| Recent Developments in the Reduction of Aromatic and Aliphatic Nitro Compounds to Amines |
53 |
| Biocatalysis Using Immobilized Enzymes in Continuous Flow for the Synthesis of Fine Chemicals |
43 |
| Light on the Horizon: Current Research and Future Perspectives in Flow Photochemistry |
39 |
| The 25th Anniversary of the Buchwald-Hartwig Amination: Development, Applications, and Outlook |
33 |
| The Evolving State of Continuous Processing in Pharmaceutical API Manufacturing: A Survey of Pharmaceutical Companies and Contract Manufacturing Organizations |
23 |
| Choosing the Right Coupling Reagent for Peptides: A Twenty-Five-Year Journey |
23 |
| The Evolution of High-Throughput Experimentation in Pharmaceutical Development and Perspectives on the Future |
22 |
| Finding the Perfect Match: A Combined Computational and Experimental Study toward Efficient and Scalable Photosensitized [2+2] Cycloadditions in Flow |
21 |
| Explosion Hazards of Sodium Hydride in Dimethyl Sulfoxide, N,N-Dimethylformamide, and N,N-Dimethylacetamide |
18 |
| Electrocatalytic Hydrogenation of Oxygenated Compounds in Aqueous Phase |
18 |
| N-Butylpyrrolidinone as Alternative Solvent for Solid-Phase Peptide Synthesis |
16 |
| Photoredox Iridium Nickel Dual-Catalyzed Decarboxylative Arylation Cross-Coupling: From Batch to Continuous Flow via Self Optimizing Segmented Flow Reactor |
16 |
| A Continuous Stirred-Tank Reactor (CSTR) Cascade for Handling Solid-Containing Photochemical Reactions |
14 |
| Metal-Reductant-Free Electrochemical Nickel-Catalyzed Couplings of Aryl and Alkyl Bromides in Acetonitrile |
14 |
| Thermal Stability Assessment of Peptide Coupling Reagents Commonly Used in Pharmaceutical Manufacturing |
14 |
| Efficient Electrocatalytic Reduction of Furfural to Furfuryl Alcohol in a Microchannel Flow Reactor |
13 |
| Ring-Closing Metathesis in Pharmaceutical Development: Fundamentals, Applications, and Future Directions |
12 |
| Expedient Asymmetric Synthesis of (S)-2-Amino-4-trifluorobutanoic Acid via Alkylation of Chiral Nucleophilic Glycine Equivalent |
12 |
| Investigating the Underappreciated Hydrolytic Instability of 8-Diazabicyclo[5.4.0]undec-7-ene and Related Unsaturated Nitrogenous Bases |
12 |
| Progress to Date in the Design and Operation of Continuous Crystallization Processes for Pharmaceutical Applications |
12 |
| Technical Considerations for Scale-Up of Imine-Reductase-Catalyzed Reductive Amination: A Case Study |
11 |
| Review of Synthetic Routes and Final Forms of Integrase Inhibitors Dolutegravir, Cabotegravir, and Bictegravir |
10 |
| Bis(4-oxadiazole)bis(methylene) Dinitrate: A High-Energy Melt-Castable Explosive and Energetic Propellant Plasticizing Ingredient |
10 |
| Silicon(II) Cation Cp*Si:(+) X-: A New Class of Efficient Catalysts in Organosilicon Chemistry |
10 |
| Potential Safety Hazards Associated with Pd-Catalyzed Cross-Coupling Reactions |
10 |
| Scalable Continuous Flow Process for the Synthesis of Eflornithine Using Fluoroform as Difluoromethyl Source |
10 |
| Development of Asymmetric Transfer Hydrogenation with a Bifunctional Oxo-Tethered Ruthenium Catalyst in Flow for the Synthesis of a Ceramide (D-erythro-CER[NDS]) |
10 |
| Palladium-Catalyzed Amidation and Amination of (Hetero)aryl Chlorides under Homogeneous Conditions Enabled by a Soluble DBU/NaTFA Dual-Base System |
10 |
| Off-Cycle Processes in Pd-Catalyzed Cross-Coupling of Carboranes |
9 |
| Biocatalysis in Drug Development-Highlights of the Recent Patent Literature |
9 |
| Semiheterogeneous Purification Protocol for the Removal of Ruthenium Impurities from Olefin Metathesis Reaction Products Using an Isocyanide Scavenger |
9 |
| Iron-Catalyzed Aerobic Oxidation of Alcohols: Lower Cost and Improved Selectivity |
9 |
| Small-Volume Continuous Manufacturing of Merestinib. Part 1. Process Development and Demonstration |
9 |
| Greening the Solid-Phase Peptide Synthesis Process. 2-MeTHF for the Incorporation of the First Amino Acid and Precipitation of Peptides after Global Deprotection |
8 |
| Synthetic Strategies toward SGLT2 Inhibitors |
8 |
| Solvent Selection Methods and Tool |
8 |
| Solubility Correlations of Common Organic Solvents |
8 |
| Raman Spectroscopy for Monitoring the Continuous Crystallization of Carbamazepine |
8 |
| Process Development and Scale-up Total Synthesis of Largazole, a Potent Class I Histone Deacetylase Inhibitor |
8 |
| Use of a Droplet Platform To Optimize Pd-Catalyzed C-N Coupling Reactions Promoted by Organic Bases |
8 |
| Asymmetric Organocatalysis in Drug Development-Highlights of Recent Patent Literature |
8 |
| Synthesis of beta(3)-Amino Esters by Iridium-Catalyzed Asymmetric Allylic Alkylation Reaction |
7 |
| Preparation of Bifunctional Allylboron Reagent and Application to Aldehyde Allylboration |
7 |
| Development of an Organometallic Flow Chemistry Reaction at Pilot-Plant Scale for the Manufacture of Verubecestat |
7 |
| Evaluating the Impact of a Decade of Funding from the Green Chemistry Institute Pharmaceutical Roundtable |
7 |
| Crystal Structures of Two Important Pharmaceuticals Solved by 3D Precession Electron Diffraction Tomography |
7 |
| Catalytic Static Mixers for the Continuous Flow Hydrogenation of a Key Intermediate of Linezolid (Zyvox) |
7 |
| Development of an Enantioselective [3+2] Cycloaddition To Synthesize the Pyrrolidine Core of ABBV-3221 on Multikilogram Scale |
7 |
| Gram-Scale Antibody-Drug Conjugate Synthesis by Site-Specific Chemical Conjugation: AJICAP First Generation |
7 |
| Rapid On-Demand Synthesis of Lomustine under Continuous Flow Conditions |
7 |
