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The Recombinant 3-Ketosteroid Δ1-Dehydrogenase Catalyzed Δ1-Dehydrogenation toward Total Synthesis of Vamorolone by Combining with Flow in Situ Silicon Nucleophile Annelation Process/Desilylatio
Author: Wu, Yake; Zeng, Chunling; Xu, Shitang; Yao, Bingting; Liu, Xirong; Sun, Chao; Jiang, Zetao; Xu, Xinhua; Peng, Lifen
Journal: ORGANIC PROCESS RESEARCH & DEVELOPMENT. 2026; Vol. 30, Issue 4, pp. 1020-1029. DOI: 10.1021/acs.oprd.6c00047
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Early Process Development of a Heterobifunctional Protein Degrade
Author: Haibach, Michael C.; Klix, Russell; Pullela, Sarma; Boukerche, Moussa; Holte, Dane; Guo, Jingyu; Yao, Jiacheng; Shen, Cheng; Moschetta, Eric G.; Wang, Jason; Chen, Shuang; Van Haandel, Leon; Du, Siqi; Kennedy, Kylie; Randstrom, Corianne; Bien, Jeffrey T.; Kamath, Vivek; Ji, Jianguo
Journal: ORGANIC PROCESS RESEARCH & DEVELOPMENT. 2026; Vol. 30, Issue 4, pp. 892-899. DOI: 10.1021/acs.oprd.5c00458
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Towards the Development of a Commercial Process To Produce Muvalaplin. Part I: Preparation of a Key Intermediate by an Evans Auxiliary-Assisted Asymmetric Alkylatio
Author: Walker, Daniel P.; Genzink, Matthew J.; Yancey, Jayda D.; Rizzo, John R.; Hawk, Mai Khanh; McGee, Kevin F.; Green, Ahren; Navarro, Antonio; Jing, Dajiang; Gangula, Srinivas; Zhang, Silong; Dai, Jianfei; Wei, Fuliang
Journal: ORGANIC PROCESS RESEARCH & DEVELOPMENT. 2026; Vol. 30, Issue 4, pp. 986-1001. DOI: 10.1021/acs.oprd.6c00010
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Toward a Telescoped Batch-Continuous Process for the KRASG12C Inhibitor GH35: Controlling a Critical Dimeric Impurity during Acryloylatio
Author: Zuo, Gaolei; Zhang, Yaobin; Liu, Zhi; Tu, Jinyue; Zhang, Mengyuan; Gou, Donghui; Xu, Bo; Wu, Ligang; Chen, Like; Zhang, Guiping
Journal: ORGANIC PROCESS RESEARCH & DEVELOPMENT. 2026; Vol. 30, Issue 3, pp. 741-752. DOI: 10.1021/acs.oprd.5c00480
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Real-Time Process Monitoring Ammonolysis of Oligonucleotides with Online FTIR Spectroscop
Author: Wang, Ran; Xu, Liming; Yang, Yifan; Wang, Wenqing; Liu, Mingzhe; Su, Xiaoye; Shao, Yu
Journal: ORGANIC PROCESS RESEARCH & DEVELOPMENT. 2026; Vol. 30, Issue 3, pp. 731-740. DOI: 10.1021/acs.oprd.5c00476
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A Chemoenzymatic Synthesis of STING Agonist MK-211
Author: An, Chihui; Murphy, Grant S.; Moore, Jeffrey C.; Guetschow, Erik D.; Chen, Yonggang; Tan, Lushi; Marshall, Nicholas M.; Huffman, Mark A.; Makarov, Alexey A.; Borra-Garske, Margie; Alvizo, Oscar; Xiao, Chengqian; Zhang, Yi; Duan, Jianjun
Journal: ORGANIC PROCESS RESEARCH & DEVELOPMENT. 2026; Vol. 30, Issue 3, pp. 707-714. DOI: 10.1021/acs.oprd.5c00448
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Development of a Sustainable Transketalization Approach to a Chiral Benzodioxole-Containing GLP-1R Agonis
Author: Balasubramaniam, Sivaraman; Bhattacharya, Gopal; Tiwari, Ashutosh P.; Ashok, Deena; Scotney, Gemma; Brandt, Thomas A.; Dai, Yijing; Eisenbeis, Shane A.; Fowble, Kristen; Hubbell, Aran K.; Mack, Chase E.; Li, Huafei; Zhao, Zhibing; Qin, Tao
Journal: ORGANIC PROCESS RESEARCH & DEVELOPMENT. 2026; Vol. , Issue , pp. -. DOI: 10.1021/acs.oprd.6c00031
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Development of a Scalable Process for the Synthesis of Red Base R
Author: Li, Shiyun; Liu, Hongtao; Chen, Wenxin; Chen, Ao; Xue, Wenchao; Wen, Bin; Huang, Jun; Chen, Xingquan; Bao, Xiaojun
Journal: ORGANIC PROCESS RESEARCH & DEVELOPMENT. 2026; Vol. , Issue , pp. -. DOI: 10.1021/acs.oprd.5c00440
