| Enhanced detection of circulating tumor DNA by fragment size analysis |
119 |
| Advances in therapeutic applications of extracellular vesicles |
93 |
| Inflammasome inhibition prevents alpha-synuclein pathology and dopaminergic neurodegeneration in mice |
90 |
| The hallmarks of successful anticancer immunotherapy |
89 |
| Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials |
85 |
| In situ formed reactive oxygen species-responsive scaffold with gemcitabine and checkpoint inhibitor for combination therapy |
84 |
| MHC proteins confer differential sensitivity to CTLA-4 and PD-1 blockade in untreated metastatic melanoma |
65 |
| Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer |
64 |
| The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells |
63 |
| Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials |
62 |
| LRRK2 activation in idiopathic Parkinson's disease |
61 |
| Enhanced preclinical antitumor activity of M a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-beta |
61 |
| A dysbiotic microbiome triggers T(H)17 cells to mediate oral mucosal immunopathology in mice and humans |
58 |
| The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms |
57 |
| Eradication of spontaneous malignancy by local immunotherapy |
57 |
| The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy |
55 |
| Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade |
54 |
| Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients |
53 |
| Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist |
52 |
| Reconstitution of the gut microbiota of antibiotic-treated patients by autologous fecal microbiota transplant |
51 |
| Noncoding regions are the main source of targetable tumor-specific antigens |
51 |
| Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome |
47 |
| T cell-induced CSF1 promotes melanoma resistance to PD1 blockade |
47 |
| Battery-free, wireless sensors for full-body pressure and temperature mapping |
46 |
| Neoadjuvant oncolytic virotherapy before surgery sensitizes triple- negative breast cancer to immune checkpoint therapy |
46 |
| TORC1 inhibition enhances immune function and reduces infections in the elderly |
46 |
| Diagnosis of genetic diseases in seriously ill children by rapid whole-genome sequencing and automated phenotyping and interpretation |
44 |
| Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms |
43 |
| Deciduous autologous tooth stem cells regenerate dental pulp after implantation into injured teeth |
42 |
| A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration |
42 |
| Remdesivir (GS-5734) protects African green monkeys from Nipah virus challenge |
41 |
| Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease |
41 |
| Reduced non-rapid eye movement sleep is associated with tau pathology in early Alzheimer's disease |
40 |
| Extended release of perioperative immunotherapy prevents tumor recurrence and eliminates metastases |
40 |
| GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells |
38 |
| Reproducing human and cross-species drug toxicities using a Liver-Chip |
38 |
| Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer |
38 |
| Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data |
37 |
| HIV latency in isolated patient CD4(+) T cells may be due to blocks in HIV transcriptional elongation, completion, and splicing |
37 |
| An engineered E-coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans |
37 |
| Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1 |
36 |
| TGF beta inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence |
36 |
| Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus |
36 |
| The vermiform appendix impacts the risk of developing Parkinson's disease |
36 |
| Proof-of-concept clinical trial of etokimab shows a key role for IL-33 in atopic dermatitis pathogenesis |
35 |
| Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state |
35 |
| PPAR gamma agonist pioglitazone reverses pulmonary hypertension and prevents right heart failure via fatty acid oxidation |
35 |
| Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease |
35 |
| Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2 |
35 |
| Microbial ecology perturbation in human IgA deficiency |
35 |
| Clinical-grade stem cell-derived retinal pigment epithelium patch rescues retinal degeneration in rodents and pigs |
34 |
| Tuberculosis following PD-1 blockade for cancer immunotherapy |
34 |
| Inhalation of peptide-loaded nanoparticles improves heart failure |
33 |
| Personalized circulating tumor DNA analysis to detect residual disease after neoadjuvant therapy in breast cancer |
33 |
| IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response |
33 |
| Circulating T-FH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity |
33 |
| Mechanobiologically optimized 3D titanium-mesh scaffolds enhance bone regeneration in critical segmental defects in sheep |
32 |
| Laminin 511 is a target antigen in autoimmune pancreatitis |
32 |
| The nonlesional skin surface distinguishes atopic dermatitis with food allergy as a unique endotype |
32 |
| Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy |
32 |
| PD-1 up-regulation on CD4(+) T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-beta 1 production |
31 |
| The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice |
31 |
| Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models |
31 |
| Oncogenic JAK2(V617F) causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms |
31 |
| Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial |
30 |
| The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans |
30 |
| Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections |
29 |
| Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia |
29 |
| Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer |
29 |
| Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy |
29 |
| Probiotic strains detect and suppress cholera in mice |
28 |
| Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma |
28 |
| Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis |
28 |
| The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs |
28 |
| Engineering precision biomaterials for personalized medicine |
28 |
| Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD51 |
28 |
| The gut microbiota influences skeletal muscle mass and function in mice |
27 |
| Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay |
27 |
| Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis |
27 |
| In vivo liquid biopsy using Cytophone platform for photoacoustic detection of circulating tumor cells in patients with melanoma |
27 |
| Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia |
27 |
| Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis |
26 |
| Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies |
26 |
| Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers |
26 |
| Quorum sensing between bacterial species on the skin protects against epidermal injury in atopic dermatitis |
26 |
| Supercharging adoptive T cell therapy to overcome solid tumor-induced immunosuppression |
26 |
| The replication-competent HIV-1 latent reservoir is primarily established near the time of therapy initiation |
26 |
| Platelet microparticles sustain autophagy-associated activation of neutrophils in systemic sclerosis |
26 |
| Cartilage-penetrating nanocarriers improve delivery and efficacy of growth factor treatment of osteoarthritis |
26 |
| A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine |
26 |
| Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy |
26 |
| Toward achieving precision health |
25 |
| Increasing tolerance of hospital Enterococcus faecium to handwash alcohols |
25 |
| Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo |
25 |
| TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy |
24 |
| Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin |
24 |
| Development of a stress response therapy targeting aggressive prostate cancer |
24 |
| Cell and fluid sampling microneedle patches for monitoring skin-resident immunity |
24 |
| Long noncoding RNA lnc-TSI inhibits renal fibrogenesis by negatively regulating the TGF-beta/Smad3 pathway |
24 |
| Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus |
24 |
| The 1918 influenza pandemic: 100 years of questions answered and unanswered |
24 |
| Glycoconjugate vaccines: Principles and mechanisms |
24 |
| Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria |
23 |
| Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma |
23 |
| Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target |
23 |
| In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis |
23 |
| Using fMRI connectivity to define a treatment-resistant form of post-traumatic stress disorder |
23 |
| PIEZO2 mediates injury-induced tactile pain in mice and humans |
23 |
| A beta and tau prion-like activities decline with longevity in the Alzheimer's disease human brain |
23 |
| Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy |
23 |
| Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy |
23 |
| Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response |
22 |
| Illusory movement perception improves motor control for prosthetic hands |
22 |
| Bioengineered human acellular vessels recellularize and evolve into living blood vessels after human implantation |
22 |
| Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment |
22 |
| An innate-like V delta 1(+) gamma delta T cell compartment in the human breast is associated with remission in triple-negative breast cancer |
22 |
| A digital microfluidic system for serological immunoassays in remote settings |
22 |
| Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis |
22 |
| Avidity-based binding to HER2 results in selective killing of HER2-overexpressing cells by anti-HER2/CD3 |
22 |
| Transcriptional signature primes human oral mucosa for rapid wound healing |
22 |
| Evaluation of mutant huntingtin and neurofilament proteins as potential markers in Huntington's disease |
22 |
| Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics |
21 |
| Mixed-effects association of single cells identifies an expanded effector CD4(+) T cell subset in rheumatoid arthritis |
21 |
| Intein-mediated protein trans-splicing expands adeno-associated virus transfer capacity in the retina |
21 |
| A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates |
21 |
| Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model |
21 |
| APOBEC mutation drives early-onset squamous cell carcinomas in recessive dystrophic epidermolysis bullosa |
21 |
| Cotrimoxazole reduces systemic inflammation in HIV infection by altering the gut microbiome and immune activation |
21 |
| Integrin alpha(4)beta(7) expression on peripheral blood CD4(+) T cells predicts HIV acquisition and disease progression outcomes |
21 |
| Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8 |
21 |
| Autologous tumor cell-derived microparticle-based targeted chemotherapy in lung cancer patients with malignant pleural effusion |
21 |
| Hematopoietic stem cell transplantation in its 60s: A platform for cellular |
21 |
| MEK inhibition enhances oncolytic virus immunotherapy through increased tumor cell killing and T cell activation |
20 |
| Nanofiber-hydrogel composite-mediated angiogenesis for soft tissue reconstruction |
20 |
| Clostridioides difficile uses amino acids associated with gut microbial dysbiosis in a subset of patients with diarrhea |
20 |
| Repeat doses of antibody to serum amyloid P component clear amyloid deposits in patients with systemic amyloidosis |
20 |
| Blood-brain barrier dysfunction in aging induces hyperactivation of TGF beta signaling and chronic yet reversible neural dysfunction |
20 |
| A biologic scaffold-associated type 2 immune microenvironment inhibits tumor formation and synergizes with checkpoint immunotherapy |
19 |
| Durable anticancer immunity from intratumoral administration of IL- IL-36 gamma, and OX40L mRNAs |
19 |
| Epidermal electronics for noninvasive, wireless, quantitative assessment of ventricular shunt function in patients with hydrocephalus |
19 |
| CD3 bispecific antibody-induced cytokine release is dispensable for cytotoxic T cell activity |
19 |
| FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis |
19 |
| Smartphone-based blood pressure monitoring via the oscillometric finger-pressing method |
19 |
| F Rapid detection of Mycobacterium tuberculosis in sputum with a solvatochromic trehalose probe |
19 |
| Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition |
19 |
| Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition |
19 |
| Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects |
19 |
| Afatinib restrains K-RAS-driven lung tumorigenesis |
19 |
| Zika virus-related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice |
19 |
| Tissue-resident mesenchymal stromal cells: Implications for tissue-specific antifibrotic therapies |
19 |
| Delivery of therapeutics to the inner ear: The challenge of the blood-labyrinth barrier |
19 |
| A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice |
19 |
| Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer |
19 |
| Rapamycin and Alzheimer's disease: Time for a clinical trial? |
19 |
| Challenges and strategies for developing efficacious and long-lasting malaria vaccines |
18 |
| Computational modeling guides tissue-engineered heart valve design for long-term in vivo performance in a translational sheep model |
18 |
| PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells |
18 |
| Vaccine waning and mumps re-emergence in the United States |
18 |
| An increase in LRRK2 suppresses autophagy and enhances Dectin-1-induced immunity in a mouse model of colitis |
18 |
| A cytochrome P450 allele confers pyrethroid resistance on a major African malaria vector, reducing insecticide-treated bednet efficacy |
18 |
| Targeted antibody and cytokine cancer immunotherapies through collagen affinity |
18 |
| Astrocyte molecular signatures in Huntington's disease |
18 |
| CD32 is expressed on cells with transcriptionally active HIV but does not enrich for HIV DNA in resting T cells |
18 |
| Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant T-FH cells |
18 |
| Graft-versus-host disease, but not graft-versus-leukemia immunity, is mediated by GM-CSF-licensed myeloid cells |
18 |
| Eosinophils increase airway sensory nerve density in mice and in human asthma |
18 |
| Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy |
17 |
| Identifying DNA methylation biomarkers for non-endoscopic detection of Barrett's esophagus |
17 |
| A machine learning approach for somatic mutation discovery |
17 |
| DP2 antagonism reduces airway smooth muscle mass in asthma by decreasing eosinophilia and myofibroblast recruitment |
17 |
| Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis |
17 |
| Exploiting an Asp-Glu switch in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia |
17 |
| The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk |
17 |
| Huntingtin suppression restores cognitive function in a mouse model of Huntington's disease |
17 |
| Targeted complement inhibition salvages stressed neurons and inhibits neuroinflammation after stroke in mice |
17 |
| A multimodality test to guide the management of patients with a pancreatic cyst |
17 |
| Auditory-somatosensory bimodal stimulation desynchronizes brain circuitry to reduce tinnitus in guinea pigs and humans |
17 |
| Alloreactive fetal T cells promote uterine contractility in preterm labor via IFN-gamma and TNF-alpha |
17 |
| Finding useful biomarkers for Parkinson's disease |
17 |
| Proprioception from a neurally controlled lower-extremity prosthesis |
17 |
| The Fas/Fap-1/Cav-1 complex regulates IL-1RA secretion in mesenchymal stem cells to accelerate wound healing |
17 |
| Therapeutically relevant engraftment of a CRISPR-Cas9-edited HSC-enriched population with HbF reactivation in nonhuman primates |
16 |
| Snake fang-inspired stamping patch for transdermal delivery of liquid formulations |
16 |
| A pannexin 1 channelopathy causes human oocyte death |
16 |
| Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism |
16 |
| Platelet regulation of myeloid suppressor of cytokine signaling 3 accelerates atherosclerosis |
16 |
| HBEGF(+) macrophages in rheumatoid arthritis induce fibroblast invasiveness |
16 |
| The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen |
16 |
| Acute and chronic neurological consequences of early-life Zika virus infection in mice |
16 |
| Wireless, battery-free, flexible, miniaturized dosimeters monitor exposure to solar radiation and to light for phototherapy |
16 |
| Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models |
16 |
| Pediatric patients with acute lymphoblastic leukemia generate abundant and functional neoantigen-specific CD8(+) T cell responses |
16 |
| Long-term mechanical function and integration of an implanted tissue-engineered intervertebral disc |
16 |
| Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain |
16 |
| An open-label phase 1 clinical trial of the anti-alpha(4)beta(7) monoclonal antibody vedolizumab in HIV-infected individuals |
16 |
| Molecular imaging of bacterial infections: Overcoming the barriers to clinical translation |
16 |
| Optogenetic stimulation of cochlear neurons activates the auditory pathway and restores auditory-driven behavior in deaf adult gerbils |
15 |
| Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells |
15 |
| Neutrophil extracellular traps, B cells, and type I interferons contribute to immune dysregulation in hidradenitis suppurativa |
15 |
| In utero gene editing for monogenic lung disease |
15 |
