| Targeting senescent cells alleviates obesity-induced metabolic dysfunction |
66 |
| Plasma proteomic signature of age in healthy humans |
52 |
| Tau protein aggregation is associated with cellular senescence in the brain |
52 |
| Reversal of epigenetic aging and immunosenescent trends in humans |
51 |
| Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice |
46 |
| Aged-senescent cells contribute to impaired heart regeneration |
41 |
| Autophagy controls mesenchymal stem cell properties and senescence during bone aging |
38 |
| Emerging roles of extracellular vesicles in cellular senescence and aging |
34 |
| Autophagy and aging: Maintaining the proteome through exercise and caloric restriction |
31 |
| Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease |
31 |
| Astrocyte senescence: Evidence and significance |
28 |
| Systemic clearance of p16(INK4a)-positive senescent cells mitigates age-associated intervertebral disc degeneration |
28 |
| Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood |
27 |
| Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults |
27 |
| Human CD8(+) EMRA T cells display a senescence-associated secretory phenotype regulated by p38 MAPK |
26 |
| The bystander effect contributes to the accumulation of senescent cells in vivo |
26 |
| NAD(+) supplementation rejuvenates aged gut adult stem cells |
24 |
| Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice |
23 |
| Effects of IGF-1 isoforms on muscle growth and sarcopenia |
22 |
| SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's disease |
22 |
| Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells |
22 |
| Wnt/beta-catenin/RAS signaling mediates age-related renal fibrosis and is associated with mitochondrial dysfunction |
21 |
| Aging and Alzheimer's disease: Comparison and associations from molecular to system level |
20 |
| Temporal and regional progression of Alzheimer's disease-like pathology in 3xTg-AD mice |
20 |
| KCNQ1OT1 promotes autophagy by regulating miR-200a/FOXO3/ATG7 pathway in cerebral ischemic stroke |
20 |
| Age-associated microRNA expression in human peripheral blood is associated with all-cause mortality and age-related traits |
20 |
| Loss of PTEN induces lung fibrosis via alveolar epithelial cell senescence depending on NF-kappa B activation |
20 |
| Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7 |
20 |
| Born this way: Hippocampal neurogenesis across the lifespan |
20 |
| MicroRNA-31a-5p from aging BMSCs links bone formation and resorption in the aged bone marrow microenvironment |
20 |
| The mitochondrial ATP synthase is a shared drug target for aging and dementia |
20 |
| Senescence promotes invivo reprogramming through p16(INK4a) and IL-6 |
19 |
| Effects of aging on liver microcirculatory function and sinusoidal phenotype |
19 |
| Interplay of pathogenic forms of human tau with different autophagic pathways |
19 |
| Mitochondria and aging: A role for the mitochondrial transition pore? |
19 |
| The role of lipid metabolism in aging, lifespan regulation, and age-related disease |
19 |
| An early-senescence state in aged mesenchymal stromal cells contributes to hematopoietic stem and progenitor cell clonogenic impairment through the activation of a pro-inflammatory program |
18 |
| Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation |
18 |
| Sirt1-hypoxia-inducible factor-1 alpha interaction is a key mediator of tubulointerstitial damage in the aged kidney |
18 |
| ATF3 represses PINK1 gene transcription in lung epithelial cells to control mitochondrial homeostasis |
17 |
| 25-Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2-antioxidant signaling and inactivation of p16/p53-senescence signaling |
17 |
| The emerging roles of protein homeostasis-governing pathways in Alzheimer's disease |
17 |
| Glucagon-like peptide-1 ameliorates cardiac lipotoxicity in diabetic cardiomyopathy via the PPAR alpha pathway |
16 |
| Inflammaging impairs peripheral nerve maintenance and regeneration |
16 |
| Trimethylamine-N-oxide promotes brain aging and cognitive impairment in mice |
16 |
| Evidence that miR-146a attenuates aging- and trauma-induced osteoarthritis by inhibiting Notch IL- and IL-1 mediated catabolism |
16 |
| Reactive oxygen species-induced changes in glucose and lipid metabolism contribute to the accumulation of cholesterol in the liver during aging |
15 |
| Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans |
15 |
| Skeletal muscle ex vivo mitochondrial respiration parallels decline in vivo oxidative capacity, cardiorespiratory fitness, and muscle strength: The Baltimore Longitudinal Study of Aging |
15 |
| Acarbose improves health and lifespan in aging HET3 mice |
15 |
