| Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake |
137 |
| Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes |
136 |
| Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1 |
116 |
| AMPK: Sensing Glucose as well as Cellular Energy Status |
94 |
| The Science and Translation of Lactate Shuttle Theory |
93 |
| Advances in Hypoxia-Inducible Factor Biology |
91 |
| Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand |
87 |
| Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence |
86 |
| RNA-Targeted Therapeutics |
86 |
| NAD(+) Intermediates: The Biology and Therapeutic Potential of NMN and NR |
82 |
| Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States |
79 |
| Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock |
78 |
| Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases |
73 |
| JAK/STAT3-Regulated Fatty Acid beta-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance |
73 |
| Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy |
71 |
| The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids |
71 |
| Macrophages and Metabolism in the Tumor Microenvironment |
69 |
| Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise |
69 |
| New Advances in Adaptive Thermogenesis: UCP1 and Beyond |
63 |
| Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism |
62 |
| Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential |
62 |
| Epigenetics in Human Obesity and Type 2 Diabetes |
59 |
| Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans |
59 |
| Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging |
58 |
| Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome |
56 |
| Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation |
54 |
| Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion |
54 |
| An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans |
53 |
| Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease |
52 |
| GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans |
51 |
| Quantitative Analysis of NAD Synthesis-Breakdown Fluxes |
51 |
| Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids |
51 |
| Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling |
49 |
| Molecular Mechanisms Linking Exercise to Cancer Prevention and Treatment |
49 |
| The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases |
48 |
| Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis |
48 |
| Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer |
47 |
| Medicine in the Fourth Dimension |
47 |
| Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota |
47 |
| Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae |
45 |
| NAD(+) in Brain Aging and Neurodegenerative Disorders |
45 |
| Remission of Human Type 2 Diabetes Requires Decrease in Liver and Pancreas Fat Content but Is Dependent upon Capacity for beta Cell Recovery |
45 |
| The Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and Causality |
45 |
| Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis |
43 |
| Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression |
43 |
| Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice |
43 |
| Dietary Fat, but Not Protein or Carbohydrate, Regulates Energy Intake and Causes Adiposity in Mice |
42 |
| Deconstructing Adipogenesis Induced by beta 3-Adrenergic Receptor Activation with Single-Cell Expression Profiling |
42 |
| Cholesterol Induces CD8(+) T Cell Exhaustion in the Tumor Microenvironment |
42 |
| Profound Perturbation of the Metabolome in Obesity Is Associated with Health Risk |
42 |
| A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease |
41 |
| Acceleration of beta Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes |
41 |
| Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids |
41 |
| Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice |
41 |
| Metabolic Effects of Dietary Nitrate in Health and Disease |
40 |
| LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation |
40 |
| Exercise-Induced Changes in Visceral Adipose Tissue Mass Are Regulated by IL-6 Signaling: A Randomized Controlled Trial |
40 |
| A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3 |
39 |
| Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies |
39 |
| Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation |
39 |
| Watch What You (Self-) Eat: Autophagic Mechanisms that Modulate Metabolism |
39 |
| The Mitochondrial Acylome Emerges: Proteomics, Regulation by Sirtuins, and Metabolic and Disease Implications |
39 |
| As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid |
38 |
| The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity |
38 |
| Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer |
38 |
| Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo |
38 |
| A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD(+) Decline |
37 |
| The Mouse Microbiome Is Required for Sex-Specific Diurnal Rhythms of Gene Expression and Metabolism |
37 |
| Lymphocyte-Derived Exosomal MicroRNAs Promote Pancreatic beta Cell Death and May Contribute to Type 1 Diabetes Development |
37 |
| Interplay between YAP/TAZ and Metabolism |
37 |
| Overlapping Brain Circuits for Homeostatic and Hedonic Feeding |
37 |
| Anatomical, Physiological, and Functional Diversity of Adipose Tissue |
36 |
| Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes |
35 |
| Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression |
35 |
| Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma |
34 |
| Functional Gut Microbiota Remodeling Contributes to the Caloric Restriction-Induced Metabolic Improvements |
34 |
| Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting |
34 |
| Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells |
33 |
| Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy |
33 |
| Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy |
33 |
| Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation |
33 |
| Glycolytic Stimulation Is Not a Requirement for M2 Macrophage Differentiation |
32 |
| Postprandial Oxidative Metabolism of Human Brown Fat Indicates Thermogenesis |
32 |
| Serine Metabolism Supports Macrophage IL-1 beta Production |
32 |
| Hallmarks of Endothelial Cell Metabolism in Health and Disease |
32 |
| Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting beta Cell Proliferation and Function in Obesity |
32 |
| Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity |
31 |
| Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis |
31 |
| Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories |
31 |
| Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A |
31 |
| Bacterial Metabolism and Antibiotic Efficacy |
30 |
| Choline Uptake and Metabolism Modulate Macrophage IL-1 beta and IL-18 Production |
30 |
| Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease |
30 |
| LEAP2 Is an Endogenous Antagonist of the Ghrelin Receptor |
30 |
| Mechanisms and Implications of Metabolic Heterogeneity in Cancer |
30 |
| Glucose Homeostasis Is Important for Immune Cell Viability during Candida Challenge and Host Survival of Systemic Fungal Infection |
30 |
| CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress |
29 |
| Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis |
29 |
| Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis |
29 |
| Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis |
29 |
| Paracrine Interactions within the Pancreatic Islet Determine the Glycemic Set Point |
29 |
| Palmitic Acid Hydroxystearic Acids Activate GPR Which Is Involved in Their Beneficial Effects on Glucose Homeostasis |
29 |
| Metformin Alters Upper Small Intestinal Microbiota that Impact a Glucose-SGLT1-Sensing Glucoregulatory Pathway |
28 |
| Preserving Insulin Secretion in Diabetes by Inhibiting VDAC1 Overexpression and Surface Translocation in beta Cells |
28 |
| Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration |
28 |
| Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting |
28 |
| Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair |
28 |
| Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations |
27 |
| A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry |
27 |
| Preclinical Models for Studying NASH-Driven HCC: How Useful Are They? |
27 |
| Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection |
27 |
| Supra-Additive Effects of Combining Fat and Carbohydrate on Food Reward |
27 |
| Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance |
27 |
| The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress |
27 |
| CD38-NAD(+)Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response |
27 |
| Three-Dimensional Adipose Tissue Imaging Reveals Regional Variation in Beige Fat Biogenesis and PRDM16-Dependent Sympathetic Neurite Density |
27 |
| Fibroblast Growth Factor 21 Drives Dynamics of Local and Systemic Stress Responses in Mitochondrial Myopathy with mtDNA Deletions |
27 |
| The Drosophila Immune Deficiency Pathway Modulates Enteroendocrine Function and Host Metabolism |
26 |
| Conventional and Neo-antigenic Peptides Presented by beta Cells Are Targeted by Circulating Naive CD8+T Cells in Type 1 Diabetic and Healthy Donors |
26 |
| Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation |
26 |
| Quiescent Endothelial Cells Upregulate Fatty Acid (beta-Oxidation for Vasculoprotection via Redox Homeostasis |
26 |
| Chrono-pharmacological Targeting of the CCL2-CCR2 Axis Ameliorates Atherosclerosis |
26 |
| Mediation of the Acute Stress Response by the Skeleton |
26 |
| Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers |
26 |
| Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes |
26 |
| A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21 |
26 |
| 13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake |
25 |
| Autoregulation of Osteocyte Sema3A Orchestrates Estrogen Action and Counteracts Bone Aging |
25 |
| Cell Clustering Promotes a Metabolic Switch that Supports Metastatic Colonization |
25 |
| Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin |
25 |
| Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction |
25 |
| Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes |
25 |
| Pancreatic beta Cell Regeneration as a Possible Therapy for Diabetes |
25 |
| The Pericyte of the Pancreatic Islet Regulates Capillary Diameter and Local Blood Flow |
25 |
| Metabolic Reprogramming in Astrocytes Distinguishes Region-Specific Neuronal Susceptibility in Huntington Mice |
25 |
| Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics |
24 |
| Non-invasive Measurement of Brown Fat Metabolism Based on Optoacoustic Imaging of Hemoglobin Gradients |
24 |
| Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells |
24 |
| Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment |
24 |
| CXCL a Brown Adipokine that Mediates Brown-Fat-to-Macrophage Communication in Thermogenic Adaptation |
24 |
| Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells |
23 |
| Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells |
23 |
| Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice |
23 |
| Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1 |
23 |
| The Homeostatic Force of Ghrelin |
23 |
| Low-Protein Diet Induces IRE1 alpha-Dependent Anticancer Immunosurveillance |
23 |
| mTORC1 Signaling: A Double-Edged Sword in Diabetic beta Cells |
23 |
| Mitochondrial Translation Efficiency Controls Cytoplasmic Protein Homeostasis |
23 |
| An Adipose Tissue Atlas: An Image-Guided Identification of Human-like BAT and Beige Depots in Rodents |
23 |
| Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis |
23 |
| Could Ceramides Become the New Cholesterol? |
22 |
| Mitochondrial Supercomplexes Do Not Enhance Catalysis by Quinone Channeling |
22 |
| Drosophila Perpetuates Nutritional Mutualism by Promoting the Fitness of Its Intestinal Symbiont Lactobacillus plantarum |
22 |
| The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase |
22 |
| Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4(+) T Cell Metabolic Rewiring |
22 |
| 12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat |
22 |
| Phospholipase PLA2G a Parkinsonism-Associated Gene, Affects Vps26 and Vps Retromer Function, and Ceramide Levels, Similar to alpha-Synuclein Gain |
22 |
| A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate |
22 |
| Metabolic Maturation during Muscle Stem Cell Differentiation Is Achieved by miR-1/133a-Mediated Inhibition of the DlK1-Dio3 Mega Gene Cluster |
22 |
| GABA and Artesunate Do Not Induce Pancreatic alpha-to-beta Cell Transdifferentiation In Vivo |
21 |
| Circulating Levels of Soluble Dipeptidyl Peptidase-4 Are Dissociated from Inflammation and Induced by Enzymatic DPP4 Inhibition |
21 |
| Gut Microbiota-Stimulated Innate Lymphoid Cells Support beta-Defensin 14 Expression in Pancreatic Endocrine Cells, Preventing Autoimmune Diabetes |
21 |
| Nucleus of the Solitary Tract Serotonin 5-HT2C Receptors Modulate Food Intake |
21 |
| OLFR734 Mediates Glucose Metabolism as a Receptor of Asprosin |
21 |
| Repression of Adipose Tissue Fibrosis through a PRDM16-GTF2IRD1 Complex Improves Systemic Glucose Homeostasis |
21 |
| The Polycomb-Dependent Epigenome Controls beta Cell Dysfunction, Dedifferentiation, and Diabetes |
20 |
| Ketosis Ameliorates Renal Cyst Growth in Polycystic Kidney Disease |
20 |
| Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation |
20 |
| Weight Gain and Impaired Glucose Metabolism in Women Are Predicted by Inefficient Subcutaneous Fat Cell Lipolysis |
20 |
| Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis |
20 |
| Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation |
20 |
| Circulating Adipose Fatty Acid Binding Protein Is a New Link Underlying Obesity-Associated Breast/Mammary Tumor Development |
20 |
| Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models |
20 |
| Toward an Understanding of How Immune Cells Control Brown and Beige Adipobiology |
19 |
| Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins |
19 |
| Physiological and Molecular Dissection of Daily Variance in Exercise Capacity |
19 |
| Short-Term Fasting Reveals Amino Acid Metabolism as a Major Sex-Discriminating Factor in the Liver |
19 |
| Substantial Metabolic Activity of Human Brown Adipose Tissue during Warm Conditions and Cold-Induced Lipolysis of Local Triglycerides |
19 |
| Microglial UCP2 Mediates Inflammation and Obesity Induced by High-Fat Feeding |
19 |
| IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties |
19 |
| Metabolism in Pluripotent Stem Cells and Early Mammalian Development |
18 |
| Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis |
18 |
| Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake |
18 |
| PML-Regulated Mitochondrial Metabolism Enhances Chemosensitivity in Human Ovarian Cancers |
18 |
| Complement Component C3 Is Highly Expressed in Human Pancreatic Islets and Prevents beta Cell Death via ATG16L1 Interaction and Autophagy Regulation |
18 |
| Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation |
18 |
| Control of Feeding Behavior by Cerebral Ventricular Volume Transmission of Melanin-Concentrating Hormone |
18 |
| Maximizing Cellular Adaptation to Endurance Exercise in Skeletal Muscle |
18 |
| Metabolite Exchange between Mammalian Organs Quantified in Pigs |
18 |
| Dietary Restriction Extends Lifespan through Metabolic Regulation of Innate Immunity |
18 |
| Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron |
18 |
| Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer |
18 |
| Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling |
17 |
| Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4(+) T Cells and Offers an Opportunity to Tackle Infection |
17 |
| Oxyphor 2P: A High-Performance Probe for Deep-Tissue Longitudinal Oxygen Imaging |
17 |
| Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression |
17 |
| Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis |
17 |
| Patients with Obesity Caused by Melanocortin-4 Receptor Mutations Can Be Treated with a Glucagon-like Peptide-1 Receptor Agonist |
17 |
| Age Mosaicism across Multiple Scales in Adult Tissues |
17 |
| ACOT12-Dependent Alteration of Acetyl-CoA Drives Hepatocellular Carcinoma Metastasis by Epigenetic Induction of Epithelial-Mesenchymal Transition |
17 |
