| Comprehensive Integration of Single-Cell Data |
671 |
| Metazoan MicroRNAs |
429 |
| Functional Classification and Experimental Dissection of Long Noncoding RNAs |
396 |
| Identifying Medical Diagnoses and Treatable Diseases by Image-Based Deep Learning |
309 |
| An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics |
300 |
| Oncogenic Signaling Pathways in The Cancer Genome Atlas |
282 |
| Reassessment of Exosome Composition |
281 |
| Molecular Architecture of the Mouse Nervous System |
262 |
| Biological Functions of Autophagy Genes: A Disease Perspective |
260 |
| Comprehensive Characterization of Cancer Driver Genes and Mutations |
246 |
| Innate Lymphoid Cells: 10 Years On |
236 |
| Cell-of-Origin Patterns Dominate the Molecular Classification of 000 Tumors from 33 Types of Cancer |
233 |
| The Landscape of Circular RNA in Cancer |
196 |
| Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates |
193 |
| A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity |
191 |
| NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control |
187 |
| The Human Transcription Factors |
180 |
| A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins |
177 |
| Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment |
168 |
| Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells |
168 |
| A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization |
168 |
| Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features |
165 |
| Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma |
162 |
| Cellular Senescence: Defining a Path Forward |
161 |
| Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains |
154 |
| Organoid Modeling of the Tumor Immune Microenvironment |
153 |
| Alzheimer Disease: An Update on Pathobiology and Treatment Strategies |
151 |
| Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain |
151 |
| VEGF in Signaling and Disease: Beyond Discovery and Development |
150 |
| Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor |
147 |
| Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation |
145 |
| Extensive Unexplored Human Microbiome Diversity Revealed by Over 000 Genomes from Metagenomes Spanning Age, Geography, and Lifestyle |
143 |
| Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory |
142 |
| Mapping the Mouse Cell Atlas by Microwell-Seq |
139 |
| BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis |
138 |
| An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma |
136 |
| CD10(+) GPR77(+) Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness |
133 |
| A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade |
132 |
| Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion |
132 |
| Recovering Gene Interactions from Single-Cell Data Using Data Diffusion |
130 |
| Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT |
129 |
| R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m(6)A/MYC/CEBPA Signaling |
121 |
| Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming |
117 |
| Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice |
117 |
| Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules |
116 |
| Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes |
115 |
| Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes |
110 |
| The Role of Non-coding RNAs in Oncology |
107 |
| Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity |
107 |
| Autophagy-Independent Functions of the Autophagy Machinery |
106 |
| Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors |
105 |
| Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single-Cell Sequencing |
104 |
| Next-Generation Machine Learning for Biological Networks |
103 |
| Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal |
103 |
| Predicting Splicing from Primary Sequence with Deep Learning |
102 |
| Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma |
100 |
| Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids |
99 |
| FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-pi Interactions |
99 |
| A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain |
97 |
| Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration |
95 |
| Pathogenic Germline Variants in 389 Adult Cancers |
95 |
| Organization of Chromatin by Intrinsic and Regulated Phase Separation |
94 |
| Inactivation of CDK12 Delineates a Distinct Immunogenic Class of Advanced Prostate Cancer |
94 |
| Stereotypic Immune System Development in Newborn Children |
93 |
| Higher-Order Inter-chromosomal Hubs Shape 3D Genome Organization in the Nucleus |
91 |
| Circulating Tumor Cell Clustering Shapes DNA Methylation to Enable Metastasis Seeding |
91 |
| Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3 |
91 |
| A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia |
90 |
| Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis |
89 |
| Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity |
89 |
| Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer |
88 |
| Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal |
88 |
| Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood |
87 |
| Deep Profiling of Mouse Splenic Architecture with CODEX Multiplexed Imaging |
87 |
| The Human Gut Microbiome: From Association to Modulation |
87 |
| Rewiring of the Fruit Metabolome in Tomato Breeding |
86 |
| The Biology of CRISPR-Cas: Backward and Forward |
84 |
| A Complete Electron Microscopy Volume of the Brain of Adult Drosophila melanogaster |
84 |
| Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity |
83 |
| A Genetically Encoded Fluorescent Sensor Enables Rapid and Specific Detection of Dopamine in Flies, Fish, and Mice |
83 |
| A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer |
82 |
| Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner |
81 |
| A Structured Tumor-Immune Microenvironment in Triple Negative Breast Cancer Revealed by Multiplexed Ion Beam Imaging |
81 |
| A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain |
81 |
| Metabolomics and Isotope Tracing |
81 |
| Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer |
80 |
| Commensal Microbiota Promote Lung Cancer Development via gamma delta T Cells |
79 |
| Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1 |
78 |
| Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses |
78 |
| Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities |
78 |
| Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome |
77 |
| Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis |
77 |
| Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation |
77 |
| US Immigration Westernizes the Human Gut Microbiome |
77 |
| Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration |
77 |
| Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1 |
76 |
| Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner |
76 |
| Metabolic Induction of Trained Immunity through the Mevalonate Pathway |
76 |
| Single-Cell Multi-omic Integration Compares and Contrasts Features of Brain Cell Identity |
75 |
| A Compendium of Mutational Signatures of Environmental Agents |
74 |
| Intelligent Image-Activated Cell Sorting |
74 |
| Identification of the Human Skeletal Stem Cell |
74 |
| Toward Minimal Residual Disease-Directed Therapy in Melanoma |
72 |
| Evolution of Metastases in Space and Time under Immune Selection |
72 |
| Structure of Microbial Nanowires Reveals Stacked Hemes that Transport Electrons over Micrometers |
72 |
| Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans |
72 |
| Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal |
71 |
| In Silico Labeling: Predicting Fluorescent Labels in Unlabeled Images |
71 |
| Visualizing Intracellular Organelle and Cytoskeletal Interactions at Nanoscale Resolution on Millisecond Timescales |
70 |
| Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma |
69 |
| The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet |
69 |
| Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer |
69 |
| The Translational Landscape of the Human Heart |
69 |
| Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders |
69 |
| Pharmacogenomics of GPCR Drug Targets |
68 |
| Microbial Interkingdom Interactions in Roots Promote Arabidopsis Survival |
68 |
| Widespread and Functional RNA Circularization in Localized Prostate Cancer |
68 |
| Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution |
68 |
| Microglia Biology: One Century of Evolving Concepts |
68 |
| Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes |
68 |
| Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis |
67 |
| Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids |
67 |
| A Single-Cell Atlas of In Vivo Mammalian Chromatin Accessibility |
67 |
| Memory B Cells Activate Brain-Homing, Autoreactive CD4(+) T Cells in Multiple Sclerosis |
66 |
| LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade |
66 |
| Opposite Roles of Salicylic Acid Receptors NPR1 and NPR3/NPR4 in Transcriptional Regulation of Plant Immunity |
65 |
| Promoter of IncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element |
65 |
| The Chara Genome: Secondary Complexity and Implications for Plant Terrestrialization |
65 |
| In Toto Imaging and Reconstruction of Post-Implantation Mouse Development at the Single-Cell Level |
65 |
| Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting |
65 |
| DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity |
65 |
| A Suite of Transgenic Driver and Reporter Mouse Lines with Enhanced Brain-Cell-Type Targeting and Functionality |
64 |
| Characterizing the Major Structural Variant Alleles of the Human Genome |
64 |
| Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism |
64 |
| RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether |
63 |
| BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis |
63 |
| Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke |
63 |
| LC3-Associated Endocytosis Facilitates beta-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer's Disease |
62 |
| Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease |
61 |
| Molecular Classification and Comparative Taxonomics of Foveal and Peripheral Cells in Primate Retina |
61 |
| Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia |
61 |
| Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma |
60 |
| An Integrated View of Immunometabolism |
60 |
| Major New Microbial Groups Expand Diversity and Alter our Understanding of the Tree of Life |
60 |
| Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus |
60 |
| The Coming Decade of Cell Death Research: Five Riddles |
60 |
| Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains |
60 |
| A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling |
60 |
| A Neural Circuit for Gut-Induced Reward |
59 |
| Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis |
59 |
| Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4(+) T Cell Immunity |
59 |
| Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair |
59 |
| Crystal Structure of the Human Cannabinoid Receptor CB2 |
59 |
| Atlas of Subcellular RNA Localization Revealed by APEX-Seq |
58 |
| Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function |
58 |
| A LINE1-Nucleolin Partnership Regulates Early Development and ESC Identity |
58 |
| Extensive Heterogeneity and Intrinsic Variation in Spatial Genome Organization |
58 |
| Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene |
58 |
| Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy |
57 |
| Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans |
56 |
| Conversion of Escherichia coli to Generate All Biomass Carbon from CO2 |
56 |
| Trans Effects on Gene Expression Can Drive Omnigenic Inheritance |
55 |
| Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer |
55 |
| Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells |
55 |
| Tempo and Mode of Genome Evolution in the Budding Yeast Subphylum |
55 |
| Deciphering the m(6)A Code via Antibody-Independent Quantitative Profiling |
55 |
| The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest |
55 |
| A Genome-wide Framework for Mapping Gene Regulation via Cellular Genetic Screens |
55 |
| Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics |
55 |
| Marine DNA Viral Macro- and Microdiversity from Pole to Pole |
55 |
| GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance |
55 |
| Light Affects Mood and Learning through Distinct Retina-Brain Pathways |
54 |
| Defining the Genetic, Genomic, Cellular, and Diagnostic Architectures of Psychiatric Disorders |
54 |
| Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells |
54 |
| Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement |
54 |
| Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity |
54 |
| The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death |
53 |
| B Cell Responses: Cell Interaction Dynamics and Decisions |
53 |
| Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex |
52 |
| Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through IncRNA PCAT19 |
52 |
| Irisin Mediates Effects on Bone and Fat via alpha V Integrin Receptors |
52 |
| Integrated Single-Cell Analysis Maps the Continuous Regulatory Landscape of Human Hematopoietic Differentiation |
52 |
| TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging |
51 |
| Genomes of Subaerial Zygnematophyceae Provide Insights into Land Plant Evolution |
51 |
| Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma |
51 |
| Influenza Infection in Humans Induces Broadly Cross-Reactive and Protective Neuraminidase-Reactive Antibodies |
51 |
| ATG8-Binding UIM Proteins Define a New Class of Autophagy Adaptors and Receptors |
50 |
| Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improves Cognition |
50 |
| The cis-Regulatory Atlas of the Mouse Immune System |
50 |
| Impairment of an Endothelial NAD(+)-H2S Signaling Network Is a Reversible Cause of Vascular Aging |
50 |
| Flavin Monooxygenase-Generated N-Hydroxypipecolic Acid Is a Critical Element of Plant Systemic Immunity |
50 |
| Impact of Genetic Polymorphisms on Human Immune Cell Gene Expression |
50 |
| T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation |
50 |
| Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons |
50 |
| Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung |
49 |
| LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer |
49 |
| mTORC1 Controls Phase Separation and the Biophysical Properties of the Cytoplasm by Tuning Crowding |
49 |
| Stress Granule Assembly Disrupts Nucleocytoplasmic Transport |
49 |
| Reconstructing the Deep Population History of Central and South America |
49 |
| In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment |
48 |
