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Condensate protein aggregation in ALS/FTD is regulated by GGGGCC-repeat RNA scaffold
Author: Liu, Yu; Song, Minghui; Wan, Liqi; Guo, Pei; Han, Da
Journal: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2026; Vol. 33, Issue 4, pp. -. DOI: 10.1038/s41594-026-01785-9
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The maternal PADI6-UHRF1-UBE2D complex regulates ubiquitination during oocyte maturation and embryogenesi
Author: Li, Jinhong; Lu, Yuechao; Xia, Zhili; Chi, Pengliang; Qi, Qianqian; Liu, Sibei; Ju, Sicheng; Li, Jialu; Zhang, Zihan; Han, Zhuo; Liu, Qingting; Meng, Wenbo; Chen, Jing; Wang, Xiang; Guo, Li; Li, Lei; Huang, Wei; Dai, Lunzhi; Han, Junhong; Gao, Shaorong; Deng, Dong
Journal: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2026; Vol. 33, Issue 3, pp. -. DOI: 10.1038/s41594-026-01758-y
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Improving the efficiency of high-fidelity Cas9 by enhancing PAM-distal interaction
Author: Zheng, Rong; Lu, Zhike; Wei, Rongwei; Shin, Young-Cheul; Du, Jiang; Zhang, Qingfeng; Li, Jianbo; Wang, Xiaoqi; Wei, Yi; Liu, Botao; Chen, Yang; Ding, Lihong; Zhang, Heng; Chen, Hui; Huang, Jing; Ma, Lijia
Journal: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2026; Vol. , Issue , pp. -. DOI: 10.1038/s41594-026-01753-3
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Structural insight into IscB's RNA-lid-based inactivation mechanis
Author: Wang, Feizuo; Guo, Ruochen; Zhang, Senfeng; Cui, Yinuo; Wang, Junlan; Hu, Tao; Liu, Kunming; Wang, Qi; Liu, Yao; Nam, Ki Hyun; Zhao, Ziqing Winston; Ji, Quanquan; Xu, Xin; Wang, Ercheng; Zhu, Youyuan; Yang, Yao; Luo, Min; Ma, Peixiang; Ma, Shengsheng; Xu, Chunlong; Hu, Chunyi
Journal: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2026; Vol. , Issue , pp. -. DOI: 10.1038/s41594-026-01761-3
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Interplay between cohesin and RNA polymerase II in regulating chromatin interactions and gene transcriptio
Author: Kim, Minji; Wang, Ping; Clow, Patricia A.; Chien, Eli; Wang, Xiaotao; Peng, Jianhao; Chai, Haoxi; Liu, Xiyuan; Lee, Byoungkoo; Ngan, Chew Yee; Milenkovic, Olgica; Chuang, Jeffrey H.; Wei, Chia-Lin; Casellas, Rafael; Cheng, Albert W.; Ruan, Yijun
Journal: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2026; Vol. , Issue , pp. -. DOI: 10.1038/s41594-025-01708-0
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An anti-CRISPR targets the sgRNA to block Cas9 and guides the design of enhanced genome editor
Author: Yu, Ling; Yin, Mingyu; Zhu, Yuwei; Lu, Zebin; Xiao, Bao; Zhou, Fengxia; Yu, Yue; Huang, Zhiwei
Journal: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2026; Vol. , Issue , pp. -. DOI: 10.1038/s41594-025-01741-z
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Distinct tau filament folds in human MAPT mutants P301L and P301
Author: Schweighauser, Manuel; Shi, Yang; Murzin, Alexey G.; Garringer, Holly J.; Vidal, Ruben; Murrell, Jill R.; Erro, M. Elena; Seelaar, Harro; Ferrer, Isidro; van Swieten, John C.; Ghetti, Bernardino; Scheres, Sjors H. W.; Goedert, Michel
Journal: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2025; Vol. , Issue , pp. -. DOI: 10.1038/s41594-025-01575-9
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Remote on-off switching of protein activity by intrinsically disordered regio
Author: Ji, Tuo; Ge, Piao; Zhang, Shan; Wan, Chanjuan; Liu, Hailong; Qu, Xiaozhan; Zhu, Feng; Gong, Qingguo; Xu, Weiya; Wang, Chao; Wang, Yucai; Huang, Chengdong
Journal: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2025; Vol. , Issue , pp. -. DOI: 10.1038/s41594-025-01585-7
