Medicinal Chemistry Research

Medicinal Chemistry Research

药物化学研究

  • 4区 中科院分区
  • Q3 JCR分区

高引用文章

文章名称 引用次数
The synthetic and therapeutic expedition of isoxazole and its analogs 20
Docking study and antiosteoporosis effects of a dibenzylbutane lignan isolated from Litsea cubeba targeting Cathepsin K and MEK1 10
Sulfa drug analogs: new classes of N-sulfonyl aminated azines and their biological and preclinical importance in medicinal chemistry (2000-2018) 9
Synthesis of chalcones with antiproliferative activity on the SH-SY5Y neuroblastoma cell line: Quantitative Structure-Activity Relationship Models 9
Synthesis, docking study, and biological evaluation of novel umbellipherone/hymecromone derivatives as acetylcholinesterase/butyrylcholinesterase inhibitors 9
Design, synthesis, and antihypertensive activity of new pyrimidine derivatives endowing new pharmacophores 8
Activity of ring-substituted 8-hydroxyquinoline-2-carboxanilides against intestinal sulfate-reducing bacteria Desulfovibrio piger 8
Synthesis and antiprotozoal activity of furanchalcone-quinoline, furanchalcone-chromone and furanchalcone-imidazole hybrids 8
Synthesis and antimicrobial evaluation of novel N-substituted 4-ethylsulfanyl-2-pyridones and triazolopyridines 8
Synthesis and in vitro antitumor evaluation of novel Schiff bases 8
Synthesis, structural characterization, and cytotoxic evaluation of chalcone derivatives 7
Synthesis of novel benzimidazole-oxadiazole derivatives as potent anticancer activity 7
Evaluation of triazole and isoxazole derivatives as potential anti-infective agents 7
5-Bis(2-fluorobenzylidene)-4-piperidone induce reactive oxygen species-mediated apoptosis in A549 cells 7
Antioxidant and anticholinesterase activities of Ferulago syriaca Boiss. and F-isaurica Pesmen growing in Turkey 7
Synthesis and antimycobacterial activity of disubstituted benzyltriazoles 7
Heterocycles 44. Synthesis, characterization and anticancer activity of new thiazole ortho-hydroxychalcones 7
Dioscin-6'-O-acetate impairs migration of lung cancer cells through attenuations of MMP-2 and MMP-9 via NF-B suppression 7
New series of 4(3H)-quinazolinone derivatives: syntheses and evaluation of antitumor and antiviral activities 7
Chemical constituents of the Vietnamese plants Dalbergia tonkinensis Prain and Cratoxylum formosum (Jack) Dyer in Hook and their DPPH radical scavenging activities 6
Convenient synthesis, antimalarial and antimicrobial potential of thioethereal 4-disubstituted 3-triazoles with ester functionality 6
Synthesis and pharmacological evaluation of combretastatin-A4 analogs of pyrazoline and pyridine derivatives as anticancer, anti-inflammatory and antioxidant agents 6
Comparative -glucosidase and -amylase inhibition studies of rhodanine-pyrazole conjugates and their simple rhodanine analogues 6
Synthesis and antimicrobial activity of some heterocyclic compounds bearing benzimidazole and pyrazoline motifs 6
Synthesis and PASS-assisted evaluation of coumarin-benzimidazole derivatives as potential anti-inflammatory and anthelmintic agents 6
Synthesis, antimalarial, antiproliferative, and apoptotic activities of benzimidazole-5-carboxamide derivatives 6
Thiazoles with cyclopropyl fragment as antifungal, anticonvulsant, and anti-Toxoplasma gondii agents: synthesis, toxicity evaluation, and molecular docking study 6
An unreported polyether macrocyclic lactone with antioxidative and anti-lipoxygenase activities from the Babylonidae gastropod mollusc Babylonia spirata 6
Design, synthesis, biological evaluation and molecular modeling of new coumarin derivatives as potent anticancer agents 6
Design, synthesis, cytotoxicity, and molecular modeling study of 6-trisubstituted pyrimidines with anthranilate ester moiety 6
Cytotoxicity, apoptosis, and QSAR studies of phenothiazine derived methoxylated chalcones as anticancer drug candidates 6
Revisiting the molecular mechanism of acquired resistance to reversible tyrosine kinase inhibitors caused by EGFR gatekeeper T790M mutation in non-small-cell lung cancer 5
Isoindolines/isoindoline-3-diones as AChE inhibitors against Alzheimer's disease, evaluated by an improved ultra-micro assay 5
Phytochemical study of Piliostigma thonningii, a medicinal plant grown in Nigeria 5
Design, synthesis and identification of novel substituted isothiochromene analogs as potential antiviral and cytotoxic agents 5
Synthesis, antimicrobial activity, and determination of the lipophilicity of ((cyclohex-3-enylmethylene)hydrazinyl)thiazole derivatives 5
Bioactive secondary metabolites from new terrestrial Streptomyces sp TN82 strain: Isolation, structure elucidation and biological activity 5
Design, synthesis, evaluation and molecular modeling studies of some novel N-substituted piperidine-3-carboxylic acid derivatives as potential anticonvulsants 5
Green synthesis, antileishmanial activity evaluation, and in silico studies of new amino acid-coupled 4-triazoles 5
Synthesis, antitumor and antimicrobial evaluation of novel 4-thiadiazole derivatives bearing disulfide bond 5
An overview of tubulin modulators deposited in protein data bank 5
Design, synthesis, anticonvulsant activity, and pharmacophore study of new 5-diaryl-1H-4-triazole-3-carboxamide derivatives 5
Synthesis of new C-dimethylated chalcones as potent antitubercular agents 5
Advance in biological activities of natural guaiane-type sesquiterpenes 5
Synthesis and antimycobacterial evaluation of new 5-(1-benzyl-1H-3-triazol-4-yl)-4-methyl-2-arylthiazole derivatives 5
Novel chromenes and benzochromenes bearing arylazo moiety: molecular docking, in-silico admet, in-vitro antimicrobial and anticancer screening 4
Novel isoxazole derivatives as potential antiparkinson agents: synthesis, evaluation of monoamine oxidase inhibitory activity and docking studies 4
The modulatory effect of green tea catechin on drug resistance in human ovarian cancer cells 4
Exploration of synthetic antioxidant flavonoid analogs as acetylcholinesterase inhibitors: an approach towards finding their quantitative structure-activity relationship 4
Synthesis and biological potentials of some new 4-oxadiazole analogues 4