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Therapy-induced cholesterol biosynthesis drives lung cancer dormancy and drug resistanc
Author: Zhao, Yikai; Zhou, Yijia; Pan, Linnuo; Tian, Geng G.; Huang, Hsin-Yi; Tang, Shijie; Lu, Ming; Zhou, Zhangsen; Zhang, Peng; Chen, Luonan; Zhang, Lele; Hu, Liang; Ji, Hongbin
Journal: JOURNAL OF CLINICAL INVESTIGATION. 2026; Vol. 136, Issue 8, pp. -. DOI: 10.1172/JCI191735
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Inflammation-and resolution-programmed myeloid circuits govern therapeutic resistance in epithelial and mesenchymal triple-negative breast cance
Author: Yu, Liqun; Rivas, Charlotte; Liu, Fengshuo; Shen, Yichao; Wu, Ling; Xu, Zhan; Ding, Yunfeng; Hao, Xiaoxin; Zhang, Weijie; Chan, Hilda L.; Liu, Jun; Wei, Bo; Gao, Yang; Becerra-Dominguez, Luis; Wu, Yi-Hsuan; Wang, Siyue; Lee, Tobie D.; Li, Xuan; Chen, Xiang; Edwards, David G.; Zhang, Xiang H. -F
Journal: JOURNAL OF CLINICAL INVESTIGATION. 2026; Vol. 136, Issue 8, pp. -. DOI: 10.1172/JCI198815
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Colonic Engyodontium fungus triggers neutrophil antimicrobial activity to suppress Lactobacillus johnsonii-derived glutamic acid-maintained Treg
Author: Wang, Xinying; Sun, Haiyang; Tan, Ying; Xu, Shaoting; Liu, Zishan; Ji, Kaile; Qiu, Ding; Deng, Jianping; Feng, Bingbing; Wu, Xueting; Iwakura, Yoichiro; Chen, Minhu; Feng, Rui; Huang, Chanyan; Tang, Ce
Journal: JOURNAL OF CLINICAL INVESTIGATION. 2026; Vol. 136, Issue 8, pp. -. DOI: 10.1172/JCI196788
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Tumor cell-derived IFN spatially reprograms osteopontin-enriched macrophage niches to promote PARP inhibitor resistanc
Author: Liu, Dan; Tao, Kangjia; Xu, Cheng; Yang, Wen; Cai, Chujun; Feng, Cui; Xiong, Kairong; Wu, Sisi; Lin, Yaying; Peng, Zikun; Chi, Jianhua; Pan, Wen; Zhong, Qing; Liu, Jiahao; Li, Xiong; Liu, Xingzhe; Zhou, Dongchen; Ma, Ding; Zhao, Guang-Nian; Xia, Yu; Fang, Yong; Gao, Qinglei
Journal: JOURNAL OF CLINICAL INVESTIGATION. 2026; Vol. 136, Issue 8, pp. -. DOI: 10.1172/JCI199035
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GSDME-IL-18 pyroptotic axis prevents myosteatosis by expanding tissue-resident macrophages to promote muscle regeneratio
Author: Cao, Qi; Liu, Jian; Huang, Gang; Wang, Su-Yuan; Lu, Guo-Dong; Huang, Yong; Chen, Yi-Ting; Zhang, Zhen; Fu, Jiang-Tao; Sun, Si-Jia; Chen, Xiao-Fei; Zhuang, Chunlin; Sheng, Chunquan; Shen, Fu-Ming; Li, Dong-Jie; Wang, Pei
Journal: JOURNAL OF CLINICAL INVESTIGATION. 2026; Vol. 136, Issue 8, pp. -. DOI: 10.1172/JCI198076
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Reduced glycoprotein hormone β5 links male aging and testosterone decline to increased adiposit
Author: Xiao, Gengmiao; Qian, Aijun; Gao, Zhuo; Dai, Tingting; Liang, Hui; Wang, Shuai; Deng, Mulan; Yan, Yunjing; Zhang, Xindan; Zhang, Xuedi; Mu, Yunping; Wang, Jiqiu; Gao, Aibo; Zhang, Huijie; Li, Fanghong; Zhao, Allan Zijian
Journal: JOURNAL OF CLINICAL INVESTIGATION. 2026; Vol. 136, Issue 6, pp. -. DOI: 10.1172/JCI192355
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BM-derived mesenchymal stem cell microvesicles protect enteric neural precursor cells and alleviate diabetes-associated enteric neuropath
Author: Shi, Huiying; Yao, Hailing; Liu, Yilin; Fan, Mengke; Cai, Sicheng; Xu, Shizhao; Jiang, Chen; Zhang, Yurui; Jiang, Weiwei; Qian, Wei; Lin, Rong
Journal: JOURNAL OF CLINICAL INVESTIGATION. 2026; Vol. 136, Issue 6, pp. -. DOI: 10.1172/JCI192437
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Vascular smooth muscle cell-derived KIF13B inhibits proinflammatory responses to protect against atherosclerosi
Author: Miao, Guolin; Han, Yufei; Chen, Jingxuan; Liu, Yiran; Zhang, Ge; Pei, Shaotong; Zhao, Yinqi; Xu, Yitong; Zheng, Liwen; Li, Zhaoling; Liu, Xiangru; Shi, Sijing; Kang, Xuya; Liu, Yahan; Zhang, Ling; Huang, Wei; Wang, Yuhui; Tang, Junnan; Dong, Erdan; Xian, Xunde
Journal: JOURNAL OF CLINICAL INVESTIGATION. 2026; Vol. 136, Issue 6, pp. -. DOI: 10.1172/JCI194175
