Nature Structural & Molecular Biology

Nature Structural & Molecular Biology

自然结构与分子生物学

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高引用文章

文章名称 引用次数
Structure and dynamics of GPCR signaling complexes 109
Structural basis for human coronavirus attachment to sialic acid receptors 98
RNA polymerase II clustering through carboxy-terminal domain phase separation 69
Atg2 mediates direct lipid transfer between membranes for autophagosome formation 66
Local translation in neurons: visualization and function 59
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites 58
Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors 50
Molecular interactions underlying liquid-liquid phase separation of the FUS low-complexity domain 45
Structural basis of small-molecule inhibition of human multidrug transporter ABCG2 43
Yeast surface display platform for rapid discovery of conformationally selective nanobodies 41
Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states 40
RPA and RAD51: fork reversal, fork protection, and genome stability 38
Phase separation of ligand-activated enhancers licenses cooperative chromosomal enhancer assembly 37
Tapping the RNA world for therapeutics 37
Nucleosome structure and dynamics are coming of age 36
Cross-linking mass spectrometry: methods and applications in structural, molecular and systems biology 36
Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms 34
Structural biology of Zika virus and other flaviviruses 33
A gel phase promotes condensation of liquid P granules in Caenorhabditis elegans embryos 32
Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation 30
RNA structure maps across mammalian cellular compartments 29
DNA G-quadruplex structures mold the DNA methylome 28
Structure and gating mechanism of the transient receptor potential channel TRPV3 27
Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation 27
Cryo-EM structures of four polymorphic TDP-43 amyloid cores 26
Structure of an endosomal signaling GPCR-G protein-beta-arrestin megacomplex 26
Structural transitions of F-actin upon ATP hydrolysis at near-atomic resolution revealed by cryo-EM 26
An anti-CRISPR protein disables type V Cas12a by acetylation 26
A novel class of microRNA-recognition elements that function only within open reading frames 26
Structural insights into the design of novel anti-influenza therapies 25
Cryo-EM structure of the human neutral amino acid transporter ASCT2 25
Cryo-EM structure of the mitochondrial protein-import channel TOM complex at near-atomic resolution 24
Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2 24
Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes 23
Structure of the core of the type III secretion system export apparatus 23
MLL2 conveys transcription-independent H3K4 trimethylation in oocytes 23
Broad-spectrum enzymatic inhibition of CRISPR-Cas12a 23
Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc 23
Structures of the 5-HT2A receptor in complex with the antipsychotics risperidone and zotepine 22
Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation 22
Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization 22
Genome-wide identification of mRNA 5-methylcytosine in mammals 22
GlcNAc-l-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation 21
The reactivity-driven biochemical mechanism of covalent KRAS(G12C) inhibitors 20
Bromodomain biology and drug discovery 20
Structures of fibrils formed by alpha-synuclein hereditary disease mutant H50Q reveal new polymorphs 20
Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers 20
Cryo-EM structure of the yeast respiratory supercomplex 20
Analyses of mRNA structure dynamics identify embryonic gene regulatory programs 19
Structural basis for the regulation of inositol trisphosphate receptors by Ca2+ and IP3 19