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KH617 API manufacturing: A synthetic biology approac
Author: Zhou, Yi; Liu, Jiong-Qin; Gao, Cheng-Guo; Luo, Hao; Zhao, Man-Xi; Ke, Xiao
Journal: CANCER RESEARCH. 2026; Vol. 86, Issue 8, pp. LB033-LB033. DOI: 10.1158/1538-7445.AM2026-LB033
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Cytomegalovirus reactivation orchestrates myeloid reprogramming to drive brain metastasis progressio
Author: Zhao, Hong; Dong, Wenjuan; Xu, Shan; Wang, Shiruo; Puri, Akshjot; Vasquez, Matthew; Gao, Dongbing; Yu, Xiaohui; Cui, Johnny; Lau, Johnson; Sampson, James; Sannes, Caitlin; Chang, Jenny; Wong, Stephen
Journal: CANCER RESEARCH. 2026; Vol. 86, Issue 8, pp. -. DOI: 10.1158/1538-7445.AM2026-LB256
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Preclinical evaluation of a novel orally bioavailable MDM2 PROTAC, NW-8-461, in acute leukemia and myelofibrosi
Author: Zhang, Qinhong; Xu, Yajing; Wu, Qiong; Tu, Cecilia Z.; Wang, Shijia; Yin, Kai; Xu, Xuesong; Zhang, Zhang; Dai, Bing; Tan, Fenlai; Chen, Yi
Journal: CANCER RESEARCH. 2026; Vol. 86, Issue 8, pp. LB038-LB038. DOI: 10.1158/1538-7445.AM2026-LB038
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Pharmacodynamic (PD) characterization of BGB-24714, a second mitochondrial-derived activator of caspases (SMAC) mimetic, in a first-in-human study in solid tumor
Author: Zhang, Jinhui; Deng, Minjuan; Jiang, Bin; Li, Jie; Wang, Judy; Hamilton, Erika; Gao, Hua-Xin; Song, Xiaomin; Shen, Zhirong; Jin, Wei; Donate, Fernando
Journal: CANCER RESEARCH. 2026; Vol. 86, Issue 8, pp. -. DOI: 10.1158/1538-7445.AM2026-CT121
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Towards a platform PBPK-QSP model for first-in-human dose selection of GenSci139, a potential best-in-class EGFR×HER2 bispecific ADC, in patients with cance
Author: Zhang, Fan; Xie, Yehua; Ma, Guangli; Liang, Xiao; Zhao, Xumin; Lin, Yihui; Ye, Xuan; Qi, Peng; Wang, Xiaozhen; Zhang, Haizhou; Zhang, Shu; Wang, Siqin; Jin, Lei
Journal: CANCER RESEARCH. 2026; Vol. 86, Issue 8, pp. -. DOI: 10.1158/1538-7445.AM2026-LB441
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Whole body PBPK/PD modeling to support first-in-human dose selection for GenSci140, a potential best-in-class FRα biparatopic ADC, in patients with cance
Author: Zhang, Fan; Xie, Yehua; Ma, Guangli; Liang, Xiao; Zhao, Xumin; Lin, Yihui; Ye, Xuan; Qi, Peng; Wang, Xiaozhen; Zhang, Haizhou; Zhang, Shu; Wang, Siqin; Jin, Lei
Journal: CANCER RESEARCH. 2026; Vol. 86, Issue 8, pp. -. DOI: 10.1158/1538-7445.AM2026-LB442
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AI guided engineering of pH responsive antibodies enables tumor selective targeting and improves the therapeutic inde
Author: Yu, Qilin; Chen, Mingchen; Lu, Ying; Wang, Yuxi
Journal: CANCER RESEARCH. 2026; Vol. 86, Issue 8, pp. LB027-LB027. DOI: 10.1158/1538-7445.AM2026-LB027
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TCE-A: An OR-gate CD19×CD20×CD3 trispecific T-cell engager for B-cell malignancies and autoimmune disease
Author: Ying, Hanxiao; Wu, Emily; Duan, Sizhu; Bai, Dongmei; Wang, Jing; Pu, Pu; Zhang, Limin; Wang, Chunyue; Hu, Min; He, Feng
Journal: CANCER RESEARCH. 2026; Vol. 86, Issue 8, pp. -. DOI: 10.1158/1538-7445.AM2026-LB270
