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Development of a Concise Process for the Synthesis of the Azaindazole Core of the CD73 Inhibitor AB680
Author: Yin, Xiaopeng; Song, Zhiguo Jake; Kalisiak, Jaroslaw; Tripp, Jonathan C.; Lei, Xiao; Li, Hongfeng; Zhang, Aimin
Journal: ORGANIC PROCESS RESEARCH & DEVELOPMENT. 2023; Vol. , Issue , pp. -. DOI: 10.1021/acs.oprd.3c00056
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Safer and Convenient Synthesis of 3,4-Bis(4-nitro-1,2,5-oxadiazol-3-yl)-1,2,5-oxadiazole-2-oxide (BNFF/DNTF)
Author: Xu, Yuangang; Wang, Shuaiqi; Li, Dongxue; Wang, Pengcheng; Lin, Qiuhan; Lu, Ming
Journal: ORGANIC PROCESS RESEARCH & DEVELOPMENT. 2023; Vol. 27, Issue 1, pp. 84-89. DOI: 10.1021/acs.oprd.2c00250
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Optimized Synthesis of a Key Intermediate of Nirmatrelvir
Author: Qin, Hongjian; Jin, Chen; Odilov, Abdullajon; Bonku, Emmanuel Mintah; Zhu, Fuqiang; Liu, Qi; Shen, Jingshan; Aisa, Haji A.
Journal: ORGANIC PROCESS RESEARCH & DEVELOPMENT. 2023; Vol. 27, Issue 1, pp. 78-83. DOI: 10.1021/acs.oprd.2c00225
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Hindered Biaryl Bond Construction and Subsequent Diastereomeric Crystallization to Produce an Atropisomeric Covalent KRASG12C Inhibitor ARS-2102
Author: Yang, Xiaogen; Li, Zhiwen; Xu, Wenwen; Zhu, Guanming; Feng, Xiantong; Zhang, Jun; Zhao, Hongbin; Chen, Yuyin; Kong, Jianshe; Mai, Wanping; Li, Lian-Sheng; Pippel, Daniel J.; Ren, Pingda; Deng, Xiaohu
Journal: ORGANIC PROCESS RESEARCH & DEVELOPMENT. 2023; Vol. 27, Issue 1, pp. 206-216. DOI: 10.1021/acs.oprd.2c00335
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Toward the Development of a Manufacturing Process for Milvexian: Scale-Up Synthesis of the Side Chain
Author: Wagschal, Simon; Broggini, Diego; Cao, Trung D. C.; Schleiss, Pascal; Paun, Kristian; Steiner, Jessica; Merk, Anna-Lena; Harsdorf, Joachim; Fiedler, Winfried; Schirling, Stefan; Hock, Sven; Strittmatter, Tobias; Dijkmans, Jan; Vervest, Ivan; Van Hoegaerden, Tim; Egle, Brecht; Mower, Matthew P.; Liu, Zhi; Cao, Zhiyong; He, Xiaoning; Chen, Lei; Qin, Lei; Tan, Hongyu; Yan, Jun; Cuniere, Nicolas Lucien; Wei, Carolyn S.; Vuyyuru, Venkata; Ayothiraman, Rajaram; Rangaswamy, Sundaramurthy; Jaleel, Mohamed; Vaidyanathan, Rajappa; Eastgate, Martin D.; Klep, Richard; Benhaim, Cyril; Vogels, Ilse; Peeters, Koen; Lemaire, Sebastien
Journal: ORGANIC PROCESS RESEARCH & DEVELOPMENT. 2023; Vol. 27, Issue 4, pp. 680-691. DOI: 10.1021/acs.oprd.2c00399
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Aqueous Electrochemical Synthesis of 5-Trifluoromethyluracil in Batch and Continuous Flow
Author: Gong, Ruoqu; Zhou, Yicheng; Sui, Dandan; Chen, Yang; Chen, Wenbo
Journal: ORGANIC PROCESS RESEARCH & DEVELOPMENT. 2023; Vol. , Issue , pp. -. DOI: 10.1021/acs.oprd.2c00361
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Expeditious Synthesis of a Potent Allosteric HIV-1 Integrase Inhibitor GSK3839919A
Author: Bobko, Mark A.; Elward, Jennifer M.; Naidu, B. Narasimhulu; Nieves-Quinones, Yexenia E.; Reiher, Christopher A.; Su, Qiaogong; Sun, Liang; Woodard, John; Xie, Shiping; Yang, Wuxing; Yin, Yunxing
Journal: ORGANIC PROCESS RESEARCH & DEVELOPMENT. 2023; Vol. , Issue , pp. -. DOI: 10.1021/acs.oprd.2c00343
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Development of Versatile Routes for the Preparation of an Intermediate to Immuno-Oncology Agonist BMS-986299
Author: Li, Dengke
Journal: ORGANIC PROCESS RESEARCH & DEVELOPMENT. 2023; Vol. , Issue , pp. -. DOI: 10.1021/acs.oprd.3c00032
