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New Binding Sites for JAK2 Inhibition in Myeloproliferative Neoplasms: Structural Insights, Therapeutic Potential, and Future Direction
Author: Zhao, Gang; Guo, Junyu; Cheng, Xinying; Wang, Renbing; Ali, Ahmed R.; Tian, Yucheng; Li, Zhiyu; Bian, Jinlei; Huang, Huidan
Journal: CHEMMEDCHEM. 2026; Vol. 21, Issue 6, pp. -. DOI: 10.1002/cmdc.202501079
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Cyclic Peptides Radiopharmaceuticals: A Concise Review of Ligand Identification, Radiolabeling, and Clinical Progres
Author: Yuan, Xiushuang; Jia, Haoyuan; Chen, Liru; Li, Jiang; Cheng, Wei; Hu, Kuan
Journal: CHEMMEDCHEM. 2026; Vol. 21, Issue 6, pp. -. DOI: 10.1002/cmdc.202501005
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Discovery of a Prodrug of Bardoxolone Methyl for the Treatment of Acute Lung Injur
Author: Wen, Shuai; Li, Yingping; Li, Xi; Huo, Fan; Chen, Qiulan; Sha, Hongkai; Wang, Yan; Zhao, Yao; Jiang, Zhengyu; Mou, Yi
Journal: CHEMMEDCHEM. 2026; Vol. 21, Issue 6, pp. -. DOI: 10.1002/cmdc.202501062
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An Internal Sulfur-Lone Pair Interaction Enabled the Discovery of Potent and Sub-Family Selective PKMYT1 Inhibitor
Author: Wang, Yazhou; Wang, Chao; Wang, Xiaomin; Liu, Tingting; Cai, Xin; Zhang, Man; Aliper, Alex; Ren, Feng; Ding, Xiao; Zhavoronkov, Alex
Journal: CHEMMEDCHEM. 2026; Vol. 21, Issue 6, pp. -. DOI: 10.1002/cmdc.202501029
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Vanadyl Complexes (VOp-Dmada) Promote Healthy Aging by Regulating Electron Transport Mediated by Mitochondrial Complex I
Author: Wang, Jiayu; Zhang, Bowen; Liu, Liwen; Li, Xin; Xie, Zhengwei; Yang, Xiaoda
Journal: CHEMMEDCHEM. 2026; Vol. 21, Issue 6, pp. -. DOI: 10.1002/cmdc.202600003
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Insights Into Vepdegestrant (ARV-471): The First-in-Class Estrogen Receptor Proteolysis-Targeting Chimera Approaching Food and Drug Administration Approval for Breast Cance
Author: Tang, Chao; Tian, Bin; Zhang, Bingxing; Zhang, Yunfei; Ke, Changhua; Chen, Mengxin; Wei, Meiyan; Wang, Wen; Deng, Xintao; Zhang, Qiannan; Wang, Mengzhou; Xia, Juan; He, Meiling; Liang, Chengyuan; Tian, Lei
Journal: CHEMMEDCHEM. 2026; Vol. 21, Issue 6, pp. -. DOI: 10.1002/cmdc.202501111
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Discovery of New CDDO-Imidazole Derivatives as Potential Antitumor Agent
Author: Li, Yanqing; Zhang, Lingjie; Luo, Qunfeng; Li, Yanzi; Zhang, Siqi; Pei, Jianghong; Qi, Mingming; Li, Na; Chen, Li
Journal: CHEMMEDCHEM. 2026; Vol. 21, Issue 6, pp. -. DOI: 10.1002/cmdc.202600008
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Synthesis of β-Carboline-Based Dimers and Hybrids and Anti-Methicillin-Resistant Staphylococcus aureus Properties by Targeting Fts
Author: Fu, Yingxue; Cao, Xuanyu; Liang, Weida; Qiu, Hongda; Zhao, Xing; Han, Bowen; Peng, Zhaoxiang; Zhao, Lingling; Zhang, Xuan; Wang, Xiao; Liang, Hongze
Journal: CHEMMEDCHEM. 2026; Vol. 21, Issue 6, pp. -. DOI: 10.1002/cmdc.202501101
