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Targeting inflammatory macrophages rebuilds therapeutic efficacy of DOT1L inhibition in hepatocellular carcinoma
Author: Yang, Yi-Bin; Wu, Cai-Yuan; Wang, Xu-Yan; Deng, Jia; Cao, Wen-Jie; Tang, Yun-Zhi; Wan, Chao-Chao; Chen, Zhi-Tian; Zhan, Wan-Yu; Shan, Hong; Kuang, Dong-Ming; Wei, Yuan
Journal: MOLECULAR THERAPY. 2023; Vol. 31, Issue 1, pp. 105-118. DOI: 10.1016/j.ymthe.2022.09.019
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NLRC3 expression in macrophage impairs glycolysis and host immune defense by modulating the NF-KB-NFAT5 complex during septic immunosuppression
Author: Xu, Jiqian; Gao, Chenggang; He, Yajun; Fang, Xiangzhi; Sun, Deyi; Peng, Zhekang; Xiao, Hairong; Sun, Miaomiao; Zhang, Pei; Zhou, Ting; Yang, Xiaobo; Yu, Yuan; Li, Ruiting; Zou, Xiaojing; Shu, Huaqing; Qiu, Yang; Zhou, Xi; Yuan, Shiying; Yao, Shanglong; Shang, You
Journal: MOLECULAR THERAPY. 2023; Vol. 31, Issue 1, pp. 154-173. DOI: 10.1016/j.ymthe.2022.08.023
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MAP7D2 reduces CD8+cytotoxic T lymphocyte infiltration through MYH9-HMGB1 axis in colorectal cancer
Author: Wu, Qian; Yue, Xiao; Liu, Huashan; Zhu, Yaxi; Ke, Haoxian; Yang, Xin; Yin, Shi; Li, Zhihao; Zhang, Yunfeng; Hu, Tuo; Lan, Ping; Wu, Xianrui
Journal: MOLECULAR THERAPY. 2023; Vol. 31, Issue 1, pp. 90-104. DOI: 10.1016/j.ymthe.2022.09.001
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CXCL11-armed oncolytic adenoviruses enhance CAR-T cell therapeutic efficacy and reprogram tumor microenvironment in glioblastoma
Author: Wang, Guoqing; Zhang, Zongliang; Zhong, Kunhong; Wang, Zeng; Yang, Nian; Tang, Xin; Li, Hexian; Lu, Qizhong; Wu, Zhiguo; Yuan, Boyang; Zheng, Meijun; Cheng, Ping; Tong, Aiping; Zhou, Liangxue
Journal: MOLECULAR THERAPY. 2023; Vol. 31, Issue 1, pp. 134-153. DOI: 10.1016/j.ymthe.2022.08.021
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A novel anti-PD-L1/IL-15 immunocytokine overcomes resistance to PD-L1 blockade and elicits potent antitumor immunity
Author: Shi, Wenqiang; Lv, Liangyin; Liu, Nan; Wang, Hui; Wang, Yang; Zhu, Wen; Liu, Zexin; Zhu, Jianwei; Lu, Huili
Journal: MOLECULAR THERAPY. 2023; Vol. 31, Issue 1, pp. 66-77. DOI: 10.1016/j.ymthe.2022.08.016
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Fibrotic immune microenvironment remodeling mediates superior anti-tumor efficacy of a nano-PD-L1 trap in hepatocellular carcinoma
Author: Liu, Xiaoyu; Zhou, Jingying; Wu, Haoran; Chen, Shufen; Zhang, Lingyun; Tang, Wenshu; Duan, Liang; Wang, Ying; McCabe, Eleanor; Hu, Mengying; Yu, Zhuo; Liu, Hanzhuang; Choi, Chung Hang Jonathan; Sung, Joseph Jao-yiu; Huang, Leaf; Liu, Rihe; Cheng, Alfred Sze-lok
Journal: MOLECULAR THERAPY. 2023; Vol. 31, Issue 1, pp. 119-133. DOI: 10.1016/j.ymthe.2022.09.012
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NAMPT is a metabolic checkpoint of IFNy-producing CD4+T cells in lupus nephritis
Author: Li, Mengyuan; Lai, Yimei; Chen, Binfeng; Guo, Chaohuan; Zhou, Mianjing; Zhao, Siyuan; Wang, Shuyi; Li, Jin; Yang, Niansheng; Zhang, Hui
Journal: MOLECULAR THERAPY. 2023; Vol. 31, Issue 1, pp. 193-210. DOI: 10.1016/j.ymthe.2022.09.013
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PD-1/PD-L1 blockade is a potent adjuvant in treatment of Staphylococcus aureus osteomyelitis in mice
Author: Li, Kaiqun; Chen, Yuhui; Lin, Yihuang; Zhang, Guangyan; Su, Jianwen; Wu, Xiaohu; Cheng, Caiyu; Wang, Yutian; Yu, Bin; Zhang, Xianrong
Journal: MOLECULAR THERAPY. 2023; Vol. 31, Issue 1, pp. 174-192. DOI: 10.1016/j.ymthe.2022.09.006
