Medicinal Chemistry

Medicinal Chemistry

药物化学

  • 4区 中科院分区
  • Q3 JCR分区

高引用文章

文章名称 引用次数
USP7: Target Validation and Drug Discovery for Cancer Therapy 24
pLoc_bal-mVirus: Predict Subcellular Localization of Multi-Label Virus Proteins by Chou's General PseAAC and IHTS Treatment to Balance Training Dataset 16
pLoc_bal-mEuk: Predict Subcellular Localization of Eukaryotic Proteins by General PseAAC and Quasi-balancing Training Dataset 13
Helminthicidal and Larvicidal Potentials of Biogenic Silver Nanoparticles Synthesized from Medicinal Plant Momordica charantia 12
Novel Guanosine Derivatives as Anti-HCV NS5b Polymerase: A QSAR and Molecular Docking Study 10
Synthesis of New Isoxazole Pyridazine Pyrimidopyrazines and their Anti-Inflammatory and Analgesic Activity 8
ZnO Nanoparticles Catalyst in the Synthesis of Bioactive Fused Pyrimidines as Anti-breast Cancer Agents Targeting VEGFR-2 8
New Hybrid Scaffolds based on Hydrazinyl Thiazole Substituted Coumarin; As Novel Leads of Dual Potential; In Vitro alpha-Amylase Inhibitory and Antioxidant (DPPH and ABTS Radical Scavenging) Activities 8
Is there a Link between Vitamin B and Multiple Sclerosis? 8
Synthesis and Structural Elucidation of Novel Benzothiazole Derivatives as Anti-tubercular Agents: In-silico Screening for Possible Target Identification 7
Synthesis, Characterization and Biological Activities of New Symmetric Bis-3-Triazoles with Click Chemistry 7
Synthesis, Cytotoxicity Evaluation, Molecular Docking and Utility of Novel Chalcones as Precursors for Heterocycles Incorporating Pyrazole Moiety 7
Design, Synthesis, and Evaluation of (2-(Pyridinyl)methyIene)-1-tetralone Chalcones for Anticancer and Antimicrobial Activity 7
Biology-Oriented Synthesis (BIOS) of Piperine Derivatives and their Comparative Analgesic and Antiinflammatory Activities 7
The Synthesis of Chalcones as Anticancer Prodrugs and their Bioactivation in CYP1 Expressing Breast Cancer Cells 6
Quinoline Fluorescent Probes for Zinc - from Diagnostic to Therapeutic Molecules in Treating Neurodegenerative Diseases 6
The Role of Vitamin D in Multiple Sclerosis: Biology and Biochemistry, Epidemiology and Potential Roles in Treatment 6
Sorbinil, an Aldose Reductase Inhibitor, in Fighting Against Diabetic Complications 5
Pyrano[2-c]quinoline Derivatives as New Class of alpha-glucosidase Inhibitors to Treat Type 2 Diabetes: Synthesis, in vitro Biological Evaluation and Kinetic Study 5
Myelin Oligodendrocyte Glycoprotein and Multiple Sclerosis 5
Rational Design of Colchicine Derivatives as Anti-HIV Agents via QSAR and Molecular Docking 5
Synthesis, Molecular Modeling and Biological Evaluation of 5-arylidene-N,N-diethylthiobarbiturates as Potential alpha-glucosidase Inhibitors 5
Synthesis and Antimalarial Activity of New Enantiopure Aminoalcoholpyrrolo[2-a]quinoxalines 5
Synthesis, Molecular odelling and Biological Studies of 3-hydroxypyrane-4-one and 3-hydroxy-nyridine-4-one Derivatives as HIV-1 Integrase Inhibitors 4
Benzoin Schiff Bases: Design, Synthesis, and Biological Evaluation as Potential Antitumor Agents 4
New Perspectives of Alzheimer Disease Diagnosis - the Most Popular and Future Methods 4
Synthesis, Structure and Antiproliferative Activity of New pyrazolo[3-e] triazolo[5-b][4] triazine Derivatives 4
Cell Cycle Arrest and Apoptosis Induction Activity of Nitidine Chloride on Acute Myeloid Leukemia Cells 4
Synthesis and Biological Evaluation of Polyfluoroalkylated Antipyrines and their Isomeric O-Methylpyrazoles 4
An Update on the Role of Matrix Metalloproteinases in the Pathogenesis of Multiple Sclerosis 4
Anti-diabetic Phenolic Compounds of Black Carrot (Daucus carota Subspecies sativus var. atrorubens Alef.) Inhibit Enzymes of Glucose Metabolism: An in silico and in vitro Validation 3
Emerging Roles of Purinergic Signaling in Diabetes 3
Prodrugs for Nitroreductase Based Cancer Therapy-1: Metabolite Profile, Cell Cytotoxicity and Molecular Modeling Interactions of Nitro Benzamides with Ssap-NtrB 3
Quinolinic Carboxylic Acid Derivatives as Potential Multi-target Compounds for Neurodegeneration: Monoamine Oxidase and Cholinesterase Inhibition 3
Xanthine Oxidase Inhibitory and Molecular Docking Studies on Pyrimidones 3
Synthesis, 2D-QSAR Studies and Biological Evaluation of Quinazoline Derivatives as Potent Anti-Trypanosoma cruzi Agents 3
The Inhibition of Polysialyltranseferase ST8SiaIV Through Heparin Binding to Polysialyltransferase Domain (PSTD) 3
Managing Neuropathic Pain in Multiple Sclerosis: Pharmacological Interventions 3
4-Dichloro-5-[(N-aryl/alkyl)sulfamoyl]benzoic Acid Derivatives: In Vitro Antidiabetic Activity, Molecular Modeling and In silico ADMET Screening 3
Design, Synthesis and Biological Evaluation of 1H-3-Triazole-Linked-1H-Dibenzo[b,h]xanthenes as Inductors of ROS-Mediated Apoptosis in the Breast Cancer Cell Line MCF-7 3
Design, Synthesis, Evaluation and Computational Studies of Nipecotic Acid-Acetonaphthone Hybrids as Potential Antiepileptic Agents 3
New N,C-Diaryl-4-triazol-3-ones: Synthesis and Evaluation as Anticancer Agents 3
Diclofenac 4-Oxadiazole Derivatives; Biology-Oriented Drug Synthesis (BIODS) in Search of Better Non-Steroidal, Non-Acid Antiinflammatory Agents 3
Investigation on the Effects of Antimicrobial Imidazo[1-b]Thiazol Derivatives on the Genitourinary Microflora 3
Antimicrobial Evaluation of Erythrinan Alkaloids from Erythrina crista-galli L. 3
Evaluation of Antiplasmodial Potential of C2 and C8 Modified Quinolines: in vitro and in silico Study 3
In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley? 3
Discovery of N-Phenyl-4-(1H-pyrrol-3-yl)pyrimidin-2-amine Derivatives as Potent Mnk2 Inhibitors: Design, Synthesis, SAR Analysis, and Evaluation of in vitro Anti-leukaemic Activity 3
Discovery of New Phosphoinositide 3-kinase Delta (PI3K delta) Inhibitors via Virtual Screening using Crystallography-derived Pharmacophore Modelling and QSAR Analysis 2
Novel Hybrids of Pyrazolidinedione and Benzothiazole as TZD Analogues. Rationale Design, Synthesis and In Vivo Anti-Diabetic Evaluation 2