| G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs? |
106 |
| Insights into Doxorubicin-induced Cardiotoxicity: Molecular Mechanisms, Preventive Strategies, and Early Monitoring |
21 |
| cAMP Signaling Compartmentation: Adenylyl Cyclases as Anchors of Dynamic Signaling Complexes |
19 |
| A Biased View of mu-Opioid Receptors? |
19 |
| Biased Agonism in Drug Discovery-Is It Too Soon to Choose a Path? |
18 |
| Ionotropic and Metabotropic Mechanisms of Allosteric Modulation of alpha 7 Nicotinic Receptor Intracellular Calcium |
14 |
| Organic Anion Transporting Polypeptides: Emerging Roles in Cancer Pharmacology |
13 |
| Long Noncoding RNA LINC00657 Acting as a miR-590-3p Sponge to Facilitate Low Concentration Oxidized Low-Density Lipoprotein-Induced Angiogenesis |
13 |
| Effects of Farnesoid X Receptor Activation on Arachidonic Acid Metabolism, NF-kappa B Signaling, and Hepatic Inflammation |
13 |
| Modulators of CXCR4 and CXCR7/ACKR3 Function |
13 |
| Correctors of the Major Cystic Fibrosis Mutant Interact through Membrane-Spanning Domains |
11 |
| ORKAMBI-Mediated Rescue of Mucociliary Clearance in Cystic Fibrosis Primary Respiratory Cultures Is Enhanced by Arginine Uptake, Arginase Inhibition, and Promotion of Nitric Oxide Signaling to the Cystic Fibrosis Transmembrane Conductance Regulator Channel |
11 |
| Is the Quest for Signaling Bias Worth the Effort? |
11 |
| MiR-144 Inhibits Tumor Growth and Metastasis in Osteosarcoma via Dual-suppressing RhoA/ROCK1 Signaling Pathway |
11 |
| Assessment of Substrate-Dependent Ligand Interactions at the Organic Cation Transporter OCT2 Using Six Model Substrates |
11 |
| PI3K/Akt/mTOR Signaling Pathway and the Biphasic Effect of Arsenic in Carcinogenesis |
11 |
| Small-Molecule Positive Allosteric Modulators of the beta(2)-Adrenoceptor Isolated from DNA-Encoded Libraries |
10 |
| Context-Dependent Signaling of CXC Chemokine Receptor 4 and Atypical Chemokine Receptor 3 |
10 |
| Structural Basis of p97 Inhibition by the Site-Selective Anticancer Compound CB-5083 |
10 |
| Gabapentin Is a Potent Activator of KCNQ3 and KCNQ5 Potassium Channels |
10 |
| Slowly Signaling G Protein-Biased CB2 Cannabinoid Receptor Agonist LY2828360 Suppresses Neuropathic Pain with Sustained Efficacy and Attenuates Morphine Tolerance and Dependence |
10 |
| N-Acyl Amino Acids (Elmiric Acids): Endogenous Signaling Molecules with Therapeutic Potential |
9 |
| Probing the Mechanism of Receptor Activity-Modifying Protein Modulation of GPCR Ligand Selectivity through Rational Design of Potent Adrenomedullin and Calcitonin Gene-Related Peptide Antagonists |
9 |
| A Transcriptional Regulatory Network Containing Nuclear Receptors and Long Noncoding RNAs Controls Basal and Drug-Induced Expression of Cytochrome P450s in HepaRG Cells |
9 |
| Ginsenosides Act As Positive Modulators of P2X4 Receptors |
9 |
| Gedunin- and Khivorin-Derivatives Are Small-Molecule Partial Agonists for Adhesion G Protein-Coupled Receptors GPR56/ADGRG1 and GPR114/ADGRG5 |
9 |
| Inhibition of the Warm Temperature-Activated Ca2+-Permeable Transient Receptor Potential Vanilloid TRPV3 Channel Attenuates Atopic Dermatitis |
8 |
| Human GPRC6A Mediates Testosterone-Induced Mitogen-Activated Protein Kinases and mTORC1 Signaling in Prostate Cancer Cells |
8 |
| Allosteric Agonism of alpha 7 Nicotinic Acetylcholine Receptors: Receptor Modulation Outside the Orthosteric Site |
8 |
| Identification of Global and Ligand-Specific Calcium Sensing Receptor Activation Mechanisms |
7 |
| Bitopic Binding Mode of an M-1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes |
7 |
| Blockade of the Human Ether A-Go-Go-Related Gene (hERG) Potassium Channel by Fentanyl |
7 |
| Antipruritic Effect of Natural Coumarin Osthole through Selective Inhibition of Thermosensitive TRPV3 Channel in the Skin |
7 |
| The Role of Heat Shock Proteins in Regulating Receptor Signal Transduction |
7 |
| Repeated Exposure to 4-Methyl-4-bis(4-hydroxyphenyl)pent-1-ene (MBP), an Active Metabolite of Bisphenol A, Aggressively Stimulates Breast Cancer Cell Growth in an Estrogen Receptor beta (ER beta)-Dependent Manner |
7 |
| Calcium-Sensing Receptor Internalization Is beta-Arrestin-Dependent and Modulated by Allosteric Ligands |
7 |
| Mechanistic Insights of Phenobarbital-Mediated Activation of Human but Not Mouse Pregnane X Receptor |
7 |
| Differential Effects of Integrin alpha v Knockdown and Cilengitide on Sensitization of Triple-Negative Breast Cancer and Melanoma Cells to Microtubule Poisons |
7 |
| Lipophilicity of the Cystic Fibrosis Drug, Ivacaftor (VX-770), and Its Destabilizing Effect on the Major CF-causing Mutation: F508del |
7 |
| Molecular Mechanisms for Species Differences in Organic Anion Transporter OAT1: Implications for Renal Drug Toxicity |
7 |
| Cannabidiol Inhibits Endocannabinoid Signaling in Autaptic Hippocampal Neurons |
7 |
| Restoration of Physiological Expression of 5-HT6 Receptor into the Primary Cilia of Null Mutant Neurons Lengthens Both Primary Cilia and Dendrites |
7 |
| Efficient High-Throughput Screening by Endoplasmic Reticulum Ca2+ Measurement to Identify Inhibitors of Ryanodine Receptor Ca2+-Release Channels |
7 |
| Pharmacological, Mechanistic, and Pharmacokinetic Assessment of Novel Melatonin-Tamoxifen Drug Conjugates as Breast Cancer Drugs |
7 |
| Cannabinoid CB2 Agonist AM1710 Differentially Suppresses Distinct Pathological Pain States and Attenuates Morphine Tolerance and Withdrawal |
7 |
| The Zinc Transporter SLC39A7 (ZIP7) Is Essential for Regulation of Cytosolic Zinc Levels |
6 |
| Identification of MRP4/ABCC4 as a Target for Reducing the Proliferation of Pancreatic Ductal Adenocarcinoma Cells by Modulating the cAMP Efflux |
6 |
| Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992 |
6 |
| Homogeneous, Real-Time NanoBRET Binding Assays for the Histamine H-3 and H-4 Receptors on Living Cells |
6 |
| Regulation of an Opioid Receptor Chaperone Protein, RTP by Morphine |
6 |
