Molecular Systems Biology

Molecular Systems Biology

分子系统生物学

  • 1区 中科院分区
  • Q1 JCR分区

高引用文章

文章名称 引用次数
Current best practices in single-cell RNA-seq analysis: a tutorial 112
Data-independent acquisition-based SWATH-MS for quantitative proteomics: a tutorial 99
Multi-Omics Factor Analysis-a framework for unsupervised integration of multi-omics data sets 62
A deep proteome and transcriptome abundance atlas of 29 healthy human tissues 61
Deciphering microbial interactions in synthetic human gut microbiome communities 36
Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease 30
Mapping the O-glycoproteome using site-specific extraction of O-linked glycopeptides (EXoO) 27
Thermal proteome profiling in bacteria: probing protein state in vivo 25
Integrative multi-omics analysis of intestinal organoid differentiation 24
Defining the RNA interactome by total RNA-associated protein purification 22
An integrated workflow for crosslinking mass spectrometry 20
Using single-cell genomics to understand developmental processes and cell fate decisions 18
Complex-centric proteome profiling by SEC-SWATH-MS 18
Unraveling the hidden universe of small proteins in bacterial genomes 16
Dynamic control of endogenous metabolism with combinatorial logic circuits 16
Forces driving the three-dimensional folding of eukaryotic genomes 15
Comprehensive innate immune profiling of chikungunya virus infection in pediatric cases 15
Fibroblast state switching orchestrates dermal maturation and wound healing 15
Tuning dCas9's ability to block transcription enables robust, noiseless knockdown of bacterial genes 14
Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors 13
Absolute quantification of translational regulation and burden using combined sequencing approaches 12
High-throughput discovery of functional disordered regions: investigation of transactivation domains 12
Wave patterns organize cellular protrusions and control cortical dynamics 12
Molecular transitions in early progenitors during human cord blood hematopoiesis 12
Genomewide phenotypic analysis of growth, cell morphogenesis, and cell cycle events in Escherichia coli 12
Multiplex transcriptional characterizations across diverse bacterial species using cell-free systems 12
A conserved mechanism drives partition complex assembly on bacterial chromosomes and plasmids 11
R2-P2 rapid-robotic phosphoproteomics enables multidimensional cell signaling studies 11
Widespread inter-individual gene expression variability in Arabidopsis thaliana 10
Characterizing meiotic chromosomes' structure and pairing using a designer sequence optimized for Hi-C 10
Endogenous fluctuations of OCT4 and SOX2 bias pluripotent cell fate decisions 10
Enzyme promiscuity shapes adaptation to novel growth substrates 10
INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases 10
Large-scale image-based profiling of single-cell phenotypes in arrayed CRISPR-Cas9 gene perturbation screens 10
Evidence that the human cell cycle is a series of uncoupled, memoryless phases 10
De novo gene signature identification from single-cell RNA-seq with hierarchical Poisson factorization 10
Bicoid gradient formation mechanism and dynamics revealed by protein lifetime analysis 10
Quantification and discovery of sequence determinants of protein-per-mRNA amount in 29 human tissues 9
Synthesis and degradation of FtsZ quantitatively predict the first cell division in starved bacteria 9
Deep scanning lysine metabolism in Escherichia coli 9
High-resolution mapping of cancer cell networks using co-functional interactions 9
A resource of variant effect predictions of single nucleotide variants in model organisms 9
Estrogen-dependent control and cell-to-cell variability of transcriptional bursting 9
netDx: interpretable patient classification using integrated patient similarity networks 9
Systematic characterization of pan-cancer mutation clusters 8
Proteome-wide analysis of phospho-regulated PDZ domain interactions 7
Identification of an oncogenic network with prognostic and therapeutic value in prostate cancer 7
Metabolic oscillations on the circadian time scale in Drosophila cells lacking clock genes 7
Toward an integrated map of genetic interactions in cancer cells 7
Combinatorial prediction of marker panels from single-cell transcriptomic data 6