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High glucose impairs cognitive function through Creb3 O-GlcNAcylation and increased lactate productio
Author: Xu, Jingxi; Yang, Xing; Cao, Jingxue; Hao, Yuqi; Nie, Rongrong; Zhong, Qiongsui; Gao, Yun; Hui, Ya; Kuang, Liuyu; Zhong, Yuanmei; Mo, Biwen; Zeng, Xiaoyun; Zheng, Tianpeng
Journal: SCIENCE SIGNALING. 2026; Vol. 19, Issue 933, pp. -. DOI: 10.1126/scisignal.adx4313
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The protein RAB5IF promotes BDNF signaling by stimulating the SUMOylation of Gαi1/3 to reduce depressive-like behaviors in mic
Author: Shi, Xin; Liu, Han-qi; Cai, Shi-zhong; Shen, Yi-hang; Chai, Jin-long; Zhang, Mei-qing; Xu, Chen-yang; Zhang, Zhi-qing; Marshall, John; Cao, Cong
Journal: SCIENCE SIGNALING. 2026; Vol. 19, Issue 931, pp. -. DOI: 10.1126/scisignal.aec8898
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Redox regulation of the transcription factor HAT1 limits basal defenses and promotes responses to infection in Arabidopsis thalian
Author: Zhao, Yuqing; Wei, Fan; Lao, Jiahong; Zhang, Peiyi; Zhao, Tianyue; Guo, Dongbei; Han, Qing; Lin, Honghui; Zhang, Dawei
Journal: SCIENCE SIGNALING. 2026; Vol. 19, Issue 929, pp. -. DOI: 10.1126/scisignal.aea8478
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Hour-scale single-molecule imaging reveals dynamic assembly of the Wnt co-receptors LRP6 and ROR2 into common signalosome
Author: Philippi, Michael; Dohle, Julia; Watrinet, Isabelle; Holtmannspotter, Michael; Miao, Yi; Li, Jinye; Birkholz, Oliver; Rothbauer, Ulrich; Garcia, K. Christopher; Kurre, Rainer; Piehler, Jacob; You, Changjiang
Journal: SCIENCE SIGNALING. 2026; Vol. 19, Issue 927, pp. -. DOI: 10.1126/scisignal.adr8141
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Metabolic alterations after traumatic neural injury: Mechanistic insights and potential translational targets for axon regeneratio
Author: Cao, Qianqian; Zhao, Wenwen; Yan, Junjie; Belin, Stephane; Yu, Bin; Nawabi, Homaira; Mao, Susu
Journal: SCIENCE SIGNALING. 2026; Vol. 19, Issue 926, pp. -. DOI: 10.1126/scisignal.adx9003
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T cell polarization and NFAT activation are stiffness dependent and differentially regulated by the channels PIEZO1 and ORAI
Author: Zhao, Renping; Zhang, Jingnan; Zhang, Sijia; Schwarz, Eva C.; Del Campo, Aranzazu; Hoth, Markus; Qu, Bin
Journal: SCIENCE SIGNALING. 2026; Vol. 19, Issue 922, pp. -. DOI: 10.1126/scisignal.adt9566
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Structural insights into the activation mechanism of the human metabolite receptor HCAR
Author: Gao, Mengru; Zang, ShaoKun; Zhu, Yanqing; Xi, Kun; Du, Yage; Cheng, Shizhuo; Miao, Luwei; Lu, Yanhui; Mao, Chunyou; Zhang, Yan; Ma, Xin
Journal: SCIENCE SIGNALING. 2026; Vol. 19, Issue 919, pp. -. DOI: 10.1126/scisignal.adw1483
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Amphiregulin contributes to neuropathic pain by enhancing glycolysis that stimulates histone lactylation in sensory neuron
Author: Deng, Yu-Tao; Ma, Longfei; Mei, Yixiao; Wang, Ji-Shuai; Bai, Xue-Hui; Zheng, Xuan-Jie; Ren, Jin-Xuan; Zhong, Da; Zhou, Bing-Lin; Dan, Jia; Li, Xue; Gao, Yong-Jing; Yu, Lina; Yan, Min; Jiang, Bao-Chun
Journal: SCIENCE SIGNALING. 2025; Vol. 18, Issue 891, pp. -. DOI: 10.1126/scisignal.adr9397
