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Phase separation-based HTS identifies cobimetinib as a YAP-TEAD inhibitor that suppresses hyperactivated YAP-induced cancer progressio
Author: Yang, Ruizeng; Hu, Liqiao; Wang, Jing; Wang, Jia; Yuan, Liang; Wu, Mengying; He, Lingli; Yu, Wentao; Chen, Peihao; Lu, Xiaoli; Hu, Fangzheng; Zhang, Haijiao; Gao, Haoran; Wang, Xiaodong; Zhang, Haoen; Sun, Yang; Xu, Jinjin; Huang, Jing; Zhou, Hu; Zhu, Jidong; Wei, Fang; Jin, Yunyun; Gao, Yijun; Fu, Qiang; Qi, Xiangbing; Yu, Jing; Li, Pilong; He, Xiaojing; Zhang, Lei
Journal: SCIENCE TRANSLATIONAL MEDICINE. 2026; Vol. 18, Issue 846, pp. -. DOI: 10.1126/scitranslmed.adu0814
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Site-specific methylation of SRSF2P95H by SETD2 inhibits MDSC-mediated proinflammatory niche formation in mouse models of myelodysplastic syndrom
Author: Li, Zi-Juan; Zhao, Mu-Ying; Wang, Roujia; Liu, Na; Hu, Cheng-Long; Chang, Binhe; Hu, Fang; Li, Xi-Ya; Xu, Chun-Hui; Liu, Ping; Chen, Bing-Yi; Chen, Shu-Bei; Wang, Yong; Li, Qi-Jing; Xue, Bu-Sheng; Deng, Chuhan; Chen, Xinchi; Ren, Yiyi; Jia-Cheng Jin; Yan, Xiao; Zhang, Yuanliang; Gale, Robert Peter; Fu, Jianfei; Zhang, Qun-ling; Wang, Xiaoning; Huang, Qiuhua; Liu, Yan; Qiu, Ju; Qin, Jun; Ye, Xueshi; Zhang, Jin; Liang, Yang; Chen, Zhu; Chen, Sai-Juan; He, Peng-Cheng; Chang, Chun-Kang; Sun, Xiao-Jian; Wang, Lan
Journal: SCIENCE TRANSLATIONAL MEDICINE. 2026; Vol. 18, Issue 843, pp. -. DOI: 10.1126/scitranslmed.adv1065
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Uncovering BAP1 deubiquitination landscape enhances mechanism elucidation and therapeutic precision for BAP1-deficient pancancer
Author: Hong, Jing Han; Yong, Chern Han; Heng, Hong Lee; Yao, Xiaosai; Li, Zhimei; Sun, Yichen; Wang, Peili; Xiao, Rong; Wang, Loo Chien; Chen, Jianfeng; Guan, Peiyong; Chu, Pek Lim; Hagihara, Takeshi; Ng, Sheng Rong; Jusakul, Apinya; Kongpetch, Sarinya; Nargund, Amrita M.; Chu, Wern Cui; Ng, Clara Shi Ya; Sugiura, Masahiro; Kwek, Xiu Yi; Pham, Nhu-An; Lin, Zihao; Ng, Cedric Chuan Young; Lim, Abner Herbert; Lee, Jing Yi; Chan, Jason Yongsheng; Lim, Kah Suan; Liu, Wei; Teh, Bin Sing; Iqbal, Jabed; Klanrit, Poramate; Loilome, Watcharin; Wai Meng Tai, David; Brugarolas, James; Li, Shang; Sobota, Radoslaw Mikolaj; Tan, Patrick; Jha, Sudhakar; Tan, Jing; Teh, Bin Tean
Journal: SCIENCE TRANSLATIONAL MEDICINE. 2026; Vol. 18, Issue 843, pp. -. DOI: 10.1126/scitranslmed.adr6668
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In vivo generation of CAR myeloid cells through erythrocyte-mediated mRNA delivery for cancer immunotherap
Author: Nie, Xiaoqian; Liu, Yuehua; Song, Yuting; Yao, Xingyun; Chen, Yangyang; Lee, Hsiang-Ying; Gao, Xiaofei
Journal: SCIENCE TRANSLATIONAL MEDICINE. 2026; Vol. 18, Issue 842, pp. -. DOI: 10.1126/scitranslmed.ady6730
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Quantifying myocardial oxygen consumption and efficiency with motion-resolved cardiac MR
Author: Huang, Li-Ting; Yang, Chia-Chi; Wang, Guan; Zhang, Henghui; Zhang, Ranran; Ho, Hao; Malagi, Archana; Huang, Yuheng; Li, Xinqi; Yoosefian, Ghazal; Zhang, Xinheng; Long, Ziyang; Bi, Xiaoming; Wei, Janet; Kwan, Alan C.; Nelson, Michael D.; Merz, C. Noel Bairey; Berman, Daniel; Christodoulou, Anthony; Li, Debiao; Dharmakumar, Rohan; Yang, Hsin-Jung
Journal: SCIENCE TRANSLATIONAL MEDICINE. 2026; Vol. 18, Issue 842, pp. -. DOI: 10.1126/scitranslmed.ady6269
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Disruption of the oligodendroglial miR-126a-3p-Pex5 axis inhibits remyelination in chronic demyelinating lesion
Author: Shao, Qi; Li, Zhenghao; Tan, Weixing; Pu, Yingyan; Sun, Dingya; Fang, Xue; Shi, Xiaoyu; Zhang, Xin; Liu, Weili; Liu, Mingdong; Liu, Peng; Qiu, Mengsheng; Cao, Li; He, Cheng
Journal: SCIENCE TRANSLATIONAL MEDICINE. 2026; Vol. 18, Issue 841, pp. -. DOI: 10.1126/scitranslmed.adu6987
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Patient-derived xenograft models of primary breast cancer for preclinical evaluation of neoadjuvant therapie
Author: Hutten, Stefan J.; Chao, Xue; Badoux, Madelon; Eijkman, Timo; Sheinman, Michael; de Bruijn, Roebi; Herencia-Ropero, Andrea; Llop-Guevara, Alba; Lutz, Catrin; Wesseling, Jelle; Serra, Violeta; van Rheenen, Jacco; Scheele, Colinda L. G. J.; Jonkers, Jos
Journal: SCIENCE TRANSLATIONAL MEDICINE. 2026; Vol. 18, Issue 841, pp. -. DOI: 10.1126/scitranslmed.ads9088
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Reconstitution of the uterine immune milieu after uterus or hematopoietic stem cell transplantatio
Author: Strunz, Benedikt; Ivarsson, Martin A.; Sun, Dan; Mayer, Corinna; Ziegenhain, Christoph; Crona-Guterstam, Ylva; Solders, Martin; Molne, Johan; Bjorklund, Andreas; Marquardt, Nicole; Kaipe, Helen; Floter Radestad, Angelique; Gidlof, Sebastian; Brannstrom, Mats; Bjorkstrom, Niklas K
Journal: SCIENCE TRANSLATIONAL MEDICINE. 2026; Vol. 18, Issue 840, pp. -. DOI: 10.1126/scitranslmed.adp2583
