| Human gut microbiome: hopes, threats and promises |
176 |
| Modern diagnosis of GERD: the Lyon Consensus |
151 |
| European evidence-based guidelines on pancreatic cystic neoplasms |
116 |
| British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults |
116 |
| Real-time automatic detection system increases colonoscopic polyp and adenoma detection rates: a prospective randomised controlled study |
95 |
| Real-time differentiation of adenomatous and hyperplastic diminutive colorectal polyps during analysis of unaltered videos of standard colonoscopy using a deep learning model |
86 |
| Gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis |
83 |
| Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease |
78 |
| IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer |
76 |
| Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database |
73 |
| Recovery of ethanol-induced Akkermansia muciniphila depletion ameliorates alcoholic liver disease |
73 |
| Human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study |
71 |
| Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma |
69 |
| Effects of dietary fat on gut microbiota and faecal metabolites, and their relationship with cardiometabolic risk factors: a 6-month randomised controlled-feeding trial |
64 |
| Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota |
64 |
| Increasing incidence of colorectal cancer in young adults in Europe over the last 25 years |
63 |
| International consensus conference on stool banking for faecal microbiota transplantation in clinical practice |
62 |
| Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD |
60 |
| Bacterial and fungal infections in acute-on-chronic liver failure: prevalence, characteristics and impact on prognosis |
60 |
| Role of the microbiome in human development |
58 |
| Leaky gut: mechanisms, measurement and clinical implications in humans |
57 |
| British Society of Gastroenterology guidelines on the diagnosis and management of patients at risk of gastric adenocarcinoma |
56 |
| Mucosal microbiome dysbiosis in gastric carcinogenesis |
56 |
| A randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota |
55 |
| Adherent-invasive Escherichia coli in inflammatory bowel disease |
52 |
| Major microbiota dysbiosis in severe obesity: fate after bariatric surgery |
52 |
| The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level |
50 |
| Targeting both tumour-associated CXCR2(+) neutrophils and CCR2(+) macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma |
50 |
| Deep learning Radiomics of shear wave elastography significantly improved diagnostic performance for assessing liver fibrosis in chronic hepatitis B: a prospective multicentre study |
50 |
| Global prevalence of, and risk factors for, gastro-oesophageal reflux symptoms: a meta-analysis |
49 |
| Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study |
49 |
| Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus |
48 |
| Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit |
47 |
| The oral microbiota in colorectal cancer is distinctive and predictive |
47 |
| Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial |
47 |
| Faecal microbiota transplantation alters gut microbiota in patients with irritable bowel syndrome: results from a randomised, double-blind placebo-controlled study |
47 |
| Stromal biology and therapy in pancreatic cancer: ready for clinical translation? |
46 |
| Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy |
45 |
| Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised crossover trial |
44 |
| Guidelines on the management of abnormal liver blood tests |
44 |
| Role of TLR4 in the gut-brain axis in Parkinson's disease: a translational study from men to mice |
44 |
| Colonoscopic full-thickness resection using an over-the-scope device: a prospective multicentre study in various indications |
42 |
| Small metabolites, possible big changes: a microbiota-centered view of non-alcoholic fatty liver disease |
42 |
| Effectiveness of screening colonoscopy in reducing the risk of death from right and left colon cancer: a large community-based study |
42 |
| Akkermansia muciniphila induces gut microbiota remodelling and controls islet autoimmunity in NOD mice |
40 |
| Tumour-associated macrophages-derived CXCL8 determines immune evasion through autonomous PD-L1 expression in gastric cancer |
39 |
| Campylobacter jejuni promotes colorectal tumorigenesis through the action of cytolethal distending toxin |
39 |
| Non-superiority of lumen-apposing metal stents over plastic stents for drainage of walled-off necrosis in a randomised trial |
39 |
| Serial circulating tumour DNA analysis during multimodality treatment of locally advanced rectal cancer: a prospective biomarker study |
39 |
| Non-alcoholic steatohepatitis pathogenesis: sublethal hepatocyte injury as a driver of liver inflammation |
39 |
| The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications: joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines |
38 |
| Bacteriophage transfer during faecal microbiota transplantation in Clostridium difficile infection is associated with treatment outcome |
38 |
| Inflammatory bowel disease increases the risk of Parkinson's disease: a Danish nationwide cohort study 1977-2014 |
38 |
| Treatment with camu camu (Myrciaria dubia) prevents obesity by altering the gut microbiota and increasing energy expenditure in diet-induced obese mice |
38 |
| Gut mucosal virome alterations in ulcerative colitis |
37 |
| Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade |
37 |
| Single-cell RNAseq reveals seven classes of colonic sensory neuron |
37 |
| Preoperative next-generation sequencing of pancreatic cyst fluid is highly accurate in cyst classification and detection of advanced neoplasia |
37 |
| Molecular predictors of prevention of recurrence in HCC with sorafenib as adjuvant treatment and prognostic factors in the phase 3 STORM trial |
37 |
| Randomised controlled trial of WISENSE, a real-time quality improving system for monitoring blind spots during esophagogastroduodenoscopy |
36 |
| Enteric fungal microbiota dysbiosis and ecological alterations in colorectal cancer |
36 |
| Global patterns and trends in colorectal cancer incidence in young adults |
35 |
| Liver organoids: from basic research to therapeutic applications |
34 |
| Human gastric cancer modelling using organoids |
33 |
| Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer |
32 |
| Assessment of Crohn's disease-associated small bowel strictures and fibrosis on cross-sectional imaging: a systematic review |
32 |
| Efficacy of adalimumab in patients with Crohn's disease and symptomatic small bowel stricture: a multicentre, prospective, observational cohort (CREOLE) study |
32 |
| Leveraging sequence-based faecal microbial community survey data to identify a composite biomarker for colorectal cancer |
32 |
| Natural disease course of Crohn's disease during the first 5 years after diagnosis in a European population-based inception cohort: an Epi-IBD study |
31 |
| Gut microbiota modulate T cell trafficking into human colorectal cancer |
31 |
| Impact of characteristics of organ failure and infected necrosis on mortality in necrotising pancreatitis |
31 |
| Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer |
31 |
| The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines |
30 |
| Multidimensional analyses reveal distinct immune microenvironment in hepatitis B virus-related hepatocellular carcinoma |
30 |
| Evolving role of diet in the pathogenesis and treatment of inflammatory bowel diseases |
30 |
| Prevalence and burden of hepatitis D virus infection in the global population: a systematic review and meta-analysis |
30 |
| The HLF/IL-6/STAT3 feedforward circuit drives hepatic stellate cell activation to promote liver fibrosis |
29 |
| Guidelines for the investigation of chronic diarrhoea in adults: British Society of Gastroenterology, 3rd edition |
29 |
| Long-term use of antibiotics and risk of colorectal adenoma |
29 |
| Radiation induces proinflammatory dysbiosis: transmission of inflammatory susceptibility by host cytokine induction |
29 |
| A comparison of the resection rate for cold and hot snare polypectomy for 4-9 mm colorectal polyps: a multicentre randomised controlled trial (CRESCENT study) |
29 |
| Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice |
28 |
| Enterocolitis due to immune checkpoint inhibitors: a systematic review |
28 |
| Development of diagnostic criteria and a prognostic score for hepatitis B virus-related acute-on-chronic liver failure |
28 |
| Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection |
27 |
| Human milk oligosaccharide composition predicts risk of necrotising enterocolitis in preterm infants |
27 |
| International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis |
27 |
| Genome-wide mapping of 5-hydroxymethylcytosines in circulating cell-free DNA as a non-invasive approach for early detection of hepatocellular carcinoma |
26 |
| Participation and yield of a population-based colorectal cancer screening programme in China |
26 |
| Effect of Huaier granule on recurrence after curative resection of HCC: a multicentre, randomised clinical trial |
26 |
| Antibiotic and acid-suppression medications during early childhood are associated with obesity |
26 |
| Visceral hypersensitivity is associated with GI symptom severity in functional GI disorders: consistent findings from five different patient cohorts |
26 |
| Integrated multiomic analysis reveals comprehensive tumour heterogeneity and novel immunophenotypic classification in hepatocellular carcinomas |
26 |
| Consensus guidelines on the optimal management in interventional EUS procedures: results from the Asian EUS group RAND/UCLA expert panel |
25 |
| Hepatic Hippo signaling inhibits protumoural microenvironment to suppress hepatocellular carcinoma |
25 |
| Diagnosis and management of acute lower gastrointestinal bleeding: guidelines from the British Society of Gastroenterology |
25 |
| Annexin A11 is targeted by IgG4 and IgG1 autoantibodies in IgG4-related disease |
25 |
| Alcohol dysregulates miR-148a in hepatocytes through FoxO facilitating pyroptosis via TXNIP overexpression |
25 |
| Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer |
25 |
| Resection of pancreatic cancer in Europe and USA: an international large-scale study highlighting large variations |
25 |
| Switchable CAR-T cells mediate remission in metastatic pancreatic ductal adenocarcinoma |
25 |
| Heterozygous carriage of the alpha1-antitrypsin Pi*Z variant increases the risk to develop liver cirrhosis |
25 |
| Metabolic biomarker signature to differentiate pancreatic ductal adenocarcinoma from chronic pancreatitis |
25 |
| Prospective study on the incidence, prevalence and 5-year pancreatic-related mortality of pancreatic cysts in a population-based study |
25 |
| Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis |
24 |
| Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine |
24 |
| Comparison of different histological indexes in the assessment of UC activity and their accuracy regarding endoscopic outcomes and faecal calprotectin levels |
24 |
| Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome |
24 |
| New hallmark of hepatocellular carcinoma, early hepatocellular carcinoma and high-grade dysplastic nodules on Gd-EOB-DTPA MRI in patients with cirrhosis: a new diagnostic algorithm |
24 |
| Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation |
24 |
| Update on lactose malabsorption and intolerance: pathogenesis, diagnosis and clinical management |
24 |
| Dynamics of Helicobacter pylori infection as a determinant of progression of gastric precancerous lesions: 16-year follow-up of an eradication trial |
23 |
| Induction of IFN-lambda 3 as an additional effect of nucleotide, not nucleoside, analogues: a new potential target for HBV infection |
23 |
| miRNAs and NAFLD: from pathophysiology to therapy |
23 |
| British Society of Gastroenterology and UK-PSC guidelines for the diagnosis and management of primary sclerosing cholangitis |
23 |
| Identification of TMAO-producer phenotype and host-diet-gut dysbiosis by carnitine challenge test in human and germ-free mice |
23 |
| Performance of colorectal cancer screening in the European Union Member States: data from the second European screening report |
23 |
| Cell-centred meta-analysis reveals baseline predictors of anti-TNF alpha non-response in biopsy and blood of patients with IBD |
23 |
| Gastritis staging in the endoscopic follow-up for the secondary prevention of gastric cancer: a 5-year prospective study of 1755 patients |
23 |
| Covered TIPS versus endoscopic band ligation plus propranolol for the prevention of variceal rebleeding in cirrhotic patients with portal vein thrombosis: a randomised controlled trial |
23 |
| Multivariate modelling of faecal bacterial profiles of patients with IBS predicts responsiveness to a diet low in FODMAPs |
23 |
| The effect of sustained virological response on the risk of extrahepatic manifestations of hepatitis C virus infection |
22 |
| Improved adenoma detection with Endocuff Vision: the ADENOMA randomised controlled trial |
22 |
| Vedolizumab is associated with changes in innate rather than adaptive immunity in patients with inflammatory bowel disease |
22 |
| SRSF6-regulated alternative splicing that promotes tumour progression offers a therapy target for colorectal cancer |
22 |
| High risk of hepatocellular carcinoma and death in patients with immune-tolerant-phase chronic hepatitis B |
22 |
| Targeting the gut microbiota with inulin-type fructans: preclinical demonstration of a novel approach in the management of endothelial dysfunction |
21 |
| Long-term outcome of patients with steroid-refractory acute severe UC treated with ciclosporin or infliximab |
21 |
| Population-level analysis of Blastocystis subtype prevalence and variation in the human gut microbiota |
21 |
| Impact of sustained virological response on the extrahepatic manifestations of chronic hepatitis C: a meta-analysis |
21 |
| Asia-Pacific working group consensus on non-variceal upper gastrointestinal bleeding: an update 2018 |
21 |
| Identification of distinct mutational patterns and new driver genes in oesophageal squamous cell carcinomas and adenocarcinomas |
21 |
| Depression increases the risk of inflammatory bowel disease, which may be mitigated by the use of antidepressants in the treatment of depression |
21 |
| Mucosa-associated invariant T cells link intestinal immunity with antibacterial immune defects in alcoholic liver disease |
21 |
| Enrichment of oral microbiota in early cystic precursors to invasive pancreatic cancer |
20 |
| Age-dependent changes in GI physiology and microbiota: time to reconsider? |
20 |
| DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development |
20 |
| Effect of vedolizumab (anti-alpha 4 beta 7-integrin) therapy on histological healing and mucosal gene expression in patients with UC |
20 |
| Management of patients on antithrombotic agents undergoing emergency and elective endoscopy: joint Asian Pacific Association of Gastroenterology (APAGE) and Asian Pacific Society for Digestive Endoscopy (APSDE) practice guidelines |
20 |
| High prevalence rate of digestive tract bacteria in duodenoscopes: a nationwide study |
20 |
| Cumulative burden of inflammation predicts colorectal neoplasia risk in ulcerative colitis: a large single-centre study |
19 |
| A blood-based prognostic biomarker in IBD |
19 |
| Liquid biopsies to track trastuzumab resistance in metastatic HER2-positive gastric cancer |
19 |
| Immune activation underlies a sustained clinical response to Yttrium-90 radioembolisation in hepatocellular carcinoma |
19 |
| miRNA-132 induces hepatic steatosis and hyperlipidaemia by synergistic multitarget suppression |
19 |
| Development and external validation of a nomogram and online tool to predict bowel dysfunction following restorative rectal cancer resection: the POLARS score |
19 |
| Fatty acids promote fatty liver disease via the dysregulation of 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide pathway |
19 |
| Experimental microdissection enables functional harmonisation of pancreatic cancer subtypes |
19 |
| Development of a new patient-derived xenograft humanised mouse model to study human-specific tumour microenvironment and immunotherapy |
19 |
| An Asian consensus on standards of diagnostic upper endoscopy for neoplasia |
18 |
| The active bacterial assemblages of the upper GI tract in individuals with and without Helicobacter infection |
18 |
| Adipose tissue macrophages induce hepatic neutrophil recruitment and macrophage accumulation in mice |
18 |
| Understanding the gut-kidney axis in nephrolithiasis: an analysis of the gut microbiota composition and functionality of stone formers |
18 |
| Randomised trial and open-label extension study of an anti-interleukin-6 antibody in Crohn's disease (ANDANTE I and II) |
18 |
| Clinical relevance of detecting anti-infliximab antibodies with a drug-tolerant assay: post hoc analysis of the TAXIT trial |
18 |
| Identifying optimal candidates for early TIPS among patients with cirrhosis and acute variceal bleeding: a multicentre observational study |
18 |
| Oncofetal HLF transactivates c-Jun to promote hepatocellular carcinoma development and sorafenib resistance |
18 |
| IBD prevalence in Lothian, Scotland, derived by capture-recapture methodology |
17 |
| Oral antibiotic use and risk of colorectal cancer in the United Kingdom, 1989-2012: a matched case-control study |
17 |
| Unified interpretation of liver stiffness measurement by M and XL probes in non-alcoholic fatty liver disease |
17 |
| beta-catenin-activated hepatocellular carcinomas are addicted to fatty acids |
17 |
| Association between delayed gastric emptying and upper gastrointestinal symptoms: a systematic review and meta-analysis |
17 |
| Development of an index to define overall disease severity in IBD |
17 |
| Acute lower GI bleeding in the UK: patient characteristics, interventions and outcomes in the first nationwide audit |
17 |
| Minimally invasive and endoscopic versus open necrosectomy for necrotising pancreatitis: a pooled analysis of individual data for 1980 patients |
17 |
| Evolutionary history of human colitis-associated colorectal cancer |
17 |
| Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy |
17 |
| Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis |
16 |
| Intestinal dysbiosis augments liver disease progression via NLRP3 in a murine model of primary sclerosing cholangitis |
16 |
| Fetal and early life antibiotics exposure and very early onset inflammatory bowel disease: a population-based study |
16 |
| Gut roundtable meeting paper: selected recent advances in hepatocellular carcinoma |
16 |
| Regulatory NK cells mediated between immunosuppressive monocytes and dysfunctional T cells in chronic HBV infection |
16 |
| CD177(+) neutrophils as functionally activated neutrophils negatively regulate IBD |
16 |
| CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity |
16 |
| Alcoholic and non-alcoholic fatty liver disease and associations with coronary artery calcification: evidence from the Kangbuk Samsung Health Study |
16 |
| Long-term performance of colorectal cancer screening programmes based on the faecal immunochemical test |
16 |
| Lactobacillus rhamnosus GG protects the intestinal epithelium from radiation injury through release of lipoteichoic acid, macrophage activation and the migration of mesenchymal stem cells |
16 |
| Proliferation of primary human hepatocytes and prevention of hepatitis B virus reinfection efficiently deplete nuclear cccDNA in vivo |
16 |
| Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver |
16 |
| Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+T cells in chronically HBV-infected patients with low viral load |
15 |
| IPMNs with co-occurring invasive cancers: neighbours but not always relatives |
15 |
| Tight junction proteins in gastrointestinal and liver disease |
15 |
| Modern management of perianal fistulas in Crohn's disease: future directions |
15 |
| Helicobacter pylori eradication treatment and the risk of gastric adenocarcinoma in a Western population |
15 |
| Liquid biopsy for liver diseases |
15 |
| Genomic ERBB2/ERBB3 mutations promote PD-L1-mediated immune escape in gallbladder cancer: a whole-exome sequencing analysis |
15 |
| Real-life chromoendoscopy for neoplasia detection and characterisation in long-standing IBD |
15 |
| Gastrointestinal ultrasound in inflammatory bowel disease: an underused resource with potential paradigm-changing application |
15 |
| Methylation panel is a diagnostic biomarker for Barrett's oesophagus in endoscopic biopsies and non-endoscopic cytology specimens |
15 |
| Phase II evaluation of anti-MAdCAM antibody PF-00547659 in the treatment of Crohn's disease: report of the OPERA study |
14 |
| A novel prognostic model for transplant-free survival in primary sclerosing cholangitis |
14 |
| Modifiable factors associated with patient-reported pain during and after screening colonoscopy |
14 |
| Gut microbiota metabolites, amino acid metabolites and improvements in insulin sensitivity and glucose metabolism: the POUNDS Lost trial |
14 |
| Multiple HBV transfusion transmissions from undetected occult infections: revising the minimal infectious dose |
14 |
| Development and clinical validation of the Genedrive point-of-care test for qualitative detection of hepatitis C virus |
14 |
| Fungal dysbiosis in cirrhosis |
14 |
| Surveillance of premalignant gastric lesions: a multicentre prospective cohort study from low incidence regions |
14 |
| Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis |
14 |
| Association of dietary macronutrient composition and non-alcoholic fatty liver disease in an ageing population: the Rotterdam Study |
14 |
| Molecular classification of Crohn's disease reveals two clinically relevant subtypes |
14 |
