Bioorganic Chemistry

Bioorganic Chemistry

生物有机化学

  • 2区 中科院分区
  • Q1 JCR分区

高引用文章

文章名称 引用次数
Cisplatin: The first metal based anticancer drug 73
Thiazolidinediones as antidiabetic agents: A critical review 42
Medicinal chemistry of indole derivatives: Current to future therapeutic prospectives 40
The first synthesis, carbonic anhydrase inhibition and anticholinergic activities of some bromophenol derivatives with S including natural products 37
Novel 2-aminopyridine liganded Pd(II) N-heterocyclic carbene complexes: Synthesis, characterization, crystal structure and bioactivity properties 36
Synthesis, biological evaluation and molecular docking of novel pyrazole derivatives as potent carbonic anhydrase and acetylcholinesterase inhibitors 34
The role of long noncoding RNA in major human disease 34
Synthesis and biological evaluation of novel tris-chalcones as potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and alpha-glycosidase inhibitors 33
Novel thymol bearing oxypropanolamine derivatives as potent some metabolic enzyme inhibitors - Their antidiabetic, anticholinergic and antibacterial potentials 33
Synthesis and biological evaluation of bromophenol derivatives with cyclopropyl moiety: Ring opening of cyclopropane with monoester 32
Synthesis, characterization, crystal structure of novel bis-thiomethylcyclohexanone derivatives and their inhibitory properties against some metabolic enzymes 31
Chalcone derivatives and their antibacterial activities: Current development 30
Investigation of inhibitory properties of some hydrazone compounds on hCA I, hCA II and AChE enzymes 29
Bovine Serum Albumin (BSA) coated iron oxide magnetic nanoparticles as biocompatible carriers for curcumin-anticancer drug 27
Mono- or di-substituted imidazole derivatives for inhibition of acetylcholine and butyrylcholine esterases 26
Novel tribenzylaminobenzolsulphonylimine based on their pyrazine and pyridazines: Synthesis, characterization, antidiabetic, anticancer, anticholinergic, and molecular docking studies 26
The green synthesis and molecular docking of novel N-substituted rhodanines as effective inhibitors for carbonic anhydrase and acetylcholinesterase enzymes 26
Synthesis and characterization of novel bromophenols: Determination of their anticholinergic, antidiabetic and antioxidant activities 25
Design and synthesis of novel quinazolinone-3-triazole hybrids as new anti-diabetic agents: In vitro alpha-glucosidase inhibition, kinetic, and docking study 25
Novel eugenol bearing oxypropanolamines: Synthesis, characterization, antibacterial, antidiabetic, and anticholinergic potentials 25
Synthesis and bioactivities of pyrazoline benzensulfonamides as carbonic anhydrase and acetylcholinesterase inhibitors with low cytotoxicity 25
Pyrazole[4-d]pyridazine derivatives: Molecular docking and explore of acetylcholinesterase and carbonic anhydrase enzymes inhibitors as anticholinergics potentials 24
Indole derivatives as multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity of indole hydrazones 22
Synthesis, biological evaluation and in silico studies of novel N-substituted phthalazine sulfonamide compounds as potent carbonic anhydrase and acetylcholinesterase inhibitors 22
Promising anti-inflammatory effects of chalcones via inhibition of cyclooxygenase, prostaglandin E- inducible NO synthase and nuclear factor kappa b activities 22
Synthesis of oxazolidinone from enantiomerically enriched allylic alcohols and determination of their molecular docking and biologic activities 22
Multi-target inhibitors against Alzheimer disease derived from 3-hydrazinyl 4-triazine scaffold containing pendant phenoxy methyl-3-triazole: Design, synthesis and biological evaluation 21
Design, synthesis and anticancer evaluation of thieno[3-d]pyrimidine derivatives as dual EGFR/HER2 inhibitors and apoptosis inducers 20
Novel 4-triazole derivatives as potential anticancer agents: Design, synthesis, molecular docking and mechanistic studies 20
New phenolic Mannich bases with piperazines and their bioactivities 20
Innovative nano-carriers in anticancer drug delivery-a comprehensive review 20
New azafluorenones with cytotoxic and carbonic anhydrase inhibitory properties: 2-Aryl-4-(4-hydroxyphenyl)-5H-indeno[2-b]pyridin-5-ones 20
Novel [4]triazolo [5-a]pyrimidine derivatives as potent antitubulin agents: Design, multicomponent synthesis and antiproliferative activities 19
Recent advances in the synthetic and medicinal perspective of quinolones: A review 19
Design, synthesis and anti-Alzheimer's activity of novel 3-triazole-chromenone carboxamide derivatives 19
Multi-targetable chalcone analogs to treat deadly Alzheimer's disease: Current view and upcoming advice 18
Hydroxyl alkyl ammonium ionic liquid assisted green and one-pot regioselective access to functionalized pyrazolodihydropyridine core and their pharmacological evaluation 18
Synthesis and structure-activity relationship study of multi-target triazine derivatives as innovative candidates for treatment of Alzheimer's disease 18
Novel tacrine-coumarin hybrids linked to 3-triazole as anti-Alzheimer's compounds: In vitro and in vivo biological evaluation and docking study 18
Amino acids conjugated quinazolinone-Schiff's bases as potential antimicrobial agents: Synthesis, SAR and molecular docking studies 17
3-triazole tethered Indole-3-glyoxamide derivatives as multiple inhibitors of 5-LOX, COX-2 & tubulin: Their anti-proliferative & anti-inflammatory activity 17
New anticancer drug candidates sulfonamides as selective hCA IX or hCA XII inhibitors 16
Natural constituents from Cortex Mori Radicis as new pancreatic lipase inhibitors 16
Coumarin-dithiocarbamate hybrids as novel multitarget AChE and MAO-B inhibitors against Alzheimer's disease: Design, synthesis and biological evaluation 16
Synthesis of Bis-indolylmethane sulfonohydrazides derivatives as potent alpha-Glucosidase inhibitors 16
Taurine as a green bio-organic catalyst for the preparation of bio-active barbituric and thiobarbituric acid derivatives in water media 16
Synthesis and biological evaluation of some new mono Mannich bases with piperazines as possible anticancer agents and carbonic anhydrase inhibitors 16
Synthesis of 1H-3-triazole derivatives as new alpha-glucosidase inhibitors and their molecular docking studies 16
Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity 16
Aryl fluorosulfate analogues as potent antimicrobial agents: SAR, cytotoxicity and docking studies 15