitors with antitumor activit
Author: Shi, Xiaoyu; Huang, Yaoguang; Yang, Xupeng; Wang, Mingyu; Han, Xu; Yang, Shengnan; Li, Wenjing; Jia, Jingming; Wang, Anhua; Huang, Shaohui
Journal: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2026; Vol. 311, Issue , pp. -. DOI: 10.1016/j.ejmech.2026.118804
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Discovery of novel covalent agonists for p53 Y220C through synergistic strategy combining covalent binding and scaffold hoppin
Author: Li, Linquan; Meng, Jingyi; Xu, Fengqian; Wang, Kang; Wang, Xiaoqian; Gu, Xi; Shen, Haiwei; Zhang, Sulin; Zuo, Zhili
Journal: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2026; Vol. 311, Issue , pp. -. DOI: 10.1016/j.ejmech.2026.118801
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GalNAc-CPP conjugates improve the efficiency of oligonucleotide drugs in viv
Author: Lu, Lei; Cong, Dezi; Ma, Wei; Wang, Guoxia; Wang, Haisheng; Wang, Xiaolei
Journal: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2026; Vol. 311, Issue , pp. -. DOI: 10.1016/j.ejmech.2026.118821
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Iminocarbamoyl-hybridized nitrofuranylcoumarins as broad-spectrum antibacterial agents with multitargeting potentia
Author: Huang, Shi-Yu; Ahmad, Nisar; Yu, Jia-Chen; Cheng, Qian; Zhang, Shao-Lin; Zhou, Cheng-He
Journal: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2026; Vol. 311, Issue , pp. -. DOI: 10.1016/j.ejmech.2026.118819
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Design, synthesis, and biological evaluation of 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[4,3-c]pyridine derivatives targeting the colchicine-binding site as new tubulin inhibitor
Author: Guo, Zhu; Liu, Chang; Zhang, Yujing; Xu, Qianqian; Cui, Liya; Chen, Wujun; Wang, Chao
Journal: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2026; Vol. 311, Issue , pp. -. DOI: 10.1016/j.ejmech.2026.118827
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Novel design of interleukin-2 derivatives with reversed pH and potent antitumor activit
Author: Liu, Yu; Liu, Qiuyue; Zhao, Wenjie; Wang, Zhaofeng; Zhong, Guyu; Yi, Juntao; Zheng, Yuzhou; Hao, Xinlong; Peng, Dezheng; Tang, Dongfang; Zhang, Yunxiao
Journal: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2026; Vol. 311, Issue , pp. -. DOI: 10.1016/j.ejmech.2026.118815
