Lancet Infectious Diseases

Lancet Infectious Diseases

柳叶刀传染病

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Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis 465
Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis 327
Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 128
Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: a systematic analysis for the Global Burden of Disease Study 2016 124
Middle East respiratory syndrome coronavirus: risk factors and determinants of primary, household, and nosocomial transmission 103
A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study 90
Xpert MTB/RIF Ultra for detection of Mycobacterium tuberculosis and rifampicin resistance: a prospective multicentre diagnostic accuracy study 87
Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pseudomonas aeruginosa (PhagoBurn): a randomised, controlled, double-blind phase 1/2 trial 87
The global burden of typhoid and paratyphoid fevers: a systematic analysis for the Global Burden of Disease Study 2017 86
Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: a phase open-label, single-arm, dose-escalation trial 76
Colistin alone versus colistin plus meropenem for treatment of severe infections caused by carbapenem-resistant Gram-negative bacteria: an open-label, randomised controlled trial 69
Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium 68
Human toxocariasis 64
The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates 61
Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis 58
Rapid increase in non-vaccine serotypes causing invasive pneumococcal disease in England and Wales, 2000-17: a prospective national observational cohort study 58
Human papillomavirus types from infection to cancer in the anus, according to sex and HIV status: a systematic review and meta-analysis 57
Diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculous meningitis in HIV-infected adults: a prospective cohort study 54
Institutional trust and misinformation in the response to the 2018-19 Ebola outbreak in North Kivu, DR Congo: a population-based survey 51
Determinants of dihydroartemisinin-piperaquine treatment failure in Plasmodium falciparum malaria in Cambodia, Thailand, and Vietnam: a prospective clinical, pharmacological, and genetic study 50
Guidelines for the management of cytomegalovirus infection in patients with haematological malignancies and after stem cell transplantation from the 2017 European Conference on Infections in Leukaemia (ECIL 7) 50
HIV-1 drug resistance before initiation or re-initiation of first-line antiretroviral therapy in low-income and middle-income countries: a systematic review and meta-regression analysis 50
Association between microcephaly, Zika virus infection, and other risk factors in Brazil: final report of a case-control study 49
Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies 49
Morbidity and mortality due to shigella and enterotoxigenic Escherichia coli diarrhoea: the Global Burden of Disease Study 1990-2016 46
Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study 45
Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled trial 43
Evolution and expansion of multidrug-resistant malaria in southeast Asia: a genomic epidemiology study 42
Global and regional molecular epidemiology of HIV- 1990-2015: a systematic review, global survey, and trend analysis 42
Quantifying drivers of antibiotic resistance in humans: a systematic review 39
Cefiderocol versus imipenem-cilastatin for the treatment of complicated urinary tract infections caused by Gram-negative uropathogens: a phase randomised, double-blind, non-inferiority trial 39
Ceftazidime-avibactam versus meropenem in nosocomial pneumonia, including ventilator-associated pneumonia (REPROVE): a randomised, double-blind, phase 3 non-inferiority trial 39
The global burden of tuberculosis: results from the Global Burden of Disease Study 2015' 39
Tuberculosis: advances and challenges in development of new diagnostics and biomarkers 38
Ceftolozane-tazobactam versus meropenem for treatment of nosocomial pneumonia (ASPECT-NP): a randomised, controlled, double-blind, phase non-inferiority trial 38
Surveillance for control of antimicrobial resistance 38
Global burden of recurrent vulvovaginal candidiasis: a systematic review 36
Epidemiological and clinical features of laboratory-diagnosed severe fever with thrombocytopenia syndrome in China, 2011-17: a prospective observational study 35
Safety and tolerability of a novel, polyclonal human anti-MERS coronavirus antibody produced from transchromosomic cattle: a phase 1 randomised, double-blind, single-dose-escalation study 34
Molecular surveillance of norovirus, 2005-16: an epidemiological analysis of data collected from the NoroNet network 32
Prolonged versus short-term intravenous infusion of antipseudomonal beta-lactams for patients with sepsis: a systematic review and meta-analysis of randomised trials 32
Deliberations of the Strategic Advisory Group of Experts on Immunization on the use of CYD-TDV dengue vaccine 31
The effect of global change on mosquito-borne disease 31
Current gaps in sepsis immunology: new opportunities for translational research 30
The global burden of non-typhoidal salmonella invasive disease: a systematic analysis for the Global Burden of Disease Study 2017 30
Analysis of the clinical antibacterial and antituberculosis pipeline 28
Antimalarial drug resistance in Africa: the calm before the storm? 28
Novel lipoarabinomannan point-of-care tuberculosis test for people with HIV: a diagnostic accuracy study 28
Consumption of oral antibiotic formulations for young children according to the WHO Access, Watch, Reserve (AWaRe) antibiotic groups: an analysis of sales data from 70 middle-income and high-income countries 28
Prognostic value of interferon-gamma release assays and tuberculin skin test in predicting the development of active tuberculosis (UK PREDICT TB): a prospective cohort study 28
Multiple introductions and subsequent transmission of multidrug-resistant Candida auris in the USA: a molecular epidemiological survey 28
Public health surveillance of multidrug-resistant clones of Neisseria gonorrhoeae in Europe: a genomic survey 27
Burden of HIV-associated histoplasmosis compared with tuberculosis in Latin America: a modelling study 27
Outbreak of multidrug-resistant tuberculosis in South Africa undetected by WHO-endorsed commercial tests: an observational study 27
Global, regional, and national burden of tuberculosis, 1990-2016: results from the Global Burden of Diseases, Injuries, and Risk Factors 2016 Study 27
Burden, pathology, and costs of malaria in pregnancy: new developments for an old problem 27
Enterovirus D68 and acute flaccid myelitis-evaluating the evidence for causality 26
Vaccination of haemopoietic stem cell transplant recipients: guidelines of the 2017 European Conference on Infections in Leukaemia (ECIL 7) 26
Venezuela's humanitarian crisis, resurgence of vector-borne diseases, and implications for spillover in the region 25
Evaluation of the association between the concentrations of key vaginal bacteria and the increased risk of HIV acquisition in African women from five cohorts: a nested case-control study 25
The temporal relationship between onchocerciasis and epilepsy: a population-based cohort study 24
Dolutegravir versus ritonavir-boosted lopinavir both with dual nucleoside reverse transcriptase inhibitor therapy in adults with HIV-1 infection in whom first-line therapy has failed (DAWNING): an open-label, non-inferiority, phase 3b trial 24
Scabies outbreaks in ten care homes for elderly people: a prospective study of clinical features, epidemiology, and treatment outcomes 24
Origins of the current outbreak of multidrug-resistant malaria in southeast Asia: a retrospective genetic study 24
Multiple-dose versus single-dose ivermectin for Strongyloides stercoralis infection (Strong Treat 1 to 4): a multicentre, open-label, phase randomised controlled superiority trial 23
Epidemiology of common resistant bacterial pathogens in the countries of the Arab League 23
Incarceration history and risk of HIV and hepatitis C virus acquisition among people who inject drugs: a systematic review and meta-analysis 23
An environmental cleaning bundle and health-care-associated infections in hospitals (REACH): a multicentre, randomised trial 23
Extended-spectrum beta-lactamase-producing Escherichia coli in human-derived and foodchain-derived samples from England, Wales, and Scotland: an epidemiological surveillance and typing study 23
Experimental infection of human volunteers 23
Global burden of latent multidrug-resistant tuberculosis: trends and estimates based on mathematical modelling 23
How effective are approaches to migrant screening for infectious diseases in Europe? A systematic review 22
Risk factors associated with revision for prosthetic joint infection following knee replacement: an observational cohort study from England and Wales 22
Genetic sequencing for surveillance of drug resistance in tuberculosis in highly endemic countries: a multi-country population-based surveillance study 22
Zika virus in French Polynesia 2013-14: anatomy of a completed outbreak 22
A cluster of multidrug-resistant Mycobacterium tuberculosis among patients arriving in Europe from the Horn of Africa: a molecular epidemiological study 22
Genetics of human susceptibility to active and latent tuberculosis: present knowledge and future perspectives 21
Post-exposure prophylaxis with doxycycline to prevent sexually transmitted infections in men who have sex with men: an open-label randomised substudy of the ANRS IPERGAY trial 21
Effect of carbapenem resistance on outcomes of bloodstream infection caused by Enterobacteriaceae in low-income and middle-income countries (PANORAMA): a multinational prospective cohort study 21
Risk factors associated with revision for prosthetic joint infection after hip replacement: a prospective observational cohort study 21
Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: a WHO-coordinated, prospective, international, observational cohort study 21
Clinical bacteriology in low-resource settings: today's solutions 21
Immunogenicity and safety of the adjuvanted recombinant zoster vaccine in adults with haematological malignancies: a phase randomised, clinical trial and post-hoc efficacy analysis 20
Efficacy of mass drug administration with ivermectin for control of scabies and impetigo, with coadministration of azithromycin: a single-arm community intervention trial 20
Epidemiological characteristics of an urban plague epidemic in Madagascar, August-November, 2017: an outbreak report 20
Prevalence of abdominal cystic echinococcosis in rural Bulgaria, Romania, and Turkey: a cross-sectional, ultrasound-based, population study from the HERACLES project 19
Trends over time in Escherichia coli bloodstream infections, urinary tract infections, and antibiotic susceptibilities in Oxfordshire, UK, 1998-2016: a study of electronic health records 19
Effect of HIV-1 low-level viraemia during antiretroviral therapy on treatment outcomes in WHO-guided South African treatment programmes: a multicentre cohort study 19
The effect of chloroquine dose and primaquine on Plasmodium vivax recurrence: a WorldWide Antimalarial Resistance Network systematic review and individual patient pooled meta-analysis 19
Pneumococcal lineages associated with serotype replacement and antibiotic resistance in childhood invasive pneumococcal disease in the post-PCV13 era: an international whole-genome sequencing study 19
Clinical and laboratory predictors of Lassa fever outcome in a dedicated treatment facility in Nigeria: a retrospective, observational cohort study 19
A multimodal infection control and patient safety intervention to reduce surgical site infections in Africa: a multicentre, before-after, cohort study 19
Development of vaccines against Zika virus 18
Long-term all-cause mortality in people treated for tuberculosis: a systematic review and meta-analysis 18
Efficacy of live oral rotavirus vaccines by duration of follow-up: a meta-regression of randomised controlled trials 18
Safety, pharmacokinetics, and immunogenicity of a co-formulated cocktail of three human monoclonal antibodies targeting Ebola virus glycoprotein in healthy adults: a randomised, first-in-human phase 1 study 18
Adjunctive sertraline for HIV-associated cryptococcal meningitis: a randomised, placebo-controlled, double-blind phase 3 trial 18
The WHO public health approach to HIV treatment and care: looking back and looking ahead 18
Outbreak investigation of ceftriaxone-resistant Salmonella enterica serotype Typhi and its risk factors among the general population in Hyderabad, Pakistan: a matched case-control study 18
Assessment of ultra-sensitive malaria diagnosis versus standard molecular diagnostics for malaria elimination: an in-depth molecular community cross-sectional study 17
Extended-pulsed fidaxomicin versus vancomycin for Clostridium difficile infection in patients 60 years and older (EXTEND): a randomised, controlled, open-label, phase 3b/4 trial 17
Vaccination of patients with haematological malignancies who did not have transplantations: guidelines from the 2017 European Conference on Infections in Leukaemia (ECIL 7) 17
Resurgence of scarlet fever in England, 2014-16: a population-based surveillance study 17
Hepatitis C virus treatment as prevention in an extended network of people who inject drugs in the USA: a modelling study 17
Effect of infectious disease consultation on mortality and treatment of patients with candida bloodstream infections: a retrospective, cohort study 17
Prevention of malaria in pregnancy 17
Antimicrobial resistance following mass azithromycin distribution for trachoma: a systematic review 17
Potential of marine natural products against drug-resistant bacterial infections 17
Long-term changes of gut microbiota, antibiotic resistance, and metabolic parameters after Helicobacter pylori eradication: a multicentre, open-label, randomised trial 16
Antimicrobial resistance among children in sub-Saharan Africa 16
Models of gonorrhoea transmission from the mouth and saliva 16
Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis 16
Effects of the Australian National Hand Hygiene Initiative after 8 years on infection control practices, health-care worker education, and clinical outcomes: a longitudinal study 15
Emergence of the Asian lineage of Zika virus in Angola: an outbreak investigation 15
Serocorrelates of protection against infant group B streptococcus disease 15
Pneumococcal conjugate vaccine 13 delivered as one primary and one booster dose (1+1) compared with two primary doses and a booster (2+1) in UK infants: a multicentre, parallel group randomised controlled trial 15
Peginterferon alfa-2a plus tenofovir disoproxil fumarate for hepatitis D (HIDIT-II): a randomised, placebo controlled, phase 2 trial 15
Medical countermeasures during the 2018 Ebola virus disease outbreak in the North Kivu and Ituri Provinces of the Democratic Republic of the Congo: a rapid genomic assessment 15
Long-term circulation of Zika virus in Thailand: an observational study 15
Outbreak of human monkeypox in Nigeria in 2017-18: a clinical and epidemiological report 15
Early safety and efficacy of the combination of bedaquiline and delamanid for the treatment of patients with drug-resistant tuberculosis in Armenia, India, and South Africa: a retrospective cohort study 15
Making sense of differences in pneumococcal serotype replacement 14
The persistence and oscillations of submicroscopic Plasmodium falciparum and Plasmodium vivax infections over time in Vietnam: an open cohort study 14
Incidence, aetiology, and sequelae of viral meningitis in UK adults: a multicentre prospective observational cohort study 14
Characterisation of infectious Ebola virus from the ongoing outbreak to guide response activities in the Democratic Republic of the Congo: a phylogenetic and in vitro analysis 14
Antimalarial activity of single-dose DSM a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study 14
Solithromycin versus ceftriaxone plus azithromycin for the treatment of uncomplicated genital gonorrhoea (SOLITAIRE-U): a randomised phase 3 non-inferiority trial 14
Global burden of melioidosis in 2015: a systematic review and data synthesis 14
Use of ribaxamase (SYN-004), a beta-lactamase, to prevent Clostridium difficile infection in beta-lactam-treated patients: a double-blind, phase 2b, randomised placebo-controlled trial 14
Tuberculosis susceptibility and protection in children 14
Prevalence of drug-resistant tuberculosis and imputed burden in South Africa: a national and sub-national cross-sectional survey 13
Emergence of dominant toxigenic M1T1 Streptococcus pyogenes clone during increased scarlet fever activity in England: a population-based molecular epidemiological study 13
Single-dose versus 7-day-dose metronidazole for the treatment of trichomoniasis in women: an open-label, randomised controlled trial 13
Assessment of non-prescription antibiotic dispensing at community pharmacies in China with simulated clients: a mixed cross-sectional and longitudinal study 13
Sustained transmission of high-level azithromycin-resistant Neisseria gonorrhoeae in England: an observational study 13
Treatment and secondary prophylaxis with ethanol lock therapy for central line-associated bloodstream infection in paediatric cancer: a randomised, double-blind, controlled trial 13
Cervical determinants of anal HPV infection and high-grade anal lesions in women: a collaborative pooled analysis 13
Resurgence of scarlet fever in China: a 13-year population-based surveillance study 13
Effect of Plasmodium falciparum sulfadoxine-pyrimethamine resistance on the effectiveness of intermittent preventive therapy for malaria in pregnancy in Africa: a systematic review and meta-analysis 13
Safety and immunogenicity of the chlamydia vaccine candidate CTH522 adjuvanted with CAF01 liposomes or aluminium hydroxide: a first-in-human, randomised, double-blind, placebo-controlled, phase 1 trial 13
Schistosomiasis in the first 1000 days 12
PERISCOPE: road towards effective control of pertussis 12
Once-daily oral omadacycline versus twice-daily oral linezolid for acute bacterial skin and skin structure infections (OASIS-2): a phase double-blind, multicentre, randomised, controlled, non-inferiority trial 12
Tenofovir 1% vaginal gel for prevention of HIV-1 infection in women in South Africa (FACTS-001): a phase randomised, double-blind, placebo-controlled trial 12
Immunogenicity and safety of one versus two doses of tetravalent dengue vaccine in healthy children aged 2-17 years in Asia and Latin America: 18-month interim data from a phase randomised, placebo-controlled study 12
CAL a novel antitoxin liposomal agent, in severe pneumococcal pneumonia: a first-in-human, double-blind, placebo-controlled, randomised trial 12
Improving the estimation of the global burden of antimicrobial resistant infections 12
Continuous low-dose antibiotic prophylaxis for adults with repeated urinary tract infections (AnTIC): a randomised, open-label trial 12
Safety and immunogenicity of Pfs25H-EPA/Alhydrogel, a transmission-blocking vaccine against Plasmodium falciparum: a randomised, double-blind, comparator-controlled, dose-escalation study in healthy Malian adults 12
Incidence of paediatric pneumococcal meningitis and emergence of new serotypes: a time-series analysis of a 16-year French national survey 12
An international outbreak of Salmonella enterica serotype Enteritidis linked to eggs from Poland: a microbiological and epidemiological study 12
Safety and immunogenicity of a pentavalent meningococcal conjugate vaccine containing serogroups A, C, Y, W, and X in healthy adults: a phase single-centre, double-blind, randomised, controlled study 12
Clinical utility of existing and second-generation interferon-gamma release assays for diagnostic evaluation of tuberculosis: an observational cohort study 11
Interventions to improve oral vaccine performance: a systematic review and meta-analysis 11
Transmission of drug-resistant tuberculosis in HIV-endemic settings 11
Chlamydia trachomatis and the risk of spontaneous preterm birth, babies who are born small for gestational age, and stillbirth: a population-based cohort study 11
Immunogenicity and safety of the multicomponent meningococcal B vaccine (4CMenB) in children and adolescents: a systematic review and meta-analysis 11
Maternal pertussis vaccination and its effects on the immune response of infants aged up to 12 months in the Netherlands: an open-label, parallel, randomised controlled trial 11
Cost-effectiveness of pre-exposure prophylaxis for HIV prevention in men who have sex with men in the UK: a modelling study and health economic evaluation 11
Predictors of mortality in patients with yellow fever: an observational cohort study 11
Comparative efficacy of treatments for Clostridium difficile infection: a systematic review and network meta-analysis 11
Safety and mosquitocidal efficacy of high-dose ivermectin when co-administered with dihydroartemisinin-piperaquine in Kenyan adults with uncomplicated malaria (IVERMAL): a randomised, double-blind, placebo-controlled trial 11
Active and passive case-finding in tuberculosis-affected households in Peru: a 10-year prospective cohort study 11
Group B streptococcal disease in UK and Irish infants younger than 90 days, 2014-15: a prospective surveillance study 11
Cerebral tryptophan metabolism and outcome of tuberculous meningitis: an observational cohort study 11
Long-term immunity against yellow fever in children vaccinated during infancy: a longitudinal cohort study 11
The potential effect of improved provision of rabies post-exposure prophylaxis in Gavi-eligible countries: a modelling study 10
Strategies to improve detection and management of human parechovirus infection in young infants 10
Internal migration and transmission dynamics of tuberculosis in Shanghai, China: an epidemiological, spatial, genomic analysis 10
Progression from latent infection to active disease in dynamic tuberculosis transmission models: a systematic review of the validity of modelling assumptions 10
Safety and immunogenicity of a vaccine for extra-intestinal pathogenic Escherichia coli (ESTELLA): a phase 2 randomised controlled trial 10
Cadazolid for the treatment of Clostridium difficile infection: results of two double-blind, placebo-controlled, non-inferiority, randomised phase 3 trials 10
Drug susceptibility testing and mortality in patients treated for tuberculosis in high-burden countries: a multicentre cohort study 10
Typhoid conjugate vaccines: a new tool in the fight against antimicrobial resistance 10
Effectiveness of targeted enhanced terminal room disinfection on hospital-wide acquisition and infection with multidrug-resistant organisms and Clostridium difficile: a secondary analysis of a multicentre cluster randomised controlled trial with crossover design (BETR Disinfection) 10
Risk of sudden unexplained death after use of dihydroartemisinin-piperaquine for malaria: a systematic review and Bayesian meta-analysis 10
Infectious causes of microcephaly: epidemiology, pathogenesis, diagnosis, and management 10
Determinants of antibody persistence across doses and continents after single-dose rVSV-ZEBOV vaccination for Ebola virus disease: an observational cohort study 9
Aetiology of invasive bacterial infection and antimicrobial resistance in neonates in sub-Saharan Africa: a systematic review and meta-analysis in line with the STROBE-NI reporting guidelines 9
The effects of antibiotic cycling and mixing on antibiotic resistance in intensive care units: a cluster-randomised crossover trial 9
Unexpected outbreaks of arbovirus infections: lessons learned from the Pacific and tropical America 9
A protracted mumps outbreak in Western Australia despite high vaccine coverage: a population-based surveillance study 9
The UK's pandemic influenza research portfolio: a model for future research on emerging infections 9
Prevalence of infection among asymptomatic and paucisymptomatic contact persons exposed to Ebola virus in Guinea: a retrospective, cross-sectional observational study 9
A governance framework for development and assessment of national action plans on antimicrobial resistance 9
Tracking spending on malaria by source in 106 countries, 2000-16: an economic modelling study 9
Long-term incidence of severe malaria following RTS, S/AS01 vaccination in children and infants in Africa: an open-label 3-year extension study of a phase 3 randomised controlled trial 9
Risk of Plasmodium vivax parasitaemia after Plasmodium falciparum infection: a systematic review and meta-analysis 8
Lassa virus circulating in Liberia: a retrospective genomic characterisation 8
Epidemic preparedness: why is there a need to accelerate the development of diagnostics? 8
Unanswered questions about the 1918 influenza pandemic: origin, pathology, and the virus itself 8
Comparative pathogenesis of rabies in bats and carnivores, and implications for spillover to humans 8
Persistence of Ebola virus after the end of widespread transmission in Liberia: an outbreak report 8
Efficacy of a single-dose regimen of inactivated whole-cell oral cholera vaccine: results from 2 years of follow-up of a randomised trial 8
Immunogenicity, effectiveness, and safety of measles vaccination in infants younger than 9 months: a systematic review and meta-analysis 8
Chloroquine as weekly chemoprophylaxis or intermittent treatment to prevent malaria in pregnancy in Malawi: a randomised controlled trial 8
Protection against varicella with two doses of combined measles-mumps-rubella-varicella vaccine or one dose of monovalent varicella vaccine: 10-year follow-up of a phase 3 multicentre, observer-blind, randomised, controlled trial 7
Targeted point-of-care testing compared with syndromic management of urogenital infections in women (WISH): a cross-sectional screening and diagnostic accuracy study 7
Association between urinary community-acquired fluoroquinolone-resistant Escherichia coli and neighbourhood antibiotic consumption: a population-based case-control study 7
Treatment of uncomplicated and severe malaria during pregnancy 7