| DeepLabCut: markerless pose estimation of user-defined body parts with deep learning |
168 |
| Mitophagy inhibits amyloid-beta and tau pathology and reverses cognitive deficits in models of Alzheimer's disease |
162 |
| Microglia in neurodegeneration |
146 |
| Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions |
144 |
| Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes |
102 |
| The role of brain vasculature in neurodegenerative disorders |
102 |
| Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases |
102 |
| A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer's disease |
87 |
| A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment |
86 |
| Senolytic therapy alleviates A beta-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model |
84 |
| What does dopamine mean? |
76 |
| Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning |
73 |
| CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature |
68 |
| Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry |
68 |
| Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders |
66 |
| Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE |
65 |
| Studying and modifying brain function with non-invasive brain stimulation |
64 |
| Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion |
62 |
| Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex |
61 |
| Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases |
61 |
| Epigenetic regulation of brain region-specific microglia clearance activity |
60 |
| Cerebral organoids at the air-liquid interface generate diverse nerve tracts with functional output |
60 |
| Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex |
59 |
| Animal models of neurodegenerative diseases |
58 |
| Selective vulnerability in neurodegenerative diseases |
58 |
| Thermal constraints on in vivo optogenetic manipulations |
58 |
| Single-trial neural dynamics are dominated by richly varied movements |
57 |
| GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia |
57 |
| Converging pathways in neurodegeneration, from genetics to mechanisms |
56 |
| TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD |
55 |
| The diversity and disparity of the glial scar |
54 |
| Astrocyte function from information processing to cognition and cognitive impairment |
54 |
| A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer's disease |
52 |
| Mechanisms of systems memory consolidation during sleep |
52 |
| Working memory revived in older adults by synchronizing rhythmic brain circuits |
50 |
| Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis |
49 |
| Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models |
49 |
| Tau impairs neural circuits, dominating amyloid-beta effects, in Alzheimer models in vivo |
48 |
| Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures |
46 |
| Functional boundaries in the human cerebellum revealed by a multi-domain task battery |
45 |
| Hierarchy of transcriptomic specialization across human cortex captured by structural neuroimaging topography |
45 |
| Volitional social interaction prevents drug addiction in rat models |
44 |
| Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39 |
44 |
| Mapping microglia states in the human brain through the integration of high-dimensional techniques |
43 |
| Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration |
43 |
| Lifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain |
43 |
| Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons |
43 |
| Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer's disease mouse models |
42 |
| Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull-meninges connections |
42 |
| A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation |
41 |
| Spread of alpha-synuclein pathology through the brain connectome is modulated by selective vulnerability and predicted by network analysis |
41 |
| ALS-implicated protein TDP-43 sustains levels of STMN a mediator of motor neuron growth and repair |
41 |
| Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types |
40 |
| Maternal IL-6 during pregnancy can be estimated from newborn brain connectivity and predicts future working memory in offspring |
40 |
| N-6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications |
40 |
| Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling |
39 |
| Central nervous system regeneration is driven by microglia necroptosis and repopulation |
39 |
| Human cognition involves the dynamic integration of neural activity and neuromodulatory systems |
39 |
| Classification of electrophysiological and morphological neuron types in the mouse visual cortex |
38 |
| Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood-brain barrier dysfunction module |
38 |
| An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations |
38 |
| Prefrontal cortex as a meta-reinforcement learning system |
38 |
| Dopamine neurons projecting to the posterior striatum reinforce avoidance of threatening stimuli |
38 |
| Single-cell transcriptomic profiling of the aging mouse brain |
38 |
| Studying individual differences in human adolescent brain development |
37 |
| Conserved properties of dentate gyrus neurogenesis across postnatal development revealed by single-cell RNA sequencing |
37 |
| Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals |
35 |
| Investigating large-scale brain dynamics using field potential recordings: analysis and interpretation |
35 |
| Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss |
35 |
| Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex |
34 |
| Synaptic nanomodules underlie the organization and plasticity of spine synapses |
34 |
| Circuit dissection of the role of somatostatin in itch and pain |
34 |
| Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy |
34 |
| Promises and limitations of human intracranial electroencephalography |
33 |
| Dopamine neurons create Pavlovian conditioned stimuli with circuit-defined motivational properties |
33 |
| Common brain disorders are associated with heritable patterns of apparent aging of the brain |
33 |
| A deep learning framework for neuroscience |
33 |
| Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration |
33 |
| Flexible timing by temporal scaling of cortical responses |
32 |
| Mapping projections of molecularly defined dopamine neuron subtypes using intersectional genetic approaches |
32 |
| Somatic mosaicism and neurodevelopmental disease |
32 |
| Memory formation depends on both synapse-specific modifications of synaptic strength and cell-specific increases in excitability |
32 |
| CA1 pyramidal cell diversity enabling parallel information processing in the hippocampus |
31 |
| A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment |
31 |
| Temporal evolution of cortical ensembles promoting remote memory retrieval |
31 |
| A three-dimensional single-cell-resolution whole-brain atlas using CUBIC-X expansion microscopy and tissue clearing |
31 |
| TREM2 function impedes tau seeding in neuritic plaques |
31 |
| Evidence that recurrent circuits are critical to the ventral stream's execution of core object recognition behavior |
31 |
| Integration of gene expression and brain-wide connectivity reveals the multiscale organization of mouse hippocampal networks |
30 |
| Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury |
30 |
| In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR-dCas9-activator transgenic mice |
30 |
| Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism |
30 |
| Generalizable representations of pain, cognitive control, and negative emotion in medial frontal cortex |
30 |
| Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response |
30 |
| Imbalance between firing homeostasis and synaptic plasticity drives early-phase Alzheimer's disease |
29 |
| Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type |
29 |
| Predictive and reactive reward signals conveyed by climbing fiber inputs to cerebellar Purkinje cells |
28 |
| Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes |
28 |
| Active control of arousal by a locus coeruleus GABAergic circuit |
28 |
| Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease |
28 |
| Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states |
28 |
| Aversive state processing in the posterior insular cortex |
28 |
| Striatal neurons directly converted from Huntington's disease patient fibroblasts recapitulate age-associated disease phenotypes |
28 |
| Stem-cell-derived human microglia transplanted in mouse brain to study human disease |
28 |
| A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology |
28 |
| GABA and glutamate neurons in the VTA regulate sleep and wakefulness |
27 |
| TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates |
27 |
| Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity |
27 |
| TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD |
27 |
| Nontoxic, double-deletion-mutant rabies viral vectors for retrograde targeting of projection neurons |
27 |
| Cognitive computational neuroscience |
27 |
| Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling |
27 |
| Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo |
26 |
| Advancing functional connectivity research from association to causation |
26 |
| Genetic manipulation of autonomic nerve fiber innervation and activity and its effect on breast cancer progression |
26 |
| Distinct learning-induced changes in stimulus selectivity and interactions of GABAergic interneuron classes in visual cortex |
26 |
| Inhibitory circuit gating of auditory critical-period plasticity |
26 |
| Single-nucleus analysis of accessible chromatin in developing mouse forebrain reveals cell-type-specific transcriptional regulation |
25 |
| Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer's human brains |
25 |
| In vivo neuronal gene editing via CRISPR-Cas9 amphiphilic nanocomplexes alleviates deficits in mouse models of Alzheimer's disease |
25 |
| SHANK2 mutations associated with autism spectrum disorder cause hyperconnectivity of human neurons |
25 |
| Single-cell transcriptomic analysis of the lateral hypothalamic area reveals molecularly distinct populations of inhibitory and excitatory neurons |
25 |
| Synaptotagmin-1 drives synchronous Ca2+-triggered fusion by C2B-domain-mediated synaptic-vesicle-membrane attachment |
25 |
| Distinct hippocampal engrams control extinction and relapse of fear memory |
25 |
| Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies |
25 |
| C9ORF72-ALS/FTD-associated poly(GR) binds Atp5a1 and compromises mitochondrial function in vivo |
25 |
| Targeting neuronal and glial cell types with synthetic promoter AAVs in mice, non-human primates and humans |
25 |
| Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice |
25 |
| Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration |
24 |
| Synaptic weight set by Munc13-1 supramolecular assemblies |
24 |
| Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury |
24 |
| Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice |
24 |
| Microglial immune checkpoint mechanisms |
24 |
| Cortical specialization for attended versus unattended working memory |
24 |
| Integrating new findings and examining clinical applications of pattern separation |
24 |
| Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in > 000 US veterans |
23 |
| Insular cortex mediates approach and avoidance responses to social affective stimuli |
23 |
| Widespread RNA editing dysregulation in brains from autistic individuals |
23 |
| Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a |
23 |
| The maternal vaginal microbiome partially mediates the effects of prenatal stress on offspring gut and hypothalamus |
23 |
| Encoding of error and learning to correct that error by the Purkinje cells of the cerebellum |
23 |
| Prioritized memory access explains planning and hippocampal replay |
22 |
| Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development |
22 |
| Cortico-reticulo-spinal circuit reorganization enables functional recovery after severe spinal cord contusion |
22 |
| Loss of nuclear UBE3A causes electrophysiological and behavioral deficits in mice and is associated with Angelman syndrome |
22 |
| Impaired perceptual learning in a mouse model of Fragile X syndrome is mediated by parvalbumin neuron dysfunction and is reversible |
22 |
| Coordinated cerebellar climbing fiber activity signals learned sensorimotor predictions |
22 |
| Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia |
22 |
| Principles governing the integration of landmark and self-motion cues in entorhinal cortical codes for navigation |
22 |
| Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC encoding a heat-shock protein |
22 |
| CRISPR interference-based specific and efficient gene inactivation in the brain |
22 |
| Rapid, biphasic CRF neuronal responses encode positive and negative valence |
21 |
| Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo |
21 |
| Ca2+ activity signatures of myelin sheath formation and growth in vivo |
21 |
| Thalamic regulation of switching between cortical representations enables cognitive flexibility |
21 |
| An interactive framework for whole-brain maps at cellular resolution |
21 |
| Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition |
21 |
| Coexisting representations of sensory and mnemonic information in human visual cortex |
21 |
| Perceptual bias reveals slow-updating in autism and fast-forgetting in dyslexia |
21 |
| Task representations in neural networks trained to perform many cognitive tasks |
21 |
| Characterization of human mosaic Rett syndrome brain tissue by single-nucleus RNA sequencing |
20 |
| Altered responses to social chemosignals in autism spectrum disorder |
20 |
| Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations |
20 |
| Precise multimodal optical control of neural ensemble activity |
20 |
| Triple dissociation of attention and decision computations across prefrontal cortex |
20 |
| A hypothalamic circuit for the circadian control of aggression |
20 |
| Neuronal brain-region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric trait heritability |
20 |
| The next generation of approaches to investigate the link between synaptic plasticity and learning |
20 |
| A neuronal circuit for activating descending modulation of neuropathic pain |
20 |
| Social transmission and buffering of synaptic changes after stress |
19 |
| A neural circuit for comorbid depressive symptoms in chronic pain |
19 |
| A repeated molecular architecture across thalamic pathways |
19 |
| T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses |
19 |
| Synaptic N-6-methyladenosine (m(6)A) epitranscriptome reveals functional partitioning of localized transcripts |
19 |
| Thalamic dual control of sleep and wakefulness |
19 |
| Compulsivity and impulsivity traits linked to attenuated developmental frontostriatal myelination trajectories |
19 |
| Dorsal tegmental dopamine neurons gate associative learning of fear |
18 |
| Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model |
18 |
| The timing of action determines reward prediction signals in identified midbrain dopamine neurons |
18 |
| The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning |
18 |
| Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation |
18 |
| PKC alpha integrates spatiotemporally distinct Ca2+ and autocrine BDNF signaling to facilitate synaptic plasticity |
18 |
| Locomotion-dependent remapping of distributed cortical networks |
18 |
| Locomotor activity modulates associative learning in mouse cerebellum |
18 |
| Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear |
18 |
| The intrinsic attractor manifold and population dynamics of a canonical cognitive circuit across waking and sleep |
17 |
| Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants |
17 |
| Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1-SOX2 positive-feedback loop |
17 |
| The neurobiological foundation of memory retrieval |
17 |
| Neuromodulation in circuits of aversive emotional learning |
17 |
| Impaired path integration in mice with disrupted grid cell firing |
17 |
| Circuit mechanisms for the maintenance and manipulation of information in working memory |
17 |
| Genome-wide association study implicates CHRNA2 in cannabis use disorder |
16 |
| Accumbal D2 cells orchestrate innate risk-avoidance according to orexin signals |
16 |
| The macaque anterior cingulate cortex translates counterfactual choice value into actual behavioral change |
16 |
| Learning by neural reassociation |
16 |
| Feedback determines the structure of correlated variability in primary visual cortex |
16 |
| Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to promote hunting |
16 |
| Bidirectional and long-lasting control of alcohol-seeking behavior by corticostriatal LTP and LTD |
15 |
| Unsupervised identification of the internal states that shape natural behavior |
15 |
